公开(公告)号：US08016811B2

公开(公告)日：2011-09-13

申请号：US10691968

申请日：2003-10-24

申请人： Alan Smith ,  Jonathan A. Eppstein ,  Bernadette Messier ,  Zoran Novakovic ,  Stuart McRae

发明人： Alan Smith ,  Jonathan A. Eppstein ,  Bernadette Messier ,  Zoran Novakovic ,  Stuart McRae

IPC分类号： A61M31/00

CPC分类号： A61M37/00 ,  A61K9/0009 ,  A61K9/0046 ,  A61M37/0015 ,  A61M37/0092 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61N1/0412 ,  A61N1/30 ,  A61N1/327

摘要： A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.

摘要翻译： 透皮物质经皮递送到动物膜中的方法包括在皮肤组织中形成至少一个输送口，其中所述至少一个输送口的平均开口深度在约40至约90微米之间。

公开(公告)号：US20110081675A1

公开(公告)日：2011-04-07

申请号：US12899354

申请日：2010-10-06

申请人： Gabriela Cezar ,  Alan Smith

发明人： Gabriela Cezar ,  Alan Smith

IPC分类号： C12Q1/02

CPC分类号： G01N33/5061 ,  G01N33/5014 ,  G01N33/5038 ,  G01N2800/32

摘要： The invention provides methods and biomarkers for assessing cardiac metabolic response to pharmaceuticals, environmental agents, chemical compounds and biologic therapies. The invention provides methods for identifying cellular metabolites secreted by primary cardiomyocytes, cardiomyocyte precursor cells, clonal cardiomyocytes derived from adult human heart, immortalized cardiomyocytes, human embryonic stem cell (hESC)-derived cardiomyocytes, human induced pluripotent stem cell (iPS)-derived cardiomyocytes, or any cell displaying cardiomyocyte-specific markers in response to exposure to pharmaceuticals, environmental agents, chemical compounds and biologic therapies that are cardiotoxic. Cardiomyocyte-secreted cellular metabolites provide metabolic signatures of cardiotoxicity, and can be used to screen pharmaceutical agents, lead and candidate drug compounds, biologics, and other therapeutics for cardiotoxic effects.

摘要翻译： 本发明提供了用于评估对药物，环境试剂，化合物和生物疗法的心脏代谢反应的方法和生物标志物。 本发明提供了用于鉴定原代心肌细胞，心肌细胞前体细胞，衍生自成年人心脏的克隆心肌细胞，永生化心肌细胞，人胚胎干细胞（hESC）衍生的心肌细胞，人诱导多能干细胞（iPS）衍生的心肌细胞分泌的细胞代谢物的方法 或任何显示心肌细胞特异性标志物的细胞，以应对暴露于心脏毒性的药物，环境因素，化学化合物和生物疗法。 心肌细胞分泌的细胞代谢物提供心脏毒性的代谢特征，可用于筛选药物，铅和候选药物化合物，生物制剂和其他治疗药物的心脏毒性作用。

公开(公告)号：US20100113620A1

公开(公告)日：2010-05-06

申请号：US12593440

申请日：2008-03-26

申请人： Yvonne Perrie ,  Alan Smith

发明人： Yvonne Perrie ,  Alan Smith

IPC分类号： A61K47/26 ,  B29C45/00

CPC分类号： A61K9/4816

摘要： This invention pertains generally to the field of hard enteric capsules, and more particularly, to capsules consisting of (a) a film-forming, water-soluble polymer; (b) an acid-insoluble polymer; (c) a gelatinising agent; (d) an auxiliary for gelation; (e) at least one plasticiser; (f) minor ingredients, including, optionally, a colouring agent and a flavouring agent; and the balance of the composition being water. The present invention also pertains to the use of the capsule in the delivery of active pharmaceutical ingredients or dietary supplements and methods for producing hard enteric capsules.

