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公开(公告)号:US12083249B2
公开(公告)日:2024-09-10
申请号:US18084247
申请日:2022-12-19
Applicant: Surmodics, Inc.
Inventor: Joram Slager , Toni M. Heyer , David E. Babcock
IPC: A61L29/08 , A61K31/337 , A61K31/713 , A61K47/34 , A61L29/14 , A61L29/16 , A61M25/10 , C12N15/113 , A61K9/50
CPC classification number: A61L29/085 , A61K31/337 , A61K31/713 , A61K47/34 , A61L29/14 , A61L29/16 , A61M25/10 , C12N15/113 , A61K9/5031 , A61L2300/258 , A61L2300/416 , A61L2300/606 , A61L2300/608 , A61L2300/62 , A61L2300/802 , A61L2420/06 , A61L2420/08 , A61M2025/105 , C12N2310/14 , C12N2320/32 , A61L29/085 , C08L39/06 , A61L29/085 , C08L33/26
Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.
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公开(公告)号:US11980730B2
公开(公告)日:2024-05-14
申请号:US17123512
申请日:2020-12-16
Applicant: Surmodics, Inc.
Inventor: Gregg Sutton , Charles Olson , Karl V. Ganske
IPC: A61M29/02
CPC classification number: A61M29/02 , A61M2029/025 , A61M2210/12
Abstract: An anchored dilator includes a push tube having proximal and distal push tube portions. A dilator tip is coupled with the distal push tube portion and is configured for selectable coupling with a catheter. The dilator tip includes an anchor cuff having a cuff interface. The anchor cuff is configured to transition between a shuttle configuration having a shuttle profile and an anchored configuration having an anchored profile larger than the shuttle profile. A cuff operator assembly is configured to transition the anchor cuff between the anchored and shuttle configurations. The cuff operator assembly includes a cuff operator movably coupled with the dilator tip, and an operator shaft coupled with the cuff operator. The operator shaft extends toward the proximal push tube portion. Actuation of the cuff operator with the operator shaft transitions the anchor cuff between the shuttle configuration and the anchored configuration.
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公开(公告)号:US20230338622A1
公开(公告)日:2023-10-26
申请号:US18084247
申请日:2022-12-19
Applicant: Surmodics, Inc.
Inventor: Joram Slager , Toni M. Heyer , David E. Babcock
IPC: A61L29/08 , A61K47/34 , A61K31/713 , A61L29/16 , A61K31/337 , A61L29/14 , C12N15/113 , A61M25/10 , A61K9/50
CPC classification number: A61L29/085 , A61K47/34 , A61K31/713 , A61L29/16 , A61K31/337 , A61L29/14 , C12N15/113 , A61M25/10 , A61L2300/416 , C12N2310/14 , A61L2300/62 , A61L2420/06 , A61L2300/802 , A61K9/5031 , A61M2025/105 , A61L2300/608 , A61L2300/606 , C12N2320/32 , A61L2300/258 , A61L2420/08
Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.
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公开(公告)号:US11478815B2
公开(公告)日:2022-10-25
申请号:US17149390
申请日:2021-01-14
Applicant: Surmodics, Inc.
Inventor: Ralph A. Chappa , Michael Militello
Abstract: Aspects herein relate to coating apparatus and methods for coating medical devices. In an embodiment, a coating system is included having a valve, a fluid supply reservoir in fluid communication with the valve, a reciprocating positive displacement pump in fluid communication with the valve, and a fluid applicator in fluid communication with the three-way valve. The valve can be configured to assume a first fluid transport state and a second fluid transport state, wherein the valve provides fluid communication between the fluid supply reservoir and the reciprocating positive displacement pump when in the first fluid transport state for filling of the reciprocating positive displacement pump, and wherein the valve provides fluid communication between the reciprocating positive displacement pump and the fluid applicator when in the second fluid transport state for applying a coating suspension to a medical device surface. Other embodiments are also included herein.
