公开(公告)号：US06395468B1

公开(公告)日：2002-05-28

申请号：US09216066

申请日：1998-12-18

申请人： Olga Bandman ,  Surya K. Goli

发明人： Olga Bandman ,  Surya K. Goli

IPC分类号： C12Q100

CPC分类号： C12N9/1288 ,  A61K38/00 ,  C07K2319/00 ,  Y02A50/411

摘要： The present invention provides a human phosphatidylinositol synthase (PISH) and polynucleotides which identify and encode PISH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding PISH and a method for producing PISH. The invention also provides for agonists, antibodies, or antagonists specifically binding PISH, and their use, in the prevention and treatment of diseases associated with expression of PISH. The invention also provides for the use of PISH in screening for antiprotozoal and antifungal therapeutics. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding PISH for the treatment of diseases associated with the expression of PISH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding PISH.

摘要翻译： 本发明提供了人磷脂酰肌醇合成酶（PISH）和识别和编码PISH的多核苷酸。 本发明还提供了遗传工程改造的表达载体和包含编码PISH的核酸序列和产生PISH的方法的宿主细胞。 本发明还提供了特异性结合PISH的激动剂，抗体或拮抗剂及其在预防和治疗与PISH表达相关的疾病中的用途。 本发明还提供了使用PISH筛选抗原虫和抗真菌治疗剂。 此外，本发明提供了反义分子用于编码PISH的多核苷酸用于治疗与PISH表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合PISH的抗体的诊断测定法。

公开(公告)号：US6087108A

公开(公告)日：2000-07-11

申请号：US128395

申请日：1998-08-03

申请人： Olga Bandman ,  Surya K. Goli

发明人： Olga Bandman ,  Surya K. Goli

IPC分类号： A61K38/00 ,  C12N9/00 ,  C12N15/55 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C12N9/00 ,  A61K38/00

摘要： The present invention provides a human RNA editing enzyme (REE-2) and polynucleotides which identify and encode REE-2. The invention also provides expression vectors and host cells, agonists, antibodies, or antagonists. The invention provides methods for producing REE-2 and for treating diseases associated with expression of REE-2.

摘要翻译： 本发明提供了人类RNA编辑酶（REE-2）和识别和编码REE-2的多核苷酸。 本发明还提供表达载体和宿主细胞，激动剂，抗体或拮抗剂。 本发明提供了生产REE-2和治疗与REE-2表达有关的疾病的方法。

公开(公告)号：US5977320A

公开(公告)日：1999-11-02

申请号：US96245

申请日：1998-06-11

申请人： Olga Bandman ,  Surya K. Goli

发明人： Olga Bandman ,  Surya K. Goli

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/48 ,  A61K48/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12N15/54 ,  C12R1/19 ,  C07K16/40 ,  C07K14/47

CPC分类号： C12N9/1205 ,  A61K38/00

摘要： The present invention provides a novel human phosphorylase kinase gamma subunit (HPHKG) and the polynucleotide which identifies and encodes HPHKG. The invention provides for expression vectors and host cells comprising the nucleic acid sequence encoding HPHKG. The invention also provides pharmaceutical compositions containing purified HPHKG or antisense molecules to HPHKG for the treatment of diseases associated with expression of HPHKG. The invention also includes diagnostic compositions containing the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding HPHKG or anti-HPHKG antibodies which specifically bind to HPHKG, and the use of such compositions for diagnosis of disease.

摘要翻译： 本发明提供新型人磷酸化酶激酶γ亚基（HPHKG）和识别和编码HPHKG的多核苷酸。 本发明提供了包含编码HPHKG的核酸序列的表达载体和宿主细胞。 本发明还提供含有纯化的HPHKG或HPHKG反义分子用于治疗与HPHKG表达相关的疾病的药物组合物。 本发明还包括含有多核苷酸，片段或其互补物的诊断组合物，其与编码与HPHKG特异性结合的编码HPHKG或抗HPHKG抗体的多核苷酸的基因组序列或转录物杂交，以及这些组合物用于疾病诊断的用途 。

