公开(公告)号：US20040242900A1

公开(公告)日：2004-12-02

申请号：US10487452

申请日：2004-02-24

Inventor： Martin Rudloff ,  Peter Stops ,  Erhard Henkes ,  Helmut Schmidtke ,  Rolf-Hartmuth Fischer ,  Manfred Julius ,  Rolf Lebkucher ,  Karl-Heinz Ross

IPC: C07D207/267

CPC classification number: C07D207/267 ,  C07D201/08

Abstract: A process for continuously preparing 2-pyrrolidone by reacting gamma-butyrolactone with ammonia in the liquid phase in the presence of water, wherein the reaction is carried out at a temperature of from 275 to 300null C. and an absolute pressure of from 140 to 180 bar.

Abstract translation: 一种在水存在下使γ-丁内酯与氨在液相中反应连续制备2-吡咯烷酮的方法，其中反应在275-300℃的温度下进行，绝对压力为140〜 180吧。

公开(公告)号：US20040116691A1

公开(公告)日：2004-06-17

申请号：US10472473

申请日：2004-01-20

Inventor： Cecile Rosier ,  Aline Seigneurin

IPC: C07D201/02

CPC classification number: C07D201/08

Abstract: The invention pertains to a process for cyclizing hydrolysis of an aminonitrile compound to a lactam in the presence of a catalyst. It relates more particularly to a process for cyclizing hydrolysis of an aminonitrile compound in the presence of a solid catalyst of clay type. The invention applies particularly to the preparation of null-caprolactam by cyclizing hydrolysis of aminocapronitrile.

Abstract translation: 本发明涉及在催化剂存在下使氨基腈化合物水解成内酰胺的方法。 更具体地涉及在粘土型固体催化剂存在下使氨基腈化合物水解环化的方法。 本发明特别适用于通过环化氨基己腈的水解制备ε-己内酰胺。

公开(公告)号：US20040030128A1

公开(公告)日：2004-02-12

申请号：US10381279

申请日：2003-07-31

Inventor： Rudolf Philippus Maria Guit ,  Mathieu Johannes Guillaume Notten ,  Robert Pestman

IPC: C07D201/02

CPC classification number: B01J19/02 ,  B01J23/462 ,  B01J2219/0236 ,  B01J2219/0277 ,  B01J2219/0286 ,  C07D201/08

Abstract: Process for the preparation of a mixture of null-caprolactam and null-caprolactam precursors by reductively aminating 5-formylvaleric acid and/or 5-formylvalerate ester(s) in water with hydrogen and an excess of ammonia in the presence of a hydrogenation catalyst, wherein the process is conducted in a reactor of which the inside reactor wall material is a material containing at most 8 wt. % nickel.

Abstract translation: 通过在氢化催化剂存在下，用氢和过量氨还原性胺化5-甲酰戊酸和/或5-甲酰戊酸酯在水中制备ε-己内酰胺和ε-己内酰胺前体的混合物的方法， 其中所述方法在反应器内进行，其中内反应器壁材料是含有至多8wt。 ％镍。

公开(公告)号：US20040030126A1

公开(公告)日：2004-02-12

申请号：US10450450

申请日：2003-06-19

Inventor： Kiyotaka Hatakeda ,  Osamu Sato ,  Mitsuhiro Kanakubo ,  Yutaka Ikushima ,  Kazuo Torii

IPC: C07D205/00

CPC classification number: C07D201/08 ,  Y02P20/582

Abstract: It is an object of the present invention to provide a method for synthesizing null-lactams and a method for manufacturing null-lactams in water of high-temperature and under high-pressure, and the present invention relates to a null-lactam synthesis method which is characterized in that null-lactams are synthesized by reacting null-amino acids in water at high-temperature and under high-pressure, this method being further characterized in that null-lactams are synthesized at a high speed by cyclizing null-amino acids in water at high-temperature and under high-pressure in which the temperature range is 200null C. or higher and the pressure range is 10 MPa or greater, and the present invention also relates to a method for manufacturing null-lactams which is characterized in that null-lactams are synthesized by reacting null-amino acids in water at high-temperature and under high-pressure, and are then separated and purified using a column separation medium.

