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公开(公告)号：US20230102416A1
公开(公告)日：2023-03-30
申请号：US17563421
申请日：2021-12-28
Inventor： Yanqin WANG , Wanjun GUO , Shuang XIANG , Xiaohui LIU , Yong GUO
IPC: B01J23/75 , C07C209/78 , B01J35/00 , B01J37/18 , B01J37/03 , B01J37/08 , B01J23/83 , B01J23/882 , B01J23/78
Abstract: Disclosed is a method for efficiently synthesizing primary amines, which comprises using carbonyl compounds or alcohol compounds as reaction substrate, liquid ammonia or alcohol solutions of ammonia as nitrogen source, and hydrogen as hydrogen source, and reacting in reaction medium catalyzed by a cobalt-based catalyst to obtain the primary amines. Due to high catalytic activity, the method can realize the reductive amination of carbonyl compounds and the hydrogen-borrowing amination of alcohol compounds at low temperatures in a short time to obtain the primary amines with high yield, and is applicable to a wide range of substrates. The obtained primary amines can be used as raw materials with high extra value for producing polymers, medicines, dyes and surfactants. Further, the cobalt-based catalyst has a good industrial application prospect because it is magnetic which can facilitate separation and recycling of the catalyst. Moreover, the inexpensive cobalt-based catalyst can significantly reduce industrialization cost.
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公开(公告)号：US20230002769A1
公开(公告)日：2023-01-05
申请号：US17607102
申请日：2020-04-28
Inventor： Yi YANG , Linyong ZHU , Xianjun CHEN , Dasheng ZHANG , Ni SU , Qiuning LIN
IPC: C12N15/115 , C07C255/58 , C12Q1/6876 , C12N15/10 , C07C255/53 , C07D241/20 , C07D213/74 , C07D239/42 , C07D213/85 , C07D241/24 , C07D263/56 , C07D277/64 , C07D333/60 , C07D495/04 , C09K11/06
Abstract: The present application relates to an aptamer nucleic acid molecule, a complex containing the aptamer nucleic acid molecules, a method of detecting intracellular or extracellular RNA, DNA or other target molecules, and a kit containing the aptamer. The aptamer of the present application is capable of specifically binding a kind of fluorophore micromolecules, and can significantly enhance fluorescence intensity under excitation light of appropriate wavelength.
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103.发明申请公开(公告)号：US20220301661A1
公开(公告)日：2022-09-22
申请号：US17631080
申请日：2020-12-02
Inventor： Wenli DU , Minglei YANG , Weimin ZHONG , Feng QIAN , Zhi LI
Abstract: A method and system for predicting products of an aromatic hydrocarbon isomerization production process are provided. The method includes generating multiple initial sample points, using a mechanism the actual output response values of all of the initial sample points; establishing an radial basis function (RBF) model according to the initial sample points and actual output response values thereof; using a particle swarm optimization (PSO) algorithm to find expected deviation between nearest neighbors as well as the sampling point having the largest sparsity product, using mechanism model to calculate the output response value of said sampling point on RBF model, adding output response value into the sample points, and reconstructing the surrogate model; repeating the previous step until the upper limit for the number of sample points is reached to obtain a final RBF model; and using the RBF model to predict product yield of aromatic hydrocarbon isomerization.
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公开(公告)号：US20220275282A1
公开(公告)日：2022-09-01
申请号：US17627824
申请日：2020-06-16
Inventor： Yulong CHANG , Hualin WANG , Xia JIANG , Jianping LI , Jingyi ZHU , Pengbo FU , Wei YUAN
IPC: C10G3/00
Abstract: A method and apparatus for hydrocracking mineralized refuse pyrolysis oil. The method may use the following steps: (a) crushing and pyrolyzing mineralized refuse to obtain arene and alkane precursor biomass oil; (b) hydrogenating the arene and alkane precursor biomass oil obtained in step (a), and separating the obtained hydrocrackate to obtain arene and alkane; and (c) purifying, recovering and optimizing the arene and alkane obtained in step (b), and performing deep processing to produce naphtha, jet fuel, light diesel oil, and heavy diesel oil.
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公开(公告)号：US20220226539A1
公开(公告)日：2022-07-21
申请号：US17199835
申请日：2021-03-12
Inventor： Yuan YUAN , Haoyi NIU , Hua HONG , Yongsheng LI , Lili SUN
Abstract: The present disclosure relates to a composite scaffold containing DFO and rhBMP-2 capable of synergistically stimulating bone formation, a preparation method and use thereof. The composite scaffold contains a matrix, a PEGS gel layer and rhBMP-2, wherein the matrix is an MBG scaffold grafted with DFO on the surface, the PEGS gel layer is carried on the surface of the matrix, and rhBMP-2 is carried inside the PEGS gel layer. In the present disclosure, the function of DFO and rhBMP-2 in vivo and in vitro can be regulated by precisely controlling the immobilization mode and spatial distribution of DFO and rhBMP-2 in the scaffold, and the all-round repair of “rapid enrichment of target cells—angiogenesis-guided bone” can be achieved.