公开(公告)号：US5916764A

公开(公告)日：1999-06-29

申请号：US763121

申请日：1996-12-10

申请人： Olga Bandman ,  Surya K. Goli

发明人： Olga Bandman ,  Surya K. Goli

IPC分类号： A61K38/00 ,  C12N9/12 ,  C12N15/11 ,  C12N15/63 ,  C12N1/20 ,  C07N21/04

CPC分类号： C12N9/1288 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention provides a human phosphatidylinositol synthase (PISH) and polynucleotides which identify and encode PISH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding PISH and a method for producing PISH. The invention also provides for agonists, antibodies, or antagonists specifically binding PISH, and their use, in the prevention and treatment of diseases associated with expression of PISH. The invention also provides for the use of PISH in screening for antiprotozoal and antifungal therapeutics. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding PISH for the treatment of diseases associated with the expression of PISH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding PISH.

公开(公告)号：US06632617B1

公开(公告)日：2003-10-14

申请号：US09855288

申请日：2001-05-14

申请人： Olga Bandman ,  Surya K. Goli ,  Purvi Shah ,  Neil C. Corley ,  David G. Streeter

发明人： Olga Bandman ,  Surya K. Goli ,  Purvi Shah ,  Neil C. Corley ,  David G. Streeter

IPC分类号： C07K1600

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K39/00

摘要： The invention provides a cDNA which encodes a TUAN. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of inflammatory and cell proliferative disorders, in particular, Crohn's disease and colon cancer. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

摘要翻译： 本发明提供编码TAN的cDNA。 它还提供了cDNA，片段，补体及其变体以及编码的蛋白质，其部分及其抗体用于诊断和治疗炎症和细胞增殖性疾病，特别是克罗恩病和结肠癌的用途。 本发明另外提供用于产生蛋白质的表达载体和宿主细胞和转基因模型系统

公开(公告)号：US06350581B1

公开(公告)日：2002-02-26

申请号：US09227224

申请日：1999-01-08

申请人： Olga Bandman ,  Surya K. Goli ,  Purvi Shah ,  Neil C. Corley

发明人： Olga Bandman ,  Surya K. Goli ,  Purvi Shah ,  Neil C. Corley

IPC分类号： C07K1400

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K39/00

摘要： The present invention provides a human tumor-associated antigen (TUAN) and polynucleotides which identify and encode TUAN. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing TUAN and for treating or preventing disorders associated with expression of TUAN.

摘要翻译： 本发明提供了一种人肿瘤相关抗原（TUAN）和识别和编码TUAN的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 此外，本发明提供了用于制备TAN并用于治疗或预防与TUAN表达相关的疾病的方法。

公开(公告)号：US6124123A

公开(公告)日：2000-09-26

申请号：US132861

申请日：1998-08-12

申请人： Olga Bandman ,  Surya K. Goli

发明人： Olga Bandman ,  Surya K. Goli

IPC分类号： A61K38/00 ,  C12N9/00 ,  A61K38/51

CPC分类号： C12N9/93 ,  A61K38/00

摘要： The present invention provides a human ubiquitin-conjugating enzyme (UBCPB) and polynucleotides which identify and encode UBCPB. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding UBCPB and a method for producing UBCPB. The invention also provides for agonists, antibodies, or antagonists specifically binding UBCPB, and their use, in the prevention and treatment of diseases associated with expression of UBCPB. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding UBCPB for the treatment of diseases associated with the expression of UBCPB. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding UBCPB.

摘要翻译： 本发明提供了人泛素缀合酶（UBCPB）和识别和编码UBCPB的多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码UBCPB的核酸序列和生产UBCPB的方法。 本发明还提供了特异性结合UBCPB的激动剂，抗体或拮抗剂及其在预防和治疗与UBCPB表达相关的疾病中的用途。 另外，本发明提供了反义分子用于编码UBCPB的多核苷酸用于治疗与UBCPB表达有关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合UBCPB的抗体的诊断测定法。

公开(公告)号：US5945505A

公开(公告)日：1999-08-31

申请号：US213392

申请日：1998-12-15

申请人： Olga Bandman ,  Surya K. Goli

发明人： Olga Bandman ,  Surya K. Goli

IPC分类号： G01N33/53 ,  A61K31/711 ,  A61K35/12 ,  A61K35/74 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P43/00 ,  C07K14/705 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  C07K5/00

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

摘要： The present invention provides a novel human phospholemman-like protein (HPLP) and the polynucleotides which identify and encode HPLP. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HPLP and for a method for producing the protein. The invention also provides pharmaceutical compositions containing HPLP and the use of such compositions for the prevention or treatment of diseases associated with the expression of HPLP. Additionally, the invention provides antisense molecules to HPLP and their use in the treatment of diseases associated with the expression of HPLP. The invention also provides diagnostic assays which utilize polynucleotides which hybridize with naturally occurring sequences encoding HPLP and antibodies which specifically bind to the protein.

