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公开(公告)号：US07851594B2
公开(公告)日：2010-12-14
申请号：US11829011
申请日：2007-07-26
申请人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen , Steven D. Hughes
发明人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen , Steven D. Hughes
IPC分类号： C07K14/52
CPC分类号： C07K14/715 , A61K38/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
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102.发明授权Method for expanding hematopoietic cells using cytokine zalpha11 ligand 有权使用细胞因子zalpha11配体扩增造血细胞的方法公开(公告)号：US07829075B2
公开(公告)日：2010-11-09
申请号：US11551127
申请日：2006-10-19
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。
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103.发明授权Method of using interferon-like protein ZCYTO21 (IL-29) to treat hepatitis C 有权使用干扰素样蛋白ZCYTO21（IL-29）治疗丙型肝炎的方法公开(公告)号：US07655223B2
公开(公告)日：2010-02-02
申请号：US11873272
申请日：2007-10-16
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
摘要翻译： 本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。 本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。
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公开(公告)号：US07638602B2
公开(公告)日：2009-12-29
申请号：US11782545
申请日：2007-07-24
申请人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
发明人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
IPC分类号： C07K14/705
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
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公开(公告)号：US07611699B2
公开(公告)日：2009-11-03
申请号：US11551349
申请日：2006-10-20
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。
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公开(公告)号：US20090264624A1
公开(公告)日：2009-10-22
申请号：US12435218
申请日：2009-05-04
申请人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen , Steven D. Hughes
发明人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen , Steven D. Hughes
IPC分类号： C07K14/715
CPC分类号： C07K14/715 , A61K38/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
摘要翻译： 细胞因子及其受体已被证明在基础研究和治疗方面都是有用的。 本发明提供了称为“Zcytor16”的新的人细胞因子受体。
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公开(公告)号：US07592425B2
公开(公告)日：2009-09-22
申请号：US11551362
申请日：2006-10-20
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US20090069274A1
公开(公告)日：2009-03-12
申请号：US11873272
申请日：2007-10-16
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
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公开(公告)号：US07498154B2
公开(公告)日：2009-03-03
申请号：US11925097
申请日：2007-10-26
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
摘要翻译： 本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。 本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。
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110.发明授权Nucleic acid encoding a human allelic variant of interferon-like protein ZCYTO21 有权编码干扰素样蛋白ZCYTO21的人等位基因变体的核酸公开(公告)号：US07445913B2
公开(公告)日：2008-11-04
申请号：US11548023
申请日：2006-10-10
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
摘要翻译： 本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。 本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。
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