公开(公告)号：US09056199B2

公开(公告)日：2015-06-16

申请号：US13572542

申请日：2012-08-10

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H05H13/04 ,  A61N5/10 ,  A61B6/03 ,  A61B6/04 ,  H05H7/10

CPC classification number: A61N5/10 ,  A61B6/03 ,  A61B6/0421 ,  A61B6/4258 ,  A61N5/1043 ,  A61N5/1067 ,  A61N5/1069 ,  A61N2005/1087 ,  A61N2005/1097 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises a charged particle beam, rapid patient positioning system including steps of: positioning a patient relative to a table in a substantially vertical orientation, optionally constraining motion of the patient with one or more constraints, transitioning the table through a semi-vertical orientation, such as with a robot arm, and orientating the patient and table in a substantially horizontal orientation, such as in a position for tumor therapy. Preferably, the robot arm is in common with an arm used to move the patient in traditional proton therapy. Optionally, the robot arm is used to re-orientate the patient into a substantially vertical orientation at the conclusion of a charged particle therapy session.

Abstract translation: 本发明包括带电粒子束，快速患者定位系统，其包括以下步骤：将患者相对于桌子以基本垂直的方向定位，可选地约束患者具有一个或多个约束的运动，使所述桌子跨过半垂直取向 ，例如用机器人手臂，并且以基本上水平的方向（例如用于肿瘤治疗的位置）使患者和桌子定向。 优选地，机器人臂与用于在传统质子治疗中移动患者的手臂相同。 可选地，机器人手臂用于在带电粒子治疗会话结束时将患者重新定向为基本垂直的取向。

公开(公告)号：US09018601B2

公开(公告)日：2015-04-28

申请号：US13360683

申请日：2012-01-28

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00 ,  H05H13/04 ,  A61N5/10

CPC classification number: H05H13/04 ,  A61N5/1049 ,  A61N5/1067 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1087

Abstract: The invention relates generally to treatment of solid cancers. More particularly, the invention relates to a multi-field imaging and/or a multi-field charged particle cancer therapy method and apparatus coordinated with patient respiration via use of feedback sensors used to monitor and/or control patient respiration. Preferably, the multi-field imaging, such as X-ray imaging, and the charged particle therapy are performed on a patient in a partially immobilized and repositionable position. X-ray and/or proton delivery is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and/or targeting methods and apparatus.

Abstract translation: 本发明一般涉及固体癌的治疗。 更具体地，本发明涉及通过使用用于监测和/或控制患者呼吸的反馈传感器与患者呼吸配合的多场成像和/或多场带电粒子癌治疗方法和装置。 优选地，多场成像，例如X射线成像和带电粒子治疗在部分固定和可重新定位的位置上对患者进行。 通过控制带电粒子束注射，加速，提取和/或靶向方法和装置，将X射线和/或质子传递定时到患者呼吸。

公开(公告)号：US08933651B2

公开(公告)日：2015-01-13

申请号：US13679770

申请日：2012-11-16

Applicant: Vladimir Balakin ,  Yury Valyaev

Inventor： Vladimir Balakin ,  Yury Valyaev

IPC: H05H15/00 ,  H05H7/04 ,  H05H13/04 ,  A61N5/10

CPC classification number: H05H7/04 ,  A61N5/1077 ,  H05H13/04

Abstract: The invention comprises a flattened magnet coil system that reduces space between a first magnet turning section and a second magnet turning section in a synchrotron accelerator, which reduces or eliminates need for one or more quadrupole focusing elements in the accelerator. Optionally, a coil, in the flattened magnetic coil system, is wrapped about a central metal member between yoke members of a magnet. The coil has a first width and a first thickness along the length of the magnet and a second width and a second thickness along the end of the magnet where the first width is larger than the second width and the second thickness is larger than the first thickness allowing a smaller distance between the first magnet turning section and the second magnet turning section while maintaining current flow in the coil.

Abstract translation: 本发明包括一个扁平化的磁体线圈系统，其减小同步加速器中的第一磁体转动部分和第二磁体转动部分之间的空间，这减少或消除了对加速器中的一个或多个四极聚焦元件的需要。 可选地，平坦化的电磁线圈系统中的线圈围绕磁体的轭构件之间的中心金属构件缠绕。 线圈沿着磁体的长度具有第一宽度和第一厚度，沿着磁体的端部具有第二宽度和第二厚度，其中第一宽度大于第二宽度，第二厚度大于第一厚度 允许第一磁体转动部分和第二磁体转动部分之间的距离更小，同时保持线圈中的电流。

公开(公告)号：US20140257099A1

公开(公告)日：2014-09-11

申请号：US13789235

申请日：2013-03-07

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  A61B6/02 ,  G01N23/04

CPC classification number: A61N5/1039 ,  A61B5/0878 ,  A61B6/032 ,  A61B6/4092 ,  A61B6/4258 ,  A61B6/541 ,  A61B2560/0252 ,  A61N5/103 ,  A61N5/1037 ,  A61N5/1048 ,  A61N5/1068 ,  A61N5/107 ,  A61N5/1077 ,  A61N2005/1054 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/1097 ,  H05H7/08 ,  H05H13/04

