公开(公告)号：US20220362748A1

公开(公告)日：2022-11-17

申请号：US17816154

申请日：2022-07-29

Applicant: Korea Institute of Science and Technology

Inventor： Young Suk JO ,  Jun Young CHA ,  Hyang Soo JEONG ,  Yong Min KIM ,  Hyun Tae SOHN ,  Sung Pil YOON ,  Suk Woo NAM ,  Taik Jin LEE ,  Chang Won YOON ,  Jong Hee HAN

IPC: B01J23/46 ,  B01J27/24 ,  B01J35/08 ,  B01J35/02 ,  B01J35/00 ,  B01J37/02 ,  B01J37/08 ,  C01B3/04 ,  C01B3/02 ,  C01C1/04

Abstract: The present invention relates to a catalyst in which a catalytic metal is supported on a support including a single-crystalline hexagonal material, and a preparation method therefor, wherein the catalyst can be effectively used in ammonia dehydrogenation or ammonia synthesis.

公开(公告)号：US11498976B2

公开(公告)日：2022-11-15

申请号：US16878672

申请日：2020-05-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyung Jun Ahn ,  Sungjin Lee

IPC: C07H21/04 ,  C07K16/30 ,  A61P35/00 ,  C12N15/86

Abstract: The present invention relates to a viral complex comprising a viral vector capable of delivering shRNA that suppresses an expression of epidermal growth factor receptor (EGFR) to a cell and an anti-epithelial cell adhesion molecule (EpCAM) antibody conjugated to the viral vector, a pharmaceutical composition for preventing or treating cancer, comprising the viral complex, and a method for treating cancer, comprising administering the viral complex or the pharmaceutical composition to a subject in which a cancer disease has occurred and overexpressing EpCAM. The anti-EpCAM antibody-AAV2/shEGFR complex provided in the present invention significantly reduces the expression level of EGFR in tumor cells overexpressing EpCAM without inducing an immune response in vivo, thereby inducing death of tumor cells, and thus, it can be widely utilized in more effective and safe cancer treatment.

公开(公告)号：US11498946B2

公开(公告)日：2022-11-15

申请号：US17118767

申请日：2020-12-11

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwangmeyung Kim ,  Ju Hee Ryu ,  Hong Yeol Yoon ,  Man Kyu Shim ,  Suah Yang

IPC: C07K14/47 ,  A61P35/00 ,  A61K47/10 ,  C07K16/28 ,  A61K47/64

Abstract: The present disclosure relates to a pharmaceutical composition for combination therapy for preventing or treating cancer, which contains a first pharmaceutical ingredient containing a drug conjugate wherein an anticancer agent is bound at one end of an amphiphilic peptide represented by SEQ ID NO 1 and a poloxamer; and a second pharmaceutical ingredient containing an anti-PD-L1 antibody; as active ingredients. The pharmaceutical composition significantly inhibits cancer growth in in-vivo experiments and exhibits an effect of significantly enhancing immunotherapeutic effect by activating immune cells in cancerous tissues.
In particular, the pharmaceutical composition for combination therapy according to the present disclosure has superior tumor accumulation efficiency and selectivity as compared to existing anticancer agents, and is very stable with little toxicity to normal tissues other than cancerous tissues.

公开(公告)号：US11492363B2

公开(公告)日：2022-11-08

申请号：US16395235

申请日：2019-04-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kyung Youl Baek ,  Chong Min Koo ,  Soon Man Hong ,  Seung Sang Hwang ,  Sangho Cho ,  Jin Young Seo ,  Do Xuan Huy ,  Younghan Song ,  Sejin Kim ,  Changju Sung ,  Yeojin Ahn

IPC: B01J21/06 ,  C07F7/00 ,  A62D3/35 ,  A62D5/00 ,  A62D9/00 ,  A62B18/02 ,  B01J35/10 ,  B01J35/02 ,  B01J31/12 ,  A62B7/10 ,  A62D101/02

Abstract: The present invention relates to a method for preparing size-modulated UiO-66, which is achieved by modulating the concentrations of reactants, and a catalyst with improved activity of hydrolyzing chemical warfare agents prepared by the method.

公开(公告)号：US20220347644A1

公开(公告)日：2022-11-03

申请号：US17859485

申请日：2022-07-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Young Suk JO ,  Chang Won YOON ,  Hyuntae SOHN ,  Hyangsoo JEONG ,  Seong Cheol JANG ,  Yeong Cheon KIM ,  Jonghee HAN ,  Suk Woo NAM

IPC: B01J8/02 ,  B01J19/24 ,  B01J23/46 ,  B01J23/10 ,  B01J29/08 ,  B01J35/04 ,  B01J35/00 ,  C01B3/04 ,  H01M8/0606 ,  B01J23/648

Abstract: The present specification discloses a membrane reactor comprising a reaction region; a permeate region; and a composite membrane disposed at a boundary of the reaction region and the permeate region, wherein the reaction region comprises a bed filled with a catalyst for dehydrogenation reaction, wherein the composite membrane comprises a support layer including a metal with a body-centered-cubic (BCC) crystal structure, and a catalyst layer including a palladium (Pd) or a palladium alloy formed onto the support layer, wherein ammonia (NH3) is supplied to the reaction region, the ammonia is converted into hydrogen (H2) by the dehydrogenation reaction in the presence of the catalyst for dehydrogenation reaction, and the hydrogen permeates the composite membrane and is emitted from the membrane reactor through the permeate region.

