公开(公告)号：US20120231017A1

公开(公告)日：2012-09-13

申请号：US13415404

申请日：2012-03-08

申请人： ZHAONING ZHU ,  Brian McKittrick ,  Zhong-Yue Sun ,  Yuanzan C. Ye ,  Johannes H. Voigt ,  Corey O. Strickland ,  Elizabeth M. Smith ,  Andrew Stamford ,  William J. Greenlee ,  Robert D. Mozzola ,  John P. Caldwell ,  Jared N. Cumming ,  Lingyan Wang ,  Yusheng Wu ,  Ulrich Iserloh ,  Xiaoiang Liu ,  Tao Guo ,  Thuy X. E. Le ,  Kurt W. Sainoz ,  Suresh D. Babu ,  Rachael C. Hunter ,  Michelle L. Morris ,  Huizhong Gu ,  Gang Qian ,  Dawit Tadesse ,  Ying Huang ,  Guoqing Li ,  Jianping Pan ,  Jeffrey A. Misiaszek ,  Gaifa Lai ,  Jingqi Duo ,  Chuanxing Qu ,  Yuefei Shao

发明人： ZHAONING ZHU ,  Brian McKittrick ,  Zhong-Yue Sun ,  Yuanzan C. Ye ,  Johannes H. Voigt ,  Corey O. Strickland ,  Elizabeth M. Smith ,  Andrew Stamford ,  William J. Greenlee ,  Robert D. Mozzola ,  John P. Caldwell ,  Jared N. Cumming ,  Lingyan Wang ,  Yusheng Wu ,  Ulrich Iserloh ,  Xiaoiang Liu ,  Tao Guo ,  Thuy X. E. Le ,  Kurt W. Sainoz ,  Suresh D. Babu ,  Rachael C. Hunter ,  Michelle L. Morris ,  Huizhong Gu ,  Gang Qian ,  Dawit Tadesse ,  Ying Huang ,  Guoqing Li ,  Jianping Pan ,  Jeffrey A. Misiaszek ,  Gaifa Lai ,  Jingqi Duo ,  Chuanxing Qu ,  Yuefei Shao

IPC分类号： A61K39/395 ,  C07D239/70 ,  C07F5/02 ,  C07D403/10 ,  A61K31/513 ,  A61K31/506 ,  C07D409/04 ,  C07D409/14 ,  C07D401/04 ,  C07D405/14 ,  C07D417/14 ,  C07D417/04 ,  C07D413/14 ,  C07D413/10 ,  A61K31/5377 ,  A61P29/00 ,  A61P9/00 ,  A61P25/28 ,  A61P31/10 ,  A61P33/02 ,  C07D495/04 ,  A61P25/00 ,  A61P31/04 ,  C07D239/22

CPC分类号： C07D233/88 ,  A61K31/4168 ,  A61K31/4178 ,  C07D239/22 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/10 ,  C07D417/14 ,  C07D495/10

摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

公开(公告)号：US20120230311A1

公开(公告)日：2012-09-13

申请号：US13475343

申请日：2012-05-18

申请人： Alex KESSLEMAN ,  Guoqing Li

发明人： Alex KESSLEMAN ,  Guoqing Li

IPC分类号： H04B7/212 ,  H04W84/12

CPC分类号： H04W72/121 ,  H04W16/28 ,  H04W84/18

摘要： An embodiment of the present invention provides a method, comprising configuring a transceiver for special reuse using a virtual time division multiple access (TDMA) technique in a wireless personal area network that allows additional non-interfering transceivers to perform concurrent transmissions with said transceiver.

