公开(公告)号：US20060122654A1

公开(公告)日：2006-06-08

申请号：US11343007

申请日：2006-01-30

申请人： Kerry Bradley ,  James Thacker

发明人： Kerry Bradley ,  James Thacker

IPC分类号： A61N1/37

CPC分类号： A61N1/08 ,  A61B5/053 ,  A61N1/0551

摘要： Interelectrode impedance or electric field potential measurements are used to determine the relative orientation of one lead to other leads in the spinal column or other body/tissue location. Interelectrode impedance is determined by measuring impedance vectors. The value of the impedance vector is due primarily to the electrode-electrolyte interface, and the bulk impedance between the electrodes. The bulk impedance between the electrodes is, in turn, made up of (1) the impedance of the tissue adjacent to the electrodes, and (2) the impedance of the tissue between the electrodes. In one embodiment, the present invention makes both monopolar and bipolar impedance measurements, and then corrects the bipolar impedance measurements using the monopolar measurements to eliminate the effect of the impedance of the tissue adjacent the electrodes. The orientation and position of the leads may be inferred from the relative minima of the corrected bipolar impedance values. These corrected impedance values may also be mapped and stored to facilitate a comparison with subsequent corrected impedance measurement values. Such comparison allows a determination to be made as to whether the lead position and/or orientation has changed appreciably over time. In another embodiment, one or more electrodes are stimulated and the resulting electric field potential on the non-stimulated electrodes is measured. Such field potential measurements provide an indication of the relative orientation of the electrodes. Once known, the relative orientation may be used to track lead migration, to setup stimulation configurations and parameters for nominal stimulation and/or navigation. Also, such measurements allow automatic adjustment of stimulation energy to a previously-defined optimal potential field in the case of lead migration or postural changes.

公开(公告)号：US20070197436A1

公开(公告)日：2007-08-23

申请号：US11459772

申请日：2006-07-25

申请人： James Thacker

发明人： James Thacker

IPC分类号： A61K38/16 ,  A61K38/10 ,  A61K38/08

CPC分类号： C07K7/08 ,  A61K9/0019 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  C07K7/06 ,  C07K14/00 ,  C07K14/001

摘要： Peptide and peptides that may be covalently linked to a lipid and methods of using such peptides and lipopeptides to prevent or treat disease are disclosed herein.

摘要翻译： 可以与脂质共价连接的肽和肽以及使用这些肽和脂肽预防或治疗疾病的方法在本文中公开。

公开(公告)号：US20050209655A1

公开(公告)日：2005-09-22

申请号：US11026859

申请日：2004-12-30

申请人： Kerry Bradley ,  James Thacker ,  Carla Woods ,  John King

发明人： Kerry Bradley ,  James Thacker ,  Carla Woods ,  John King

IPC分类号： A61N1/18 ,  A61N1/34 ,  A61N1/372

CPC分类号： A61N1/36071 ,  A61N1/0551 ,  Y10S128/92

摘要： Methods for selecting stimulation parameter sets guide a clinician towards an effective set(s) of stimulation parameters. The clinician first evaluates the effectiveness of a small number of trial stimulation parameters sets from a Measurement Table comprising for example, four stimulation parameter sets, measuring the perception threshold and maximum threshold levels. The maximum comfortable step size and desired field shift resolution are determined, and are used along with the measured threshold levels to determine an appropriate step size to use in the current steering process. In order to maintain paresthesia at a relatively constant level during the steering process, a Superposition Equalization (SEQ) algorithm is used to compensate for the physical characteristics of the lead array, i.e., electrode separation and size. A multiplier is determined and a modifying function is used to apply this multiplier to the electrode energy output during transition to maintain a relatively constant current density.

摘要翻译： 用于选择刺激参数集的方法指导临床医生朝向有效的一组或多个刺激参数。 临床医生首先从包括例如四个刺激参数组，测量感知阈值和最大阈值水平的测量表中评估少量试验刺激参数集的有效性。 确定最大舒适的步长和期望的场移动分辨率，并且与测量的阈值水平一起使用以确定在当前转向过程中使用的适当步长。 为了在转向过程期间将感觉异常保持在相对恒定的水平，使用叠加均衡（SEQ）算法来补偿引线阵列的物理特性，即电极分离和尺寸。 确定乘法器，并且使用修改函数将该乘数应用于转换期间的电极能量输出，以维持相对恒定的电流密度。

公开(公告)号：US07853330B2

公开(公告)日：2010-12-14

申请号：US11938490

申请日：2007-11-12

申请人： Kerry Bradley ,  James Thacker ,  Michael Moffitt

发明人： Kerry Bradley ,  James Thacker ,  Michael Moffitt

IPC分类号： A61N1/00

CPC分类号： A61N1/08 ,  A61B5/053 ,  A61N1/0551 ,  A61N1/3605 ,  A61N1/37247

摘要： A method for determining whether the relative position of electrodes used by a neurostimulation system has changed within a patient comprises determining the amplitude of a field potential at each of at least one of the electrodes, determining if a change in each of the determined electric field amplitudes has occurred, and analyzing the change in each of the determined electric field amplitudes to determine whether a change in the relative position of the electrodes has occurred. Another method comprises measuring a first monopolar impedance between a first electrode and a reference electrode, measuring a second monopolar impedance between second electrode and the reference electrode, measuring a bipolar impedance between the first and second electrodes, and estimating an amplitude of a field potential at the second electrode based on the first and second monopolar impedances and the bipolar impedance.

