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    COATING APPLICATION SYSTEM AND METHODS FOR COATING ROTATABLE MEDICAL DEVICES
    1.
    发明申请
    COATING APPLICATION SYSTEM AND METHODS FOR COATING ROTATABLE MEDICAL DEVICES 有权

    公开(公告)号：US20220219194A1

    公开(公告)日：2022-07-14

    申请号：US17571095

    申请日：2022-01-07

    Applicant: Surmodics, Inc.

    Inventor： Ralph A. Chappa

    IPC: B05D1/00 ,  A61L29/16 ,  A61L31/16 ,  A61M25/10

    Abstract: Embodiments herein relate to a system for coating rotatable medical devices and related methods. In an embodiment, a coating system for coating rotatable medical devices is included. The coating system can include a rotation mechanism, wherein the rotation mechanism is configured to mount and rotate a rotatable medical device. The coating system can also include a fluid applicator unit. The fluid applicator unit can include a rotating retention sleeve, the rotating retention sleeve defining a channel, wherein the rotatable medical device fits within the channel. The fluid applicator unit can also include a retention sleeve drive mechanism, wherein the retention sleeve drive mechanism is configured to rotate the rotating retention sleeve. The coating system can also include an inner collar, wherein the inner collar fits within the channel of the rotating retention sleeve. Other embodiments are also included herein.

    APPARATUS AND METHODS FOR COATING MEDICAL DEVICES
    2.
    发明申请
    APPARATUS AND METHODS FOR COATING MEDICAL DEVICES 有权
    用于涂敷医疗器械的装置和方法

    公开(公告)号：US20130337147A1

    公开(公告)日：2013-12-19

    申请号：US13906599

    申请日：2013-05-31

    Applicant: SurModics, Inc.

    Inventor： Ralph A. Chappa ,  Andrew G. Bach ,  Mark MacGregor

    IPC: A61M25/10 ,  A61L29/08

    CPC classification number: A61M25/1029 ,  A61L29/08 ,  A61M25/1027 ,  A61M2025/1031 ,  A61M2025/105 ,  B05B13/0442

    Abstract: Embodiments of the invention include apparatus and methods for coating drug eluting medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit comprising a movement restriction structure; a fluid applicator; and an air nozzle. The apparatus can further include a rotation mechanism and an axial motion mechanism, the axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.

    Abstract translation: 本发明的实施方案包括用于涂敷药物洗脱医学装置的装置和方法。 在一个实施例中，本发明包括涂覆装置，其包括包括运动限制结构的涂布施加单元; 流体施加器; 和空气喷嘴。 该装置还可包括旋转机构和轴向运动机构，所述轴向运动机构构造成使涂层施加单元和旋转机构中的至少一个相对于彼此移动。 本文还包括其它实施例。

    COATING SYSTEMS FOR MEDICAL DEVICES
    5.
    发明申请
    COATING SYSTEMS FOR MEDICAL DEVICES 有权

    公开(公告)号：US20210220866A1

    公开(公告)日：2021-07-22

    申请号：US17149390

    申请日：2021-01-14

    Applicant: Surmodics, Inc.

    Inventor： Ralph A. Chappa ,  Michael Militello

    IPC: B05C11/10 ,  A61L29/08 ,  B05C11/08

    Abstract: Aspects herein relate to coating apparatus and methods for coating medical devices. In an embodiment, a coating system is included having a valve, a fluid supply reservoir in fluid communication with the valve, a reciprocating positive displacement pump in fluid communication with the valve, and a fluid applicator in fluid communication with the three-way valve. The valve can be configured to assume a first fluid transport state and a second fluid transport state, wherein the valve provides fluid communication between the fluid supply reservoir and the reciprocating positive displacement pump when in the first fluid transport state for filling of the reciprocating positive displacement pump, and wherein the valve provides fluid communication between the reciprocating positive displacement pump and the fluid applicator when in the second fluid transport state for applying a coating suspension to a medical device surface. Other embodiments are also included herein.

    APPARATUS AND METHODS FOR COATING MEDICAL DEVICES
    6.
    发明申请
    APPARATUS AND METHODS FOR COATING MEDICAL DEVICES 审中-公开

    公开(公告)号：US20200171531A1

    公开(公告)日：2020-06-04

    申请号：US16696234

    申请日：2019-11-26

    Applicant: Surmodics, Inc.

    Inventor： Ralph A. Chappa ,  Michael Militello

    IPC: B05C17/02 ,  B05C17/03

    Abstract: Embodiments of the invention include apparatus and methods for coating drug coated medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit. The coating application unit can include a fluid applicator having a lengthwise axis and a width. The fluid applicator can include a tip comprising a first face across the width of the fluid applicator. The first face of the fluid applicator can be oriented at an angle of from about 15 to about 75 degrees with respect to the lengthwise axis of the fluid applicator. The fluid applicator can define a second face intersecting the first face. The coating apparatus can further include a rotation mechanism and an axial motion mechanism. Other embodiments are also included herein.

    Lubricious medical device elements
    7.
    发明授权
    Lubricious medical device elements 有权

    公开(公告)号：US10124088B2

    公开(公告)日：2018-11-13

    申请号：US14860128

    申请日：2015-09-21

    Applicant: SurModics, Inc.

