公开(公告)号：US20210104720A1

公开(公告)日：2021-04-08

申请号：US16948998

申请日：2020-10-08

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： HAIPING HONG ,  ROB HRABE

IPC: H01M4/04 ,  H01M4/38 ,  H01M10/0525

Abstract: The present disclosure relates to methods, and the resultant compositions, of preparing doped electrode materials comprising doping electrode compositions via a cold spray method. Preferably, the electrode materials are doped with hetero atoms and/or silicon-based compounds. The doped electrode materials preferably have a well-distributed deposition of the hetero atoms and/or silicon-based compounds.

公开(公告)号：US10765776B1

公开(公告)日：2020-09-08

申请号：US15791720

申请日：2017-10-24

Applicant: South Dakota Board of Regents (SDBOR)

Inventor： Gudiseva Chandrasekher ,  Somshuvra Bhattacharya

IPC: A61L27/36 ,  A61L27/38 ,  A61K35/30

Abstract: The present disclosure relates to a composition and methods for preparing a tissue-derived, dissolved extracellular matrix. In implementations, the extracellular matrix composition includes components native to the cornea including liquefied corneal tissue. The extracellular matrix composition can be prepared by dissolving extracted corneas in an aqueous solution of inorganic base. The resulting solution is then dialyzed to achieve a physiological pH. In some implementations, the extracellular matrix composition can be seeded and/or chemically cross-linked to form a gel matrix. The extracellular matrix and/or the gel matrix can be seeded with a desired cell type (e.g., endothelial cells, epithelial cells, stromal keratocytes, etc.) to stimulate cell proliferation and regeneration.

公开(公告)号：US10675598B2

公开(公告)日：2020-06-09

申请号：US15561503

申请日：2016-03-23

Applicant: South Dakota Board of Regents

Inventor： Ilchgerel Dash ,  Robb M. Winter

IPC: B01F7/00 ,  B01F15/06 ,  B82Y40/00 ,  B01F3/14 ,  C08J3/20 ,  C08J5/00

Abstract: An improved a device and method for dispersion and simultaneous orientation of nanoparticles within a matrix is provided. A mixer having a shaft and a stator is provided. The shaft may have a rupture region and erosion region. Further, an orienter having an angled stationary plate and a moving plate are provided. The nanoparticles and the matrix are fed into the mixer. A rotational force is applied to the shaft to produce shearing forces. The shearing forces disperse and exfoliate the nanoparticles within the matrix. The dispersed mixture is outputted onto the moving plate. The moving plate is forced across the angled stationary plate to produce fully developed laminar shear flow. The fully developed laminar shear flow or the two-dimensional extensional drag flow orients the dispersed nanoparticles-matrix mixture.

公开(公告)号：US10519580B2

公开(公告)日：2019-12-31

申请号：US14551348

申请日：2014-11-24

Applicant: Hao Fong ,  Lifeng Zhang ,  Yong Zhao ,  Zhengtao Zhu

Inventor： Hao Fong ,  Lifeng Zhang ,  Yong Zhao ,  Zhengtao Zhu

IPC: C01B32/00 ,  D04H1/728 ,  D04H1/4209 ,  D04H1/4382 ,  B82Y30/00 ,  B82Y40/00 ,  C04B35/622 ,  D01D5/00 ,  C04B35/56 ,  C04B35/634 ,  D01F9/12 ,  C01B32/921 ,  H01G11/36

Abstract: A method of synthesizing mechanically resilient titanium carbide (TiC) nanofibrous felts comprising continuous nanofibers or nano-ribbons with TiC crystallites embedded in carbon matrix, comprising: (a) electrospinning a spin dope for making precursor nanofibers with diameters less than 0.5 J.Lm; (b) overlaying the nanofibers to produce a nano-fibrous mat (felt); and then (c) heating the nano-felts first at a low temperature, and then at a high temperature for making electrospun continuous nanofibers or nano-ribbons with TiC crystallites embedded in carbon matrix; and (d) chlorinating the above electrospun nano-felts at an elevated temperature to remove titanium for producing carbide derived carbon (CDC) nano-fibrous felt with high specific surface areas.