摘要翻译： 本发明提供了一种新的人类磷酸核糖体样蛋白（HPLP）和识别和编码HPLP的多核苷酸。 本发明提供了基因工程表达载体和宿主细胞，其包含编码HPLP的核酸序列和用于产生蛋白质的方法。 本发明还提供含有HPLP的药物组合物以及这些组合物用于预防或治疗与HPLP表达相关的疾病的用途。 此外，本发明提供了HPLP的反义分子及其在治疗与HPLP表达相关的疾病中的用途。 本发明还提供诊断测定法，其利用与编码HPLP的天然存在的序列和特异性结合蛋白质的抗体杂交的多核苷酸。

公开(公告)号：US5935812A

公开(公告)日：1999-08-10

申请号：US715527

申请日：1996-09-18

申请人： Olga Bandman ,  Surya K. Goli ,  Lynn E. Murry

发明人： Olga Bandman ,  Surya K. Goli ,  Lynn E. Murry

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61P35/00 ,  C07K14/705 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/566 ,  C12P21/00

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The present invention provides a polynucleotide which identifies and encodes a novel human GTP binding protein gamma-3 (HGPG) and HGPG itself. The invention provides for genetically engineered expression vectors, host cells containing the vector and a method for producing HGPG. The invention also provides a method for identifying pharmaceutical compositions inhibiting the expression and activity of HGPG and for the use of such compositions for the treatment of cancer. The invention also provides diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding HGPG or anti-HGPG antibodies which specifically bind to HGPG in normal or diseased tissues.

摘要翻译： 本发明提供鉴定和编码新的人GTP结合蛋白γ-3（HGPG）和HGPG本身的多核苷酸。 本发明提供了遗传工程表达载体，含有载体的宿主细胞和用于产生HGPG的方法。 本发明还提供了用于鉴定抑制HGPG的表达和活性以及使用这些组合物治疗癌症的药物组合物的方法。 本发明还提供了利用多核苷酸与编码在正常或患病组织中特异性结合HGPG的HGPG或抗HGPG抗体的转录物进行杂交的诊断测定。

公开(公告)号：US5922321A

公开(公告)日：1999-07-13

申请号：US102732

申请日：1998-06-22

申请人： Olga Bandman ,  Surya K. Goli

发明人： Olga Bandman ,  Surya K. Goli

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K45/00 ,  A61P35/00 ,  C07K16/40 ,  C12N1/21 ,  C12N9/64 ,  C12N15/57 ,  C12Q1/68 ,  C12R1/19 ,  A61K38/48 ,  C12N9/48

CPC分类号： C12N9/6445 ,  A61K38/00 ,  Y10S435/971

摘要： The present invention provides a human prostate-specific kallikrein (HPSK) and polynucleotides which identify and encode HPSK. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPSK and a method for producing HPSK. The invention also provides for agonists, antibodies, or antagonists specifically binding HPSK, and their use, in the prevention and treatment of diseases associated with expression of HPSK. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPSK for the treatment of diseases associated with the expression of HPSK. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPSK.

摘要翻译： 本发明提供了人前列腺特异性激肽释放酶（HPSK）和识别和编码HPSK的多核苷酸。 本发明还提供了包含编码HPSK的核酸序列的基因工程表达载体和宿主细胞以及用于产生HPSK的方法。 本发明还提供特异性结合HPSK的激动剂，抗体或拮抗剂及其在预防和治疗与HPSK表达相关的疾病中的用途。 另外，本发明提供反义分子用于编码HPSK的多核苷酸用于治疗与HPSK表达相关的疾病。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HPSK的抗体的诊断测定法。