公开(公告)号：US5366493A

公开(公告)日：1994-11-22

申请号：US652039

申请日：1991-02-04

申请人： Avram Scheiner ,  E. Byron Marsolais ,  J. Thomas Mortimer ,  Thomas P. Kicher

发明人： Avram Scheiner ,  E. Byron Marsolais ,  J. Thomas Mortimer ,  Thomas P. Kicher

IPC分类号： A61N1/05 ,  A61N1/18

CPC分类号： A61N1/05

摘要： First and second electrical wires (10), (12) are wrapped helically around a polyprolene core (22). Along a single helical portion (A), a sheath (24) is placed over the spiral wound wires and core. In an open double helix portion (B), the core with spiral wound wires is wrapped into an open helix. At an electrical stimulation portion (C), insulation is removed from the wires such that bare conductors (14), (16) are wrapped spirally around the core. The core with the spiral wrapped conductors is wrapped in an open helix. A plurality of barbs (32) are mechanically connected along the entire length of the exposed electrical conductor surface. The core extends beyond the end of the electrical conductor surface to facilitate insertion into a selected site with a cannula (64).

摘要翻译： 第一和第二电线（10），（12）围绕聚烯烃芯（22）螺旋缠绕。 沿着单个螺旋部分（A），鞘（24）被放置在螺旋缠绕的线和芯上。 在开放的双螺旋部分（B）中，具有螺旋缠绕线的芯被包裹成开放螺旋。 在电刺激部分（C）处，从电线去除绝缘体，使得裸导体（14），（16）围绕磁芯螺旋缠绕。 具有螺旋缠绕导体的芯被包裹在开放螺旋中。 多个倒钩（32）沿着暴露的电导体表面的整个长度机械连接。 芯延伸超过电导体表面的端部以便于用插管（64）插入到选定的部位。

公开(公告)号：US08818508B2

公开(公告)日：2014-08-26

申请号：US13046387

申请日：2011-03-11

申请人： Avram Scheiner

发明人： Avram Scheiner

IPC分类号： A61N1/365 ,  A61N1/36

CPC分类号： A61N1/365 ,  A61N1/0551 ,  A61N1/36 ,  A61N1/36114

摘要： The present disclosure is directed to a method of using an implantable medical device. One embodiment of the present disclosure comprises delivering electrical stimulation proximate nerve tissue of a patient during a transient physiological effect period separated by a recovery period. The transient physiological effect period is when electrical stimulation has an increased level of efficacy and the recovery period is when additional electrical stimulation does not provide a beneficial physiological effect to the patient.

摘要翻译： 本公开涉及使用可植入医疗装置的方法。 本公开的一个实施例包括在由恢复期隔开的瞬时生理效应期间输送患者的神经组织附近的电刺激。 瞬时生理效应期是当电刺激具有增加的功效水平时，并且当额外的电刺激不为患者提供有益的生理作用时的恢复期。

公开(公告)号：US08725247B2

公开(公告)日：2014-05-13

申请号：US13532469

申请日：2012-06-25

申请人： Imad Libbus ,  Avram Scheiner

发明人： Imad Libbus ,  Avram Scheiner

IPC分类号： A61N1/00

CPC分类号： A61N1/36057 ,  A61B5/021 ,  A61B5/024 ,  A61N1/0551 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/37217 ,  A61N1/37282 ,  A61N1/37288

摘要： An embodiment relates to a method for delivering a unidirectional afferent nerve stimulation treatment. A test neural stimulation is delivered, and a physiologic response to the test neural stimulation is monitored. At least one neural stimulation parameter for the test neural stimulation is adjusted if the test neural stimulation does not elicit a desired physiologic response. If the test neural stimulation does elicit the desired physiologic response, at least one treatment parameter for a unidirectional afferent nerve stimulation is determined using the at least one neural stimulation parameter for the test neural stimulation that provided the desired physiologic response. The unidirectional afferent nerve stimulation is delivered using the at least one treatment parameter.

