公开(公告)号：US20060247421A1

公开(公告)日：2006-11-02

申请号：US10556781

申请日：2004-05-13

申请人： Ko Fujimori ,  Koichi Saito

发明人： Ko Fujimori ,  Koichi Saito

IPC分类号： C07K14/705 ,  C07K16/28 ,  C07H21/04 ,  C12P21/06

CPC分类号： G01N33/92 ,  A01K2217/05 ,  C07K14/705

摘要： The present invention provides a liver X receptor α splicing mutant protein which is an isoform of a liver X receptor α, and which comprises at least an amino acid sequence encoded by exon 5 of a liver X receptor α gene, a gene thereof, and use thereof, and these can be utilized in development of methods and agents useful for preventing, diagnosing or treating diseases and abnormalities involved in inhibition of normal cholesterol metabolism by a normal liver X receptor α.

摘要翻译： 本发明提供肝X受体α剪接突变蛋白，其是肝X受体α的同种型，并且至少包含由肝X受体α基因的外显子5编码的氨基酸序列，其基因和使用 并且这些可用于开发可用于预防，诊断或治疗由正常肝脏X受体α抑制正常胆固醇代谢的疾病和异常的方法和药剂。

公开(公告)号：US20060167201A1

公开(公告)日：2006-07-27

申请号：US11394009

申请日：2006-03-30

申请人： Taketoshi Yamada ,  Hiroshi Kita ,  Koichi Saito ,  Yasushi Okubo

发明人： Taketoshi Yamada ,  Hiroshi Kita ,  Koichi Saito ,  Yasushi Okubo

IPC分类号： C08G77/06 ,  B29C55/00

CPC分类号： C08L81/06 ,  C08B3/22 ,  C08B15/05 ,  C08J5/18 ,  C08L1/10 ,  C08L1/14 ,  C08L79/02 ,  H01L51/52 ,  Y10T428/31663 ,  Y10T428/31971 ,  C08L2666/02 ,  C08L2666/26

摘要： A film substrate of an electronic displaying element, an electronic optical element, a touch panel, or a solar battery is disclosed which is composed mainly of an organic polymer having water solubility of 0 to 5 g based on 100 g of 25° C. water and having acetone solubility of 25 to 100 g based on 100 g of 25° C. acetone and an inorganic condensation polymer of a reactive metal compound capable of being condensed.

公开(公告)号：US20060061635A1

公开(公告)日：2006-03-23

申请号：US11231853

申请日：2005-09-22

申请人： Hideyuki Ogawa ,  Koichi Saito ,  Nagamitsu Takashima ,  Katsumi Motojima ,  Katsunori Ono

发明人： Hideyuki Ogawa ,  Koichi Saito ,  Nagamitsu Takashima ,  Katsumi Motojima ,  Katsunori Ono

IPC分类号： B41J2/045

CPC分类号： B41J2/1632 ,  B41J2/162 ,  Y10T29/49401 ,  Y10T29/49826

摘要： An apparatus of fabricating a liquid ejection head is provided. The apparatus includes: a first dic including projected streak portions aligned in parallel by a predetermined pitch and gap portions formed between the adjacent projected streak portions, wherein the first die is adapted to form the groove-like recess portions by pressing the projected streak portions to a metal plate; and a second die for supporting the metal plate to which the projected streak portions of the first die are pressed. Each of the projected streak portions includes: an inner wall forming portion for forming an inner wall of the corresponding groove-like recess portion extending in a depth direction of the corresponding groove-like recess portion; a connecting face portion; and an inclined face portion, continuous via the connecting face portion to the inner wall forming portion, for forming a bottom portion of the corresponding groove like recess portion into a substantially V-like shape.

摘要翻译： 提供一种制造液体喷射头的装置。 该装置包括：包括预定间距平行排列的突出条纹部分和形成在相邻突出条纹部分之间的间隙部分的第一部分，其中，第一模具适于通过将突出条纹部分按压而形成凹槽部分 金属板; 以及用于支撑第一模具的突出条纹部分的金属板的第二模具。 每个突出部分包括：内壁形成部分，用于形成在相应的槽状凹部的深度方向上延伸的相应的槽状凹部的内壁; 连接面部; 以及经由连接面部分连接到内壁形成部分的倾斜面部分，用于将相应的凹槽状凹部的底部形成为大致V形的形状。

公开(公告)号：US20060055732A1

公开(公告)日：2006-03-16

申请号：US11225052

申请日：2005-09-14

申请人： Hideyuki Ogawa ,  Koichi Saito ,  Nagamitsu Takashima ,  Katsunori Ono

发明人： Hideyuki Ogawa ,  Koichi Saito ,  Nagamitsu Takashima ,  Katsunori Ono

IPC分类号： B41J2/04 ,  B41J2/16 ,  B21D53/76

CPC分类号： B41J2/045 ,  B41J2/1612 ,  B41J2/1623 ,  B41J2/1632 ,  B41J2/1634 ,  B41J2/1637 ,  B41J2/1643 ,  Y10T29/49401

摘要： The invention is directed to a method of working a small recess portion. In the method, prior to press-forming small recess portions arrayed in a row by pressing a predetermined number of pieces of aligned male dies to a metal base plate, the metal base plate is previously formed with a highly rigid portion at a predetermined portion at a vicinity of an imaginary line extending in a row direction along end portions of predicted press portions to which the respective male dies are pressed.