Abstract translation: 本发明的一个目的是提供一种合成β-内酰胺的方法和一种在高温和高压水中制备β-内酰胺的方法，本发明涉及一种β-内酰胺合成方法， 其特征在于β-内酰胺是通过在高温和高压下在水中使β-氨基酸反应合成的，该方法的进一步特征在于通过使β-氨基酸在高温和高压下环化β-氨基酸来高速合成β-内酰胺 在温度范围为200℃以上且压力范围为10MPa以上的高温高压下的水，本发明还涉及β-内酰胺的制造方法，其特征在于， 该β-内酰胺通过在高温和高压下在水中使β-氨基酸反应合成，然后使用柱分离介质分离和纯化。

公开(公告)号：US06683178B2

公开(公告)日：2004-01-27

申请号：US10257877

申请日：2002-10-17

Applicant: Frank Ohlbach ,  Andreas Ansmann ,  Peter Bassler ,  Rolf-Hartmuth Fischer ,  Hermann Luyken ,  Stefan Maixner ,  Johann-Peter Melder

Inventor： Frank Ohlbach ,  Andreas Ansmann ,  Peter Bassler ,  Rolf-Hartmuth Fischer ,  Hermann Luyken ,  Stefan Maixner ,  Johann-Peter Melder

IPC: C07D20108

CPC classification number: C07D201/08 ,  C07D201/16

Abstract: The invention relates to a method for producing cyclic lactams of formula (II) by reacting a compound (I) of formula (I) with water in the presence of an organic, liquid dilution agent in the liquid phase. In formula (II), n and m respectively can have the values 0, 1, 2, 3, 4, 5, 6, 7, 8 and 9 and the sum of n+m is at least 3, preferably at least 4 and R1 and R2 represent C1-C6 alkyl, C5-C7 cycloalkyl or C6-C12 aryl groups. In formula (I), R1, R2, m and n are defined as above and R represents nitrile, carboxylic acid amide and carboxylic acid groups. The inventive method is characterized in that a) compound (I) is reacted with water in the liquid phase in the presence of an organic, liquid dilution agent (III) to form a mixture (IV) containing a lactam (II) and said mixture (IV) is subjected to an aqueous treatment to obtain a two-phase system.

Abstract translation: 本发明涉及在液相中有机液体稀释剂存在下使式（I）化合物（I）与水反应制备式（II）的环状内酰胺的方法。 在式（II）中，n和m分别具有0,1,2,3,4,5,6,7,8和9的值，并且n + m的和至少为3，优选至少为4，并且 R 1和R 2代表C 1 -C 6烷基，C 5 -C 7环烷基或C 6 -C 12芳基。 在式（I）中，R 1，R 2，m和n如上定义，R代表腈，羧酸酰胺和羧酸基团。 本发明的方法的特征在于：a）化合物（I）在液相中在有机液体稀释剂（III）的存在下与水反应，形成含有内酰胺（II）的混合物（IV），所述混合物 （IV）进行水处理以获得两相体系。

公开(公告)号：US06683177B1

公开(公告)日：2004-01-27

申请号：US08952208

申请日：1997-11-06

Applicant: Eberhard Fuchs ,  Johann-Peter Melder ,  Werner Schnurr ,  Rolf Fischer

Inventor： Eberhard Fuchs ,  Johann-Peter Melder ,  Werner Schnurr ,  Rolf Fischer

IPC: C07D20108

CPC classification number: C07D201/08 ,  C07D223/12

Abstract: A process for preparing caprolactam by reacting 6-aminocapronitrile with water in the presence of catalysts comprises using a starting mixture of 6-aminocapronitrile and the tetrahydroazepine derivative of the formula and conducting the reaction in liquid phase in the presence of a heterogeneous catalyst. Also describes a process for preparing said tetrahydroazepine derivative I and its use for preparing caprolactam and polycaprolactam.

Abstract translation: 在催化剂存在下使6-氨基己腈与水反应制备己内酰胺的方法包括使用6-氨基己腈和下式的四氢氮杂衍生物的起始混合物，并在非均相催化剂存在下进行液相反应。 还描述了制备所述四氢氮杂衍生物I的方法及其制备己内酰胺和聚己内酰胺的用途。

公开(公告)号：US06677448B1

公开(公告)日：2004-01-13

申请号：US09744157

申请日：2001-06-11

Applicant: Jean-Pierre Brunelle ,  Christophe Nedez

Inventor： Jean-Pierre Brunelle ,  Christophe Nedez

IPC: B01J3812

CPC classification number: C07D201/08 ,  B01J38/12 ,  Y02P20/584

Abstract: The present invention relates to a process for regenerating a catalyst for the cyclizing hydrolysis of an aminonitrile for the manufacture of lactams. It relates more particularly to the regeneration of the solid catalysts used in the processes for producing lactams by the cyclizing hydrolysis of aminonitriles. This regeneration process consists in treating the spent catalyst or the catalyst at the end of the cycle at a temperature of between 300° C. and 600° C. with an oxidizing atmosphere.

