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    Epidithiodioxopiperazine compound or its derivatives, and the use thereof
    102.
    发明授权
    Epidithiodioxopiperazine compound or its derivatives, and the use thereof 有权

    公开(公告)号：US10045995B2

    公开(公告)日：2018-08-14

    申请号：US15440655

    申请日：2017-02-23

    Applicant: EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION

    Inventor： Sang Won Kang ,  Dong Hoon Kang ,  Doo Jae Lee

    IPC: A61K31/535 ,  A61K31/548

    Abstract: The present invention relates to an epidithiodioxopiperazine derivative represented by the following Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mimicking the activity of 2-Cys-Prx in its reduced form in the cells; a pharmaceutical composition for preventing or treating vascular diseases comprising an epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient; a drug delivery device for local administration including the pharmaceutical composition; and a pharmaceutical composition for inhibiting melanoma metastasis comprising the epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient.

    BINDING INHIBITOR BETWEEN TCTP DIMER TYPE IGE-DEPENDENT HISTAMINE RELEASING FACTOR AND RECEPTOR THEREOF, AND USE THEREOF
    107.
    发明申请
    BINDING INHIBITOR BETWEEN TCTP DIMER TYPE IGE-DEPENDENT HISTAMINE RELEASING FACTOR AND RECEPTOR THEREOF, AND USE THEREOF 审中-公开

    公开(公告)号：US20170158761A1

    公开(公告)日：2017-06-08

    申请号：US15382277

    申请日：2016-12-16

    Applicant: EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION

    Inventor： Kyunglim Lee ,  Dong Hae Shin ,  Mi-Sun Kim ,  Mi Young Kim ,  Jeehye Maeng ,  Hee-Won Lee

    IPC: C07K16/24 ,  A61K9/48 ,  A61K9/20 ,  A61K39/395 ,  A61K9/14

    Abstract: The present invention relates to a receptor-binding domain of an IgE-dependent histamine releasing factor (HRF), and a use thereof, and more specifically, ascertains, as an HRF structual region, and a FL domain and an H2 domain which bind to a receptor of HRF existing in a cell membrane, ascertains the C-terminus domain of the HRF, and ascertains that a material binding thereto inhibits IL-8 secretion, thereby determining that the FL and H2 domains and the C-terminus domain can be utilized in: the development of a therapeutic agent for treatment and prevention of HRF-related disease including allergic diseases such as asthma, bronchitis, chronic obstructive pulmonary disease, bronchiectasis, rhinitis, atopic dermatitis, hives (urticaria), hay fever, conjunctivitis, and anaphylaxis; inflammatory diseases such as bronchitis, pneumonia, arthritis, nephritis, psoriasis, dermatitis, Crohn's disease, enteritis, gingivitis, arteriosclerosis, coronary arteritis, hepatitis, Behcet's disease, bladder cancer, prostatitis, pyelonephritis, glomerulonephritis, osteomyelitis, thyroiditis, uveitis, abdominal cavity inflammation, meningitis, pulmonary fibrosis and rheumatoid arthritis; and malaria, and a method for screening for the HRF-related diseases.

    PEPTIDE HAVING CELL MEMBRANE PENETRATING ACTIVITY
    109.
    发明申请
    PEPTIDE HAVING CELL MEMBRANE PENETRATING ACTIVITY 有权
    具有细胞膜活化活性的肽

    公开(公告)号：US20160324976A1

    公开(公告)日：2016-11-10

    申请号：US15141731

    申请日：2016-04-28

    Applicant: EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION

    Inventor： Kyunglim LEE

    IPC: A61K47/48 ,  C07K7/06 ,  A61K48/00 ,  C07K14/46

    CPC classification number: A61K47/64 ,  A61K47/65 ,  A61K48/0008 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  C07K14/46 ,  C07K14/47 ,  C07K16/18

    Abstract: Provided are transmembrane complexes that contain a protein transduction domain (PTD) from the N-terminus of IgE-dependent histamine-releasing factor (HRF) and a target substance that is to be delivered into a cell. Also provided are nucleic acid molecules encoding the transmembrane complex and methods of delivering the target substance into a cell interior by contacting the transmembrane complex with a cell. Also provided are transfection kits containing the PTD and the target substance.

    Abstract translation: 提供了包含来自IgE依赖性组胺释放因子（HRF）的N末端的蛋白转导结构域（PTD）和待递送至细胞的靶物质的跨膜复合物。 还提供了编码跨膜复合物的核酸分子和通过使跨膜复合物与细胞接触将靶物质递送到细胞内部的方法。 还提供了含有PTD和目标物质的转染试剂盒。

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