公开(公告)号：US10123841B2

公开(公告)日：2018-11-13

申请号：US15107401

申请日：2014-12-23

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Nam Kug Kim ,  Sang Min Lee ,  Min Ho Lee ,  Joon Beom Seo ,  Se Youn Park

IPC: A61B34/10 ,  A61B6/03 ,  A61B10/02 ,  A61B17/34 ,  A61B34/30 ,  A61N1/05 ,  A61N1/372 ,  G06K9/62 ,  G06T7/00 ,  G06T15/06 ,  G06F19/00 ,  G06T17/00 ,  G06T19/20 ,  G06T7/12 ,  A61B34/37 ,  A61B90/00

Abstract: The present disclosure relates to a method for generating an insertion trajectory of a surgical needle from an entry point to a target, including the steps of: preparing a medical image including the target and an anatomical structure; and extracting an insertion trajectory in consideration of at least one of a degree of invasion into the anatomical structure through the insertion trajectory and a distance of the insertion trajectory. Further, the present disclosure relates to a method for generating an insertion trajectory of a medical device, and a robot for interventional procedures including needle insertion.

公开(公告)号：US20170367595A1

公开(公告)日：2017-12-28

申请号：US15546245

申请日：2015-08-25

Applicant: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Chae Hun LEEM ,  Young Boum LEE ,  Moo Yong RHEE

IPC: A61B5/0285 ,  A61B5/021 ,  A61B5/02

CPC classification number: A61B5/0285 ,  A61B5/02 ,  A61B5/02007 ,  A61B5/021

Abstract: The present invention relates to an apparatus for measuring blood circulation disorders, and a method therefor. The apparatus for measuring blood circulation disorders using a pulse wave transit time includes a measurement unit configured to measure a pulse wave and an electrocardiogram of a subject to be measured, a detection unit configured to detect time information of a peak value point of the electrocardiogram and a peak value point and a foot value point of the pulse wave, an operation unit configured to calculate an average pulse wave transit time using the time information of the peak value point of the electrocardiogram and the peak value point and the foot value point of the pulse wave and calculate a blood circulation disorder determination index using the average pulse wave transit time, and a diagnosis unit configured to diagnose a blood circulation disorder using the blood circulation disorder determination index.

公开(公告)号：US20170016867A1

公开(公告)日：2017-01-19

申请号：US14927911

申请日：2015-10-30

Applicant: University of Ulsan Foundation For Industry Cooperation

Inventor： Gwiy-Sang CHUNG

IPC: G01N33/00 ,  H01B1/04

CPC classification number: G01N33/0036 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  H01B1/04 ,  Y10S977/752 ,  Y10S977/773 ,  Y10S977/892 ,  Y10S977/957

Abstract: A flexible nitrogen dioxide sensor based on tungsten trioxide nanoparticles-loaded multi-walled carbon nanotubes-reduced graphene oxide (WO3 NPs-loaded MWCNTs-RGO) hybrid on a polyimide/polyethylene terephthalate substrate. A viscous gel of the hybrid materials can be prepared by the assistance of α-terpineol. The fabricated sensor shows excellent sensing performance toward NO2 which may have a maximum response of 17% (to 5 ppm), a limit of detection of 1 ppm, and relatively short response/recovery time (7/15 min). The sensor may exhibit excellent mechanical flexibility and sensing properties at room temperature without any significant performance degradation even at a curvature angle of 90° and after 106 times of bending/relaxing processes. Low cost, light weight and mechanical robustness of the proposed WO3 NPs-MWCNTs-RGO hybrid based sensor can be a promising element for the development of flexible NO2 gas sensors having higher performance.

Abstract translation: 在聚酰亚胺/聚对苯二甲酸乙二醇酯基材上的基于三氧化硫纳米粒子负载的多壁碳纳米管还原型石墨烯氧化物（WO 3 NPs负载MWCNTs-RGO）混合物的柔性二氧化氮传感器。 混合材料的粘稠凝胶可以通过α-萜品醇的辅助来制备。 制造的传感器显示出对NO2的优异的感测性能，其可以具有17％（至5ppm）的最大响应，1ppm的检测限和相对较短的响应/恢复时间（7/15分钟）。 传感器在室温下表现出优异的机械灵活性和感测特性，即使在曲率角为90°和106次弯曲/松弛过程之后也不会显着降低性能。 所提出的WO3 NPs-MWCNTs-RGO混合型传感器的低成本，轻量化和机械鲁棒性可以是开发具有更高性能的柔性NO 2气体传感器的有前途的元素。