摘要翻译： 一种用于确定神经刺激系统使用的电极的相对位置是否在患者内已经改变的方法包括确定每个电极中的每个电极处的场电位的幅度，确定每个确定的电场幅度是否发生变化 并且分析每个确定的电场幅度的变化，以确定是否发生了电极的相对位置的变化。 另一种方法包括测量第一电极和参考电极之间的第一单极阻抗，测量第二电极和参考电极之间的第二单极阻抗，测量第一和第二电极之间的双极性阻抗，以及估计第一和第二电极之间的场电位的振幅 基于第一和第二单极阻抗的第二电极和双极性阻抗。

公开(公告)号：US20060036286A1

公开(公告)日：2006-02-16

申请号：US11246719

申请日：2005-10-07

申请人： Todd Whitehurst ,  James McGivern ,  Kelly McClure ,  Goran Marnfeldt ,  James Thacker

发明人： Todd Whitehurst ,  James McGivern ,  Kelly McClure ,  Goran Marnfeldt ,  James Thacker

IPC分类号： A61N1/18

CPC分类号： A61B5/413 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/41 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/4244 ,  A61B2560/0219 ,  A61M5/14276 ,  A61M5/1723 ,  A61N1/30 ,  A61N1/32

摘要： An implantable system control unit (SCU) includes means for measuring tissue impedance or other condition to determine allograft health, in order to predict or detect allograft rejection. The SCU also includes at least two electrodes coupled to means for delivering electrical stimulation to a patient within whom the device is implanted, and may also include a reservoir for holding one or more drugs and a driver means for delivering the drug(s) to the patient. In certain embodiments, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters. Alternatively, this sensory “SCU” sounds an alarm, communicates an alarm to an external device, and/or is responsive to queries regarding sensed information, such as tissue impedance.

摘要翻译： 可植入系统控制单元（SCU）包括用于测量组织阻抗或其他条件以确定同种异体移植物健康的装置，以便预测或检测同种异体移植排斥。 SCU还包括至少两个电极，其耦合到用于将电刺激递送到其中植入该装置的患者的装置，并且还可以包括用于容纳一种或多种药物的储存器和用于将药物递送至 患者。 在某些实施例中，系统能够进行开环和闭环操作。 在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。 或者，该感官“SCU”发出警报，向外部设备通报警报，和/或响应关于感测信息（例如组织阻抗）的查询。

公开(公告)号：US20050279649A1

公开(公告)日：2005-12-22

申请号：US10870363

申请日：2004-06-17

申请人： James Thacker

发明人： James Thacker

IPC分类号： A61B19/02 ,  A61C19/02

CPC分类号： A61C19/02

摘要： A denture accessories carrying case having a form factor which belies its true function. In one embodiment, a carrying case comprises a container portion and a lid in a hinged, “clam-shell” relationship. The carrying case is configured to be of a size and shape that bears at least a passing resemblance to a common, everyday item not normally associated with dentures or denture accessories. In one embodiment, the carrying case is configured to resemble a typical cellular telephone, and is capable of containing a denture cleaning brush having a foreshortened handle alongside a small tube of denture adhesive.

摘要翻译： 义齿配件手提箱具有隐藏其真实功能的外形尺寸。 在一个实施例中，携带箱包括以铰链“蛤壳”关系的容器部分和盖。 手提箱的尺寸和形状至少与通常与假牙或义齿配件相关联的日常用品至少具有相似性。 在一个实施例中，手提箱被配置为类似于典型的蜂窝电话，并且能够容纳具有缩短的手柄的义齿清洁刷和义齿粘合剂的小管旁边。

公开(公告)号：US06344332B1

公开(公告)日：2002-02-05

申请号：US09148491

申请日：1998-09-04

申请人： James Thacker

发明人： James Thacker

IPC分类号： C01N3353

CPC分类号： G01N33/569 ,  C12Q1/04 ,  C12Q2304/24 ,  Y10S435/968

摘要： A method for the rapid detection of actively respiring microorganisms comprises the steps of detecting the presence of microorganisms utilizing microbial enzymatic conversion of tetrazolium salts to formazan products, detecting the presence of formazan product.