摘要翻译： 本发明一般涉及硬肠溶胶囊领域，更具体地涉及由（a）成膜水溶性聚合物组成的胶囊; （b）酸不溶性聚合物; （c）胶凝剂; （d）凝胶辅助剂; （e）至少一种增塑剂; （f）次要成分，包括任选的着色剂和调味剂; 并且组合物的余量为水。 本发明还涉及胶囊在递送活性药物成分或膳食补充剂和用于生产硬肠溶胶囊的方法中的用途。

公开(公告)号：US07328416B1

公开(公告)日：2008-02-05

申请号：US11042043

申请日：2005-01-24

申请人： Ming Yin ,  Toshinari Takayanagi ,  Alan Smith

发明人： Ming Yin ,  Toshinari Takayanagi ,  Alan Smith

IPC分类号： G06F17/50

CPC分类号： G06F17/5031

摘要： A method is provided for modeling timing characteristics of a circuit block of an integrated circuit, which includes a main circuit and a timing circuit. The method comprises determining an output pin output delay and determining a timing circuit delay. The output pin output delay is an interval of time from a clock signal reaching a clock reference point (CRP) to an output signal arriving at the output pin. The clock reference point is positioned between the timing circuit and the main circuit. The timing circuit delay is an interval of time from a clock signal arriving at a clock input pin to a clock signal arriving at the CRP. The determination of the timing circuit delay is based on a computer simulation of a netlist of circuit elements in the timing circuit.

摘要翻译： 提供了一种用于对包括主电路和定时电路的集成电路的电路块的定时特性进行建模的方法。 该方法包括确定输出引脚输出延迟并确定定时电路延迟。 输出引脚输出延迟是从到达时钟参考点（CRP）的时钟信号到到达输出引脚的输出信号的时间间隔。 时钟参考点位于定时电路和主电路之间。 定时电路延迟是从到达时钟输入引脚的时钟信号到到达CRP的时钟信号的时间间隔。 定时电路延迟的确定是基于定时电路中电路元件网表的计算机模拟。

公开(公告)号：US20070169619A1

公开(公告)日：2007-07-26

申请号：US10596642

申请日：2004-12-14

申请人： Alan Smith

发明人： Alan Smith

IPC分类号： F01B13/06

CPC分类号： F04B9/042 ,  F04B17/03 ,  F04B2201/0201 ,  Y10T74/2101 ,  Y10T74/2107

摘要： A pump primarily for liquid paint comprising first and second pistons (19, 21) reciprocable rectilinearly in respective first and second cylinders (17, 18), said first and second pistons being moved relative to their respective pistons by operation of an A. C. electric motor (13) the rotary output shaft of which is coupled to said first and second pistons by means including a constant velocity cam (31) and cam follower (32, 33) mechanism converting rotary motion of the output shaft into reciprocatory motion of said first and second pistons 180° out of phase with one another.

摘要翻译： 一种主要用于液体涂料的泵，包括在相应的第一和第二气缸（17,18）中直线往复运动的第一和第二活塞（19,21），所述第一和第二活塞通过AC电动机（ 13），其旋转输出轴通过包括恒速凸轮（31）和凸轮从动件（32,33）的机构联接到所述第一和第二活塞，机构将输出轴的旋转运动转换成所述第一和第二活塞的往复运动 活塞彼此相位相差180°。

公开(公告)号：US20070078865A1

公开(公告)日：2007-04-05

申请号：US11242516

申请日：2005-10-03

申请人： Alan Smith

发明人： Alan Smith

IPC分类号： G06F7/00

CPC分类号： G06F17/30569

摘要： An apparatus, system, and method are disclosed for analyzing computer events recorded in a plurality of computer datasets. The apparatus includes a read module configured to access chronicle records in two datasets, an extraction module configured to extract a timestamp from each chronicle record, a generation module configured to generate a chronicle time indicator for each chronicle record based on the extracted timestamp, and a placement module configured to place the generated chronicle time indicator into the associated chronicle record. Typically, chronicle records in a first chronicle record have records with desired timestamp characteristics while chronicle records in a second dataset have chronicle records with incompatible timestamp characteristics. The apparatus, system, and method generate the chronicle time indicator to be compatible with desired timestamp characteristics of the first dataset and place the generated chronicle time indicator in each incompatible chronicle record.

