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154 条记录 (耗时 0.028 秒)

    Tumor-associated antigen
    1.
    发明授权
    Tumor-associated antigen 失效
    肿瘤相关抗原

    公开(公告)号：US06632617B1

    公开(公告)日：2003-10-14

    申请号：US09855288

    申请日：2001-05-14

    申请人： Olga Bandman ,  Surya K. Goli ,  Purvi Shah ,  Neil C. Corley ,  David G. Streeter

    发明人： Olga Bandman ,  Surya K. Goli ,  Purvi Shah ,  Neil C. Corley ,  David G. Streeter

    IPC分类号： C07K1600

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K39/00

    摘要： The invention provides a cDNA which encodes a TUAN. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of inflammatory and cell proliferative disorders, in particular, Crohn's disease and colon cancer. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

    摘要翻译： 本发明提供编码TAN的cDNA。 它还提供了cDNA，片段，补体及其变体以及编码的蛋白质，其部分及其抗体用于诊断和治疗炎症和细胞增殖性疾病，特别是克罗恩病和结肠癌的用途。 本发明另外提供用于产生蛋白质的表达载体和宿主细胞和转基因模型系统

    Tumor-associated antigen
    5.
    发明授权
    Tumor-associated antigen 失效
    肿瘤相关抗原

    公开(公告)号：US06350581B1

    公开(公告)日：2002-02-26

    申请号：US09227224

    申请日：1999-01-08

    申请人： Olga Bandman ,  Surya K. Goli ,  Purvi Shah ,  Neil C. Corley

    发明人： Olga Bandman ,  Surya K. Goli ,  Purvi Shah ,  Neil C. Corley

    IPC分类号： C07K1400

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K39/00

    摘要： The present invention provides a human tumor-associated antigen (TUAN) and polynucleotides which identify and encode TUAN. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing TUAN and for treating or preventing disorders associated with expression of TUAN.

    摘要翻译： 本发明提供了一种人肿瘤相关抗原（TUAN）和识别和编码TUAN的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 此外，本发明提供了用于制备TAN并用于治疗或预防与TUAN表达相关的疾病的方法。

    Protein phosphatase
    6.
    发明授权
    Protein phosphatase 失效
    蛋白磷酸酶

    公开(公告)号：US06436637B1

    公开(公告)日：2002-08-20

    申请号：US09206646

    申请日：1998-12-07

    申请人： Olga Bandman ,  Surya K. Goli ,  Preeti Lal ,  Neil C. Corley ,  Hong Zhang

    发明人： Olga Bandman ,  Surya K. Goli ,  Preeti Lal ,  Neil C. Corley ,  Hong Zhang

    IPC分类号： C12N916

    CPC分类号： C12N9/16 ,  A61K38/00

    摘要： The invention provides a human protein phosphatase (PROPHO) and polynucleotides which identify and encode PROPHO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PROPHO.

    摘要翻译： 本发明提供了人蛋白磷酸酶（PROPHO）和识别和编码PROPHO的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了治疗与PROPHO表达相关的疾病的方法。

    Subunits of NADH dehydrogenase
    10.
    发明授权
    Subunits of NADH dehydrogenase 失效
    NADH脱氢酶亚基

    公开(公告)号：US06399345B2

    公开(公告)日：2002-06-04

    申请号：US09151412

    申请日：1998-09-10

    申请人： Olga Bandman ,  Surya K. Goli ,  Jennifer L. Hillman

    发明人： Olga Bandman ,  Surya K. Goli ,  Jennifer L. Hillman

    IPC分类号： C12N906

    CPC分类号： C12N9/0036 ,  A61K38/00

    摘要： The present invention provides four NADH dehydrogenase subunits (designated individually as NDS-1, NDS-2, NDS-3, and NDS-4 and collectively as NDS) and polynucleotides which identify and encode NDS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NDS and a method for producing NDS. The invention also provides for use of NDS and agonists, antibodies, or antagonists specifically binding NDS, in the prevention and treatment of diseases associated with expression of NDS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NDS for the treatment of diseases associated with the expression of NDS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NDS.

    摘要翻译： 本发明提供四种NADH脱氢酶亚基（分别称为NDS-1，NDS-2，NDS-3和NDS-4，统称为NDS）和鉴定和编码NDS的多核苷酸。 本发明还提供了遗传工程改造的表达载体和包含编码NDS的核酸序列和产生NDS的方法的宿主细胞。 本发明还提供使用NDS和特异性结合NDS的激动剂，抗体或拮抗剂来预防和治疗与NDS表达相关的疾病。 另外，本发明提供反义分子用于编码NDS的多核苷酸用于治疗与NDS表达相关的疾病。 本发明还提供了利用多核苷酸或其片段或其补体以及特异性结合NDS的抗体的诊断测定法。