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公开(公告)号：US09005586B2
公开(公告)日：2015-04-14
申请号：US14098635
申请日：2013-12-06
Applicant: Colgate-Palmolive Company
Inventor： Michael Prencipe
IPC: A61K8/00 , A61K8/33 , A61K8/24 , A61K8/25 , A61K8/27 , A61Q11/00 , A61K8/21 , A61K8/41 , A61K8/42 , A61K8/43 , A61K8/49 , A61K8/55 , A61K8/58 , A61K8/64
CPC classification number: A61K8/27 , A61K8/0241 , A61K8/21 , A61K8/24 , A61K8/25 , A61K8/33 , A61K8/416 , A61K8/42 , A61K8/43 , A61K8/49 , A61K8/4926 , A61K8/4953 , A61K8/4973 , A61K8/55 , A61K8/58 , A61K8/64 , A61K2800/412 , A61Q11/00
Abstract: The invention includes a dentifrice composition that comprises a zinc ion source, a polyphosphate ion source, an anethole and a silica. The silica has a mean particle size of about 5 to about 12 microns, an Einlehner hardness of about 1 to about 20, and an oil absorption of about 40 to less than about 100 cc/100 g. The composition contains zinc ions and polyphosphate ions in a weight ratio of about 0.1:1 to about 10:1 and has a RDA value of about 100 to about 200 and a PCR value of about 75 to about 110. Related methods are also included.
Abstract translation: 本发明包括含有锌离子源，多磷酸根离子源，anethole和二氧化硅的洁牙剂组合物。 二氧化硅具有约5至约12微米的平均粒度，约1至约20的爱因纳硬度，以及约40至小于约100cc / 100g的吸油量。 该组合物含有约0.1:1至约10:1的重量比的锌离子和多磷酸根离子，并且RDA值为约100至约200，PCR值为约75至约110.相关方法也包括在内。
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112.发明申请公开(公告)号：US20130259810A1
公开(公告)日：2013-10-03
申请号：US13905280
申请日：2013-05-30
Applicant: Colgate-Palmolive Company
Inventor： James R. Brown , Linh Fruge , Tao Xu , Michael Prencipe
CPC classification number: A61K8/21 , A61K8/03 , A61K8/19 , A61K8/20 , A61K8/24 , A61K8/25 , A61K8/55 , A61K8/69 , A61K8/8164 , A61K2800/28 , A61K2800/591 , A61Q11/00
Abstract: Oral care compositions containing a stannous salt and sodium tripolyphosphate are provided where stannous tripolyphosphate ionic intermediates comprise less than about 1% of the compositions Tetrasodium pyrophosphate, a methylvinyl ether-maleic anhydride copolymer and/or a silica oral polishing agent may be added for further efficacy. In a single phase blend, the oral care composition may be effectively limited to comprise less than about 10% water. In a dual-phase blend, a mixture having the stannous salt in a first phase and the sodium tripolyphosphate in a second phase may be generated from a dual chamber storage tube (with each phase provided from a separate chamber) immediately prior to dental care usage.
Abstract translation: 提供含有亚锡盐和三聚磷酸钠的口腔护理组合物，其中三聚磷酸三钠离子中间体包含少于组合物的约1％焦磷酸四钠，甲基乙烯基醚 - 马来酸酐共聚物和/或二氧化硅口服抛光剂可用于进一步的功效 。 在单相共混物中，口腔护理组合物可以有效地限制为包含小于约10％的水。 在双相共混物中，可以在牙科保健使用之前立即从双室储存管（每个阶段由独立的室提供）产生具有第一相中的亚锡盐和第二相中的三聚磷酸钠的混合物 。
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公开(公告)号：US20240315941A1
公开(公告)日：2024-09-26
申请号：US18594760
申请日：2024-03-04
Applicant: Colgate-Palmolive Company
Inventor： Xiao Yi Huang , Michael Prencipe , Amy Russo , Hansruedi Stettler , Vyoma Patel , Betty Won , Peng Yan , André Morgan
CPC classification number: A61K8/44 , A61K8/21 , A61K8/25 , A61K8/27 , A61K8/345 , A61K8/362 , A61K8/365 , A61Q11/00 , A61K2800/28 , A61K2800/92
Abstract: This invention relates to oral care compositions comprising arginine or lysine, zinc citrate and zinc oxide, a fluoride source, and glycerin, as well as to methods of using and of making these compositions.
