公开(公告)号：US06915160B2

公开(公告)日：2005-07-05

申请号：US10071875

申请日：2002-02-08

申请人： Angelo Auricchio ,  Julio C. Spinelli ,  Andrew P. Kramer

发明人： Angelo Auricchio ,  Julio C. Spinelli ,  Andrew P. Kramer

IPC分类号： A61B5/0452 ,  A61N1/362 ,  A61N1/368 ,  A61N1/365

CPC分类号： A61N1/3627 ,  A61B5/0452 ,  A61N1/3684

摘要： A cardiac rhythm management device in which amplitudes of electrograms from one or more cardiac sites are measured in order to ascertain the extent of hypertrophy. The device may then pace the heart by delivering pacing therapy in a manner that unloads the hypertrophied myocardium to effect reversal of undesirable remodeling.

摘要翻译： 一种心律管理装置，其中测量来自一个或多个心脏部位的电描记图，以确定肥大程度。 然后，该装置可以通过以卸载肥厚心肌来实现不期望的重塑逆转的方式通过输送起搏治疗来对心脏进行加速。

公开(公告)号：US06885890B2

公开(公告)日：2005-04-26

申请号：US10027794

申请日：2001-12-20

申请人： Julio C. Spinelli ,  Qingsheng Zhu ,  Andrew P. Kramer ,  Jeffrey E. Stahmann

发明人： Julio C. Spinelli ,  Qingsheng Zhu ,  Andrew P. Kramer ,  Jeffrey E. Stahmann

IPC分类号： A61N1/362 ,  A61N1/368

CPC分类号： A61N1/3622 ,  A61N1/3684

摘要： An apparatus and method for treating ventricular tachycardia in which paces are delivered to the ventricles at multiple pacing sites in accordance with an anti-tachycardia pacing protocol. Paces are delivered at a selected offset interval in a manner that both resynchronizes ventricular contractions and increases the probability of terminating the tachycardia.

摘要翻译： 一种用于治疗室性心动过速的装置和方法，其中根据抗心动过速起搏方案，将步道在多个起搏部位输送到心室。 以选择的偏移间隔以两者重新同步心室收缩并增加终止心动过速的可能性的方式递送步态。

公开(公告)号：US06704598B2

公开(公告)日：2004-03-09

申请号：US09862181

申请日：2001-05-23

申请人： Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

发明人： Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

IPC分类号： A61N1365

CPC分类号： A61N1/3684 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/368

摘要： A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction-evoking stimulation therapy is delivered from the selected electrode.

摘要翻译： 心脏节律管理系统基于在多个电极处的去极化基准点的检测之间的相对定时或基于在多个电极之间的去极化基准点的检测之间的延迟来选择与特定心室相关联的多个电极中的一个，以及 在与相同或不同的心室相关联的另一电极处检测参考去极化基准点。 随后的收缩诱导刺激疗法从所选择的电极递送。

公开(公告)号：US06363278B1

公开(公告)日：2002-03-26

申请号：US09549862

申请日：2000-04-14

申请人： Jeffrey E. Stahmann ,  Andrew P. Kramer ,  Julio C. Spinelli

发明人： Jeffrey E. Stahmann ,  Andrew P. Kramer ,  Julio C. Spinelli

IPC分类号： A61N1368

CPC分类号： A61N1/3627 ,  A61N1/3622 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3716

摘要： A cardiac rhythm management system for coordination therapy includes a pulse generator to generate pacing and discharging of recharge pulses. A pulse delivery controller coupled to the pulse generator, times the delivery of the pacing and discharging of recharge pulses in a desired sequence. A therapy circuit coupled to the pulse delivery controller, receives the timed pulses from the pulse delivery controller and delivers the timed pulses to one or more electrodes disposed in or around a heart to communicate the timed pacing and discharging of recharge pulses to different sites of a heart, to avoid any interactions resulting from the electric fields surrounding the electrodes during a multiple site pacing required by the coordination therapy.

