公开(公告)号：US11406646B2

公开(公告)日：2022-08-09

申请号：US17094432

申请日：2020-11-10

Applicant: Virginia Commonwealth University ,  Durect Corporation

Inventor： Shunlin Ren ,  Leyuan Xu ,  Yanxia Ning ,  Jin Koung Kim ,  WeiQi Lin ,  Andrew R. Miksztal ,  Hongwei Wu ,  Min L. Lee

IPC: A61K31/565 ,  A61P1/16 ,  A61K31/724 ,  A61K47/10 ,  A61K31/575 ,  A61K47/40 ,  A61P17/06 ,  A61P3/06 ,  A61P31/04 ,  A61Q19/00 ,  A61K8/73 ,  A61K9/19 ,  A61K9/00 ,  A61K8/63 ,  C07J31/00

Abstract: Compositions comprising 5-cholesten-3,25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide, e.g., a cyclodextrin (CD), are provided. The compositions may be used to prevent and/or treat a variety of diseases and conditions, including organ failure (e.g. acute liver failure), high cholesterol/high lipids, and various inflammatory diseases and conditions.

公开(公告)号：US11319292B2

公开(公告)日：2022-05-03

申请号：US17468035

申请日：2021-09-07

Applicant: King Abdulaziz University ,  Virginia Commonwealth University

Inventor： Abdelsattar Mansour Ebeid Omar ,  Moustafa El-Sayed El-Araby ,  Martin K. Safo

IPC: A61P7/00 ,  A61K31/34 ,  C07D233/64 ,  C07D307/46

Abstract: 5-HMF derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.

公开(公告)号：US20220081425A1

公开(公告)日：2022-03-17

申请号：US17478187

申请日：2021-09-17

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY INTELLECTUAL PROPERTY FOUNDATION

Inventor： Juan WANG ,  Hu YANG

IPC: C07D405/06 ,  A61P27/06 ,  A61K9/00 ,  A61K31/4178 ,  A61K45/06

Abstract: The present disclosure provides pilocarpine ionic liquid analogs useful in the treatment of ophthalmological disorders such as glaucoma.

公开(公告)号：US20220054824A1

公开(公告)日：2022-02-24

申请号：US17519817

申请日：2021-11-05

Applicant: BioCircuit Technologies, Inc. ,  Virginia Commonwealth University

Inventor： Jonathan Isaacs ,  Isaac Perry Clements ,  Andrew Willsie ,  James David Ross ,  Alex Weidenbach

IPC: A61N1/05 ,  A61B5/00 ,  A61B5/24 ,  A61N1/36

Abstract: An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.

公开(公告)号：US11141989B2

公开(公告)日：2021-10-12

申请号：US16476676

申请日：2018-02-08

Applicant: Virginia Commonwealth University

Inventor： Daren Chen ,  Hong Zhao

IPC: B41J2/175 ,  B41J2/14

Abstract: An electrohydrodynamic (EHD) jet printing apparatus or system may include circulation of printing fluid to minimize or eliminate clogging in a nozzle. An exemplary nozzle comprises at least two ink channels—one allowing flow to a droplet emitting opening and one allowing flow away from the droplet emitting opening—configured for circulating ink. The nozzle may transfer ink to a substrate with an EHD technique involving voltage or current modulation. For example, an electric field may be applied between the nozzle and printing substrate such that the ink meniscus changes shape and releases ink from the tip of the liquid cone. A multi-channel nozzle may take a variety of configurations, including two co-axially aligned capillaries, side-by-side parallel capillaries, or capillaries arranged at an angle with respect to one another but converging at a single point where the conical meniscus is formed.

公开(公告)号：US20210238219A1

公开(公告)日：2021-08-05

申请号：US17122647

申请日：2020-12-15

Applicant: Virginia Commonwealth University

Inventor： Shunlin Ren

IPC: C07J31/00 ,  A61J1/14

Abstract: 5-cholesten, 3(3, 25-diol, disulfate (25HCDS) has been found to be an authentic PPARγ agonist and LXR antagonist, and is used for the therapy of lipid disorders and inflammatory diseases, including without limitation fatty liver, inflammatory bowel, and atherosclerotic disease.

公开(公告)号：US20210236737A1

公开(公告)日：2021-08-05

申请号：US17050573

申请日：2019-04-26

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Alexandria Ritchie ,  Bennett Ward ,  Hilton Bennett ,  Matthew Leccadito ,  Patrick Jones ,  Aayushi Agarwal

IPC: A61M5/315

Abstract: A device for facilitating positioning of a needle during a medical procedure may include a needle receiver configured for removable/reversible attachment of a proximal end of a needle; a stop set back from a distal end of the needle receiver and against which a needle received by the needle receiver abuts; and a trigger configured to move the needle receiver relative to the stop when activated by a user such that the stop forces detachment between the needle receiver and the needle. The device may monitor the pressure at the distal end of the needle as the needle is advanced and provide indication to a user when a predetermined pressure or pressure differential is reached.

公开(公告)号：US20210205472A1

公开(公告)日：2021-07-08

申请号：US15998948

申请日：2017-02-17

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Yan ZHANG ,  Hu YANG ,  Dana SELLEY ,  William DEWEY ,  Hamid AKBARALI

IPC: A61K47/69 ,  A61K31/485

Abstract: Provided herein are nanoparticle conjugated synthetic opioid prodrugs that target the peripheral mu opioid receptor (MOR). The prodrugs exhibit long-lived bioavailability, do not compromise the analgesic effects of opioids administered for pain relief (and in some cases can be used for pain relief), and do not induce opioid withdrawal symptoms, when their use is discontinued. Certain of the prodrugs are especially useful for the prevention and/or treatment of unwanted opioid-induced side effects such as opioid-induced constipation (OIC).

公开(公告)号：US20210177776A1

公开(公告)日：2021-06-17

申请号：US17169662

申请日：2021-02-08

Applicant: Enzo Therapeutics, Inc. ,  Virginia Commonwealth University

Inventor： Sarah SPIEGEL ,  Robert Elliot ZIPKIN ,  Jeffrey Kroll ADAMS

IPC: A61K31/135 ,  A61P11/06 ,  A61K31/40 ,  C07C323/32 ,  C07D263/06 ,  C07D295/092 ,  C07C215/28 ,  C07C217/64 ,  C07C233/18

Abstract: Provided are inhibitors of sphingosine kinase Type I that are useful in the treatment of neuropathic pain.

公开(公告)号：US11007227B2

公开(公告)日：2021-05-18

申请号：US17029112

申请日：2020-09-23

Applicant: Virginia Commonwealth University

Inventor： Martin J. Mangino ,  Loren K. Liebrecht

IPC: A61K35/14 ,  A61K35/18 ,  A61K9/00 ,  A61K47/02 ,  A61K47/34

Abstract: A composition for restoring or increasing tissue perfusion is provided. The composition includes polyethylene glycol polymers (PEG) with a molecular weight of 18,000-100,000 Da at a concentration of 5-20% by weight; PEG with a molecular weight of 1,000-10,000 Da at a concentration of 1-30% by weight; and water, wherein said PEG with a molecular weight of 18,000-100,000 Da and said PEG with a molecular weight of 1,000-10,000 Da are dissolved or dispersed in said water.