公开(公告)号：US20100021114A1

公开(公告)日：2010-01-28

申请号：US12487753

申请日：2009-06-19

Applicant: Xin Chen ,  Joohyun Koh ,  Ming-Jun Li

Inventor： Xin Chen ,  Joohyun Koh ,  Ming-Jun Li

IPC: G02B6/06 ,  G02B6/036

CPC classification number: G02B6/02276 ,  G02B6/02028 ,  G02B6/02214 ,  G02B6/02342 ,  G02B6/02347 ,  G02B6/02357 ,  G02B6/02366 ,  G02B6/03633

Abstract: A double-clad optical fiber includes a core, an inner cladding and an outer cladding of silica-based glass. The core may have a radius of less than about 5 μm, a first index of refraction n1 and does not contain any active rare-earth dopants. The inner cladding may surround the core and includes a radial thickness of at least about 25 μm, a numerical aperture of at least about 0.25, and a second index of refraction n2 such that n2

Abstract translation: 双包层光纤包括芯，内包层和二氧化硅基玻璃的外包层。 芯可以具有小于约5μm的半径，第一折射率n1并且不包含任何活性稀土掺杂剂。 内包层可以围绕芯部并且包括至少约25μm的径向厚度，至少约0.25的数值孔径和第二折射率n2，使得n2

公开(公告)号：US20100014344A1

公开(公告)日：2010-01-21

申请号：US12586147

申请日：2009-09-17

Applicant: Naijuan Wu ,  Xin Chen ,  Alex Ignatiev

Inventor： Naijuan Wu ,  Xin Chen ,  Alex Ignatiev

IPC: G11C11/00 ,  H01L45/00

CPC classification number: G11C13/0007 ,  G11C2213/31 ,  H01C7/006 ,  H01L45/04 ,  H01L45/12 ,  H01L45/1233 ,  H01L45/147

Abstract: A switchable resistive device has a multi-layer thin film structure interposed between an upper conductive electrode and a lower conductive electrode. The multi-layer thin film structure comprises a perovskite layer with one buffer layer on one side of the perovskite layer, or a perovskite layer with buffer layers on both sides of the perovskite layer. Reversible resistance changes are induced in the device under applied electrical pulses. The resistance changes of the device are retained after applied electric pulses. The functions of the buffer layer(s) added to the device include magnification of the resistance switching region, reduction of the pulse voltage needed to switch the device, protection of the device from being damaged by a large pulse shock, improvement of the temperature and radiation properties, and increased stability of the device allowing for multivalued memory applications.

Abstract translation: 可切换电阻器件具有介于上导电电极和下导电电极之间的多层薄膜结构。 多层薄膜结构体包括在钙钛矿层的一侧具有一个缓冲层的钙钛矿层或在钙钛矿层的两侧具有缓冲层的钙钛矿层。 在施加的电脉冲下在器件中产生可逆电阻变化。 器件的电阻变化在施加电脉冲后保持不变。 添加到器件中的缓冲层的功能包括电阻切换区域的放大率，切换器件所需的脉冲电压的降低，器件受到大脉冲冲击的损害，温度的改善以及 辐射性能和增加的设备的稳定性，允许多值存储器应用。

公开(公告)号：US07642358B2

公开(公告)日：2010-01-05

申请号：US11326616

申请日：2006-01-04

Applicant: Zuchun Zhao ,  Xin Chen ,  Jianchao Wang ,  Hongbin Sun ,  Jack Shih-Chieh Liang

Inventor： Zuchun Zhao ,  Xin Chen ,  Jianchao Wang ,  Hongbin Sun ,  Jack Shih-Chieh Liang

IPC: A61K31/423 ,  C07D263/57

CPC classification number: C07D207/325 ,  C07D231/12 ,  C07D235/18 ,  C07D239/26 ,  C07D249/08 ,  C07D249/20 ,  C07D261/08 ,  C07D263/57 ,  C07D271/06 ,  C07D277/66 ,  C07D413/04 ,  C07D413/12

Abstract: Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid metabolism and insulin secretion.