公开(公告)号：US07828711B2

公开(公告)日：2010-11-09

申请号：US10919016

申请日：2004-08-16

申请人： Jeffrey Ross ,  Julio C. Spinelli

发明人： Jeffrey Ross ,  Julio C. Spinelli

IPC分类号： A61N1/362 ,  A61K9/22 ,  A61M31/00

CPC分类号： A61M5/14276 ,  A61M1/1006 ,  A61M1/1086 ,  A61M1/12 ,  A61M1/122 ,  A61M5/1723 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2210/125

摘要： A system delivers combined ventricular assist device (VAD) therapy and chemical and/or biological therapy to modulate myocardial tissue growth in a heart after myocardial infarction (MI). The system includes an agent delivery device to release one or more agents to an MI region to modulate myocardial tissue growth in that region, and a VAD to enhance the effects of the one or more agents by reducing myocardial wall stress and the overall cardiac workload. In one embodiment, the system is an implantable system including an implantable agent delivery device and an implantable VAD for long-term use in a patient.

摘要翻译： 系统提供组合心室辅助装置（VAD）治疗和化学和/或生物治疗以调节心肌梗死（MI）后心脏中的心肌组织生长。 该系统包括将一种或多种药剂释放到MI区域以调节该区域中的心肌组织生长的药剂递送装置和VAD，以通过降低心肌壁压力和整体心脏负荷来增强一种或多种药剂的作用。 在一个实施例中，该系统是可植入系统，其包括可植入剂递​​送装置和用于患者长期使用的可植入VAD。

公开(公告)号：US08295927B2

公开(公告)日：2012-10-23

申请号：US12254631

申请日：2008-10-20

申请人： Jiang Ding ,  Yinghong Yu ,  Julio C. Spinelli ,  Jeffrey E. Stahmann

发明人： Jiang Ding ,  Yinghong Yu ,  Julio C. Spinelli ,  Jeffrey E. Stahmann

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61B5/053 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.

摘要翻译： 本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。 第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。 第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。 第三个例子测量峰 - 峰体积或最大心室容积变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

公开(公告)号：US08214026B2

公开(公告)日：2012-07-03

申请号：US12976397

申请日：2010-12-22

申请人： Yinghong Yu ,  Jiang Ding ,  Jeng Mah ,  Julio C. Spinelli

发明人： Yinghong Yu ,  Jiang Ding ,  Jeng Mah ,  Julio C. Spinelli

IPC分类号： A61B5/0452

CPC分类号： A61B5/0452 ,  A61B5/0456 ,  A61B34/20 ,  A61B2034/2072 ,  A61N1/3627 ,  A61N1/3682

摘要： Systems and methods for determining the coronary sinus vein branch location of a left ventricle electrode are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart including sensing one or more of the electrical events with the electrode and then analyzing the electrical events to determine the electrode's position. The determination of electrode position may be used to automatically adjust operating parameters of a VRT device. Furthermore, the determination of electrode position may be made in real-time during installation of the electrode and a visual indication of the electrode position may be provided on a display screen.

摘要翻译： 公开了用于确定左心室电极的冠状静脉窦静脉分支位置的系统和方法。 系统和方法涉及检测患者心脏内的电事件的发生，包括用电极感测一个或多个电事件，然后分析电气事件以确定电极的位置。 电极位置的确定可用于自动调整VRT器件的工作参数。 此外，可以在电极的安装期间实时地确定电极位置，并且可以在显示屏上提供电极位置的视觉指示。

公开(公告)号：US20110040347A1

公开(公告)日：2011-02-17

申请号：US12902844

申请日：2010-10-12

申请人： Imad Libbus ,  Julio C. Spinelli ,  Randy Westlund ,  Julia Moffitt ,  Tong Wang

发明人： Imad Libbus ,  Julio C. Spinelli ,  Randy Westlund ,  Julia Moffitt ,  Tong Wang

IPC分类号： A61N1/362 ,  A61N1/08

CPC分类号： A61N1/3627 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/057 ,  A61N1/0587 ,  A61N1/36114 ,  A61N2001/0585

摘要： An embodiment includes a main lead assembly having a proximal portion adapted for connection to a device and a distal portion adapted for placement in a coronary sinus, the distal portion terminating in a distal end for placement proximal a left ventricle. Additionally, the main lead assembly includes a left ventricular electrode located at its distal end which is adapted to deliver cardiac resynchronization therapy to reduce ventricular wall stress. The main lead assembly also includes a fat pad electrode disposed along the main lead assembly a distance from the distal end to position the fat pad electrode proximal to at least one parasympathetic ganglia located in a fat pad bounded by an inferior vena cava and a left atrium. The fat pad electrode is adapted to stimulate the parasympathetic ganglia to reduce ventricular wall stress.