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公开(公告)号：US11406573B2
公开(公告)日：2022-08-09
申请号：US16897701
申请日：2020-06-10
Applicant: Colgate-Palmolive Company
Inventor： Aarti Rege , Michael Prencipe , Madhuleena Bhadra
Abstract: An oral care composition comprising zinc phosphate, stannous fluoride and an organic acid buffer system, as well as methods of using the same.
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公开(公告)号：US11154468B2
公开(公告)日：2021-10-26
申请号：US15708556
申请日：2017-09-19
Applicant: Colgate-Palmolive Company
Inventor： Aarti Rege , Michael Prencipe , Paul Thomson
IPC: A61K8/24 , A61K8/27 , A61Q11/00 , A61K8/19 , A61K8/21 , A61K8/34 , A61K8/81 , A61K8/362 , A61K8/365
Abstract: This invention relates to oral care compositions comprising a zinc source comprising zinc oxide and zinc citrate; a stannous source comprising stannous pyrophosphate; a fluoride ion source comprising sodium fluoride; and an organic buffer, as well as to methods of using and of making these compositions.
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Patent Agency Ranking
公开(公告)号：US11135144B2
公开(公告)日：2021-10-05
申请号：US15538285
申请日：2014-12-26
Applicant: Colgate-Palmolive Company
Inventor： Kavita Vemishetti , Linh Fruge , Michael Prencipe
Abstract: The present disclosure provides low water dentifrice compositions comprising an effective amount of a zinc ion source, a tin ion source, a polyphosphate and an acid. The acid lowers the pH of the composition to enable stabilization of the metal ions and extend shelf-life of the composition.
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公开(公告)号：US10966910B2
公开(公告)日：2021-04-06
申请号：US16841735
申请日：2020-04-07
Applicant: Colgate-Palmolive Company
Inventor： Aarti Rege , Michael Prencipe , Paul Thomson , Rehana Begum-Gafur
Abstract: This invention relates to oral care compositions comprising zinc phosphate, a first source of stannous (e.g., stannous fluoride); and a second source of stannous, wherein the second source of stannous comprises stannous pyrophosphate, as well as to methods of using and of making these compositions.
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公开(公告)号：US10959936B2
公开(公告)日：2021-03-30
申请号：US16934596
申请日：2020-07-21
Applicant: Colgate-Palmolive Company
Inventor： Lynette A. Zaidel , Guisheng Pan , Suman K. Chopra , Prakasarao Mandadi , Michael Prencipe
IPC: A61K8/22 , A61K8/81 , A61K8/02 , A61Q11/00 , A61Q11/02 , A61K8/24 , A61K8/90 , A61K8/49 , A61K8/891
Abstract: Oral care compositions comprising: (a) a peroxide complex comprising a peroxide component and an N-vinyl heterocyclic polymer (e.g., poly-N-vinyl polylactam, or poly-N-vinyl-polyimide); (b) a whitening agent (e.g., hydrogen peroxide); and (c) an orally acceptable carrier. In one embodiment, the carrier comprises a film forming material. Methods are also provided for making an oral care composition comprising: (a) mixing a whitening agent, silicone adhesive and carrier fluid to form a homogenous mixture; (b) adding a peroxide complex to said homogenous mixture, wherein said complex comprises hydrogen peroxide and an N-vinyl heterocyclic polymer; and (c) mixing under vacuum.
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119.发明授权公开(公告)号：US10682532B2
公开(公告)日：2020-06-16
申请号：US15964138
申请日：2018-04-27
Applicant: Colgate-Palmolive Company
Inventor： Steven Fisher , Linh Fruge , Michael Prencipe
Abstract: A dentifrice composition having a low water phase comprising effective amounts of polyphosphate and ionic active ingredients.
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120.发明授权公开(公告)号：US10668306B2
公开(公告)日：2020-06-02
申请号：US15964167
申请日：2018-04-27
Applicant: Colgate-Palmolive Company
Inventor： Steven Fisher , Linh Fruge , Michael Prencipe
IPC: A61Q11/00 , A61K8/21 , A61K8/27 , A61K8/49 , C07D207/00 , C07D207/26 , A61K8/20 , A61K8/24 , A61K8/365
Abstract: A dentifrice composition having a low water phase comprising effective amounts of polyphosphate and ionic active ingredients.
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