公开(公告)号：US07011895B2

公开(公告)日：2006-03-14

申请号：US10874755

申请日：2004-06-24

申请人： Kiyokazu Ishizuka ,  Hidetoshi Shindo ,  Koichi Saito ,  Motohiro Sasaki ,  Atsuhiko Tounaka

发明人： Kiyokazu Ishizuka ,  Hidetoshi Shindo ,  Koichi Saito ,  Motohiro Sasaki ,  Atsuhiko Tounaka

IPC分类号： B32B15/04 ,  B32B15/08 ,  B32B15/18

CPC分类号： C23C28/3225 ,  C09D5/082 ,  C23C22/83 ,  C23C28/00 ,  C23C28/345 ,  Y10T428/12569 ,  Y10T428/12799 ,  Y10T428/31678

摘要： The present invention is intended to provide an inorganic-organic composite-treated zinc-plated steel sheet whose treated coatings do not contain any hazardous chromate and which is excellent in corrosion resistance after alkaline degreasing and coating adhesion.An inorganic-organic composite-treated zinc-plated steel sheet which has a zinc phosphate coating, in a coating weight of 0.3 to 5 g/m2, on the zinc-plated steel sheet surface and, thereon, a post-treatment coating, in a coating weight of 0.01 to 1 g/m2, containing an organic resin (A), a zirconium compound (B), an inorganic corrosion inhibitor (C) and an organic corrosion inhibitor (D).

摘要翻译： 本发明旨在提供一种无机 - 有机复合处理的镀锌钢板，其经处理的涂层不含有任何有害的铬酸盐，并且在碱性脱脂和涂层粘合之后具有优异的耐腐蚀性。 一种无机 - 有机复合处理的镀锌钢板，其镀锌钢板表面上镀锌钢板表面上涂覆重量为0.3至5g / m 2的磷酸锌涂层 （A），锆化合物（B），无机腐蚀抑制剂（C）和无机防腐蚀剂（C）的涂布重量为0.01〜1g / m 2 有机腐蚀抑制剂（D）。

公开(公告)号：US20060042435A1

公开(公告)日：2006-03-02

申请号：US11213837

申请日：2005-08-30

申请人： Hideyuki Ogawa ,  Koichi Saito ,  Nagamitsu Takashima ,  Nobuyuki Soma ,  Katsunori Ono

发明人： Hideyuki Ogawa ,  Koichi Saito ,  Nagamitsu Takashima ,  Nobuyuki Soma ,  Katsunori Ono

IPC分类号： B26D1/00

CPC分类号： B41J2/162 ,  B41J2/1433 ,  B41J2/1632 ,  Y10T29/494 ,  Y10T29/49401 ,  Y10T83/04

摘要： A punching apparatus forms a hole at a bottom portion of each of recesses which are formed in a metal plate in advance and arrayed in a first direction. A female die supports the metal plate. A male die is opposed to the recess and provided with a punch array in which a plurality of punches in the first direction. The male die is movable in a second direction perpendicular to the first direction to form the hole with each of the punches. The punches include first punches each having a distal end face which is slant in the second direction. A slant angle of the distal end face corresponds to a warp of the plate member due to the formation of the recesses.

摘要翻译： 冲孔装置在预先形成在金属板上的每个凹部的底部上形成孔，并且沿第一方向排列。 阴模支撑金属板。 阳模与凹部相对设置有冲头阵列，其中在第一方向上具有多个冲头。 阳模可以在垂直于第一方向的第二方向上移动，以与每个冲头形成孔。 冲头包括每个具有在第二方向上倾斜的远端面的第一冲头。 由于形成凹部，远端面的倾斜角对应于板构件的翘曲。

公开(公告)号：US20060031033A1

公开(公告)日：2006-02-09

申请号：US11195466

申请日：2005-08-01

申请人： Kyoji Shimoda ,  Koichi Saito

发明人： Kyoji Shimoda ,  Koichi Saito

IPC分类号： G01R29/26

CPC分类号： G02B5/09 ,  G01R29/26 ,  G02B26/0816

摘要： The present invention measures jitter in a galvano scanner that scans a light beam on a surface to be scanned by periodically turning a reflection mirror in a reciprocating manner. Two detectors for detecting and receiving the light beam are mounted near both ends of the scan region of the light beam, a first detection signal of each of the two detectors is extracted whenever the reflection mirror is activated for one scanning, a required time for one scanning is computed from the extracted detection signals, and a variation in the required time for each scanning is measured based on the computed required time.