公开(公告)号：US10468674B2

公开(公告)日：2019-11-05

申请号：US16249330

申请日：2019-01-16

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： David R. Salem ,  Chunhui Chen ,  Abdulmenan Hussein

IPC: H01M4/36 ,  H01M4/38 ,  H01M4/587 ,  H01M4/02

Abstract: This application relates to anode compositions and methods of making and using the same. In particular, the anode compositions are preferably layered. Preferably, the methods of making the anode compositions comprise a surfactant mediated assembly of layers. The anode compositions have improved structural integrity and capacity while reducing capacity fade due to cycling.

公开(公告)号：US10383943B2

公开(公告)日：2019-08-20

申请号：US15441191

申请日：2017-02-23

Applicant: South Dakota Board of Regents

Inventor： Hemachand Tummala ,  Pratik Muley

IPC: A61K45/06 ,  A61K31/555 ,  A61K47/54

Abstract: Compositions and methods for the use thereof for the treatment of cancer in a subject in need thereof comprising administering to the subject an effective amount of a composition comprising an anticancer composition comprising a antineoplastic compound and a conjugated targeting moiety with or without a chemical linker. In certain aspects the antineoplastic compound is a platin and the conjugated targeting moiety is an amino acid.

公开(公告)号：US10316010B2

公开(公告)日：2019-06-11

申请号：US15383935

申请日：2016-12-19

Applicant: South Dakota Board of Regents

Inventor： Grigoriy Sereda ,  Joseph Keppen

IPC: C08K3/04 ,  C07D307/52 ,  C07C225/06 ,  C07C227/14 ,  C07D207/448 ,  C07D405/14 ,  C07F9/38 ,  C08J3/24 ,  C08K3/22 ,  C08K7/06 ,  C08K9/04

Abstract: Disclosed is a non-destructive universal method of functionalization of graphitic carbonaceous materials that enables their alignment, cross-linking, and effective integration into composite materials.

公开(公告)号：US20180171086A1

公开(公告)日：2018-06-21

申请号：US15843828

申请日：2017-12-15

Applicant: South Dakota Board of Regents

Inventor： Haoran Sun

IPC: C08J5/18 ,  C08G12/08

CPC classification number: C08J5/18 ,  C08G12/08 ,  C08J2361/22

Abstract: Synthesis and growth of large area free-standing ultra-thin two-dimensional (2D) polymeric films including 2D covalent organic frameworks (COF) are achieved by utilizing fluorocarbon-soluble fluorinated aldehyde derivatives and hydrocarbon-soluble amine derivatives at a liquid-liquid interface of respective fluorocarbon and hydrocarbon solvents.

公开(公告)号：US09925181B2

公开(公告)日：2018-03-27

申请号：US15682218

申请日：2017-08-21

Applicant: South Dakota Board of Regents

Inventor： Ying Deng ,  Bo Yang

IPC: A61K31/4745 ,  A61K31/155

CPC classification number: A61K31/4745 ,  A61K31/155

Abstract: A method of producing a drug-loaded Poly (Glycerol Sebacate) (PGS) comprising providing PGS; dissolving at least one drug in a solvent; incubating the PGS in the solvent; and evaporating the solvent.

公开(公告)号：US20180056253A1

公开(公告)日：2018-03-01

申请号：US15561503

申请日：2016-03-23

Applicant: South Dakota Board of Regents

Inventor： Ilchgerel Dash ,  Robb M. Winter

IPC: B01F7/00 ,  C08J5/00 ,  C08J3/20 ,  B01F15/06

Abstract: An improved a device and method for dispersion and simultaneous orientation of nanoparticles within a matrix is provided. A mixer having a shaft and a stator is provided. The shaft may have a rupture region and erosion region. Further, an orienter having an angled stationary plate and a moving plate are provided. The nanoparticles and the matrix are fed into the mixer. A rotational force is applied to the shaft to produce shearing forces. The shearing forces disperse and exfoliate the nanoparticles within the matrix. The dispersed mixture is outputted onto the moving plate. The moving plate is forced across the angled stationary plate to produce fully developed laminar shear flow. The fully developed laminar shear flow or the two-dimensional extensional drag flow orients the dispersed nanoparticles-matrix mixture.