Abstract translation: 提供取代的苯乙酸，苯乙醇和相关化合物，其可用于治疗或控制与葡萄糖代谢，脂质代谢和胰岛素分泌相关的许多疾病。

公开(公告)号：US07638541B2

公开(公告)日：2009-12-29

申请号：US11964461

申请日：2007-12-26

Applicant: Xin Chen ,  Peng Cheng ,  L. Edward Clemens ,  Jeffrey D. Johnson ,  Jingyuan Ma ,  Alison Murphy ,  Imad Nashashibi ,  Christoper J. Rabbat ,  Jiangao Song ,  Maria E. Wilson ,  Yan Zhu ,  Zuchun Zhao

Inventor： Xin Chen ,  Peng Cheng ,  L. Edward Clemens ,  Jeffrey D. Johnson ,  Jingyuan Ma ,  Alison Murphy ,  Imad Nashashibi ,  Christoper J. Rabbat ,  Jiangao Song ,  Maria E. Wilson ,  Yan Zhu ,  Zuchun Zhao

IPC: A61K31/425

CPC classification number: A61K31/506 ,  A61K31/454 ,  C07D277/42 ,  C07D401/04 ,  C07D401/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: Compounds, compositions, and methods relating to 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine or a pharmaceutically acceptable salt thereof are provided for the treatment of Type II diabetes and other diseases associated with poor glycemic control.

Abstract translation: 与5-乙基-2- {4- [4-（4-四唑-1-基 - 苯氧基甲基） - 噻唑-2-基] - 哌啶-1-基} - 嘧啶或其药学上可接受的化合物，组合物和方法 提供其可接受的盐用于治疗II型糖尿病和与血糖控制不良相关的其它疾病。

公开(公告)号：US20090197862A1

公开(公告)日：2009-08-06

申请号：US12365325

申请日：2009-02-04

Applicant: Arno G. Steinig ,  Mark J. Mulvihill ,  Jing Wang ,  Douglas S. Werner ,  Qinghua Weng ,  Julie Kan ,  Heather Coate ,  Xin Chen

Inventor： Arno G. Steinig ,  Mark J. Mulvihill ,  Jing Wang ,  Douglas S. Werner ,  Qinghua Weng ,  Julie Kan ,  Heather Coate ,  Xin Chen

IPC: A61K31/4439 ,  C07D401/14 ,  C07D417/14 ,  C07D451/02 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/4725 ,  A61K31/5377 ,  A61K31/4545

CPC classification number: C07D417/14 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D451/04

Abstract: 2-Aminopyridine compounds having the structure of Formula I, and pharmaceutically acceptable salts of these compounds. Compounds of Formula I inhibit the activity of tyrosine kinase enzymes in animals, including humans, and are useful in the treatment and/or prevention of various diseases and conditions. In particular, compounds disclosed herein are inhibitors of kinases, in particular, but not limited to, KDR, Tie-2, Flt3, FGFR3, Ab1, Aurora A, c-Src, IGF-1R, ALK, c-MET, RON, PAK1, PAK2, and TAK1, and can be used in the treatment of proliferative diseases, such as, but not limited to, cancer. The present invention is also directed to a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The present invention is further directed to a method of treating a patient having a condition which is mediated by protein kinase activity by administering to the patient a therapeutically effective amount of the above-mentioned pharmaceutical composition.

Abstract translation: 具有式I结构的2-氨基吡啶化合物和这些化合物的药学上可接受的盐。 式I的化合物抑制动物（包括人）中酪氨酸激酶的活性，并且可用于治疗和/或预防各种疾病和病症。 特别地，本文公开的化合物是激酶抑制剂，特别是但不限于KDR，Tie-2，Flt3，FGFR3，Ab1，Aurora A，c-Src，IGF-1R，ALK，c-MET，RON， PAK1，PAK2和TAK1，并且可用于治疗增殖性疾病，例如但不限于癌症。 本发明还涉及包含治疗有效量的式I化合物或其药学上可接受的盐和药学上可接受的载体的药物组合物。 本发明还涉及通过向患者施用治疗有效量的上述药物组合物来治疗具有由蛋白激酶活性介导的病症的患者的方法。

公开(公告)号：US20090110239A1

公开(公告)日：2009-04-30

申请号：US11980033

申请日：2007-10-30

Applicant: Xin Chen ,  William Gale

Inventor： Xin Chen ,  William Gale

IPC: G06K9/00 ,  G06K9/36

CPC classification number: G06T11/001 ,  G06T15/205

Abstract: Disclosed are a system and method for identifying objects in an image dataset that occlude other objects and for transforming the image dataset to reveal the occluded objects. In some cases, occluding objects are identified by processing the image dataset to determine the relative positions of visual objects. Occluded objects are then revealed by removing the occluding objects from the image dataset or by otherwise de-emphasizing the occluding objects so that the occluded objects are seen behind it. A visual object may be removed simply because it occludes another object, because of privacy concerns, or because it is transient. When an object is removed or de-emphasized, the objects that were behind it may need to be “cleaned up” so that they show up well. To do this, information from multiple images can be processed using interpolation techniques. The image dataset can be further transformed by adding objects to the images.