摘要翻译： 公开了用于分析记录在多个计算机数据集中的计算机事件的装置，系统和方法。 该装置包括被配置为访问两个数据集中的记录记录的读取模块，被配置为从每个记录记录中提取时间戳的提取模块，被配置为基于所提取的时间戳生成每个纪事记录的记录时间指示符的生成模块，以及 放置模块被配置成将生成的纪事时间指示符放置在相关联的纪事记录中。 通常，第一纪事记录中的纪事记录具有期望时间戳特征的记录，而第二数据集中的记录记录具有不兼容的时间戳特征的记录记录。 该装置，系统和方法产生记录时间指示符以与第一数据集的期望时间戳特征兼容，并将生成的记录时间指示符放置在每个不兼容的纪事记录中。

公开(公告)号：US20070045259A1

公开(公告)日：2007-03-01

申请号：US11533624

申请日：2006-09-20

申请人： Richard Beeson ,  Stephen Li ,  Alan Smith

发明人： Richard Beeson ,  Stephen Li ,  Alan Smith

IPC分类号： B23K9/10

CPC分类号： B23K9/0956 ,  B23K9/1006

摘要： A method and apparatus for welding with an engine driven inverter power supply includes generating an ac output with an engine and generator. The output is rectified and inverted to provide an ac inverter output. The engine is controlled using feedback indicative of a welding output operating parameter. The feedback may also be taken from the inverter or generator, and the generator may be controlled instead of or in addition to the engine. Engine parameters that may be controlled include engine speed, selecting between an idle speed and a run speed, a throttle position, a fuel pump, an injection timer, a fuel to air ratio, fuel consumption and ignition timing. Another aspect of the invention is having the feedback be responsive to one or more of the welding current, welding voltage, welding power, or functions thereof. The feedback may be responsive to the current, voltage, power, ripple and functions thereof. An aux power output is derived directly from the generator and feedback from the aux load is used to determine if the engine should be idling or running at high speed.

摘要翻译： 一种用发动机驱动的逆变器电源进行焊接的方法和装置，包括用发动机和发电机产生交流输出。 输出整流和反相，提供交流逆变器输出。 使用反馈表示焊接输出操作参数来控制发动机。 也可以从逆变器或发电机获取反馈，并且发动机可以被控制而不是发动机或除了发动机之外。 可以控制的发动机参数包括发动机转速，怠速和运行速度之间的选择，节气门位置，燃料泵，喷射定时器，燃料空气比，燃料消耗和点火正时。 本发明的另一方面是使反馈响应于焊接电流，焊接电压，焊接功率或其功能中的一个或多个。 反馈可以响应于电流，电压，功率，纹波和功能。 辅助功率输出直接来自发电机，来自辅助负载的反馈用于确定发动机是否应空转或高速运行。

公开(公告)号：US20070031495A1

公开(公告)日：2007-02-08

申请号：US11455899

申请日：2006-06-19

申请人： Jonathan Eppstein ,  David Enscore ,  Frank Tagliaferri ,  Gaurav Tolia ,  Shulun Chang ,  Alan Smith ,  Yogi Patel ,  Stuart McRae

发明人： Jonathan Eppstein ,  David Enscore ,  Frank Tagliaferri ,  Gaurav Tolia ,  Shulun Chang ,  Alan Smith ,  Yogi Patel ,  Stuart McRae

IPC分类号： A61K9/24

CPC分类号： A61K9/7053 ,  A61K9/0009

摘要： Disclosed is a device for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject. The device comprises a delivery reservoir comprising: i) a non-biodegradable matrix having a bottom surface and defining a plurality of conduits therein the matrix, at least a portion of the plurality of conduits being in communication with the bottom surface; and ii)an undissolved hydrophilic per meant disposed therein at least a portion of the plurality of conduits of the matrix, wherein the hydrophilic per meant can come in contact with subcutaneous fluid from the subject when the bottom surface of the matrix is positioned in fluid communication with the at least one formed pathway. Also disclosed are systems and methods for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject.

