公开(公告)号：US20060241722A1

公开(公告)日：2006-10-26

申请号：US11115789

申请日：2005-04-26

申请人： James Thacker ,  Carla Woods ,  Sridhar Kothandaraman ,  John King ,  Kerry Bradley

发明人： James Thacker ,  Carla Woods ,  Sridhar Kothandaraman ,  John King ,  Kerry Bradley

IPC分类号： A61N1/34

CPC分类号： G06F19/3481 ,  A61N1/36071 ,  G06F19/00 ,  G16H40/63

摘要： A tissue stimulation system is provided that evaluates and/or scores stimulation sets based on both patient feedback and frequency of use. Stimulation sets and any associated scores and/or usage may be stored in a retrievable database. Upon subsequent stimulation sessions, a patient may select stimulation sets that have a high score and/or usage in order to effectively meet therapeutic objectives. Methods of determining patient satisfaction, which involve evaluating patient pain before and after stimulation pulses are applied, are also provided herein.

摘要翻译： 提供组织刺激系统，其基于患者反馈和使用频率来评估和/或评估刺激组。 刺激集和任何相关的分数和/或使用可以存储在可检索的数据库中。 在随后的刺激会话中，患者可以选择具有高得分和/或使用的刺激组，以便有效地满足治疗目标。 本文还提供了确定患者满意度的方法，其涉及在刺激脉冲之前和之后评估患者疼痛。

公开(公告)号：US07072715B1

公开(公告)日：2006-07-04

申请号：US10637850

申请日：2003-08-07

申请人： Kerry Bradley

发明人： Kerry Bradley

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/3684

摘要： An implantable cardiac stimulation device has a system and method that monitors progression or regression in a patient's heart disease. A pulse generator delivers pacing pulses to the heart to cause evoked responses of the heart. A sensing circuit senses the evoked responses of the heart and generates evoked response signals. A processor is programmed to analyze the evoked response signals, to isolate a given characteristic of the evoked response signals and to quantify the isolated characteristics to provide corresponding quantized values. Relative changes in the quantized values over time are indicative of the progression or regression in the patient's heart disease. A memory stores the quantized values and a telemetry circuit transmits the stored quantized values to an external receiver for analysis.

公开(公告)号：US20060122653A1

公开(公告)日：2006-06-08

申请号：US11342989

申请日：2006-01-30

申请人： Kerry Bradley ,  James Thacker

发明人： Kerry Bradley ,  James Thacker

IPC分类号： A61N1/37

CPC分类号： A61N1/08 ,  A61B5/053 ,  A61N1/0551

摘要： Interelectrode impedance or electric field potential measurements are used to determine the relative orientation of one lead to other leads in the spinal column or other body/tissue location. Interelectrode impedance is determined by measuring impedance vectors. The value of the impedance vector is due primarily to the electrode-electrolyte interface, and the bulk impedance between the electrodes. The bulk impedance between the electrodes is, in turn, made up of (1) the impedance of the tissue adjacent to the electrodes, and (2) the impedance of the tissue between the electrodes. In one embodiment, the present invention makes both monopolar and bipolar impedance measurements, and then corrects the bipolar impedance measurements using the monopolar measurements to eliminate the effect of the impedance of the tissue adjacent the electrodes. The orientation and position of the leads may be inferred from the relative minima of the corrected bipolar impedance values. These corrected impedance values may also be mapped and stored to facilitate a comparison with subsequent corrected impedance measurement values. Such comparison allows a determination to be made as to whether the lead position and/or orientation has changed appreciably over time. In another embodiment, one or more electrodes are stimulated and the resulting electric field potential on the non-stimulated electrodes is measured. Such field potential measurements provide an indication of the relative orientation of the electrodes. Once known, the relative orientation may be used to track lead migration, to setup stimulation configurations and parameters for nominal stimulation and/or navigation. Also, such measurements allow automatic adjustment of stimulation energy to a previously-defined optimal potential field in the case of lead migration or postural changes.

公开(公告)号：US20050143781A1

公开(公告)日：2005-06-30

申请号：US11066962

申请日：2005-02-25

申请人： Rafael Carbunaru ,  Jordi Parramon ,  Kerry Bradley

发明人： Rafael Carbunaru ,  Jordi Parramon ,  Kerry Bradley

IPC分类号： A61N1/36 ,  A61N1/362 ,  A61N1/372

CPC分类号： A61N1/37211 ,  A61N1/3605 ,  A61N1/37205 ,  A61N1/37247 ,  A61N1/3787

摘要： A method of adjusting operation of a stimulator for treatment of a patient using the stimulator includes adjusting stimulation parameters of the stimulator subsequent to a fitting session with a clinician, where the adjusting is performed by the patient who has the stimulator. A system for patient adjustment of operation of a stimulator used by the patient subsequent to a fitting session with a clinician includes an external device for communicating with the stimulator and a user interface of the external device configured to receive input from the patient to adjust stimulation parameters of the stimulator.

