公开(公告)号：US20220009300A1

公开(公告)日：2022-01-13

申请号：US17321048

申请日：2021-05-14

Applicant: The Texas A&M University System

Inventor： Moble Benedict ,  Sean M. McHugh ,  Chase B. Wiley ,  Ramsay A. Ramsey ,  Adam Kellen ,  Yin Lu Young

IPC: B60F3/00 ,  B63H1/06 ,  B63H3/00 ,  B63H21/17 ,  B63H25/42

Abstract: An amphibious vehicle for traversing land and bodies of water includes a chassis, and a cycloidal propeller coupled to the chassis and which includes a plurality of cycloidal propeller blades rotatably coupled to the chassis and each extending parallel a rotational axis of the cycloidal propeller, and an extension/retraction system configured to extend the plurality of cycloidal propeller blades away from the chassis and to retract the plurality of cycloidal propeller blades towards the chassis.

公开(公告)号：US20210364442A1

公开(公告)日：2021-11-25

申请号：US17325109

申请日：2021-05-19

Applicant: The Texas A&M University System

Inventor： Pao Tai Lin

IPC: G01N21/65 ,  G01J3/44

Abstract: Raman spectroscopy of chemical and biological samples can be accomplished with photonic sensors amenable to chip-scale integration. In various embodiments, such a photonic sensor includes first and second optical waveguides coupled via an optical ring resonator, the ring resonator configured to resonantly enhance, and selectively couple into the second optical waveguide, a Raman scattering signal generated, when the first waveguide and/or resonator are exposed to a sample, by interaction of an analyte in the sample with excitation light coupled into the first optical waveguide.

公开(公告)号：US20210324869A1

公开(公告)日：2021-10-21

申请号：US17271066

申请日：2019-08-26

Applicant: The Texas A&M University System

Inventor： Abhay R. Patil ,  Gerald Morrison ,  Adolfo Delgado

IPC: F04D29/22 ,  F04D29/041 ,  F04D29/051 ,  F04D13/08 ,  F04D7/02

Abstract: A turbomachine includes a housing having an inlet and an outlet. A shaft is rotationally disposed in the housing. The shaft is rotatable about a longitudinal axis. An impeller is coupled to the shaft between the inlet and the outlet and rotates with the shaft. The impeller includes a single impeller inlet and an impeller outlet, a first set of vanes disposed on a first side of the impeller, and a second set of vanes disposed on a second side of the impeller. A passage is formed through a thickness of the impeller. The passage facilitates transmission of fluid from the first side of the impeller to the second side of the impeller such that fluid is supplied to the first set of vanes and the second set of vanes via the single impeller inlet. Transmission of fluid through the impeller reduces net axial thrust imparted to at least one of the impeller and the shaft.

公开(公告)号：US20210290571A1

公开(公告)日：2021-09-23

申请号：US17257770

申请日：2019-07-12

Applicant: The Texas A&M University System

Inventor： Shivatheja Soma ,  Vishal M. Gohil ,  James C. Sacchettini ,  Liam Guthrie

IPC: A61K31/165 ,  A61K33/34 ,  A61P3/02

Abstract: In an embodiment, the present disclosure relates to a method of restoring cytochrome c oxidase (CcO) activity in a subject in need thereof. In some embodiments, the method includes administering a therapeutically effective amount of elesclomol or analog thereof and rescuing defects of cells in the subject with deficiencies or mutations in at least one of SOD1, AT-1, API SI, COA6, SC02, COX6B1, CTRL ATOX1, CCS, GSX1, ATP7A, ATP7B, CLCN5, and CLCN7. In a further embodiment, the present disclosure relates to a method of treating disorders of copper metabolism. In some embodiments, the method includes administering a therapeutically effective amount of elesclomol or analog to a subject, where the disorder is caused by a deficiency or mutation to a gene including, without limitation, SOD1, AT-1, API SI, COA6, SC02, COX6B1, CTR1, ATOX1, CCS, GSX1, ATP7A, ATP7B, CLCN5, CLCN7, or combinations thereof.

