Temperature sensor circuit and semiconductor device including the same

    公开(公告)号:US10594303B2

    公开(公告)日:2020-03-17

    申请号:US16221341

    申请日:2018-12-14

    Abstract: A temperature sensor circuit may include a ring oscillator being enabled according to an enable signal and outputting a square wave signal with a first frequency, a divider dividing the first frequency of the square wave signal from the ring oscillator to generate a pulse signal with a second frequency, a counter counting a time interval of the pulse signal outputted from the divider according to an external clock to generate a count signal, a latch temporarily storing a value of the counter signal according to the pulse signal and outputting a digital code, and a supply voltage monitor being enabled according to the pulse signal, comparing a reference voltage to one or more comparison voltages and generating a switching logic signal. The reference voltage is kept at a substantially constant level when a level of a supply voltage changes.

    TEMPERATURE SENSOR CIRCUIT AND SEMICONDUCTOR DEVICE INCLUDING THE SAME

    公开(公告)号:US20190207591A1

    公开(公告)日:2019-07-04

    申请号:US16221341

    申请日:2018-12-14

    Abstract: A temperature sensor circuit may include a ring oscillator being enabled according to an enable signal and outputting a square wave signal with a first frequency, a divider dividing the first frequency of the square wave signal from the ring oscillator to generate a pulse signal with a second frequency, a counter counting a time interval of the pulse signal outputted from the divider according to an external clock to generate a count signal, a latch temporarily storing a value of the counter signal according to the pulse signal and outputting a digital code, and a supply voltage monitor being enabled according to the pulse signal, comparing a reference voltage to one or more comparison voltages and generating a switching logic signal. The reference voltage is kept at a substantially constant level when a level of a supply voltage changes.

    DNA-RNA hybrid particles and manufacturing method thereof

    公开(公告)号:US10253317B2

    公开(公告)日:2019-04-09

    申请号:US15321748

    申请日:2015-06-30

    Abstract: Disclosed are particles which are introduced into target cells and suppress the expression of specific genes, and a method of manufacturing such particles. More particularly, the present invention relates to DNA-RNA hybrid particles that comprise a DNA strand and an RNA strand that binds to the DNA strand through partial complementary base pairing, in which the DNA strand comprises an aptamer sequence that is able to bind to a target protein produced in a target cell, and the RNA strand comprises an siRNA sequence that binds to a target RNA in the target cell to suppress protein expression from the target RNA. Such hybrid particles are capable of effectively delivering an siRNA therapeutic agent into target cells for the treatment of disease, and have resistance against digestion by in vivo nucleases, DNase and RNase, owing to complementary binding formed between DNA and RNA strands. Also, the present invention relates to a method of manufacturing such DNA-RNA hybrid particles.

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