摘要翻译： 调整用于使用刺激器治疗患者的刺激器的操作的方法包括在与临床医生进行装配会话之后调整刺激器的刺激参数，其中由具有刺激器的患者进行调整。 用于患者调整患者在与临床医生进行装配会话之后使用的刺激器的操作的系统包括用于与刺激器通信的外部设备和外部设备的用户接口，其被配置为从患者接收输入以调整刺激参数 的刺激物。

公开(公告)号：US06810284B1

公开(公告)日：2004-10-26

申请号：US09996306

申请日：2001-11-21

申请人： Kerry Bradley

发明人： Kerry Bradley

IPC分类号： A61N137

CPC分类号： A61N1/3712 ,  A61N1/368

摘要： A cardiac stimulation device and method perform a diastolic function test during which an amplitude-based feature of an evoked response is determined for a number of AV or PV delay settings. Stimulation operating parameters may be adjusted in response to a detected change in diastolic function. The diastolic function test may be repeated periodically with results stored in memory for later downloading to an external device allowing a physician to monitor the diastolic response to a selected treatment.

摘要翻译： 心脏刺激装置和方法执行舒张功能测试，在此期间，针对多个AV或PV延迟设置确定诱发反应的基于幅度的特征。 可以响应于检测到的舒张功能的变化来调节刺激操作参数。 可以周期性地重复舒张功能测试，结果存储在存储器中用于随后下载到外部设备，允许医师监测对所选择的治疗的舒张反应。

公开(公告)号：US06473647B1

公开(公告)日：2002-10-29

申请号：US09691689

申请日：2000-10-18

申请人： Kerry Bradley

发明人： Kerry Bradley

IPC分类号： A61N1362

CPC分类号： A61N1/3627 ,  A61N1/3684

摘要： An implantable cardiac stimulation device has a system and method that monitors progression or regression in a patient's heart disease. A pulse generator delivers pacing pulses to the heart to cause evoked responses of the heart. A sensing circuit senses the evoked responses of the heart and generates evoked response signals. A processor is programmed to analyze the evoked response signals, to isolate a given characteristic of the evoked response signals and to quantify the isolated characteristics to provide corresponding quantized values. Relative changes in the quantized values over time are indicative of the progression or regression in the patient's heart disease. A memory stores the quantized values and a telemetry circuit transmits the stored quantized values to an external receiver for analysis.

摘要翻译： 可植入心脏刺激装置具有监测患者心脏病进展或消退的系统和方法。 脉冲发生器向心脏输送起搏脉冲以引起心脏的诱发反应。 感测电路感测心脏的诱发反应并产生诱发反应信号。 处理器被编程为分析诱发的响应信号，以分离诱发的响应信号的给定特征并量化隔离特征以提供对应的量化值。 随着时间的推移，量化值的相对变化表明患者心脏病发展或消退。 存储器存储量化值，并且遥测电路将存储的量化值发送到外部接收机用于分析。

公开(公告)号：US09463323B2

公开(公告)日：2016-10-11

申请号：US12819107

申请日：2010-06-18

申请人： Dongchul Lee ,  Bradley Hershey ,  Kerry Bradley

发明人： Dongchul Lee ,  Bradley Hershey ,  Kerry Bradley

IPC分类号： A61N1/00 ,  A61N1/36 ,  A61N1/06

CPC分类号： A61N1/36167 ,  A61N1/06 ,  A61N1/36007 ,  A61N1/36071

摘要： A method of providing therapy to a patient using at least one electrode is provided. The patient has a neural tissue region that is relatively close to the at least one electrode, and a neural tissue region that is relatively far from the at least one electrode. The method comprises conveying time-varying electrical energy from the electrode(s) into the relatively close and far neural tissue regions, wherein the electrical energy has a frequency and amplitude that blocks stimulation of the relatively close neural tissue region, while stimulating the relatively far neural tissue region.