公开(公告)号：US20160040168A1

公开(公告)日：2016-02-11

申请号：US14779874

申请日：2014-03-27

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Tae Won Kim ,  Dong Hoon Jin ,  Seung Woo Hong ,  Jai Hee MOON ,  Jae Sik Shin ,  Jin Sun Kim ,  Kyung Ah Jung ,  Jung Shin Lee ,  Eun Kyung Choi ,  Jae Lyun Lee ,  Yong Sang Hong ,  Kyu Pyo Kim ,  Ky Youb Nam ,  Bong Cheol Kim

IPC: C12N15/113 ,  A23L1/30 ,  G01N33/50 ,  A61K31/4245 ,  C12Q1/68

CPC classification number: C12N15/1137 ,  A23L33/13 ,  A23V2002/00 ,  A61K31/4245 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2310/531 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011

Abstract: The present invention relates to a composition for treatment or metastasis suppression of cancers which includes a p34 expression inhibitor or activity inhibitor as an active ingredient. According to the present invention, the p34 protein knock-down causes monoubiquitination of PTEN and accordingly nuclear localization of PTEN is induced, as a result, an Akt pathway which is related to survival, proliferation, invasive properties and metastatic properties of tumors is inhibited, and thus there is an effect of significantly reducing clonogenic potential and tumor forming potential of various cancer cells which simultaneously express PTEN and NEDD4-1. Consequently, the p34 gene expression inhibitor or p34 protein activity inhibitor according to the present invention can be effectively used as a treatment agent or a metastasis suppression agent for cancers.

Abstract translation: 本发明涉及包含p34表达抑制剂或活性抑制剂作为活性成分的癌症治疗或转移抑制组合物。 根据本发明，p34蛋白敲低引起PTEN的单泛素化，因此诱导PTEN的核定位，结果与抑制肿瘤的存活，增殖，侵袭性质和转移性质有关的Akt途径， 因此具有显着降低同时表达PTEN和NEDD4-1的各种癌细胞的克隆潜能和肿瘤形成潜力的作用。 因此，本发明的p34基因表达抑制剂或p34蛋白活性抑制剂可以有效地用作癌症的治疗剂或转移抑制剂。

公开(公告)号：US20140377737A1

公开(公告)日：2014-12-25

申请号：US14381972

申请日：2013-03-04

Applicant: Dalim Tissen Inc. ,  University of Ulsan Foundation for Industry Cooperation

Inventor： Song Cheol Kim ,  Si-Nae Park ,  Sun Young Kong ,  Jae-hyung Ko

IPC: A61K35/39

CPC classification number: A61K35/39 ,  A61L27/26 ,  A61L27/3804 ,  C12N5/0676 ,  C12N11/02 ,  C12N2533/54 ,  C12N2533/74 ,  C08L89/06 ,  C08L5/04

Abstract: The present invention provides a method of culturing pancreatic islet cells using a cationized atelocollagen prepared by ionization of high purity atelocollagen, a method of preparing a carrier for pancreatic islet cell transplantation using a cationized atelocollagen, and an artificial pancreas prepared using the same. According to the present invention, it is possible to increase the viability and/or glucose-dependent insulin secretion of pancreatic islet cells during culture of the cells by the use of a cationized atelocollagen or crosslinked atelocollagen scaffold obtained by ionization of high purity atelocollagen. In addition, it is possible to increase the viability and glucose-dependent insulin secretion of cultured and transplanted pancreatic islet cells by the use of a highly stable carrier for pancreatic islet cell transplantation that comprises cationized atelocollagen and alginate.