Abstract translation: 公开了一种用于识别封闭其他对象的图像数据集中的对象并用于变换图像数据集以显露遮挡对象的系统和方法。 在某些情况下，通过处理图像数据集以确定可视对象的相对位置来识别遮挡对象。 然后通过从图像数据集中移除遮挡物体或通过其他方式去除遮挡物体来遮蔽遮挡物体，以便在其后面看到遮挡的物体。 视觉对象可能被删除，因为它隐藏另一个对象，因为隐私问题，或因为它是暂时的。 当对象被删除或去除强调时，其后面的对象可能需要“清理”，以使它们显示得很好。 为此，可以使用插值技术来处理来自多个图像的信息。 通过向图像中添加对象可以进一步转换图像数据集。

公开(公告)号：US20080304800A1

公开(公告)日：2008-12-11

申请号：US12070845

申请日：2008-02-21

Applicant: Scott Robertson Bickham ,  Dana Craig Bookbinder ,  Xin Chen ,  Ming-Jun Li ,  Snigdharaj Kumar Mishra ,  Daniel Aloysius Nolan ,  Pushkar Tandon

Inventor： Scott Robertson Bickham ,  Dana Craig Bookbinder ,  Xin Chen ,  Ming-Jun Li ,  Snigdharaj Kumar Mishra ,  Daniel Aloysius Nolan ,  Pushkar Tandon

IPC: G02B6/02

CPC classification number: G02B6/02014 ,  G02B6/02019 ,  G02B6/02357 ,  G02B6/02366 ,  G02B6/0365 ,  G02B6/03661 ,  G02B6/03688

Abstract: An optical fiber comprising: a glass core extending from a centerline to a radius R1; a glass cladding surrounding and in contact with the core, the cladding comprising:a first annular region extending from R1 to a radius R2, the first annular region comprising a radial width, W2=R2−R1, a second annular region extending from R2 to a radius R3, the second annular region comprising a radial width, W3=R3−R2, and a third annular region extending from R3 to an outermost glass radius R4; wherein (i) the core comprises a maximum relative refractive index, Δ1MAX, relative to the third annular region; (ii) wherein the first annular region comprises a radial width W2; and (iii) the second annular region comprises a minimum relative refractive index, Δ3MIN, relative to the third annular region wherein Δ1MAX>Δ2MAX>Δ3MIN, and Δ2MIN>Δ3MIN; and the core and the cladding provide a fiber with cable cutoff less than 1500 nm, dispersion at 1550 nm less than 12 ps/nm/km, effective area at 1550 nm greater than 60 μm2, and preferably greater than 70 μm2. The second annular cladding region may contain a plurality of randomly dispersed holes.

Abstract translation: 一种光纤，包括：从中心线延伸到半径R1的玻璃芯; 围绕并与芯接触的玻璃包层，所述包层包括：从R1延伸到半径R2的第一环形区域，所述第一环形区域包括径向宽度W2 = R2-R1，从R2延伸到第二环形区域 半径R3，第二环形区域包括径向宽度，W3 = R3-R2，以及从R3延伸到最外侧玻璃半径R4的第三环状区域; 其中（i）所述芯包括相对于所述第三环形区域的最大相对折射率Delta1MAX; （ii）其中所述第一环形区域包括径向宽度W2; 和（iii）第二环形区域包括相对于第三环形区域的最小相对折射率Delta3MIN，其中Delta1MAX> Delta2MAX> Delta3MIN和Delta2MIN> Delta3MIN; 并且芯和包层提供具有小于1500nm的电缆截止的光纤，在1550nm处的色散小于12ps / nm / km，在1550nm处的有效面积大于60mum2，优选大于70mum2。 第二环形包层区域可以包含多个随机分布的孔。

公开(公告)号：US20080279517A1

公开(公告)日：2008-11-13

申请号：US12151171

申请日：2008-05-05

Applicant: Scott Robertson Bickham ,  Dana Craig Bookbinder ,  Xin Chen ,  Ming-Jun Li ,  Snigdharaj Kumar Mishra ,  Daniel Aloysius Nolan

Inventor： Scott Robertson Bickham ,  Dana Craig Bookbinder ,  Xin Chen ,  Ming-Jun Li ,  Snigdharaj Kumar Mishra ,  Daniel Aloysius Nolan