摘要翻译： 本发明的实施例提供了一种方法，其包括在无线个域网中使用虚拟时分多址（TDMA）技术来配置用于特殊重用的收发器，所述无线个域网允许附加的非干扰收发器与所述收发器执行并发传输。

公开(公告)号：US20120057517A1

公开(公告)日：2012-03-08

申请号：US12877152

申请日：2010-09-08

申请人： Srikanth Kambhatla ,  Guoqing Li

发明人： Srikanth Kambhatla ,  Guoqing Li

IPC分类号： H04J3/08

CPC分类号： H04W28/02 ,  G06F3/1423 ,  G06F3/1454 ,  G09G2340/0407 ,  G09G2350/00 ,  G09G2370/025 ,  G09G2370/045 ,  G09G2370/10 ,  G09G2370/12 ,  G09G2370/16 ,  H04N21/4122 ,  H04N21/43615 ,  H04N21/43635 ,  H04N21/43637 ,  H04W80/00

摘要： Wireless sinks, such as displays, may receive wirelessly transmitted audio/video information in clone mode. In one embodiment, the same audio/video stream may be provided to a plurality of sinks daisy chained from a wireless receiver.

摘要翻译： 诸如显示器的无线接收器可以以克隆模式接收无线传输的音频/视频信息。 在一个实施例中，相同的音频/视频流可以被提供给从无线接收器菊花链链接的多个接收器。

公开(公告)号：US20110294513A1

公开(公告)日：2011-12-01

申请号：US13057363

申请日：2009-08-07

申请人： Guoqing Li ,  Li Chen ,  Jiayi Fang

发明人： Guoqing Li ,  Li Chen ,  Jiayi Fang

IPC分类号： H04W72/04

CPC分类号： H04W74/008 ,  H04W74/0833 ,  H04W74/0866

摘要： A method, a system and a device for indicating and transmitting the preamble are used to solve the problem existing in the prior art, which reduces the resource utilization efficiency due to that the user equipment (UE) sends the preamble to the evolution base station through the physical random access channel (PRACH) selected by itself in the present random access. The method includes: determining the channel signature associated with the PRACH assigned to the terminal side; sending the determined channel signature to the terminal side, and indicating the terminal side to transmit the preamble using the PRACH associated with the channel signature. Adopting said method can improve the resource utilization efficiency.

摘要翻译： 用于指示和发送前同步码的方法，系统和装置用于解决现有技术中存在的问题，这降低了资源利用效率，这是由于用户设备（UE）将前导码发送到演进基站，通过 在当前随机接入中自身选择的物理随机接入信道（PRACH）。 该方法包括：确定与分配给终端侧的PRACH相关联的信道签名; 将确定的信道签名发送到终端侧，并且指示终端侧使用与频道签名相关联的PRACH来发送前导码。 采用该方法可以提高资源利用效率。

公开(公告)号：US08012953B2

公开(公告)日：2011-09-06

申请号：US12571840

申请日：2009-10-01

申请人： Andrew W. Stamford ,  Ying Huang ,  Guoqing Li ,  Corey O. Strickland ,  Johannes H. Voigt

发明人： Andrew W. Stamford ,  Ying Huang ,  Guoqing Li ,  Corey O. Strickland ,  Johannes H. Voigt

IPC分类号： A61K31/33 ,  C07D513/00

CPC分类号： C07D498/04 ,  C07D413/06

摘要： Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, n and X are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease. Also disclosed are methods of treating a cognitive or neurodegenerative disease comprising administering to a patient I need of such treatment a combination of at least one compound of formula I and at least one compound selected from the group consisting of β-secretase inhibitors other than those of formula I, HMG-CoA reductase inhibitors, gamma-secretase inhibitors, non-steroidal anti-inflammatory agents, N-methyl-D-aspartate receptor antagonists, cholinesterase inhibitors and anti-amyloid antibodies.

摘要翻译： 公开了下式的新化合物或其药学上可接受的盐或溶剂化物，其中R1，R2，R3，n和X如说明书中所定义。 还公开了包含式I化合物的药物组合物。还公开了治疗认知或神经变性疾病如阿尔茨海默病的方法。 还公开了治疗认知或神经退行性疾病的方法，包括向需要这种治疗的患者施用至少一种式I化合物和至少一种选自除了那些的那些之外的其他化合物 式I，HMG-CoA还原酶抑制剂，γ-分泌酶抑制剂，非甾体抗炎剂，N-甲基-D-天冬氨酸受体拮抗剂，胆碱酯酶抑制剂和抗淀粉样蛋白抗体。