Abstract translation: 本发明提供使用通过离子化高纯度成纤维细胞而制备的阳离子化的无血清胶原蛋白培养胰岛细胞的方法，使用阳离子化的atelocollagen制备用于胰岛细胞移植的载体的方法和使用其制备的人造胰腺。 根据本发明，可以通过使用通过离子化高纯度胶原蛋白获得的阳离子化的胶原蛋白或交联的胶原骨架来增加细胞培养期间胰岛细胞的存活力和/或葡萄糖依赖性胰岛素分泌。 此外，通过使用包含阳离子化的胶原和藻酸盐的胰岛细胞移植的高度稳定的载体，可以增加培养和移植的胰岛细胞的存活力和葡萄糖依赖性胰岛素分泌。

公开(公告)号：US12211203B2

公开(公告)日：2025-01-28

申请号：US17633113

申请日：2020-08-05

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Soo Jin Kang ,  Hyun Seok Min

IPC: G06T7/00 ,  A61B5/00 ,  A61B5/02 ,  G16H30/40 ,  G16H50/20

Abstract: The disclosure purposes to provide an optical coherence tomography (OCT)-based system for diagnosing a high risk lesion such as a vulnerable atheromatous plaque by using an artificial intelligence model through deep learning. A deep learning-based diagnostic method of diagnosing a high risk lesion of a coronary artery includes: acquiring an OCT image of a coronary artery lesion of a patient; extracting a first feature of a thin cap from the OCT image; setting a region of interest included in the OCT image on a basis of the first feature; and determining whether the region of interest includes a high risk lesion.

公开(公告)号：US20240369412A1

公开(公告)日：2024-11-07

申请号：US18557769

申请日：2022-04-28

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Sang Yeob KIM ,  Chan Gi PACK

IPC: G01J3/457 ,  G01J3/44 ,  G01N21/64 ,  G01N33/58 ,  G01N33/68

Abstract: A method of quantifying fluorescent dyes labeled on extracellular vesicles, including providing an extracellular vesicle molecule labeled with a fluorescence dye molecule, and determining a brightness of each of the extracellular vesicle molecule labeled with the fluorescence dye molecule and the fluorescence dye molecule through fluorescence correlation spectroscopy (FCS) of the extracellular vesicle molecule and the fluorescence dye molecule.

公开(公告)号：US12090566B2

公开(公告)日：2024-09-17

申请号：US17293038

申请日：2018-11-14

Applicant: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Sung-Tae Hong ,  Doo-Man Chun ,  Hong-Seok Park ,  Heung Nam Han ,  Ju Won Park ,  Yongfang Li ,  Dinh Son Nguyen

IPC: B23K11/30 ,  B33Y10/00 ,  B33Y80/00

CPC classification number: B23K11/30 ,  B33Y10/00 ,  B33Y80/00

Abstract: An electrically assisted pressure joining apparatus and an electrically assisted pressure joining method join a first metal member and a second metal member together, and includes an electrode portion, an intermediate portion including a plurality of micropores and inserted between a first metal member and a second metal member, and a pressure portion connected to the electrode portion to receive a current from the electrode portion and transfer the current to the first metal member and the second metal member to apply a pressure to the first metal member such that the first metal member and the second metal member are joined together by the intermediate portion.

公开(公告)号：US12070487B2

公开(公告)日：2024-08-27

申请号：US17418684

申请日：2019-12-24

Applicant: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  THE ASAN FOUNDATION

Inventor： You Sook Cho ,  Jun Pyo Choi ,  In Jeoung Baek ,  Hyouk Soo Kwon ,  So Young Park

IPC: A61K38/17 ,  A61K45/06 ,  A61P11/06

CPC classification number: A61K38/1709 ,  A61K45/06 ,  A61P11/06

Abstract: The present invention relates to a pharmaceutical composition comprising a progesterone-induced blocking factor (PIBF) protein as an active ingredient for prevention or treatment of inflammatory disease. In the present invention, menopausal asthma animal models have been experimentally identified to decrease airway inflammation when treated with PIBF protein. Thus, the composition can be advantageously used in postmenopausal female asthma patients.

公开(公告)号：US20240115614A1

公开(公告)日：2024-04-11

申请号：US18262341

申请日：2022-01-14

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Hun Sik KIM ,  Seong Who KIM ,  Eunbi YI ,  Hyojeong KIM ,  Jung Min KIM ,  Woo Seon CHOI

IPC: A61K35/28 ,  A61P37/06 ,  C07K14/705 ,  C12N5/0775 ,  C12N15/86

CPC classification number: A61K35/28 ,  A61P37/06 ,  C07K14/70503 ,  C12N5/0662 ,  C12N15/86 ,  C12N2740/15043

Abstract: A method for treating a cell damage-related disease, including administering a composition to a subject in need thereof. The composition contains, as an active ingredient, one or more selected from the group consisting of stem cells genetically engineered to overexpress a carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family protein, cells differentiated from the stem cells, and components derived from the stem cells.