公开(公告)号：US11121211B2

公开(公告)日：2021-09-14

申请号：US16642283

申请日：2018-09-28

Applicant: The Texas A&M University System

Inventor： Michael Everett Babb ,  Harlan Rusty Harris

IPC: H01L29/06 ,  H01L21/02 ,  H01L21/285 ,  H01L21/306 ,  H01L21/308 ,  H01L29/20 ,  H01L29/45 ,  H01L29/66 ,  H01L29/861

Abstract: A lateral superjunction includes a substrate layer, a selective epitaxy layer deposited on the substrate layer, a trench formed into the selective epitaxy layer to expose a portion of the substrate layer, a first layer of semiconductor deposited in the trench, a second layer of semiconductor deposited adjacent to the first layer, and a first end layer of semiconductor deposited adjacent to the first layer of semiconductor and a second end layer of semiconductor deposited adjacent to the second layer of semiconductor.

公开(公告)号：US20210246030A1

公开(公告)日：2021-08-12

申请号：US16973378

申请日：2019-06-14

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Ahmad Amiri ,  Mohammad Naraghi

IPC: C01B32/19 ,  C01B32/194

Abstract: A method for manufacturing graphene-based materials includes (a) positioning graphite into an inner chamber of a rotatable housing of a rod mill. A plurality of elongate rigid rods are loosely positioned in the housing. In addition, the method includes (b) rotating the housing of the rod-mill after (a). Further, the method includes (c) rod milling the graphite with the rods during (b) to produce a first portion of the graphene-based materials and milled graphite. The first portion of the graphene-based materials include 30 layers or less of graphene and the milled graphite comprises more than 30 layers of graphene.

公开(公告)号：US11083717B2

公开(公告)日：2021-08-10

申请号：US16720160

申请日：2019-12-19

Applicant: The Texas A&M University System

Inventor： Manchi C M Reddy ,  James C. Sacchettini ,  Nian E. Zhou ,  Billy F. McCutchen

IPC: A61K31/44 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/541 ,  A61P33/02 ,  A61K31/423 ,  A61K31/496 ,  A61K31/498 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/7036 ,  A61K31/427 ,  A61K31/5355 ,  A61K31/353 ,  A61K31/517

Abstract: Compositions and methods for inhibiting and/or sensitizing or re-sensitizing a parasite to an antiparasitic drug are provided. The compositions can comprise a an arylphenoxypropionate derivative, an aryloxyphenoxyacetate derivative, an aryloxyphenylacetate derivative, one or more substituted quinols, or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, or a combination thereof in an amount and formulation sufficient to sensitize the parasite to the drug, treating infection of a patient by a parasite with a drug, or to prevent symptomatic infection of a patient by a parasite with a drug.

公开(公告)号：US20210236434A1

公开(公告)日：2021-08-05

申请号：US17160836

申请日：2021-01-28

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Naga Venkata Ravi Kumar MAJETI ,  Raghu GANUGULA ,  Meenakshi ARORA ,  Dianxiong ZOU

IPC: A61K9/51 ,  A61K31/282

Abstract: The present disclosure provides nanoparticle compositions comprising i) a polymeric nanoparticle, ii) one or more ligands conjugated to the polymeric nanoparticle, and iii) urolithin A. The disclosure also provides methods and pharmaceutical compositions comprising the nanoparticle compositions for use in treating patients with various disease states.

公开(公告)号：US11066379B2

公开(公告)日：2021-07-20

申请号：US16977444

申请日：2019-03-05

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM ,  UNIVERSIDADE DE SANTIAGO DE COMPOSTELA

Inventor： Daniel Romo ,  Mikail E. Abbasov ,  Eva Alonso Lopez ,  Maria Amparo Alfonso Rancano ,  Miguel Luis Botana Lopez

IPC: C07D307/89 ,  C07D307/88

Abstract: Gracilin A congeners and methods for their use as immunosuppressive and neuroprotective agents.

公开(公告)号：US20210169030A1

公开(公告)日：2021-06-10

申请号：US17106881

申请日：2020-11-30

Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS ,  THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Jason Keith Norsworthy ,  Muthukumar Bagavathiannan ,  William L. Rooney ,  George L. Hodnett

IPC: A01H6/46 ,  A01H5/10

Abstract: A fluazifop-resistant sorghum cultivar designated ‘X’ and plants comprising a polynucleotide encoding the polypeptide of SEQ ID NO: 39 are disclosed herein. The present invention provides seeds, plants, and plant parts derived from sorghum cultivar ‘X’ and those including SEQ ID NO: 39. Further, it provides methods for producing a sorghum plant by crossing ‘X’ with itself or another sorghum variety. The invention also encompasses any sorghum seeds, plants, and plant parts produced by the methods disclosed herein, including those in which additional traits have been transferred into ‘X’ through the introduction of a transgene or by breeding ‘X’ with another sorghum cultivar.