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公开(公告)号：US4440356A
公开(公告)日：1984-04-03
申请号：US285987
申请日：1981-07-23
申请人： John C. Lang
发明人： John C. Lang
CPC分类号： B65H35/02 , B65H18/16 , B65H41/00 , B65H2301/4148 , B65H2301/41486
摘要： Machine for separating and longitudinally slitting thin sheet, especially double-rolled aluminum sheet or foil, and for winding it onto two winding shafts in abutting strip coils, each winding station including a displaceable cylinder-biased winding carriage with a deflecting roll and a pressure roll defining a terminal sheet run unaffected by the carriage position. Slitting knives arranged on a rotatable swivel shaft in the winding carriage reach into the sheet path in its terminal run, just ahead of the winding point, the slitting knives being retractable into a safe position through rotation of the swivel shaft.
摘要翻译： 用于分离和纵向分切薄板，特别是双轧铝板或箔的机器，并将其卷绕到邻接的带状线圈中的两个卷绕轴上，每个卷绕站包括具有偏转辊和压力辊的可移位的气缸偏置的卷绕托架 定义不受托架位置影响的端子板运行。 布置在卷绕托架上的可旋转的旋转轴上的分切刀在其终端运行中到达卷绕点的前方的片材路径中，通过旋转轴的旋转可以将分切刀缩回到安全位置。
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公开(公告)号：US06716447B1
公开(公告)日：2004-04-06
申请号：US10088188
申请日：2002-03-14
申请人： John C. Lang
发明人： John C. Lang
IPC分类号： A61K4700
CPC分类号： A61K31/52 , A23L33/105 , A23L33/15 , A23L33/16 , A61K36/53 , A61K31/375 , A61K31/07 , A61K31/355 , A61K2300/00
摘要： Beadlets comprising xanthophylls and carotenes and/or retinoids, dietary supplements comprising these beadlets and methods of use are disclosed.
摘要翻译： 公开了包含叶黄素和胡萝卜素和/或类视色素的珠粒，包含这些珠粒的膳食补充剂和使用方法。
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公开(公告)号：US5858345A
公开(公告)日：1999-01-12
申请号：US833635
申请日：1997-04-08
IPC分类号： A61K31/19 , A61K31/25 , A61K31/78 , A61K31/785 , C08F20/04 , C08F20/22 , C08F22/10 , A61K31/74 , A61K47/30
CPC分类号： C08F20/22 , A61K31/19 , A61K31/25 , A61K31/78 , A61K31/785 , C08F20/04 , C08F22/105 , Y10S514/919
摘要： Ophthalmic compositions containing biocompatible, bioadhesive polymerizable amphipathic mesophase materials useful for repairing retinal tissue tears or retinal detachments are disclosed. In one embodiment, the polymerizable materials, which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated fluorophobic ends, are polymerized in vivo to provide effective, long-lasting repair of torn, ruptured or detached retinal tissue. Ophthalmic applications of these materials are not limited to retinal repair.
摘要翻译： 公开了含有用于修复视网膜组织撕裂或视网膜脱离的生物相容性，生物粘附性可聚合两亲中间相材料的眼用组合物。 在一个实施方案中，包含在不饱和氟疏离末端具有阴离子，阳离子和/或非离子表面活性官能团的取代的氟代烷基或全氟烷基单体的可聚合材料在体内聚合，以提供有效的，持久的修复撕裂，破裂或 分离的视网膜组织。 这些材料的眼科应用不限于视网膜修复。
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公开(公告)号：US5403841A
公开(公告)日：1995-04-04
申请号：US108824
申请日：1993-08-18
IPC分类号： A61K9/08 , A61K9/00 , A61K31/53 , A61K47/36 , A61K31/54 , A61K31/415 , A61K31/715
CPC分类号： A61K9/0048 , Y10S514/912
摘要： Topical ophthalmic compositions of carrageenans which are administrable as a drop but which become more viscous or gel upon instillation in the eye are disclosed. Methods for use of the compositions as topical ophthalmic vehicles for pharmaceutically active agents, and alone as lubricants or tear supplements, are also disclosed.
摘要翻译： 公开了角叉菜胶的局部眼用组合物，其可以滴剂施用，但在滴眼时变得更粘或凝胶。 还公开了将组合物用作药物活性剂的局部眼用载体，以及单独用作润滑剂或泪液补充剂的方法。
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5.发明授权Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions 失效在局部眼用组合物中使用胶凝多糖和细碎药物载体底物的组合
公开(公告)号：US5212162A
公开(公告)日：1993-05-18
申请号：US857673
申请日：1992-03-25
申请人： Paul J. T. Missel , John C. Lang , Rajni Jani
发明人： Paul J. T. Missel , John C. Lang , Rajni Jani
CPC分类号： A61K47/48184 , A61K47/4823 , A61K9/0048 , Y10S514/912 , Y10S514/913
摘要： Ophthalmic compositions comprising combinations of gelling polysaccharides and finely-divided drug carrier substrates which become relatively more viscous on contact with the eye are disclosed. These ophthalmic compositions are both comfortable and long-lasting Ophthalmic compositions further comprising a pharmaceutically active drug are also disclosed, as are methods of use.