摘要翻译： 公开了一种用于通过穿过受试者的皮肤层的至少一个形成的途径使每个意图的经皮通量引入受试者的装置。 所述装置包括递送贮存器，其包括：i）具有底表面并且在其中限定所述基质中的多个导管的不可生物降解的基质，所述多个导管的至少一部分与所述底表面连通; 和ii）未溶解的亲水剂，其中每个意图在其中设置多个基质管道的至少一部分，其中，当基质的底表面位于流体连通中时，每个意图的亲水剂可以与来自受试者的皮下流体接触 与至少一个形成的途径。 还公开了用于通过穿过受试者的皮肤层的至少一个形成的途径使每个意图的经皮通量引入受试者的系统和方法。

公开(公告)号：US20060262879A1

公开(公告)日：2006-11-23

申请号：US11136269

申请日：2005-05-23

申请人： Alan Smith ,  Julie Stuart ,  Zhi-Zhong Yu

发明人： Alan Smith ,  Julie Stuart ,  Zhi-Zhong Yu

IPC分类号： H04L25/49

CPC分类号： H04W52/52 ,  H03G3/3047 ,  H04L27/0008

摘要： A method and a power control device moving the resynchronisation point within the guard period to coincide with a calculated reduction in the RF PA power level such that the spurious frequency products are attenuated as much as possible and moved to be as central as possible within the guard period such that neither the previous burst nor the next burst are affected.

公开(公告)号：US20060234366A1

公开(公告)日：2006-10-19

申请号：US10534218

申请日：2003-11-07

申请人： Alan Smith ,  Margaretha Wegman

发明人： Alan Smith ,  Margaretha Wegman

IPC分类号： C12N9/02

CPC分类号： C12N9/0006 ,  C12N9/96

摘要： Described is a method for the preparation of crosslinked enzyme aggregates, comprising enzyme molecules being associated with an enzyme activity-enhancing agent, the enzyme activity-enhancing agent interacting with the said enzyme molecules, comprising the steps of: A—providing a plurality of enzyme molecules, B—aggregating the enzyme molecules in a liquid medium, by means of addition of a precipitating agent, C—crosslinking the aggregated enzyme molecules to one another by providing a crosslinking agent in the liquid medium, the method comprising, during or between steps A, B or C, the step of adding an enzyme activity-enhancing agent and allowing the enzyme molecules to become and to remain associated with the enzyme activity-enhancing agent. The resulting CLEA are advantageous due to increase in activity, their suitability for recycle, enhanced stability and low requirements for additional enzyme activity-enhancing agent. Further, crosslinked enzyme aggregates are described, comprising an enzyme activity-enhancing agent associated therewith.

摘要翻译： 描述了制备交联酶聚集体的方法，其包括与酶活性增强剂相关的酶分子，所述酶活性增强剂与所述酶分子相互作用，所述方法包括以下步骤：A提供多种酶 分子，通过添加沉淀剂将聚合的酶分子B聚集在液体介质中，通过在液体介质中提供交联剂将聚集的酶分子彼此交联，该方法包括在步骤 A，B或C，添加酶活性增强剂并使酶分子变成并保持与酶活性增强剂相关的步骤。 所得到的CLEA由于活性增加，它们对再循环的适用性，增强的稳定性和对另外的酶活性增强剂的低要求而是有利的。 此外，描述了包含与其相关的酶活性增强剂的交联的酶聚集体。