摘要翻译： 用于快速检测积极呼吸微生物的方法包括以下步骤：利用微生物将四唑盐微生物酶转化成甲an an an an of of，an an an an an an an an an an an an an an an an an an

公开(公告)号：US20180244140A1

公开(公告)日：2018-08-30

申请号：US15442076

申请日：2017-02-24

申请人： James Thacker

发明人： James Thacker

IPC分类号： B60J11/08

CPC分类号： B60J11/08

摘要： A vehicle opening covering assembly for recreational vehicles includes a panel that is flexible. The panel is substantially rectangularly shaped and water resistant. The panel is configured to couple to a recreational vehicle such that panel is configured to cover an opening, such as a window, of the recreational vehicle.

公开(公告)号：US20070293914A1

公开(公告)日：2007-12-20

申请号：US11625281

申请日：2007-01-19

申请人： Carla Woods ,  James Thacker ,  David Peterson

发明人： Carla Woods ,  James Thacker ,  David Peterson

IPC分类号： A61N1/02

CPC分类号： A61N1/36071 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36185 ,  A61N1/37235 ,  A61N1/37241 ,  A61N1/37247 ,  A61N1/37252 ,  A61N1/3787

摘要： The invention is a system and method for detecting the status of a rechargeable battery included within an implantable medical device. The medical device can incorporate a status indicator which signals the user concerning the battery status, e.g., low battery level. The signal may be audible or it may arise from an electrical stimulation that is perceptually distinguished from the operative, therapeutic stimulation. The external programmer may also incorporate a second battery status indicator that is visual, audible, or physically felt. Battery status data may be conveyed on visual displays on the external programmer by uploading this information from the medical device using a bidirectional telemetry link. Such battery status data are helpful to the user to indicate when the battery should be recharged and to the clinician to monitor patient compliance and to determine end-of-useful life of the rechargeable battery.

摘要翻译： 本发明是一种用于检测包括在可植入医疗装置内的可再充电电池的状态的系统和方法。 医疗设备可以包括状态指示器，其向用户通知有关电池状态的信号，例如电池电量低。 该信号可能是可听见的，或者它可能由感觉上区别于手术治疗刺激的电刺激引起。 外部编程器还可以包括视觉，听觉或物理感觉的第二电池状态指示器。 电池状态数据可以通过使用双向遥测链路从医疗设备上传该信息而在外部编程器上的视觉显示器上传送。 这样的电池状态数据有助于用户指示电池何时被充电，并且临床医师监测患者的依从性并确定可再充电电池的使用寿命。

公开(公告)号：US20050245987A1

公开(公告)日：2005-11-03

申请号：US11105643

申请日：2005-04-13

申请人： Carla Woods ,  James Thacker ,  David Peterson ,  Holly Segel ,  Susan Ford ,  Margaret Theriot ,  Kerry Bradley

发明人： Carla Woods ,  James Thacker ,  David Peterson ,  Holly Segel ,  Susan Ford ,  Margaret Theriot ,  Kerry Bradley

IPC分类号： A61N1/18 ,  A61N1/34 ,  A61N1/372

CPC分类号： A61N1/36071 ,  A61N1/08 ,  A61N1/36185 ,  A61N1/37241 ,  A61N1/37247

摘要： A method for selecting Spinal Cord Stimulation (SCS) stimulation parameter sets guides a clinician towards an effective set of stimulation parameters. The clinician first evaluates the effectiveness of a small number of trial stimulation parameters sets from a Measurement Table comprising for example, four stimulation parameter sets. Based on the patient's assessment, the trial stimulation parameter sets are ranked. Then the clinician selects a starting or benchmark row in a Steering Table corresponding to the highest ranked trial stimulation parameter set. The clinician moves either up or down form the starting row, testing consecutive parameter sets. The clinician continues as long as the patient indicates that the stimulation results are improving. When a local optimum is found, the clinician returns to the benchmark row, and tests in the opposite direction for another local optimum. If an acceptable set of stimulation parameters is found, the selection process is complete. If an acceptable set is not found, a new starting row in the Steering Table is selected based on the next ranked trial set from the Measurement Table, and the process of searching for local optima is repeated.

摘要翻译： 用于选择脊髓刺激（SCS）刺激参数组的方法引导临床医生朝向有效的一组刺激参数。 临床医生首先从包括例如四个刺激参数组的测量表中评估少量试验刺激参数集的有效性。 根据患者的评估，对试验刺激参数集进行排序。 然后，临床医生在对应于最高排名的试验刺激参数集的转向表中选择起始或基准行。 临床医生从起始行向上或向下移动，测试连续的参数集。 只要患者表明刺激结果正在改善，临床医生就会继续进行。 当找到局部最佳值时，临床医生返回到基准行，并以相反方向测试另一个局部最佳值。 如果发现可接受的一组刺激参数，则选择过程完成。 如果没有找到可接受的集合，则基于从测量表中的下一个排序的试验集，选择转向表中的新起始行，并且重复搜索局部最优的处理。