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    SERS SENSOR
    122.
    发明申请
    SERS SENSOR 审中-公开

    公开(公告)号：US20190170650A1

    公开(公告)日：2019-06-06

    申请号：US16098058

    申请日：2016-07-21

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Ning Ge ,  Anita Rogacs ,  Steven J. Simske ,  Milo Overbay ,  Viktor Shkolnikov

    IPC: G01N21/65

    Abstract: A surface enhanced Raman spectroscopy (SERS) sensor may include a nano structured surface and a nonstoichiometric oxide layer. The nano structured surfers may include a first peak, a second peak and a valley between the first peak and the second peak. The non-stoichiometric oxide layer may include a first portion on the first peak and a second portion on the second peak.

    PCR KIT-OF-PARTS, METHOD AND SYSTEM
    126.
    发明申请
    PCR KIT-OF-PARTS, METHOD AND SYSTEM 有权

    公开(公告)号：US20250101506A1

    公开(公告)日：2025-03-27

    申请号：US18291403

    申请日：2021-07-26

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Viktor Shkolnikov ,  Alexander Govyadinov

    IPC: C12Q1/686 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/6823

    Abstract: A PCR kit-of-parts is described. The kit-of-parts comprises a first oligonucleotide bound to a bead by a cleavable linker; a second oligonucleotide bound to a bead by a cleavable linker; and an enzyme bound to a bead by a cleavable linker; wherein the first and second oligonucleotide form an oligonucleotide pair complementary to a nucleic acid of interest and the enzyme is capable of extending nucleic acid strands; and each cleavable linker is independently selected from a photocleavable linker and a thermally cleavable linker. Also described is a method of performing PCR and a PCR system.

    MICROFLUIDIC DEVICE
    127.
    发明申请
    MICROFLUIDIC DEVICE 有权

    公开(公告)号：US20240367171A1

    公开(公告)日：2024-11-07

    申请号：US18557564

    申请日：2021-04-30

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Michael Cumbie ,  Viktor Shkolnikov

    IPC: B01L3/00 ,  B01L7/00

    Abstract: A microfluidic device is described. The device comprises a reaction chamber, wherein the reaction chamber comprises at least one reaction reagent disposed on at least one inner surface of the reaction chamber. A heater is also provided. A thermally dissolvable or degradable or thermally degradable film is applied to the at least one inner surface of the reaction chamber on which the reaction reagent is disposed. Also described is a PCR apparatus and a method of performing PCR.

    OVERFILL-TOLERANT MICROFLUIDIC STRUCTURES
    128.
    发明公开
    OVERFILL-TOLERANT MICROFLUIDIC STRUCTURES 审中-公开

    公开(公告)号：US20240226878A1

    公开(公告)日：2024-07-11

    申请号：US18559496

    申请日：2021-05-07

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Michael W. Cumbie ,  Viktor Shkolnikov ,  Brian J. Keefe

    IPC: B01L3/00 ,  B01L7/00

    CPC classification number: B01L3/502707 ,  B01L7/52 ,  B01L2200/0684 ,  B01L2300/048 ,  B01L2300/0838

    Abstract: An example overfill-tolerant microfluidic structure can include an inlet microfluidic channel. A sample chamber can be connected to the inlet microfluidic channel to receive liquid from the inlet microfluidic channel. A gas-permeable liquid barrier can be connected to the sample chamber and positioned to allow gas to flow out of the sample chamber. An overflow chamber can be connected to the inlet microfluidic channel. A capillary break can be positioned between the inlet microfluidic channel and the overflow chamber. The capillary break can include a narrowed opening with a smaller width than a width of the inlet microfluidic channel. In some examples, the gas-permeable liquid barrier can allow gas to flow out of the sample chamber at a pressure lower than the break pressure, and prevent liquid from flowing out of the sample chamber at the break pressure.

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