Abstract: The invention relates to a method and apparatus for control of a charged particle cancer therapy system. A treatment delivery control system is used to directly control multiple subsystems of the cancer therapy system without direct communication between selected subsystems, which enhances safety, simplifies quality assurance and quality control, and facilitates programming. For example, the treatment delivery control system directly controls one or more of: an imaging system, a positioning system, an injection system, a radio-frequency quadrupole system, a ring accelerator or synchrotron, an extraction system, a beam line, an irradiation nozzle, a gantry, a display system, a targeting system, and a verification system. Generally, the control system integrates subsystems and/or integrates output of one or more of the above described cancer therapy system elements with inputs of one or more of the above described cancer therapy system elements.

公开(公告)号：US08718231B2

公开(公告)日：2014-05-06

申请号：US13398446

申请日：2012-02-16

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  A61B6/04

CPC classification number: A61N5/1064 ,  A61B6/032 ,  A61B6/0421 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/1097

Abstract: The invention comprises an X-ray tomography method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. In various embodiments, 3-D images are generated from a series of 2-D X-rays images; the X-ray source and detector are stationary while the patient rotates; the 2-D X-ray images are generated using an X-ray source proximate a charged particle beam in a charged particle cancer therapy system; and the X-ray tomography system uses an electron source having a geometry that enhances an electron source lifetime, where the electron source is used in generation of X-rays. The X-ray tomography system is optionally used in conjunction with systems used to both move and constrain movement of the patient, such as semi-vertical, sitting, or laying positioning systems. The X-ray images are optionally used in control of a charged particle cancer therapy system.

Abstract translation: 本发明包括与多轴带电粒子或癌肿瘤的质子束放射治疗结合使用的X射线断层摄影方法和装置。 在各种实施例中，从一系列2-D X射线图像生成3-D图像; X射线源和检测器在患者旋转时是静止的; 使用在带电粒子癌症治疗系统中的带电粒子束附近的X射线源产生2-D X射线图像; 并且X射线断层摄影系统使用具有增强电子源寿命的几何形状的电子源，其中电子源用于产生X射线。 X射线断层摄影系统可选地与用于移动和约束患者运动的系统结合使用，例如半垂直，坐着或铺设定位系统。 X射线图像任选用于控制带电粒子癌症治疗系统。

公开(公告)号：US08598543B2

公开(公告)日：2013-12-03

申请号：US12985039

申请日：2011-01-05

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: A61N5/10 ,  A61N5/1048 ,  A61N5/1082 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention relates to a method and apparatus for treatment of solid cancer. More particularly, the invention comprises a multi-axis and/or multi-field raster beam charged particle cancer therapy system. The system independently controls patient translation position, patient rotation position, two-dimensional beam trajectory, delivered beam energy, delivered beam intensity, beam movement velocity, timing of charged particle delivery, and/or distribution of radiation striking healthy tissue. The system operates in conjunction with a negative ion beam source, synchrotron, patient positioning, imaging, and/or targeting method and apparatus to deliver an effective and uniform dose of radiation to a tumor while distributing radiation striking healthy tissue.

Abstract translation: 本发明涉及一种治疗实体性癌症的方法和装置。 更具体地，本发明包括多轴和/或多场光栅束带电粒子癌治疗系统。 该系统独立地控制患者平移位置，患者旋转位置，二维束轨迹，递送的束能，递送的束强度，束移动速度，带电粒子传递的时间和/或辐射进入健康组织的分布。 该系统与负离子束源，同步加速器，患者定位，成像和/或靶向方法和装置一起运行，以在分布辐射进入健康组织的同时向肿瘤递送有效且均匀的辐射。

公开(公告)号：US08569717B2

公开(公告)日：2013-10-29

申请号：US12711609

申请日：2010-02-24

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: A61N5/10 ,  A61N5/1043 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention relates to treatment of solid cancers and more particularly to a method and apparatus correlating proton beam intensity with proton delivery efficiency, optionally in a raster beam scanning system. The system induces betatron oscillation on the proton beam causing the beam to traverse an extraction material resulting in slowed protons and a feedback current proportional to the proton flux. A controller receives the desired intensity from an irradiation plan and the feedback current and adjusts the radio-frequency field in the radio-frequency cavity system to yield an intensity of the proton beam that matches the desired intensity from the irradiation plan. Preferably, the intensity of the proton beam correlates with radiation delivery efficiency. The system preferably operates in conjunction with a multi-field charged particle cancer therapy system, with charged particle beam injection, particle beam acceleration, multi-axis charged particle beam control, and/or targeting methods and apparatus.