摘要翻译： 一个实施例包括具有适于连接到装置的近端部分和适于放置在冠状窦中的远端部分的主引导组件，该远端部分终止于用于放置在左心室附近的远端。 另外，主引线组件包括位于其远端处的左心室电极，其适于递送心脏再同步治疗以减少心室壁应力。 主引线组件还包括脂肪垫电极，沿着主引线组件设置距离远端的距离，以将脂肪垫电极定位在靠近由下腔静脉和左心房限定的脂肪垫中的至少一个副交感神经节 。 脂肪垫电极适于刺激副交感神经节以减少心室壁应力。

公开(公告)号：US07840266B2

公开(公告)日：2010-11-23

申请号：US11077970

申请日：2005-03-11

申请人： Imad Libbus ,  Julio C. Spinelli ,  Randy Westlund ,  Julia Moffitt ,  Sophia H. Wang

发明人： Imad Libbus ,  Julio C. Spinelli ,  Randy Westlund ,  Julia Moffitt ,  Sophia H. Wang

IPC分类号： A61N1/08

CPC分类号： A61N1/3627 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/057 ,  A61N1/0587 ,  A61N1/36114 ,  A61N2001/0585

摘要： An embodiment includes a main lead assembly having a proximal portion adapted for connection to a device and a distal portion adapted for placement in a coronary sinus, the distal portion terminating in a distal end for placement proximal a left ventricle. Additionally, the main lead assembly includes a left ventricular electrode located at its distal end which is adapted to deliver cardiac resynchronization therapy to reduce ventricular wall stress. The main lead assembly also includes a fat pad electrode disposed along the main lead assembly a distance from the distal end to position the fat pad electrode proximal to at least one parasympathetic ganglia located in a fat pad bounded by an inferior vena cava and a left atrium. The fat pad electrode is adapted to stimulate the parasympathetic ganglia to reduce ventricular wall stress.

摘要翻译： 一个实施例包括具有适于连接到装置的近端部分和适于放置在冠状窦中的远端部分的主引导组件，该远端部分终止于用于放置在左心室附近的远端。 另外，主引线组件包括位于其远端处的左心室电极，其适于递送心脏再同步治疗以减少心室壁应力。 主引线组件还包括脂肪垫电极，沿着主引线组件设置距离远端的距离，以将脂肪垫电极定位在靠近由下腔静脉和左心房限定的脂肪垫中的至少一个副交感神经节 。 脂肪垫电极适于刺激副交感神经节以减少心室壁应力。

公开(公告)号：US07738953B2

公开(公告)日：2010-06-15

申请号：US11203756

申请日：2005-08-15

申请人： Qingsheng Zhu ,  Avram Scheiner ,  Julio C. Spinelli

发明人： Qingsheng Zhu ,  Avram Scheiner ,  Julio C. Spinelli

IPC分类号： A61N1/36

CPC分类号： A61N1/326 ,  A61N1/0587

摘要： A method and device for preventing plaque build-up in a coronary artery includes providing an electrical field generating device, and generating an electrical field in the coronary artery to prevent plaque build-up in the coronary artery. The method further includes sensing the heart rhythm and generating the electrical field after a depolarization wave in the heart. The electrical field is generated by circuitry, in one embodiment implanted circuitry, connected to leads which are epicardially or intracardially positioned on the heart.

摘要翻译： 用于防止冠状动脉斑块积聚的方法和装置包括提供电场产生装置，并且在冠状动脉中产生电场以防止冠状动脉中的斑块积聚。 该方法还包括感测心脏节律并在心脏中去极化波之后产生电场。 电场由电路产生，在一个实施例中，植入电路连接到心外膜或心内置于心脏上的引线。