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公开(公告)号：US11969397B2
公开(公告)日：2024-04-30
申请号：US17290637
申请日：2019-11-07
Inventor： Mi-La Cho , Dong-Yun Shin , Jong-Young Choi , Chul-Woo Yang , Sung-Hwan Park , Seon-Yeong Lee , Min-Jung Park , Joo-Yeon Jhun , Se-Young Kim , Hyeon-Beom Seo , Jae-Yoon Ryu , Keun-Hyung Cho
IPC: A61K31/155 , A61K31/436 , A61K38/13 , A61P37/06
CPC classification number: A61K31/155 , A61K31/436 , A61K38/13 , A61P37/06
Abstract: The present invention relates to a composition for preventing or treating transplantation rejection or a transplantation rejection disease, comprising a novel compound and a calcineurin inhibitor. A co-administration of the present invention 1) reduces the activity of pathogenic Th1 cells or Th17 cells, 2) increases the activity of Treg cells, 3) has an inhibitory effect against side effects, such as tissue damage, occurring in the sole administration thereof, 4) inhibits various pathogenic pathways, 5) inhibits the cell death of inflammatory cells, and 6) increases the activity of mitochondria, in an in vivo or in vitro allogenic model, a transplantation rejection disease model, a skin transplantation model, and a liver-transplanted patient, and thus inhibits transplantation rejection along with mitigating side effects possibly occurring in the administration of a conventional immunosuppressant alone. Thus, the present invention may be used in the field of pharmaceutics relating to transplantation rejection or various immune disorders possibly occurring after transplantation.
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122.发明公开公开(公告)号：US20240131027A1
公开(公告)日：2024-04-25
申请号：US18286677
申请日：2022-04-06
Inventor： Chul Woo YANG , Dongyun SHIN , Sun Woo LIM , Mi La CHO , Yoo Jin SHIN , Seon Yeong LEE , A Ram LEE
IPC: A61K31/502 , A61P37/06
CPC classification number: A61K31/502 , A61P37/06
Abstract: The present invention relates to a pharmaceutical composition comprising a novel compound as an active ingredient for prevention or treatment of transplant rejection. The novel compound SD911 of the present invention was identified to repress the migration of immune cells, increase the engraftment and viability of a grafted tissue, and regulate immune cells. In addition, it was found in a kidney transplantation model that the compound restrained human PBMC from suppressing the engraftment and damaging renal tissues and downregulated the expression of the inflammatory cytokine IL-17, with the consequent effective prevention and treatment of transplant rejection.
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公开(公告)号：US20240118165A1
公开(公告)日：2024-04-11
申请号：US18377504
申请日：2023-10-06
Inventor： Hosik Hwang
CPC classification number: G01M11/0257 , A61F2/1618
Abstract: Disclosed is a defocus curve measuring apparatus for a multifocal intraocular lens capable of automatically measuring an objective defocus curve. A defocus curve measuring apparatus for a multifocal intraocular lens according to an aspect of the present invention may include a light source passed through a target image for focusing; a first lens that infinitely refracts the focus as the light source passes through it; a beam splitter having a polarization function that passes p-polarized light of the light source that has passed through the first lens and reflects s-polarized light; an intraocular lens module that refracts the light source that has passed through the beam splitter as it passes, thereby determining the focus; and a camera that captures an image of s-polarized light reflected by the beam splitter after the light source reflected from a retina passes through the intraocular lens module.
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公开(公告)号：US11931000B2
公开(公告)日：2024-03-19
申请号：US16982308
申请日：2018-10-10
Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION , S-MEDION CO., LTD.
Inventor： Jin Sung Kim , Ji Woon Chun , Hyang Mi Oh
CPC classification number: A61B1/00105 , A61B1/00066 , A61B1/00073 , A61B1/00135 , A61B1/018 , A61B1/04 , A61B1/317
Abstract: The present disclosure relates to an openable/closable vertebral endoscopic device. The openable/closable vertebral endoscopic device includes an endoscope body including a working channel for providing an access route of a surgical instrument to a diseased area of a human body, the working channel having an open channel formed by opening a portion of the working channel such that a portion of the surgical instrument inserted into the working channel is exposed to the outside; and a cover member provided on the endoscope body to selectively open or close the open channel of the endoscope body.