摘要翻译： 一个实施方案涉及用于递送单向传入神经刺激治疗的方法。 传递测试神经刺激，并监测对测试神经刺激的生理反应。 如果测试神经刺激不引起所需的生理反应，则调整用于测试神经刺激的至少一个神经刺激参数。 如果测试神经刺激确实引起所需的生理反应，则使用提供所需生理反应的测试神经刺激的至少一个神经刺激参数确定单向传入神经刺激的至少一个治疗参数。 使用至少一个治疗参数递送单向传入神经刺激。

公开(公告)号：US08554336B2

公开(公告)日：2013-10-08

申请号：US11277333

申请日：2006-03-23

申请人： Mark J. Bly ,  Brian D. Soltis ,  Bruce A. Tockman ,  Avram Scheiner

发明人： Mark J. Bly ,  Brian D. Soltis ,  Bruce A. Tockman ,  Avram Scheiner

IPC分类号： A61N1/00

CPC分类号： A61N1/056 ,  A61N2001/0585

摘要： According to one embodiment, the present invention includes an elongate implantable medical lead having a distal portion that is relatively flexible, a proximal portion that is relatively stiff, and a transition portion which has a variable transition stiffness. The transition stiffness varies over the length of the transition portion that generally decreases in a distal direction. The relatively stiff proximal portion of the lead gives the lead steerability while the gradual change in stiffness in the transition portion reduces the likelihood that the lead will prolapse when it is guided into a branch vein. The distal stiffness is less than the proximal stiffness giving the lead a safe end that is unlikely to puncture vascular walls and is able to maneuver around various tortuosities when the lead is implanted into a patient.

摘要翻译： 根据一个实施例，本发明包括细长的可植入医疗引线，其具有相对柔性的远侧部分，相对刚性的近端部分和具有可变过渡刚度的过渡部分。 过渡刚度在远端方向上通常减小的过渡部分的长度上变化。 引线的相对刚性的近端部分具有引导操纵性，而过渡部分中刚度的逐渐变化降低了当引导到分支静脉时引线脱垂的可能性。 远端刚度小于近端刚度，使得引线成为不可能穿透血管壁的安全端，并且当铅被植入患者时能够围绕各种曲折进行操纵。

公开(公告)号：US08498721B2

公开(公告)日：2013-07-30

申请号：US13251466

申请日：2011-10-03

申请人： Avram Scheiner ,  Ronald W. Heil, Jr. ,  Peter T. Kelley ,  Bruce Tockman ,  Randy Westlund ,  Jay A. Warren ,  Christina Repasky ,  Lyle A. Bye ,  Brian D. Soltis

发明人： Avram Scheiner ,  Ronald W. Heil, Jr. ,  Peter T. Kelley ,  Bruce Tockman ,  Randy Westlund ,  Jay A. Warren ,  Christina Repasky ,  Lyle A. Bye ,  Brian D. Soltis

IPC分类号： A61N1/00

CPC分类号： A61N1/056 ,  A61N1/057 ,  A61N2001/0585

摘要： A lead having a pre-formed biased portion is adapted for implantation with a body vessel and for connection to a signal generator. The lead is constructed and arranged so that when it is implanted, the electrodes are biased toward a vessel wall by the preformed biased portion, which operates to fixate the lead against the vessel wall.

摘要翻译： 具有预成形的偏置部分的引线适于用身体容器注入并连接到信号发生器。 引线被构造和布置成使得当其被植入时，电极通过预先形成的偏压部分朝向血管壁偏压，该部分操作以将引线固定在血管壁上。

公开(公告)号：US08478391B2

公开(公告)日：2013-07-02

申请号：US13456795

申请日：2012-04-26

申请人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur L. Olive ,  Don Villalta

发明人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur L. Olive ,  Don Villalta

IPC分类号： A61B5/025

CPC分类号： A61B7/04 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/04012 ,  A61B5/04014 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/1118 ,  A61B5/742 ,  A61B7/023 ,  G06F19/00

摘要： An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.

公开(公告)号：US20120215294A1

公开(公告)日：2012-08-23

申请号：US13251466

申请日：2011-10-03

申请人： Avram Scheiner ,  Ronald W. Heil ,  Peter T. Kelley ,  Bruce Tockman ,  Randy Westlund ,  Jay A. Warren ,  Christina Repasky ,  Lyle A. Bye ,  Brian D. Soltis

发明人： Avram Scheiner ,  Ronald W. Heil ,  Peter T. Kelley ,  Bruce Tockman ,  Randy Westlund ,  Jay A. Warren ,  Christina Repasky ,  Lyle A. Bye ,  Brian D. Soltis

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/057 ,  A61N2001/0585

摘要： A lead having a pre-formed biased portion is adapted for implantation with a body vessel and for connection to a signal generator. The lead is constructed and arranged so that when it is implanted, the electrodes are biased toward a vessel wall by the preformed biased portion, which operates to fixate the lead against the vessel wall.