IPC: G02B6/028

CPC classification number: G02B6/0365 ,  G02B6/02019

Abstract: An optical fiber according to an embodiment of the present invention comprises: a glass core extending from a centerline to a radius R1 wherein R1 is greater than about 5 μm; a glass cladding surrounding and in contact with the core, the cladding comprising: (i) a first annular region extending from the radius R1 to a radius R2, the first annular region comprising a radial width, W2=R2−R1, (ii) a second annular region extending from the radius R2 to a radius R3, and comprising a radial width, W3=R3−R2, and (iii) a third annular region surrounding the second annular region and extending from the radius R3 to an outermost glass radius R4; wherein the core comprises a maximum relative refractive index, Δ1MAX, relative to the third annular region, and wherein Δ1MAX is greater than about 0.1% and less than about 0.3%; the first annular region has a refractive index delta Δ2(r) is less than about 0.025%; wherein the second annular region comprises a minimum relative refractive index, Δ3MIN, relative to the third annular region;wherein Δ1MAX>Δ2MAX>Δ3MIN, and Δ2MIN>Δ3MIN

Abstract translation: 根据本发明实施例的光纤包括：从中心线延伸到半径R 1的玻璃芯，其中R 1>大于5μm; 围绕并与芯接触的玻璃包层，所述包层包括：（i）从半径R 1> 1半径R 2> 2延伸的第一环形区域，第一 包括径向宽度的第二环形区域，（ii）从半径R < SUB> 2 到半径R 3 3，并且包括径向宽度，W 3 3 = R 3→N < 2，和（iii）围绕第二环形区域并从半径R 3 3延伸到最外侧玻璃半径R 4的第三环形区域; 其中所述芯包括相对于所述第三环形区域的最大相对折射率，Δ1MAX1，并且其中Δ1MAX1大于约0.1％且小于约0.3％ ; 第一环形区域具有小于约0.025％的折射率差ΔΔ2（r）; 其中所述第二环形区域包括相对于所述第三环形区域的最小相对折射率，Δ3 NIN; 其中Delta 1MAX 增量2MAX 三角洲3MIN和三角洲2MIN 三角洲3IN > <0; 并且其中所述芯和所述包层提供具有小于1500nm的电缆截止的光纤，并且在1550nm处的有效面积大于95μm2，并且在20℃下的弯曲损耗为<= 0.5dB / mm直径心轴。

公开(公告)号：US07432394B2

公开(公告)日：2008-10-07

申请号：US11525201

申请日：2006-09-20

Applicant: Peng Cheng ,  Jingyuan Ma ,  Xin Chen ,  Yan Zhu ,  Zuchun Zhao

Inventor： Peng Cheng ,  Jingyuan Ma ,  Xin Chen ,  Yan Zhu ,  Zuchun Zhao

IPC: C07C59/56

CPC classification number: C07C233/18 ,  C07B57/00 ,  C07C51/487 ,  C07C231/14 ,  C07C59/88

Abstract: The present invention provides a methods and compounds for producing an enantiomerically enriched α-(phenoxy)phenylacetic acid compound of the formula: from a mixture of its enantiomers, where R1 is alkyl or haloalkyl and X is halide.

Abstract translation: 本发明提供用于制备下式的对映异构体富集的α-（苯氧基）苯乙酸化合物的方法和化合物：其对映异构体的混合物，其中R 1是烷基或卤代烷基，X是卤素 。

公开(公告)号：US07412142B2

公开(公告)日：2008-08-12

申请号：US11437897

申请日：2006-05-19

Applicant: Xin Chen ,  Joohyun Koh ,  Ming-Jun Li ,  Daniel Aloysius Nolan

Inventor： Xin Chen ,  Joohyun Koh ,  Ming-Jun Li ,  Daniel Aloysius Nolan

IPC: G02B6/00 ,  G02B6/02 ,  G02B6/028 ,  G02B6/32 ,  G02B6/36

CPC classification number: C03B37/014 ,  C03B37/01217 ,  C03B2201/10 ,  C03B2201/28 ,  C03B2201/31 ,  C03B2203/14 ,  C03B2203/302 ,  C03B2203/31 ,  G02B6/02333 ,  G02B6/02366 ,  G02B6/024

Abstract: An optical fiber comprising: (i) a silica based passive core having a first index of refraction n1; (ii) a silica based cladding surrounding the core and having a second index of refraction n2, such that n1>n2, said cladding having at least one stress rod and at least one air hole extending longitudinally through the length of said optical fiber; and (iii) wherein said optical fiber supports a single polarization mode or poses polarization maintaining properties within the operating wavelength range.

Abstract translation: 一种光纤，包括：（i）具有第一折射率n 1的二氧化硅基无源芯; （ii）围绕所述芯并且具有第二折射率n 2 2的二氧化硅基包层，使得所述第二折射率n 2 2 < 包层具有至少一个应力杆和沿所述光纤的长度纵向延伸的至少一个气孔; 和（iii）其中所述光纤支持单一偏振模式或在工作波长范围内产生偏振维持特性。