公开(公告)号：US20200224171A1

公开(公告)日：2020-07-16

申请号：US16499333

申请日：2018-04-03

Applicant: Yea Research and Development Co. Ltd.

Inventor： Ravid STRAUSSMAN ,  Nancy GAVERT

IPC: C12N5/09 ,  G01N33/50 ,  C12M1/12 ,  A61P35/00 ,  A61K33/243 ,  A61K31/513 ,  A61K31/4545 ,  A61K31/337 ,  A61K31/704 ,  A61K31/675 ,  A61K31/4748 ,  A61K31/7068 ,  A61K31/5377 ,  A61K31/138 ,  A61K31/502 ,  A61K31/519 ,  A61K31/439

Abstract: Ex-vivo culture systems are provided. Accordingly there is provided a culture system comprising a culture medium and a precision-cut tissue slice placed on a tissue culture insert, wherein the precision-cut tissue slice is maintained in a highly oxygenated atmosphere containing at least 50% oxygen and wherein said culture is rotationally agitated facilitating intermittent submersion of the tissue slice in the culture medium. Also provided are methods of culturing a tissue and methods of using the culture system for selecting a drug for the treatment of a disease.

公开(公告)号：US20200150125A1

公开(公告)日：2020-05-14

申请号：US16487849

申请日：2018-03-12

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Ayelet EREZ

IPC: G01N33/574

Abstract: Methods of diagnosing cancer are provided. Accordingly there is provided a method of diagnosing cancer in a subject, the method comprising determining a level of urea and/or a pyrimidine synthesis metabolite in a biological sample of the subject, wherein a level of urea below a predetermined threshold; and/or a said level of pyrimidine synthesis metabolite above a predetermined threshold; is indicative of cancer. Also provided are methods of prognosing and treating cancer.

公开(公告)号：US20200110144A1

公开(公告)日：2020-04-09

申请号：US15749518

申请日：2018-02-01

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Lucio FRYDMAN ,  Zhiyong ZHANG ,  Shimon Michael LUSTIG

IPC: G01R33/561 ,  G01R33/54

Abstract: A method for MRI imaging of a subject includes spatially encoding spins in a slice of the subject in orthogonal first and second directions. The encoding includes applying a chirped radiofrequency (RF) pulse concurrently with application of a magnetic field gradient pulse along the first direction. After applying of the RF pulse, a second chirped RF pulse is applied concurrently with application of a second magnetic field gradient pulse, with polarity opposite that of the first gradient pulse. An encoding magnetic field gradient, constant from applying the first RF pulse until the end of applying the second RF pulse, is concurrently applied along the second direction. Following the encoding, a spin signal is measured concurrently with application of a constant readout magnetic field gradient.

公开(公告)号：US20200095282A1

公开(公告)日：2020-03-26

申请号：US16704010

申请日：2019-12-05

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Moshe OREN ,  Varda ROTTER ,  Perry TAL

IPC: C07K7/06 ,  C07K14/47 ,  C07K7/08 ,  C07K14/00 ,  A61K38/08 ,  A61K38/16

Abstract: The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and isolation of such peptides, in a precise, cost and time effective manner. In particular, there are provided mutant p53 reactivating peptides that can restore the native wild type p53 folding, and hence the tumor suppressor activity, to the mutant p53 protein. Such peptides are useful for treating various conditions and diseases in which p53 is mutated.

公开(公告)号：US10590467B2

公开(公告)日：2020-03-17

申请号：US15303741

申请日：2015-04-16

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido Amit ,  David Lara-Astiaso ,  Meital Gury

IPC: C12Q1/68 ,  C07H21/00 ,  C12Q1/6816 ,  G01N33/53

Abstract: A method of analyzing DNA which, in a cell, is bound to a DNA binding moiety, the method comprising: (a) obtaining at least two samples of complexes of DNA bound to a DNA binding moiety; (b) isolating the complexes on a solid support; (c) labeling the DNA of the complexes, wherein the labeling distinguishes between the complexes of the first of the at least two samples and the complexes of the second of the at least two samples; (d) pooling the at least two samples of complexes; and (e) isolating the complexes using an agent which specifically binds to the DNA binding moiety; and (f) analyzing the DNA of the complexes.

公开(公告)号：US10589132B2

公开(公告)日：2020-03-17

申请号：US15772065

申请日：2016-10-27

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Eldad Tzahor ,  Elad Bassat

IPC: A61K38/17 ,  A61P9/10 ,  C12N5/077 ,  C07K14/47 ,  A61L27/54

Abstract: An Agrin peptide which induces proliferation of cardiomyocytes for treating a heart disease is provided.

公开(公告)号：US20200060994A1

公开(公告)日：2020-02-27

申请号：US16676495

申请日：2019-11-07

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michael Fainzilber ,  Nicolas Panayotis

IPC: A61K31/135 ,  A61K31/575 ,  A61K31/395 ,  A61K31/397 ,  A61K31/44 ,  A61P25/22

Abstract: Agents and methods of treating a psychiatric stress disorder, Rett syndrome, MeCP2 duplication syndrome or multiple sclerosis are provided. Accordingly there is provided an agent capable of down-regulating activity and/or expression of importin alpha5 for use in the treatment of a medical condition selected from the group consisting of psychiatric stress disorder, Rett syndrome, MeCP2 duplication syndrome and multiple sclerosis. Also provided are methods of identifying an agent that inhibits activity of importin alpha5.

公开(公告)号：US20200046935A1

公开(公告)日：2020-02-13

申请号：US16545007

申请日：2019-08-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Anat ARZI ,  Lee SELA ,  Anton PLOTKIN ,  Aharon WEISSBROD ,  Noam SOBEL

IPC: A61M21/02 ,  A61M16/10 ,  A61M15/08

Abstract: A device for controlling respiration during sleep based on the user physiological characteristic. The device includes an odor disperser for dispersing an odor; at least one detector for detecting a physiological characteristic of a user; and a controller for controlling respiration of the user by instructing the odor dispenser to disperse an odor responsive to detections by the at least one detector.

公开(公告)号：US10557853B2

公开(公告)日：2020-02-11

申请号：US15640545

申请日：2017-07-02

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David Margulies ,  Leila Motiei ,  Linor Unger

IPC: C07D417/06 ,  G01N33/58 ,  C07D417/14 ,  C07K7/06 ,  C09K11/06 ,  G01N33/573 ,  G01N33/574

Abstract: The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.

公开(公告)号：US20190382827A1

公开(公告)日：2019-12-19

申请号：US16525669

申请日：2019-07-30

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran ELINAV ,  Eran SEGAL

IPC: C12Q1/689 ,  A61P1/00 ,  A61K31/132 ,  A61K31/417

Abstract: A method of determining the therapeutic effect of an agent, such as a metabolite, comprising: (a) exposing a pathological microbiome to the agent; and (b) comparing the signature of the pathological microbiome following the exposing with a reference signature of a healthy microbiome, wherein when the signature of the microbiome is statistically significantly similar to the healthy microbiome reference signature, it is indicative that the agent has a therapeutic effect on the microbiome. The agent may be provided to a subject having a pathological microbiome once it has been classified as therapeutic.