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公开(公告)号:US11278647B2
公开(公告)日:2022-03-22
申请号:US15474601
申请日:2017-03-30
Applicant: Surmodics, Inc.
Inventor: Mike Militello
Abstract: Embodiments of the disclosure include lubricious coatings. In an embodiment the disclosure includes a lubricious coating for a medical device including an acrylic acid polymer, an acrylamide copolymer comprising at least one photoreactive group, and a cross-linking agent comprising at least two photoreactive groups. The coating can be used on a catheter surface to facilitate its movement in the body.
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公开(公告)号:US20210212721A1
公开(公告)日:2021-07-15
申请号:US17128138
申请日:2020-12-20
Applicant: Surmodics, Inc.
Inventor: Derek Stratton , John Bridgeman
IPC: A61B17/3207 , A61M25/10
Abstract: In an example, a scoring device is configured for retention of a catheter shaft. The scoring device incudes a proximal portion and a distal portion. A retention sleeve extends between the proximal and distal portions. The retention sleeve has a catheter socket configured to selectively receive and mechanically engage the catheter shaft. The scoring device includes a scoring tool coupled with the retention sleeve, for instance proximate to the distal portion. The scoring tool includes a balloon socket configured to selectively receive a balloon of the catheter shaft. The scoring tool includes one or more scoring elements extending around the balloon socket, the one or more scoring elements configured to provide localized scoring to vasculature.
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公开(公告)号:US20210178134A1
公开(公告)日:2021-06-17
申请号:US17123512
申请日:2020-12-16
Applicant: Surmodics, Inc.
Inventor: Gregg Sutton , Charles Olson , Karl V. Ganske
IPC: A61M29/02
Abstract: An anchored dilator includes a push tube having proximal and distal push tube portions. A dilator tip is coupled with the distal push tube portion and is configured for selectable coupling with a catheter. The dilator tip includes an anchor cuff having a cuff interface. The anchor cuff is configured to transition between a shuttle configuration having a shuttle profile and an anchored configuration having an anchored profile larger than the shuttle profile. A cuff operator assembly is configured to transition the anchor cuff between the anchored and shuttle configurations. The cuff operator assembly includes a cuff operator movably coupled with the dilator tip, and an operator shaft coupled with the cuff operator. The operator shaft extends toward the proximal push tube portion. Actuation of the cuff operator with the operator shaft transitions the anchor cuff between the shuttle configuration and the anchored configuration.
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公开(公告)号:US10905802B2
公开(公告)日:2021-02-02
申请号:US15643564
申请日:2017-07-07
Applicant: Surmodics, Inc.
Inventor: David E. Babcock
Abstract: Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.
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119.
公开(公告)号:US10898446B2
公开(公告)日:2021-01-26
申请号:US15840540
申请日:2017-12-13
Applicant: Surmodics, Inc.
Inventor: Timothy M. Kloke
IPC: A61K9/70 , A61L29/16 , A61L29/08 , A61L31/10 , A61L31/16 , A61L27/34 , A61K31/337 , A61K31/436 , A61K47/34 , A61K47/32 , A61L27/54
Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, a drug delivery coating is included herein having a base polymeric layer, the base polymeric layer including a hydrophilic polyether block amide copolymer and having a hydrophilic surface. The drug delivery coating can further include a therapeutic agent layer forming an exterior surface the drug delivery coating, the therapeutic agent layer contacting the hydrophilic surface of the base polymeric layer and having a composition different than the base polymeric layer, the therapeutic agent layer including a particulate hydrophobic therapeutic agent and a cationic agent. Other embodiments are also included herein.
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公开(公告)号:US20200237971A1
公开(公告)日:2020-07-30
申请号:US16847272
申请日:2020-04-13
Applicant: Surmodics, Inc.
Inventor: Joram Slager , Toni M. Heyer , David E. Babcock
IPC: A61L29/08 , C12N15/113 , A61M25/10 , A61K47/34 , A61K31/713 , A61K31/337 , A61L29/14 , A61L29/16
Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.
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