Abstract translation: 本发明涉及治疗固体癌症，更具体地涉及将质子束强度与质子传递效率相关联的方法和装置，可选地在光栅束扫描系统中。 该系统引起质子束上的贝塔振荡，导致光束穿过提取材料，导致质子减慢，反馈电流与质子通量成比例。 控制器从照射计划和反馈电流接收期望的强度，并且调整射频腔系统中的射频场，以产生与照射计划匹配所需强度的质子束的强度。 优选地，质子束的强度与辐射传递效率相关。 该系统优选与具有带电粒子束注入，粒子束加速，多轴带电粒子束控制和/或靶向方法和装置的多场带电粒子癌治疗系统结合操作。

公开(公告)号：US08373146B2

公开(公告)日：2013-02-12

申请号：US12619278

申请日：2009-11-16

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: H05H7/10 ,  A61N2005/1087 ,  H05H13/04

Abstract: The invention comprises a radio-frequency accelerator method and apparatus used in conjunction with multi-axis charged particle radiation therapy of cancerous tumors. An RF synthesizer provides a low voltage RF signal, that is synchronized to the period of circulation of protons in the proton beam path, to a set of integrated microcircuits, loops, and coils where the coils circumferentially enclose the proton beam path in a synchrotron. The integrated components combine to provide an accelerating voltage to the protons in the proton beam path in a size compressed and price reduced format. The integrated RF-amplifier microcircuit/accelerating coil system is operable from about 1 MHz, for a low energy proton beam, to about 15 MHz, for a high energy proton beam.

Abstract translation: 本发明包括与癌肿瘤的多轴带电粒子放射治疗结合使用的射频加速器方法和装置。 RF合成器提供与质子束路径中的质子循环周期同步的低电压RF信号到一组集成的微电路，环路和线圈，其中线圈周向地包围同步加速器中的质子束路径。 集成组件结合在质量压缩和价格降低的格式中为质子束路径中的质子提供加速电压。 对于高能量质子束，集成的RF放大器微电路/加速线圈系统可操作于约1MHz，对于低能量质子束至约15MHz。

公开(公告)号：US08229072B2

公开(公告)日：2012-07-24

申请号：US13041365

申请日：2011-03-05

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10

CPC classification number: A61N5/10 ,  A61N2005/1061 ,  A61N2005/1087

Abstract: The system uses an X-ray imaging system having an elongated lifetime. Further, the system uses an X-ray beam that lies in substantially the same path as a charged particle beam path of a particle beam cancer therapy system. The system creates an electron beam that strikes an X-ray generation source located proximate to the charged particle beam path. By generating the X-rays near the charged particle beam path, an X-ray path running collinear, in parallel with, and/or substantially in contact with the charged particle beam path is created. The system then collects X-ray images of localized body tissue region about a cancerous tumor. Since, the X-ray path is essentially the charged particle beam path, the generated image is usable for precisely target the tumor with a charged particle beam.

Abstract translation: 该系统使用具有延长寿命的X射线成像系统。 此外，该系统使用位于与粒子束癌治疗系统的带电粒子束路径基本相同的路径中的X射线束。 该系统产生电子束，该电子束撞击位于带电粒子束路径附近的X射线产生源。 通过在带电粒子束路径附近产生X射线，产生与带电粒子束路径并联并且/或基本上与带电粒子束路径接触的X射线路径。 然后系统收集关于癌性肿瘤的局部的身体组织区域的X射线图像。 由于X射线路径基本上是带电粒子束路径，所以生成的图像可用于用带电粒子束精确地靶向肿瘤。

公开(公告)号：US08178859B2

公开(公告)日：2012-05-15

申请号：US12618718

申请日：2009-11-14

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: H05H7/10 ,  A61N5/1048 ,  A61N5/1067 ,  A61N2005/1087 ,  H01J3/04 ,  H01J3/14 ,  H05H13/04

Abstract: The invention comprises a proton beam positioning method and apparatus used in conjunction with multi-axis charged particle radiation therapy of cancerous tumors. The proton beam verification system allows for monitoring of the actual proton beam position in real-time without destruction of the proton beam. The system includes a coating or thin layer substantially in contact with a foil covering the end of an exit nozzle or is a layer located after the x- and y-axis proton beam scanning controllers and before the patient. The coating yields a measurable spectroscopic response, spatially viewable by the detector, as a result of transmission by the proton beam. The proton beam position is monitored by the detector and compared to the calibration and/or treatment plan to verify accurate proton delivery to the tumor and/or as a proton beam shutoff safety indicator.

Abstract translation: 本发明包括与癌肿瘤的多轴带电粒子放射治疗结合使用的质子束定位方法和装置。 质子束验证系统允许实时监测实际的质子束位置，而不破坏质子束。 该系统包括基本上与覆盖出口喷嘴的端部的箔接触的涂层或薄层，或者是位于x轴和y轴质子束扫描控制器之后且位于患者之前的层。 作为质子束传输的结果，涂层产生可测量的光谱响应，由检测器空间可见。 质子束位置由检测器监测，并与校准和/或治疗计划进行比较，以验证对肿瘤的精确质子传递和/或作为质子束截止安全指示剂。