公开(公告)号：US11486777B2

公开(公告)日：2022-11-01

申请号：US17259636

申请日：2019-07-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jinseok Kim ,  Sungwook Yang ,  Min Su Jang ,  Jun Sik Kim ,  Kyumin Kang ,  Bum-Jae You

IPC: G01L1/24 ,  G01L3/12

Abstract: Embodiments relate to a torsion sensor device which measures a degree of torsion of a measurement object by using a fiber Bragg gratings (FBG) sensor, the sensor device comprising: an FBG sensor including a sensing unit formed in one section of an elongated optical fiber; and a fixing device for fixing and supporting the FBG sensor to cause displacement of the FBG sensor according to motion of the measurement object, wherein the fixing device includes a bending prevention member to enable the sensing unit to have torsion displacement without bending displacement, according to the motion of the measurement object.

公开(公告)号：US20220319001A1

公开(公告)日：2022-10-06

申请号：US17710026

申请日：2022-03-31

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyung Min KIM ,  Kyungho YOON ,  Tae Young PARK ,  Heekyung KOH

IPC: G06T7/00 ,  G16H20/30

Abstract: A real-time acoustic simulation method based on artificial intelligence according to an embodiment of the present disclosure includes acquiring medical image data of a target area to be treated; determining ultrasound parameters related to the output of an ultrasonic transducer based on the medical image data; inputting the ultrasound parameters to a numerical model to generate a numerical model based acoustic simulation image for a specific position of the ultrasonic transducer; training an artificial intelligence model using the medical image data and the numerical model based acoustic simulation image; generating an artificial intelligence model based acoustic simulation image for an arbitrary position of the ultrasonic transducer using the trained artificial intelligence model; and outputting a real-time acoustic simulation image with a position change of the ultrasonic transducer.

公开(公告)号：US20220302528A1

公开(公告)日：2022-09-22

申请号：US17544726

申请日：2021-12-07

Applicant: Hyundai Motor Company ,  Kia Corporation ,  Korea Institute of Science and Technology

Inventor： Gwang Seok Oh ,  Kyoung Han Ryu ,  Young Suk Cho ,  Won Keun Kim ,  Hun Gi Jung ,  Seung Ho Yu ,  Min Ah Lee ,  Hee Dae Lim ,  Min Gi Jeong

IPC: H01M12/08 ,  H01M10/0567 ,  H01M12/02

Abstract: Disclosed are a lithium-air battery including a redox mediator in an electrolyte and having a protective layer on an anode, and a method of manufacturing the same. The lithium-air battery includes an anode including a lithium metal, a protective layer positioned on the anode and including lithium fluoride (LiF), a cathode, and an electrolyte positioned between the protective layer and the cathode. Particularly, the electrolyte includes a halogen ion (X−) which is a redox mediator.

公开(公告)号：US20220302232A1

公开(公告)日：2022-09-22

申请号：US17698334

申请日：2022-03-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sangho CHO ,  Kyung Youl BAEK

IPC: H01L27/32 ,  G06F1/16

Abstract: Provided is a display device including a film structure having excellent flexibility and moisture infiltration prevention effects via a structure including a first polymer and a second polymer in which an inorganic compound penetrates into the first polymer. The display device may have excellent durability without causing problems such as peeling off of a sealing layer and moisture infiltration even after the display device is repeatedly stretched.

公开(公告)号：US11426421B2

公开(公告)日：2022-08-30

申请号：US16212116

申请日：2018-12-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  REPUBLIC OF KOREA(MANAGEMENT : RURAL DEVELOPMENT ADMINISTRATION)

Inventor： Yongsoo Choi ,  Jin-Chul Kim ,  Su-Nam Kim ,  Kyungsu Kang ,  Seung-Hoon Yang ,  Keunwan Park ,  Hee Ju Lee ,  Dae-geun Song ,  Kwang-Hyun Cha ,  Joo Yeong Jeon ,  Chang Geon Kim ,  Jung Kyung Moon ,  Man Soo Choi ,  Soo Kwon Park ,  Nam Hee Jeong

IPC: A61K36/00 ,  A61K31/7048 ,  A23L33/105 ,  A61P17/00 ,  A61P29/00 ,  A61K9/00 ,  A61K31/352 ,  A61K36/48

Abstract: Provided are a composition for preventing or improving inflammation, the composition including an extract of a seed of soybean Glycine max (L.) Merrill cultivar SCEL-1, and a method of preventing occurrence of inflammation in a subject or improving inflammation in a subject, the method including injecting the composition to a subject.