    Inventor： Ralph A. Chappa ,  Nathan A. Lockwood ,  Joseph Schmidt McGonigle

    IPC: A61L29/14 ,  A61L29/08 ,  A61L29/04 ,  C08J3/20 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14

    Abstract: Embodiments of the invention include medical device elements formed from polymers with lubricious properties. In an embodiment, a method of forming a medical device element is included. The method can include mixing a first polymeric component and a second polymeric component to form a polymer mixture. The method can further include forming the polymer mixture into the medical device element. The method can also include treating the polymer mixture with at least one of an acid or a base. In an embodiment, a medical device is included. The medical device can include a lubricious element, the lubricious element comprising a mixture of a first polymeric component and a second polymeric component. The second polymeric component can include a polymer that is treated with at least one of an acid or a base after formation of the element. Other embodiments are also included herein.

    Apparatus and methods for coating medical devices
    9.
    发明授权
    Apparatus and methods for coating medical devices 有权
    用于涂敷医疗器械的装置和方法

    公开(公告)号：US09308355B2

    公开(公告)日：2016-04-12

    申请号：US13906599

    申请日：2013-05-31

    Applicant: SurModics, Inc.

    Inventor： Ralph A. Chappa ,  Andrew G. Bach ,  Mark MacGregor

    IPC: A61M25/10 ,  B05B13/02 ,  B05B13/04 ,  A61L29/08

    CPC classification number: A61M25/1029 ,  A61L29/08 ,  A61M25/1027 ,  A61M2025/1031 ,  A61M2025/105 ,  B05B13/0442

    Abstract: Embodiments of the invention include apparatus and methods for coating drug eluting medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit comprising a movement restriction structure; a fluid applicator; and an air nozzle. The apparatus can further include a rotation mechanism and an axial motion mechanism, the axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.

    Abstract translation: 本发明的实施方案包括用于涂敷药物洗脱医学装置的装置和方法。 在一个实施例中，本发明包括涂覆装置，其包括包括运动限制结构的涂布施加单元; 流体施加器; 和空气喷嘴。 该装置还可包括旋转机构和轴向运动机构，所述轴向运动机构构造成使涂层施加单元和旋转机构中的至少一个相对于彼此移动。 本文还包括其它实施例。

    COATINGS WITH CRYSTALLIZED ACTIVE AGENT(S) AND METHODS
    10.
    发明申请
    COATINGS WITH CRYSTALLIZED ACTIVE AGENT(S) AND METHODS 有权
    具有结晶活性剂（S）和方法的涂料

    公开(公告)号：US20150374886A1

    公开(公告)日：2015-12-31

    申请号：US14753186

    申请日：2015-06-29

    Applicant: SurModics, Inc.

    Inventor： Ralph A. Chappa ,  Kimberly K.M. Lindsoe

    IPC: A61L31/16 ,  A61L31/14 ,  A61L31/10

    CPC classification number: A61L31/16 ,  A61K6/0017 ,  A61K31/56 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L31/10 ,  A61L31/14 ,  A61L2300/216 ,  A61L2300/222 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/63 ,  A61L2420/02 ,  A61L2420/06

    Abstract: The present invention relates to coatings with crystallized active agent(s) and related methods. In an embodiment, the invention includes a method for coating a medical device including selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a coating composition having the selected concentration of the active agent, and applying the coating composition to the medical device. In an embodiment, the invention includes an elution control coating disposed on a medical device, the elution control coating including a polymer, and an active agent, wherein the active agent is at least about 80% crystallized within one week of being disposed on the medical device. In an embodiment, the invention includes a method for enhancing the formation of active agent crystals within a coating layer including forming a coating solution and adjusting the concentration of the active agent in the coating solution to reach some percentage of the active agent saturation point. In an embodiment, the invention includes a method of enhancing crystallization of an active agent, the method including forming a coating solution comprising a polymer, an active agent, and a solvent; applying the coating solution to a substrate; and increasing the rate of active agent nucleation within the coating.

    Abstract translation: 本发明涉及具有结晶活性剂的涂层和相关方法。 在一个实施方案中，本发明包括用于涂覆医疗装置的方法，包括选择溶剂和聚合物，选择至少一定量饱和度的活性剂的浓度，形成具有选定浓度的活性剂的涂料组合物 ，并将所述涂料组合物施用于所述医疗装置。 在一个实施方案中，本发明包括设置在医疗装置上的洗脱控制涂层，洗脱控制涂层包括聚合物和活性剂，其中活性剂在被放置在医疗上的一周内至少约80％结晶 设备。 在一个实施方案中，本发明包括一种用于增强涂层内活性剂晶体形成的方法，包括形成涂层溶液并调节涂层溶液中活性剂的浓度达到活性剂饱和点的一定百分比。 在一个实施方案中，本发明包括增强活性剂结晶的方法，所述方法包括形成包含聚合物，活性剂和溶剂的包衣溶液; 将涂布溶液涂布到基材上; 并增加涂层内活性剂成核的速率。

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