摘要:
The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating α4 integrin mediated disorders. More particularly, the pyridazinone urea compounds of the present invention are α4β7 integrin inhibitors useful for treating integrin mediated disorders.
摘要:
A single intranet, internet, or World Wide Web-accessible interface is provided for, initiation of, interactive adjustments to, and access to the outputs of an integrated workflow of a plurality of analytical computer applications for characterization and analysis of traits and optimal management of the extraction of oil, gas, and water from a subsurface reservoir. By combining disparate analytical application tools in a seamless and remotely accessible, package, incompatibility problems caused by the disparate nature of petroleum analysis methods is reduced. The assumptions, analytic processes, and input data used for one analysis may be readily retrieved and re-evaluated for that reservoir or for future evaluations of the same or other reservoirs. Thus a flexible database of analysis tools and data may be implemented for access, input, and output of workflow and analytical data in the field, in conjunction with standard main computer servers, software and plug-ins, and portable remote computers.
摘要:
This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.
摘要:
This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.
摘要:
A method is disclosed for inverting 3-D seismic reflection data obtained from seismic surveys to derive impedance models for a subsurface region, and for inversion of multiple 3-D seismic surveys (i.e., 4-D seismic surveys) of the same subsurface volume, separated in time to allow for dynamic fluid migration, such that small scale structure and regions of fluid and dynamic fluid flow within the subsurface volume being studied can be identified. The method allows for the mapping and quantification of available hydrocarbons within a reservoir and is thus useful for hydrocarbon prospecting and reservoir management. An iterative seismic inversion scheme constrained by actual well log data which uses a time/depth dependent seismic source function is employed to derive impedance models from 3-D and 4-D seismic datasets. The impedance values can be region grown to better isolate the low impedance hydrocarbon bearing regions. Impedance data derived from multiple 3-D seismic surveys of the same volume can be compared to identify regions of dynamic evolution and bypassed pay. Effective Oil Saturation or net oil thickness can also be derived from the impedance data and used for quantitative assessment of prospective drilling targets and reservoir management.
摘要:
A soft cushion having a mechanism mounted therein for imparting electromagnetic hammering mode massage to its user, the device including an electromagnetic hammering mechanism, a clamping plate frame, and an electric control unit. The device is portable and may be used either as a soft cushion or as a hammering mode massage unit in which selection of the massage frequency, intensity and massage status is possible. The device may be held by hand, or put on a sofa, chair, bed, or car seat.
摘要:
FIG. 1 is a front, right, and top perspective view of the wireless earphones with charging case showing my new design, the charging case is shown separately for ease of illustration; FIG. 2 is a rear, left and bottom perspective view thereof; FIG. 3 is a front view thereof; FIG. 4 is a rear view thereof; FIG. 5 is a left side view thereof; FIG. 6 is a right side view thereof; FIG. 7 is a top plan view thereof; FIG. 8 is a bottom plan view thereof; FIG. 9 is a front, right, and top perspective view of the wireless earphones with charging case, with the wireless earphones shown separately for ease of illustration; FIG. 10 is a rear, left and bottom perspective view thereof; FIG. 11 is a front view thereof; FIG. 12 is a rear view thereof; FIG. 13 is a left side view thereof; FIG. 14 is a right side view thereof; FIG. 15 is a top plan view thereof; FIG. 16 is a bottom plan view thereof; and, FIG. 17 is a front, right and top perspective view of the wireless earphones with charging case with the two parts assembled together. The broken lines shown in the drawings illustrate portions of the wireless earphones with charging case that form no part of the claimed design.
摘要:
Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.
摘要:
The Figures illustrate an apparatus 2 comprising: a conductive element 4 comprising an area of conductive material 5 defined by a plurality of edges 6, 7 including a first edge 7 wherein the conductive element 4 comprises an interior aperture 12 in the area of conductive material 5 and an elongate portion 20 defined by a gap 14 at the first edge 7 of the conductive element 4 and by at least a portion of the interior aperture 12. The apparatus 2 may comprise a further interior aperture in the area of conductive material and a second elongate portion defined by a second gap, by at least a portion of the interior aperture and by at least a portion of the further interior aperture.
摘要:
Provided are a positive electrode material for lithium ion batteries and a process for preparing the same. The positive electrode material for lithium ion batteries comprises a composite positive electrode material consists of LiCoO2 and an auxiliary positive electrode material, the general formula of the auxiliary positive electrode material is LiCo1-x-yNixMnyO2, wherein 0