Abstract translation: 本发明涉及用于再生用于制备内酰胺的氨腈的环化水解催化剂的方法。 更具体地涉及通过氨基腈的环化水解制备内酰胺的方法中所用的固体催化剂的再生。 该再生方法包括在循环结束时在300℃至600℃的温度下用氧化气氛处理废催化剂或催化剂。

公开(公告)号：US06670483B2

公开(公告)日：2003-12-30

申请号：US10280462

申请日：2002-10-25

Applicant: Todd Werpy ,  John G. Frye, Jr. ,  Yong Wang ,  Alan H. Zacher

Inventor： Todd Werpy ,  John G. Frye, Jr. ,  Yong Wang ,  Alan H. Zacher

IPC: C07D207267

CPC classification number: C07D207/267 ,  C07D201/02 ,  C07D201/08

Abstract: The present invention provides methods for making N-methylpyrrolidine and analogous compounds via hydrogenation. Novel catalysts for this process, and novel conditions/yields are also described. Other process improvements may include extraction and hydrolysis steps. Some preferred reactions take place in the aqueous phase. Starting materials for making N-methylpyrrolidine may include succinic acid, N-methylsuccinimide, and their analogs.

公开(公告)号：US06632964B2

公开(公告)日：2003-10-14

申请号：US09886215

申请日：2001-06-22

Applicant: Masaru Fujii ,  Tohru Setoyama

Inventor： Masaru Fujii ,  Tohru Setoyama

IPC: C07C51245

CPC classification number: C07D201/08 ,  B01J29/061 ,  B01J29/072 ,  B01J29/14 ,  C07C51/313 ,  Y02P20/588 ,  C07C59/147 ,  C07C55/14

Abstract: A process of producing an aliphatic aldehyde-acid (e.g., adipaldehyde-acid) and/or an aliphatic dicarboxylic acid (e.g., adipic acid) comprising oxidizing a cyclic ketone (e.g., cyclohexanone) with molecular oxygen in the presence of a fixed catalyst which comprises a composite of a carrier and at least one metal element belonging to the groups 4 to 11 of the Periodic Table supported on the carrier and has an acid amount of 0.06 mmol/g or more per unit weight of the carrier.

Abstract translation: 一种生产脂肪族醛酸（例如己二酸 - 酸）和/或脂族二羧酸（例如己二酸）的方法，包括在固定催化剂存在下用分子氧氧化环酮（例如环己酮） 包括载体和属于载体上的元素周期表第4至11族的至少一种金属元素的复合物，并且每单位载体的酸量为0.06mmol / g以上。

公开(公告)号：US06632951B2

公开(公告)日：2003-10-14

申请号：US10280622

申请日：2002-10-25

Applicant: Todd Werpy ,  John G. Frye, Jr. ,  Yong Wang ,  Alan H. Zacher

Inventor： Todd Werpy ,  John G. Frye, Jr. ,  Yong Wang ,  Alan H. Zacher

IPC: C07C207263

CPC classification number: C07D207/267 ,  C07D201/02 ,  C07D201/08

Abstract: The present invention provides methods for making N-methylpyrrolidine and analogous compounds via hydrogenation. Novel catalysts for this process, and novel conditions/yields are also described. Other process improvements may include extraction and hydrolysis steps. Some preferred reactions take place in the aqueous phase. Starting materials for making N-methylpyrrolidine may include succinic acid, N-methylsuccinimide, and their analogs.

Abstract translation: 本发明提供了通过氢化制备N-甲基吡咯烷和类似化合物的方法。 还描述了用于该方法的新型催化剂和新的条件/收率。 其他工艺改进可以包括提取和水解步骤。 一些优选的反应发生在水相中。 用于制备N-甲基吡咯烷的原料可包括琥珀酸，N-甲基琥珀酰亚胺及其类似物。