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公开(公告)号：US06632617B1
公开(公告)日：2003-10-14
申请号：US09855288
申请日：2001-05-14
申请人： Olga Bandman , Surya K. Goli , Purvi Shah , Neil C. Corley , David G. Streeter
发明人： Olga Bandman , Surya K. Goli , Purvi Shah , Neil C. Corley , David G. Streeter
IPC分类号： C07K1600
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00
摘要： The invention provides a cDNA which encodes a TUAN. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of inflammatory and cell proliferative disorders, in particular, Crohn's disease and colon cancer. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
摘要翻译： 本发明提供编码TAN的cDNA。 它还提供了cDNA，片段，补体及其变体以及编码的蛋白质，其部分及其抗体用于诊断和治疗炎症和细胞增殖性疾病，特别是克罗恩病和结肠癌的用途。 本发明另外提供用于产生蛋白质的表达载体和宿主细胞和转基因模型系统
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公开(公告)号：US5965706A
公开(公告)日：1999-10-12
申请号：US66262
申请日：1998-04-24
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides a human regulator of gene transcription (HRGT) and polynucleotides which encode HRGT. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HRGT.
摘要翻译： 本发明提供编码HRGT的人基因转录调节子（HRGT）和多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，反义分子，抗体或拮抗剂。 本发明还提供了治疗与HRGT表达相关的疾病的方法。
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公开(公告)号：US5776698A
公开(公告)日：1998-07-07
申请号：US839710
申请日：1997-04-14
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides a human regulator of gene transcription (HRGT) and polynucleotides which encode HRGT. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HRGT.
摘要翻译： 本发明提供编码HRGT的人基因转录调节子（HRGT）和多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，反义分子，抗体或拮抗剂。 本发明还提供了治疗与HRGT表达相关的疾病的方法。
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公开(公告)号：US5989818A
公开(公告)日：1999-11-23
申请号：US941262
申请日：1997-09-30
CPC分类号： C07K14/47
摘要： The invention provides a human rSec6 related vesicle transport protein (HSEC6) and polynucleotides which identify and encode HSEC6. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HSEC6.
摘要翻译： 本发明提供了一种人类rSec6相关囊泡转运蛋白（HSEC6）和识别和编码HSEC6的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了治疗与HSEC6表达相关的疾病的方法。
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公开(公告)号：US5175251A
公开(公告)日：1992-12-29
申请号：US785155
申请日：1991-10-29
CPC分类号： C07K14/78 , A61K38/00 , Y10S930/26
摘要： Human laminin B.sub.1 peptides have been produced. The invention provides novel peptides which contain substantial amino acid sequence similarity to amino acids 897 to 936 in the human sequence. These peptides have been found to have enhanced antimetastatic activity.
摘要翻译： 已经生产了人层粘连蛋白B1肽。 本发明提供了新的肽，其含有与人序列中的氨基酸897至936相当的氨基酸序列相似性。 已经发现这些肽具有增强的抗转移活性。
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公开(公告)号：US06544742B1
公开(公告)日：2003-04-08
申请号：US09653119
申请日：2000-08-31
申请人： Mary Faris , David G. Streeter
发明人： Mary Faris , David G. Streeter
IPC分类号： C12Q168
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a combination comprising a plurality of polynucleotide probes that are modulated in response to EGF and which are associated with breast cancer, and which may be used in their entirety or in part as to diagnose, to stage, to treat, or to monitor the treatment of a subject with a breast cancer.
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公开(公告)号：US06524819B1
公开(公告)日：2003-02-25
申请号：US09614474
申请日：2000-07-11
IPC分类号： C12P2106
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C12Q1/6883 , C12Q2600/158
摘要： The invention provides a mammalian nucleic acid molecule and fragments thereof. It also provides for the use of the mammalian nucleic acid molecule for the characterization, diagnosis, evaluation, treatment, of conditions, diseases and disorders associated with gene expression and for the production of a model system. The invention additionally provides expression vectors and host cells for the production of the protein encoded by the mammalian nucleic acid molecule.
摘要翻译： 本发明提供哺乳动物核酸分子及其片段。 它还提供了哺乳动物核酸分子用于表征，诊断，评估，治疗，与基因表达相关的病症，疾病和病症以及模型系统的生产的用途。 本发明另外提供用于产生由哺乳动物核酸分子编码的蛋白质的表达载体和宿主细胞。
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