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    DETECTING NEOPLASM
    112.
    发明申请
    DETECTING NEOPLASM 有权
    检测NEOPLASM

    公开(公告)号：US20160040246A1

    公开(公告)日：2016-02-11

    申请号：US14775435

    申请日：2014-03-12

    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH ,  EXACT SCIENCES CORPORATION

    Inventor： David A. Ahlquist ,  John B. Kisiel ,  William R. Taylor ,  Tracy C. Yab ,  Douglas W. Mahoney ,  Graham P. Lidgard ,  Hatim T. Allawi

    IPC: C12Q1/68

    CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer. Accordingly, provided herein is technology for pancreatic cancer screening markers and other gastrointestinal cancer screening markers that provide a high signalto-noise ratio and a low background level when detected from samples taken from a subject (e.g., stool sample). As described herein, the technology provides a number of methylated DNA markers and subsets thereof (e.g., sets of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or more markers) with high discrimination for G1 neoplasms overall and/or at individual tumor sites.

    Abstract translation: 本文提供了涉及检测瘤形成的技术，特别但并非排他地涉及用于检测恶变和恶性肿瘤如胰腺癌和结肠直肠癌的方法，组合物和相关用途。 因此，本文提供了当从取自受试者（例如粪便样品）的样品检测时，提供高信噪比和低背景水平的胰腺癌筛选标记物和其他胃肠癌筛选标记物的技术。 如本文所述，该技术提供了许多甲基化DNA标记及其亚组（例如，2,3,4,5,6,7,8,9,10,11,12或更多标记的组） G1整体肿瘤和/或单个肿瘤部位。

    COLLECTING AND PROCESSING COMPLEX MACROMOLECULAR MIXTURES
    115.
    发明申请
    COLLECTING AND PROCESSING COMPLEX MACROMOLECULAR MIXTURES 审中-公开
    收集和处理复杂的大分子混合物

    公开(公告)号：US20140205517A1

    公开(公告)日：2014-07-24

    申请号：US14229435

    申请日：2014-03-28

    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

    Inventor： David A. Ahlquist ,  Jonathan J. Harrington ,  Hongzhi Zou ,  Patrick S. Quint ,  William R. Taylor

    IPC: B01L3/00

    CPC classification number: B01L3/00 ,  A61B10/0038 ,  A61B10/0096 ,  B01L3/5029 ,  C12Q1/6806 ,  C12Q2565/507 ,  C12Q2563/143 ,  C12Q2527/125

    Abstract: This document provides methods and materials involved in collecting and processing complex macromolecular mixtures (e.g., stool samples). For example, stool collection devices, buffers for stabilizing nucleic acid and polypeptides present in stool, and kits for using sequence-specific capture probes (e.g., nucleic acid sequences designed to hybridize with particular target nucleic acids) to capture target nucleic acids directly from complex macromolecular mixtures (e.g., stool samples) without the need to perform prior steps to enrich, isolate, or purify the nucleic acid component are provided.

    Abstract translation: 本文件提供了收集和处理复杂大分子混合物（例如粪便样品）中涉及的方法和材料。 例如，粪便收集装置，用于稳定存在于粪便中的核酸和多肽的缓冲液以及使用序列特异性捕获探针（例如，设计为与特定靶核酸杂交的核酸序列）直接从复合物捕获靶核酸的试剂盒 提供大分子混合物（例如，粪便样品），而不需要执行先前的富集，分离或纯化核酸组分的步骤。

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