Mass compromise/point of compromise analytic detection and compromised card portfolio management system
    121.
    发明申请
    Mass compromise/point of compromise analytic detection and compromised card portfolio management system 有权
    质量妥协/折衷点分析检测和受损卡组合管理系统

    公开(公告)号:US20070061259A1

    公开(公告)日:2007-03-15

    申请号:US11475722

    申请日:2006-06-26

    IPC分类号: G06Q40/00

    摘要: A system and method for managing mass compromise of financial transaction devices is disclosed. A method includes maintaining a summary of a transaction history for a financial transaction device, and forming a device history profile based on the transaction history, the device history profile including predictive variables indicative of fraud associated with the financial transaction device. A method further includes generating a fraud score based on the predictive variables, the fraud score representing a likelihood that the financial transaction device is compromised will be used fraudulently.

    摘要翻译: 公开了一种用于管理金融交易设备的大规模妥协的系统和方法。 一种方法包括维护金融交易设备的交易历史的摘要,以及基于交易历史形成设备历史简档,设备历史简档包括指示与金融交易设备相关联的欺诈的预测变量。 一种方法还包括基于预测变量产生欺诈分数,欺诈分数表示金融交易设备被破坏的可能性将被欺诈地使用。

    Identification of virulence determinants activators in prokaryotic pathogens
    124.
    发明申请
    Identification of virulence determinants activators in prokaryotic pathogens 审中-公开
    鉴定原核病原体中毒力决定簇活化剂

    公开(公告)号:US20050058665A1

    公开(公告)日:2005-03-17

    申请号:US10860727

    申请日:2004-06-03

    申请人: John Murphy Li Sun

    发明人: John Murphy Li Sun

    摘要: Disclosed is a method for identifying activators of a transition metal-dependent repressor of virulence gene expression in infectious prokaryotic pathogens. The method utilizes genetic circuitry that represents the response of a given prokaryote to nutritional stress and the expression of genes that contribute to the establishment of the infectious process. The exposure of recombinant cells or a cell-free system containing the genetic circuitry to a non-metal ion test substance that activates the repressor produces a detectable response. The method is applicable for any prokaryote employing metal ion-dependent repressors to regulate specific gene expression, specifically as it pertains to virulence determinant expression.

    摘要翻译: 公开了用于鉴定感染性原核病原体中毒性基因表达的过渡金属依赖性阻遏物的活化剂的方法。 该方法利用代表给定原核生物对营养压力的反应的遗传回路和有助于建立感染过程的基因的表达。 将包含遗传电路的重组细胞或无细胞系统暴露于激活阻遏物的非金属离子测试物质产生可检测的反应。 该方法适用于任何使用金属离子依赖性阻遏物调节特异性基因表达的原核生物,特别是与毒力决定簇表达有关。

    3-heteroarylidene-2-indolinone protein kinase inhibitors
    129.
    发明授权
    3-heteroarylidene-2-indolinone protein kinase inhibitors 失效
    3-杂芳基-2-二氢吲哚酮蛋白激酶抑制剂

    公开(公告)号:US06486185B1

    公开(公告)日:2002-11-26

    申请号:US09191458

    申请日:1998-11-12

    IPC分类号: C07D40314

    CPC分类号: C07D209/34 C07D471/04

    摘要: The present invention relates to novel 3-heteroarylidene-2-indolinone compounds and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

    摘要翻译: 本发明涉及调节蛋白激酶活性的新型3-杂杂亚杂-2-二氢吲哚酮化合物及其生理上可接受的盐,因此预期可用于预防和治疗与蛋白激酶相关的细胞病症例如癌症。

    Pyrrole substituted 2-indolinone protein kinase inhibitors
    130.
    发明授权
    Pyrrole substituted 2-indolinone protein kinase inhibitors 有权
    吡咯取代的2-二氢吲哚酮蛋白激酶抑制剂

    公开(公告)号:US06395734B1

    公开(公告)日:2002-05-28

    申请号:US09322297

    申请日:1999-05-28

    IPC分类号: A61K314045

    CPC分类号: C07D403/06 C07D209/34

    摘要: The present invention relates to novel pyrrole substituted 2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

    摘要翻译: 本发明涉及调节蛋白激酶活性的新型吡咯取代的2-二氢吲哚酮化合物及其生理上可接受的盐和前药,因此预期可用于预防和治疗蛋白激酶相关的细胞病症例如癌症。