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119 条记录 (耗时 0.027 秒)

    Synthesis of 2-acyl substituted chromanes and intermediates thereof
    102.
    发明授权
    Synthesis of 2-acyl substituted chromanes and intermediates thereof 失效
    2-酰基取代的苯并吡喃的合成及其中间体

    公开(公告)号：US06903227B2

    公开(公告)日：2005-06-07

    申请号：US10297103

    申请日：2001-06-01

    申请人： James Kanter ,  John J. G. Mullins ,  Anjali Pandey ,  Robert Scarborough

    发明人： James Kanter ,  John J. G. Mullins ,  Anjali Pandey ,  Robert Scarborough

    IPC分类号： C07D311/22 ,  C07D311/58 ,  C12P17/06

    CPC分类号： C07D311/58 ,  C07D311/22

    摘要： Novel processes for producing enantiomerically enriched and enantiomerically pure compositions of 2-acyl substituted chromane compounds, and 2-acylchromane compounds that are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors are disclosed. Further disclosed are processes for producing salts such as acid addition salts for such enantiomerically enriched compositions.

    摘要翻译： 公开了用于产生2-酰基取代的色烯化合物的对映体富集和对映体纯的组合物的新方法和作为制备血小板聚集抑制剂的中间体和/或本身是有效的血小板聚集抑制剂的2-酰基苯并二氢吡喃化合物。 进一步公开的是制备盐的方法，例如这种对映异构体富集的组合物的酸加成盐。

    2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists
    104.
    发明授权
    2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists 失效
    可用作NMDA受体拮抗剂的2-哌啶羧酸衍生物

    公开(公告)号：US5260286A

    公开(公告)日：1993-11-09

    申请号：US961811

    申请日：1992-10-16

    申请人： John A. Lawson ,  Anjali Pandey ,  Dennis Yasuda ,  Masato Tanabe

    发明人： John A. Lawson ,  Anjali Pandey ,  Dennis Yasuda ,  Masato Tanabe

    IPC分类号： C07F9/59 ,  C07F9/06 ,  C07F9/38 ,  A61K31/675

    CPC分类号： C07F9/598 ,  C07F9/592

    摘要： Compounds of formula I ##STR1## wherein X is ##STR2## or .dbd.N--O--, in which R.sub.4 is hydrogen or halogen, R.sub.1, R.sub.2, and R.sub.3 independently represent hydrogen or a C.sub.1-4 alkyl group, and n has a value of zero to four are disclosed. Also disclosed are pharmaceutically acceptable salts of these compounds, pharmaceutical compositions of these compounds or salts with a pharmaceutically acceptable carrier, the use of these materials as N-methyl-D-aspartate receptor antagonists, processes for preparing these compounds and salts, and methods to treat cerebral diseases by administering an effective amount of these compounds, salts or compositions.

    摘要翻译： 式Ⅰ的化合物其中X为X或= NO-，其中R 4为氢或卤素，R 1，R 2和R 3独立地表示氢或C 1-4烷基，并且n的值为零 到四个被公开。 还公开了这些化合物的药学上可接受的盐，这些化合物的药物组合物或与药学上可接受的载体的盐，这些物质用作N-甲基-D-天冬氨酸受体拮抗剂，制备这些化合物和盐的方法和方法 通过施用有效量的这些化合物，盐或组合物来治疗脑疾病。