公开(公告)号：US20110044303A1

公开(公告)日：2011-02-24

申请号：US12542741

申请日：2009-08-18

申请人： Xuquan Ji ,  Guoqing Li ,  Lei Shen

发明人： Xuquan Ji ,  Guoqing Li ,  Lei Shen

IPC分类号： H04W4/00 ,  H04L12/43

CPC分类号： H04W74/085

摘要： Device, system, and method of adjusting a contention window for wireless transmission. In some embodiments, a wireless communication unit may control transmissions of a wireless communication device in a wireless area network during a contention period, wherein the wireless communication unit is to select a back-off period within a contention-window having a contention-window size, which is adjusted based on a number of stations included in the wireless area network, and wherein the wireless communication unit is to wait for the back-off period prior to beginning a wireless transmission during the contention period. Other embodiments are described and claimed.

摘要翻译： 调整无线传输竞争窗口的装置，系统和方法。 在一些实施例中，无线通信单元可以在竞争时段期间控制无线区域网络中的无线通信设备的传输，其中所述无线通信单元将在具有竞争窗口大小的竞争窗口内选择退避时段 ，其基于包括在无线区域网络中的多个站点进行调整，并且其中无线通信单元将在竞争周期期间等待开始无线传输之前的退避时段。 描述和要求保护其他实施例。

公开(公告)号：US07598250B2

公开(公告)日：2009-10-06

申请号：US10911030

申请日：2004-08-04

申请人： Jared N. Cumming ,  Ying Huang ,  Guoqing Li ,  Ulrich Iserloh ,  Andrew Stamford ,  Corey Strickland ,  Johannes H. Voigt ,  Yusheng Wu ,  Jianping Pan ,  Tao Guo ,  Douglas W. Hobbs ,  Thuy X. H. Le ,  Jeffrey F. Lowrie

发明人： Jared N. Cumming ,  Ying Huang ,  Guoqing Li ,  Ulrich Iserloh ,  Andrew Stamford ,  Corey Strickland ,  Johannes H. Voigt ,  Yusheng Wu ,  Jianping Pan ,  Tao Guo ,  Douglas W. Hobbs ,  Thuy X. H. Le ,  Jeffrey F. Lowrie

IPC分类号： A61K31/506 ,  A61K31/496 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

CPC分类号： C04B35/632 ,  C07D207/277 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

摘要： Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is X is —O—, —C(R14)2— or —N(R)—; Z is —C(R14)2— or —N(R)—; t is 0, 1, 2 or 3; each R and R2 is independently H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, alkenyl or alkynyl; each R14 is H, alkyl, alkenyl, alkynyl, halo, —CN, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, —OR35, —N(R24)(R25) or —SR35; R41 is alkyl, cycloalkyl, —SO2(alkyl), —C(O)-alkyl, —C(O)-cycloalkyl or -alkyl-NH—C(O)CH3; and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I and methods of treating cognitive or neurodegenerative diseases with compounds of formula I.Also disclosed are pharmaceutical compositions and methods of treatment comprising compounds of formula I in combination with other agents useful in treating cognitive or neurodegenerative diseases.

摘要翻译： 公开了下式的新化合物或其药学上可接受的盐或溶剂合物，其中R 1是X是-O - ， - C（R 14）2 - 或-N（R） - ; Z是-C（R 14）2 - 或-N（R） - ; t为0,1,2或3; 每个R和R 2独立地为H，烷基，环烷基，环烷基烷基，芳基，杂芳基，杂环烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，烯基或炔基; 每个R 14是H，烷基，烯基，炔基，卤素，-CN，卤代烷基，环烷基，环烷基烷基，芳基，杂芳基，杂环烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，-OR 35，-N（R 24）（R 25）或-SR 35; R41是烷基，环烷基，-SO2（烷基），-C（O） - 烷基，-C（O） - 环烷基或 - 烷基-NH-C（O）CH3; 其余变量如本说明书中所定义。 还公开了包含式I化合物的药物组合物和用式I化合物治疗认知障碍或神经变性疾病的方法。还公开了药物组合物和治疗方法，其包含式I化合物与用于治疗认知或神经变性的其它药剂 疾病