摘要翻译： 公开了包含与眼睛接触变得相对更粘稠的胶凝多糖和细碎药物载体基质组合的眼科组合物。 这些眼用组合物既舒适又持久，还公开了进一步包含药物活性药物的眼用组合物，以及使用方法。
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6.发明授权Composition and methods for inhibiting the progression macular degeneration and promoting healthy vision 有权用于抑制黄斑变性进展和促进健康视力的组合物和方法公开(公告)号：US07842722B2
公开(公告)日：2010-11-30
申请号：US10580940
申请日：2004-12-14
申请人： John C. Lang
发明人： John C. Lang
IPC分类号： A61K31/355 , A61K31/07
CPC分类号： A61K45/06 , A23L33/105 , A23L33/15 , A23L33/155 , A23L33/16 , A23V2002/00 , A61K31/015 , A61K31/07 , A61K31/12 , A61K31/355 , A61K31/375 , A61K33/30 , A61K33/34 , A61K36/53 , Y10S514/912 , A61K2300/00 , A23V2200/302 , A23V2250/708 , A23V2250/712 , A23V2250/1588 , A23V2250/1642 , A23V2250/211 , A23V2200/30 , A23V2250/702 , A23V2250/21
摘要： The present invention provides improved dietary supplements and methods for inhibiting the progression of macular degeneration and promoting healthy vision. The dietary supplements of the invention contain cobeadlets comprising vitamin E and carotenoids in the form of Vitamin A, lutein and/or zeaxanthing. The dietary supplements of the invention further contain Vitamin C, copper and zinc and may also contain such ingredients as rosemary, DHA, other vitamins and minerals.
摘要翻译： 本发明提供改善的膳食补充剂和抑制黄斑变性进展并促进健康视力的方法。 本发明的膳食补充剂含有维生素E和维生素A，叶黄素和/或玉米淀粉形式的类胡萝卜素的cobeadlet。 本发明的膳食补充剂还含有维生素C，铜和锌，还可以含有迷迭香，DHA，其他维生素和矿物质等成分。
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公开(公告)号：US20080152710A1
公开(公告)日：2008-06-26
申请号：US12047378
申请日：2008-03-13
申请人： John C. Lang
发明人： John C. Lang
CPC分类号： A61K36/02 , A61K9/167 , A61K9/2081 , A61K9/5073 , A61K31/20 , A61K36/53 , A61K2300/00
摘要： The present invention provides improved beadlet formulations useful for inclusion in dietary supplements customized for improving and maintaining ocular nutrition. In particular, the improved beadlets comprise DHA (docosahexaenoic acid); rosemary and/or its components; and excipients.
摘要翻译： 本发明提供了可用于包含在用于改善和维持眼部营养的膳食补充剂中的改进的珠粒制剂。 特别地，改良的珠粒包含DHA（二十二碳六烯酸）; 迷迭香和/或其成分; 和赋形剂。
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8.发明授权公开(公告)号：US06582721B1
公开(公告)日：2003-06-24
申请号：US09397472
申请日：1999-09-17
申请人： John C. Lang
发明人： John C. Lang
IPC分类号： A61K4700
CPC分类号： A61K31/52 , A23L33/105 , A23L33/15 , A23L33/16 , A61K36/53 , A61K31/375 , A61K31/07 , A61K31/355 , A61K2300/00
摘要： Beadlets comprising xanthophylls and carotenes and/or retinoids, dietary supplements comprising these beadlets and methods of use are disclosed.
摘要翻译： 公开了包含叶黄素和胡萝卜素和/或类视色素的珠粒，包含这些珠粒的膳食补充剂和使用方法。
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公开(公告)号：US06180687B2
公开(公告)日：2001-01-30
申请号：US09313226
申请日：1999-05-17
IPC分类号： C08F2210
CPC分类号： C09K19/3842 , A61K31/19 , A61K31/25 , A61K31/78 , A61K31/785 , C08F20/04 , C08F20/22 , C08F22/105 , Y10S514/912 , Y10S623/905
摘要： In vivo polymerizable intraocular lens compositions which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated fluorophobic ends. The compositions are preferably cured by UV photoinitiation and are useful in repairing torn or detached retinal tissue or forming intraocular lenses in situ.
摘要翻译： 包含在不饱和氟疏离末端具有阴离子，阳离子和/或非离子表面活性官能团的取代氟烷基或全氟烷基单体的体内可聚合眼内透镜组合物。 组合物优选通过UV光引发固化，并且可用于修复撕裂或分离的视网膜组织或原位形成眼内透镜。
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10.发明授权
公开(公告)号：US5874469A
公开(公告)日：1999-02-23
申请号：US583381
申请日：1996-01-05
申请人： Manoj L. Maniar , John C. Lang
发明人： Manoj L. Maniar , John C. Lang
IPC分类号： A61K9/00 , A61K31/08 , A61K31/045 , A61K31/20 , A61K31/22
CPC分类号： A61K9/0048 , A61K9/0026
摘要： Fluoroalkyl hydrocarbons as vehicles for pharmaceutical drugs are disclosed. These vehicles are particularly well-suited for delivering drugs which are insoluble in water or chemically unstable in aqueous media. Pharmaceutical solution compositions based on these vehicles have long shelf lives and provide improved drug bioavailability. In addition, the pharmaceutical compositions of the present invention are nonaqueous, and therefore do not require preservatives or tonicity agents. The invention is particularly useful in the field of ophthalmology.
摘要翻译： 公开了作为药物载体的氟烷基烃。 这些载体特别适用于输送不溶于水或在水性介质中化学不稳定的药物。 基于这些载体的药物溶液组合物具有长的保质期并提供改善的药物生物利用度。 此外，本发明的药物组合物是非水性的，因此不需要防腐剂或张力剂。 本发明在眼科领域特别有用。
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