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公开(公告)号：US20240042141A1
公开(公告)日：2024-02-08
申请号：US18347713
申请日：2023-07-06
Inventor： Min Suk CHAE
IPC: A61M5/32
CPC classification number: A61M5/3293 , A61M2202/0028
Abstract: An embodiment provides a medical needle unit with an air filter part for preventing air injection, the medical needle unit being designed to prevent qualitative deterioration of ultrasound images due to unexpected air injection in ultrasound-guided procedure and operation environments.
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Patent Agency Ranking
126.发明公开公开(公告)号：US20240024643A1
公开(公告)日：2024-01-25
申请号：US18254912
申请日：2021-12-01
Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY , THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION
Inventor： Hong Soo CHOI , Sung Woong JEON , Sung Won KIM , Sun Hwa PARK , Jin Young KIM
CPC classification number: A61M31/002 , A61K9/0043 , A61K35/32 , A61K9/5115
Abstract: Disclosed are a method for fabricating a microrobot for delivery of a cell therapy product and a microrobot for delivery of a cell therapy product according thereto. A method for fabricating a microrobot for delivery of a cell therapy product is configured to comprise the steps of: coating a magnetic material with a coating material capable of promoting adhesion, proliferation, and differentiation of stem cells; and internalizing or attaching the coated magnetic material into stem cells. The microrobot for delivery of a cell therapy product, fabricated by the fabrication method, is configured to comprise: a stem cell; a magnetic material attached to the surface of the stem cell or injected into the stem cell and enabling migration in response to an external magnetic field; and a coating material applied to the surface of the magnetic material and promoting attachment, proliferation, and differentiation of the stem cell.
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公开(公告)号：US20230404394A1
公开(公告)日：2023-12-21
申请号：US18320270
申请日：2023-05-19
Inventor： Yong Chan KIM
CPC classification number: A61B3/113 , G16H50/20 , A61B3/0091
Abstract: The disclosure relates to a glaucoma determination device and method. In particular, there may be provided a glaucoma determination device and method capable of determining the presence or absence of glaucoma from gaze tracking information. Specifically, there may be provided a glaucoma determination device and method capable of determining the presence or absence by determining the start time point and end time point of a gaze movement from gaze movement information and calculating area information about the gaze movement based thereupon.
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公开(公告)号：US11819223B2
公开(公告)日：2023-11-21
申请号：US17400946
申请日：2021-08-12
Inventor： Sang Hwa Lee
CPC classification number: A61B17/17 , A61B17/176 , A61B34/10 , B33Y80/00 , A61B2017/00477 , A61B2017/00526 , A61B2034/108
Abstract: Provided is a customizable surgical bone-cutting jigsaw puzzle-type guide device. The customizable surgical bone-cutting jigsaw puzzle-type guide device includes: a main guide portion that includes a main contact surface lengthily formed along a required main incision line of a bone to be cut and shaped to be brought into contact with the bone, and a main guide surface forming a guide line together with the main contact surface along the same line as the main incision line and shaped to be brought into contact with a cutting blade for guiding the movement of the cutting blade during cutting of the bone; and a connection portion extending from the main guide portion and connected to a side of the bone such that the main guide portion may be supported on the bone, the connection portion being configured to be detachably attached to the side of the bone.
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公开(公告)号：US11814690B2
公开(公告)日：2023-11-14
申请号：US17089432
申请日：2020-11-04
Inventor： Jeong Won Jang , Hye Seon Kim , Jin Seoub Kim , Eung Ryoung Lee
IPC: C12Q1/70 , C12Q1/6874
CPC classification number: C12Q1/706 , C12Q1/6874
Abstract: A probe for detecting hepatitis B virus and a method for detecting an insertion site of hepatitis B virus at high efficiency based on the analysis method of next-generation sequencing using the probe is disclosed. A probe can be provided that is capable of confirming the insertion site of HBV in the human genome with a possibility of developing into liver cancer. In addition, by applying the probe to the analysis method of next-generation sequencing, HBV insertion sites in the human genome can be analyzed at low cost and high efficiency.
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130.发明公开公开(公告)号：US20230360808A1
公开(公告)日：2023-11-09
申请号：US18026333
申请日：2021-09-17
Inventor： Min-Hyeon PARK , Eun Kyung CHOI , Ha Yeon KIM , Ji Yea KIM
Abstract: An apparatus and method, and a recording medium thereof, wherein the apparatus receives image data, recognizes, from the received image data, information selected from among image information and text information, controls one of the recognized image information and text information to be discriminately stored in a predetermined data format according to patient information, clinical information, and post-treatment change progress information, and displays, according to a request, a personal health record including the stored patient information, clinical information, and post-treatment change progress information.
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