公开(公告)号：US20090232035A1

公开(公告)日：2009-09-17

申请号：US12157216

申请日：2008-06-09

申请人： Carlos Cordeiro ,  Guoqing Li ,  Praveen Gopalakrishnan

发明人： Carlos Cordeiro ,  Guoqing Li ,  Praveen Gopalakrishnan

IPC分类号： H04B7/00

CPC分类号： H01Q3/26 ,  H04B7/0682 ,  H04W72/046

摘要： In a wireless communications network containing network devices capable of both directional and omnidirectional communications, a network controller may arrange a series of superframes into groups of multiple consecutive superframes, in which only one superframe in each group contains an omnidirectional beacon, and the remainder of the superframes in the group contain only directional beacons.

摘要翻译： 在包含能够进行定向和全向通信的网络设备的无线通信网络中，网络控制器可以将一系列超帧排列成多个连续超帧的组，其中每个组中只有一个超帧包含全向信标，而其余的 组中的超帧只包含方向信标。

公开(公告)号：US20090052574A1

公开(公告)日：2009-02-26

申请号：US11843171

申请日：2007-08-22

申请人： Guoqing Li ,  Srikathyayani Srikanteswara ,  Christian Maciocco

发明人： Guoqing Li ,  Srikathyayani Srikanteswara ,  Christian Maciocco

IPC分类号： H04L25/00

CPC分类号： H04L1/0001 ,  H04W16/14

摘要： Disclosed is a Media Access Control (MAC) adaptation method for adapting transmission of packets by a wireless device in response to interference in a wireless medium. On detecting interference in the wireless medium, the wireless device triggers sensing of wireless spectrum to determine presence of a periodic interference signal. A first energy level and a second energy level of the periodic interference signal are estimated and a threshold energy level is set between the first energy level and the second energy level for transmission of packets by the wireless device. Based on the threshold energy level and a current energy level in the wireless medium, the wireless device transmits packets over the wireless medium.

摘要翻译： 公开了一种媒体接入控制（MAC）适配方法，用于响应于无线介质中的干扰，适配无线设备对分组的传输。 在检测无线介质中的干扰时，无线设备触发对无线频谱的感测以确定周期性干扰信号的存在。 估计周期性干扰信号的第一能级和第二能级，并且在第一能级和第二能级之间设置阈值能级以便无线设备传输分组。 基于无线介质中的阈值能级和当前能级，无线设备通过无线介质发送分组。

公开(公告)号：US20090047906A1

公开(公告)日：2009-02-19

申请号：US11837996

申请日：2007-08-13

申请人： Guoqing Li

发明人： Guoqing Li

IPC分类号： H04B1/00

CPC分类号： H04B1/1027 ,  H04W16/14 ,  H04W74/08

摘要： Disclosed are a method and system for triggering a wireless device to perform sensing of wireless spectrum to detect microwave signal interference in a wireless medium. The wireless device transmits one or more packets and checks the status of transmission for each packet. Based on the status of transmission of the packet, counters are updated. Symbols are generated to correspond to an ON/OFF pattern of an interference signal, when the counters exceed a pre-defined threshold value. A plurality of symbols corresponding to transmission of one or more packets forms a sequence. The sequence is compared with a pre-defined pattern. The occurrence of a match between the sequence and the pre-defined pattern signifies presence of a periodic interference signal. Sensing of wireless spectrum is then triggered to detect microwave signal interference.

摘要翻译： 公开了一种用于触发无线设备来执行无线频谱的感测以检测无线介质中的微波信号干扰的方法和系统。 无线设备发送一个或多个分组，并检查每个分组的传输状态。 根据分组的传输状态，更新计数器。 当计数器超过预定义的阈值时，生成符号以对应于干扰信号的ON / OFF模式。 对应于一个或多个分组的传输的多个符号形成序列。 将序列与预定义模式进行比较。 序列和预定义模式之间的匹配的出现表示存在周期性干扰信号。 然后触发无线频谱的检测，以检测微波信号的干扰。