摘要翻译： 本发明测量电动扫描仪中的抖动，其通过以往复方式周期性地转动反射镜来扫描要扫描的表面上的光束。 用于检测和接收光束的两个检测器安装在光束的扫描区域的两端附近，每当反射镜被激活用于一次扫描时，两个检测器中的每一个的第一检测信号被提取，一个所需的时间 根据所提取的检测信号计算扫描，并且基于所计算的所需时间来测量每次扫描的所需时间的变化。

公开(公告)号：US20050266258A1

公开(公告)日：2005-12-01

申请号：US11194435

申请日：2005-08-01

申请人： Koichi Saito

发明人： Koichi Saito

IPC分类号： G02B5/30 ,  C08J5/18 ,  C08K5/103 ,  C08L1/10 ,  B32B23/04

CPC分类号： C08J5/18 ,  C08J2301/10 ,  C08L1/10 ,  Y10T428/31971

摘要： A cellulose ester film is disclosed which comprises a polyhydric alcohol ester, which is an ester of one or more kinds of monocarboxylic acids with an aliphatic polyhydric alcohol, wherein the cellulose ester film has a water vapor transmission rate of from 20 to 260 g/m2·24 hours measured under conditions of 25° C. and 90% RH.

公开(公告)号：US20050158371A1

公开(公告)日：2005-07-21

申请号：US10921960

申请日：2004-08-20

申请人： Fumio Nishikado ,  Shuzo Tagashira ,  Koichi Saito ,  Toshiyuki Hosokawa

发明人： Fumio Nishikado ,  Shuzo Tagashira ,  Koichi Saito ,  Toshiyuki Hosokawa

IPC分类号： A61K9/70 ,  A61K31/277 ,  A61K31/42 ,  A61K31/5377 ,  A61K47/06 ,  A61K47/08 ,  A61K47/10

CPC分类号： A61K31/5377 ,  A61K9/0014 ,  A61K9/7023 ,  A61K31/277 ,  A61K31/42 ,  A61K47/06 ,  A61K47/08 ,  A61K47/10

摘要： The present invention relates to a transdermal administration preparation for external application such as ointment, cream and the like, which contains SMP-114 or leflunomide or a pharmaceutically acceptable acid addition salt thereof as an active ingredient. The present invention further relates to a pharmaceutical composition for transdermal administration which contains, a) as an active ingredient, N-(4-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide or an active motabolite thereof or a pharmaceutically acceptable salt thereof; and B)(1) a carrier for transdermal administration which contains a base for dissolution in a proportion of not less than 40 w/w %, or (2) a carrier for transdermal administration which contains a hydrophobic base for suspension having no polar group in a molecule in a proportion of not less than 70 w/w %. According to the present invention, a novel means of transdermal administration of SMP-114 or leflunomide or an active motabolite thereof or a pharmaceutically acceptable acid addition salt thereof can be provided.

摘要翻译： 本发明涉及含有SMP-114或来氟米特或其药学上可接受的酸加成盐作为活性成分的外用施用皮肤给药制剂，如软膏，霜剂等。 本发明还涉及用于透皮给药的药物组合物，其包含a）作为活性成分的N-（4-三氟甲基苯基）-5-甲基异恶唑-4-甲酰胺或其活性成分代谢物或其药学上可接受的盐; 和B）（1）经皮给药的载体，其含有不少于40w / w％的比例溶解的碱，或（2）用于透皮给药的载体，其含有不具有极性基团的悬浮的疏水性碱 在分子中的比例不小于70w / w％。 根据本发明，可以提供透皮给药SMP-114或来氟米特或其活性成
胶体或其药学上可接受的酸加成盐的新方法。

公开(公告)号：US20050158330A1

公开(公告)日：2005-07-21

申请号：US11016389

申请日：2004-12-17

申请人： Koichi Saito ,  Yoko Kishimoto ,  Tokuji Miyahara ,  Kouzou Takase

发明人： Koichi Saito ,  Yoko Kishimoto ,  Tokuji Miyahara ,  Kouzou Takase

IPC分类号： A61K39/39 ,  A61K9/00 ,  A61K9/107 ,  A61K9/113 ,  A61K39/00 ,  A61K47/44 ,  A61K31/765

CPC分类号： A61K9/113

摘要： The present invention provides a W/O/W type oil adjuvant vaccine containing an outer aqueous phase containing 0.5 wt %-20 wt % of a polyethylene glycol derivative having a molecular weight of 400-20,000, and an inner aqueous phase containing a biologically acceptable and effective amount of an antigen. The constitution of the present invention that a polyethylene glycol derivative having a specific molecular weight is contained in the outer aqueous phase enables preparation of a W/O/W type oil adjuvant vaccine showing a high adjuvant effect, reduced side effects such as topical response, superior preparation stability and superior workability to allow a person to give an injection easily due to the lowered viscosity.

摘要翻译： 本发明提供一种W / O / W型油佐剂疫苗，其含有含有0.5重量％〜20重量％的分子量为400〜20,000的聚乙二醇衍生物的外层水相和含有生物可接受的内水相 和有效量的抗原。 在外部水相中含有特定分子量的聚乙二醇衍生物的本发明的结构能够制备显示高佐剂效果的W / O / W型油佐剂疫苗，减少副作用，如局部反应， 优异的制备稳定性和优异的加工性，使得人们由于粘度降低而容易地进行注射。