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Patent Agency Ranking
106.发明授权公开(公告)号：US11384036B2
公开(公告)日：2022-07-12
申请号：US17403321
申请日：2021-08-16
Inventor： Yanqin Wang , Yaxuan Jing , Yong Guo , Xiaohui Liu , Ning Yan
Abstract: Disclosed is a method for preparing aromatic hydrocarbons by hydrocracking a polymer containing aromatic rings, which includes reacting the polymer fragment with hydrogen under the action of a catalyst at a temperature of no more than 350° C.; separating a reaction product to obtain the aromatic hydrocarbons. The catalyst comprises a carrier and an active ingredient supported on the carrier, the active ingredient is at least one selected from Ru, Rh, Pt, Pd, Fe, Ni, Cu and Co, the carrier is at least one selected from metal oxide, phosphate, molecular sieve, SiO2 and sulfonated carbon, the metal oxide is at least one selected from Al2O3, Nb2O5, Nb2O5—Al2O3, Nb2O5—SiO2, TiO2, ZrO2, CeO2 and MoO3; the phosphate is at least one selected from NbOPO4 and ZrOPO4; and the molecule sieve is at least one selected from Nb-SBA-15, Nafion, H-ZSM-5, H-Beta and H-Y.
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公开(公告)号：US11320353B2
公开(公告)日：2022-05-03
申请号：US17286567
申请日：2019-10-10
Inventor： Fuzhen Xuan , Tianye Niu , Jianguo Gong
Abstract: A creep strength analysis and assessment method includes comparing whether a maximum value of a local strain and a membrane strain are less than a corresponding allowable strain, and if less, determining that a component is safe; otherwise, performing the following steps: performing stress linearization on a path to obtain a local primary membrane stress PL and a local primary bending stress Pb; averaging shear stress components on the path to obtain an average shear stress τm; obtaining a strength limit Smt, a time-independent minimum stress strength value Sm and a temperature- and time-dependent stress strength limit St for a given material, a design lifetime and a design temperature; comparing whether PL, PL+Pb and PL+Pb/Kt are less than Smt, KSm and St; and comparing whether τm is less than 0.6Sm and 0.6St, and if less, the component is safe, otherwise, the component is unsafe.
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公开(公告)号：US20210341365A1
公开(公告)日：2021-11-04
申请号：US17286567
申请日：2019-10-10
Inventor： Fuzhen Xuan , Tianye Niu , Jianguo Gong
Abstract: A creep strength analysis and assessment method includes comparing whether a maximum value of a local strain and a membrane strain are less than a corresponding allowable strain, and if less, determining that a component is safe; otherwise, performing the following steps: performing stress linearization on a path to obtain a local primary membrane stress PL and a local primary bending stress Pb; averaging shear stress components on the path to obtain an average shear stress τm; obtaining a strength limit Smt, a time-independent minimum stress strength value Sm and a temperature- and time-dependent stress strength limit St for a given material, a design lifetime and a design temperature; comparing whether PL, PL+Pb and PL+Pb/Kt are less than Smt, KSm and St; and comparing whether τm is less than 0.6Sm and 0.6St, and if less, the component is safe, otherwise, the component is unsafe.
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公开(公告)号：US20210155752A1
公开(公告)日：2021-05-27
申请号：US17058739
申请日：2019-06-13
Inventor： Runhui Liu , Yueming Wu
Abstract: The present invention relates to a strong base-initiated N-carboxyanhydride rapid ring-opening polymerisation method. Specifically, the method comprises steps of: performing a polymerisation reaction with one or more amino acid N-carboxyanhydride monomers in an organic solvent in the presence of an initiator, so as to form an amino acid polymer, wherein the initiator is selected from the following group: LiHMDS, NaHMDS, KHMDS, or a combination thereof. The method significantly increases the speed of traditional NCA polymerisation and prepares a long-chain polymer, and the prepared amino acid polymer may be used as an anti-bacterial material, an anti-tumour material, a tissue engineering scaffold or a self-assembling material.
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110.发明授权公开(公告)号：US10895560B2
公开(公告)日：2021-01-19
申请号：US16651722
申请日：2018-03-18
Inventor： Daqi Gao , Zejian Wang , Xiaoqin Zhang , Jiamin Song
Abstract: Provided is a sensory quality evaluation method for tobacco and tobacco products using an electronic nose instrument. The electronic nose instrument includes a gas sensor array module, an automatic smoke sampling system, a computer control and data analysis system, and an automatic ignition device. These components are integrated in a test box to make the instrument be structure miniaturization and work automation. The large tobacco data is established, in which the relationship between the responses of gas sensor array and the brand labels and sensory quality index scores by testing a large number of standard cigarette samples. A cascade type of modular neural networks is proposed with revised activation function and new decision-making and quantification rules to simulate the smoking and evaluating process of the professional panel. The electronic nose instrument and method realize on-site detection, discrimination and quality score estimation of a large number of tobacco and tobacco products.
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