摘要翻译： 提供了使用至少一个电极向患者提供治疗的方法。 患者具有相对靠近至少一个电极的神经组织区域和相对远离至少一个电极的神经组织区域。 该方法包括将时间变化的电能从电极传送到相对靠近和远的神经组织区域，其中电能具有阻止刺激相对较近的神经组织区域的频率和幅度，同时刺激相对较远 神经组织区域。

公开(公告)号：US09463321B2

公开(公告)日：2016-10-11

申请号：US12606050

申请日：2009-10-26

申请人： Kerry Bradley ,  Bradley Hershey ,  Dongchul Lee

发明人： Kerry Bradley ,  Bradley Hershey ,  Dongchul Lee

IPC分类号： A61N1/08 ,  A61N1/36 ,  A61N1/372

CPC分类号： A61N1/36192 ,  A61N1/36071 ,  A61N1/37247

摘要： A method of stimulating nerve tissue, a tissue stimulation system, and an external control device are provided. The method, system, and control device cause an electrical stimulus to be applied to at least one electrode adjacent the nerve tissue of a patient. The applied electrical stimulus comprises a plurality of pulses defined by a pulse width value and an amplitude value. The pulse amplitude value is increased (e.g., manually), and the pulse width value is automatically decreased in response to increasing the pulse amplitude value in a manner that increases the intensity of the applied electrical stimulus. Alternatively, the pulse width value may be decreased (e.g., manually), and the pulse amplitude value automatically increased in response to decreasing the pulse width value in a manner that increases the intensity of the applied electrical stimulus.

摘要翻译： 提供刺激神经组织，组织刺激系统和外部控制装置的方法。 该方法，系统和控制装置使电刺激施加到邻近患者神经组织的至少一个电极。 所施加的电刺激包括由脉冲宽度值和振幅值定义的多个脉冲。 脉冲幅度值增加（例如，手动），并且响应于以增加所施加的电刺激的强度的方式增加脉冲幅值来自动减小脉冲宽度值。 或者，可以减小脉冲宽度值（例如，手动地），并且响应于以增加所施加的电刺激的强度的方式减小脉冲宽度值，脉冲振幅值自动增加。

公开(公告)号：US09446249B2

公开(公告)日：2016-09-20

申请号：US13244458

申请日：2011-09-24

申请人： David K. L. Peterson ,  Kerry Bradley

发明人： David K. L. Peterson ,  Kerry Bradley

IPC分类号： A61N1/36 ,  A61N1/372

CPC分类号： A61N1/37247 ,  A61N1/0551 ,  A61N1/3605 ,  A61N1/36185 ,  A61N1/372

摘要： A system and method for locating an implantable tissue stimulation lead within a patient. A measurement indicative of a coupling efficiency between the tissue stimulation lead and tissue at a location is taken. The location of the tissue stimulation lead relative to the tissue is tracked. Coupling efficiency information based on the measurement from the monitoring device is generated, tracking information based on the tissue stimulation lead location is generated, and the coupling efficiency information and tracking information is concurrently conveyed to the user.

摘要翻译： 一种用于定位患者内的可植入组织刺激引线的系统和方法。 采用指示组织刺激引线和组织在一处的耦合效率的测量。 跟踪组织刺激引线相对于组织的位置。 生成基于来自监视装置的测量的耦合效率信息，生成基于组织刺激引导位置的跟踪信息，并且耦合效率信息和跟踪信息被同时传送给用户。

公开(公告)号：US09192760B2

公开(公告)日：2015-11-24

申请号：US12856905

申请日：2010-08-16

申请人： Kerry Bradley ,  James R. Thacker ,  Michael A. Moffitt

发明人： Kerry Bradley ,  James R. Thacker ,  Michael A. Moffitt

IPC分类号： A61N1/00 ,  A61N1/08 ,  A61N1/05 ,  A61B5/053

CPC分类号： A61N1/08 ,  A61B5/053 ,  A61N1/0551 ,  A61N1/3605 ,  A61N1/37247

摘要： A method for determining whether the relative position of electrodes used by a neurostimulation system has changed within a patient comprises determining the amplitude of a field potential at each of at least one of the electrodes, determining if a change in each of the determined electric field amplitudes has occurred, and analyzing the change in each of the determined electric field amplitudes to determine whether a change in the relative position of the electrodes has occurred. Another method comprises measuring a first monopolar impedance between a first electrode and a reference electrode, measuring a second monopolar impedance between second electrode and the reference electrode, measuring a bipolar impedance between the first and second electrodes, and estimating an amplitude of a field potential at the second electrode based on the first and second monopolar impedances and the bipolar impedance.

摘要翻译： 一种用于确定神经刺激系统使用的电极的相对位置是否在患者内已经改变的方法包括确定每个电极中的每个电极处的场电位的幅度，确定每个确定的电场幅度是否发生变化 并且分析每个确定的电场幅度的变化，以确定是否发生了电极的相对位置的变化。 另一种方法包括测量第一电极和参考电极之间的第一单极阻抗，测量第二电极和参考电极之间的第二单极阻抗，测量第一和第二电极之间的双极性阻抗，以及估计第一和第二电极之间的场电位的振幅 基于第一和第二单极阻抗的第二电极和双极性阻抗。