摘要翻译： 具有预成形的偏置部分的引线适于用身体容器注入并连接到信号发生器。 引线被构造和布置成使得当其被植入时，电极通过预先形成的偏压部分朝向血管壁偏压，该部分操作以将引线固定在血管壁上。

公开(公告)号：US20120158090A1

公开(公告)日：2012-06-21

申请号：US13402196

申请日：2012-02-22

申请人： Abhi Chavan ,  Anthony Caparso ,  Avram Scheiner

发明人： Abhi Chavan ,  Anthony Caparso ,  Avram Scheiner

IPC分类号： A61N1/378

CPC分类号： A61N1/36117 ,  A61N1/3605 ,  A61N1/36071 ,  A61N1/36135 ,  A61N1/37205 ,  A61N1/37217 ,  A61N1/37288 ,  A61N1/3787

摘要： One aspect of the present subject matter relates to an implantable medical device. An embodiment of the device comprises a rechargeable power supply adapted to be recharged through an ultrasound signal, a neural stimulator connected to the rechargeable power supply, and a controller connected to the rechargeable power supply. The neural stimulator is adapted to generate a neural stimulation signal for delivery to a neural stimulation target through an electrode. The controller is further connected to the neural stimulator to control the neural stimulator according to a neural stimulation protocol. Other aspects are provided herein.

摘要翻译： 本主题的一个方面涉及可植入医疗装置。 该装置的实施例包括适于通过超声信号再充电的可再充电电源，连接到可再充电电源的神经刺激器和连接到可再充电电源的控制器。 神经刺激器适于产生用于通过电极递送到神经刺激靶的神经刺激信号。 控制器进一步连接到神经刺激器，以根据神经刺激方案来控制神经刺激器。 本文提供了其他方面。

公开(公告)号：US08167811B2

公开(公告)日：2012-05-01

申请号：US13004543

申请日：2011-01-11

申请人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur L. Olive ,  Don Villalta

发明人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur L. Olive ,  Don Villalta

IPC分类号： A61B5/02

CPC分类号： A61B7/04 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/04012 ,  A61B5/04014 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/1118 ,  A61B5/742 ,  A61B7/023 ,  G06F19/00

摘要： An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.

摘要翻译： 用于输出心音的装置包括可植入系统和外部系统。 可植入系统包括用于产生表示检测到的心音的感测信号的传感器，接口电路和用于接收感测信号的控制电路，产生表示心音的数据，以及经由接口电路将数据发送到外部系统。 外部系统包括用于与可植入系统进行通信的接口电路，以及用于接收表示心脏声音的数据的控制电路，以及用于产生使输出设备产生表示声音的输出的控制信号。 可植入系统还可以包括用于检测心脏电信号的传感器。 在这种情况下，还输出表示心电信号的输出。

公开(公告)号：US08126561B2

公开(公告)日：2012-02-28

申请号：US12613094

申请日：2009-11-05

申请人： Abhi V. Chavan ,  Anthony V. Caparso ,  Avram Scheiner

发明人： Abhi V. Chavan ,  Anthony V. Caparso ,  Avram Scheiner

IPC分类号： A61N1/00

CPC分类号： A61N1/36117 ,  A61N1/3605 ,  A61N1/36071 ,  A61N1/36135 ,  A61N1/37205 ,  A61N1/37217 ,  A61N1/37288 ,  A61N1/3787

摘要： One aspect of the present subject matter relates to an implantable medical device. An embodiment of the device comprises a rechargeable power supply adapted to be recharged through an ultrasound signal, a neural stimulator connected to the rechargeable power supply, and a controller connected to the rechargeable power supply. The neural stimulator is adapted to generate a neural stimulation signal for delivery to a neural stimulation target through an electrode. The controller is further connected to the neural stimulator to control the neural stimulator according to a neural stimulation protocol. Other aspects are provided herein.

摘要翻译： 本主题的一个方面涉及可植入医疗装置。 该装置的实施例包括适于通过超声信号再充电的可再充电电源，连接到可再充电电源的神经刺激器和连接到可再充电电源的控制器。 神经刺激器适于产生用于通过电极递送到神经刺激靶的神经刺激信号。 控制器进一步连接到神经刺激器，以根据神经刺激方案来控制神经刺激器。 本文提供了其他方面。