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236 条记录 (耗时 0.024 秒)

    Quinazoline-3-alkanoic acid derivatives, their salts and their preparation processes
    131.
    发明授权
    Quinazoline-3-alkanoic acid derivatives, their salts and their preparation processes 失效
    喹诺酮-3-碱性酸衍生物及其制备方法

    公开(公告)号：US5234928A

    公开(公告)日：1993-08-10

    申请号：US721610

    申请日：1991-07-17

    申请人： Shizuyoshi Fujimori ,  Michiro Ohnota ,  Yoshihiro Hirata ,  Koji Murakami

    发明人： Shizuyoshi Fujimori ,  Michiro Ohnota ,  Yoshihiro Hirata ,  Koji Murakami

    IPC分类号： A61K31/505 ,  A61K31/517 ,  A61P3/08 ,  A61P3/10 ,  A61P7/02 ,  A61P43/00 ,  C07D239/80 ,  C07D239/95 ,  C07D239/96 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D491/056 ,  C07D521/00 ,  C12N9/99

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D239/80 ,  C07D239/95 ,  C07D239/96 ,  C07D249/08 ,  C07D401/06 ,  C07D403/04 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  Y02P20/55

    摘要： The present invention relates to quinazoline-3-alkanoic acid derivatives having both an inhibitory effect on platelet aggregation and a hindering effect on aldose reductase together, represented by a general formula [I] ##STR1## [wherein R is hydrogen or a protecting group for carboxyl group, R.sup.1 is a lower alkyl group, alkenyl group, alkinyl group, lower alkoxy group, lower alkylthio group, halogen, phenyl group (this phenyl group may be substituted by one to three of lower alkyls, lower alkoxys, halogens, trifluoromethyls, carboxyethylenes or ethoxycarbonylethylenes, naphthyl group, heterocycle (this heterocycle may be substituted by one to three of lower alkyls), cycloalkyl group or benzoyl group (this benzoyl group may be substituted by lower alkyl or halogen), R.sup.2 and R.sup.3 are identically or differently hydrogens, halogens, lower alkyl groups, lower alkoxy groups, aralkyl groups which may be substituted, nitro groups, imidazolyl groups, imidazolylmethyl groups or ##STR2## (R.sup.4 and R.sup.5 indicate identically or differently hydrogens or lower alkyl groups, or connected with each other to make five- or six-membered heterocycles which may contain other hetero atom, X is carbonyl, thiocarbonyl or methylene group (this methylene group may be substituted by lower alkyl group), A is lower alkylene or lower alkenylene, and n indicates an integer of 1 to 3],their salts, their preparation processes and medicinal drugs containing them.

    摘要翻译： PCT No.PCT / JP90 / 01600 Sec。 371日期：1991年7月17日 102（e）日期1991年7月17日PCT 1990年12月10日PCT PCT。 出版物WO91 / 0902400 日本1991年6月27日。本发明涉及具有对血小板聚集的抑制作用和对醛糖还原酶的阻碍作用的喹唑啉-3-链烷酸衍生物，其通式[I]表示[其中R 是氢或羧基的保护基，R1是低级烷基，烯基，炔基，低级烷氧基，低级烷硫基，卤素，苯基（该苯基可被一至三个低级烷基取代， 低级烷氧基，卤素，三氟甲基，羧乙烯或乙氧基羰基乙烯，萘基，杂环（该杂环可被一至三个低级烷基取代），环烷基或苯甲酰基（该苯甲酰基可被低级烷基或卤素取代），R2 和R 3是相同或不同的氢，卤素，低级烷基，低级烷氧基，可被取代的芳烷基，硝基，咪唑基，咪唑基甲基或IM （R 4和R 5表示相同或不同的氢或低级烷基，或彼此连接以形成可含有其它杂原子的五或六元杂环，X为羰基，硫代羰基或亚甲基（该亚甲基可以 被低级烷基取代），A是低级亚烷基或低级亚烯基，n表示1〜3的整数]，它们的盐，它们的制备方法和含有它们的药用药物。

    Benzimidazole Derivatives
    133.
    发明授权
    Benzimidazole Derivatives 失效
    苯并咪唑衍生物

    公开(公告)号：US4942245A

    公开(公告)日：1990-07-17

    申请号：US180065

    申请日：1988-04-11

    申请人： Kuniyoshi Masuzawa ,  Kyuya Okamura ,  Keigo Nishino ,  Mitsuo Ohashi ,  Katsuya Awano

    发明人： Kuniyoshi Masuzawa ,  Kyuya Okamura ,  Keigo Nishino ,  Mitsuo Ohashi ,  Katsuya Awano

    IPC分类号： C07D235/12 ,  C07D235/28

    CPC分类号： C07D235/28 ,  C07D235/12

    摘要： Benzimidazole derivatives of the following formula, ##STR1## wherein R.sup.1 indicates hydrogen atom, lower alkyl group having carbon atoms of 1 to 6 or dimethylaminopropyl group, R.sup.2 indicates hydrogen atom or lower alkanoyl group having carbon atoms of 1 to 3, R.sup.3 indicates hydrogen atom, lower alkyl group having carbon atoms of 1 to 3 or lower alkanoyl group having carbon atoms of 1 to 3, X indicates sulfur atom, sulfinyl group, sulfonyl group, amino group or methylene group, A indicates alkylene group having carbon atoms of 1 to 12, which alkylene group may optionally be substituted by hydroxy group or lower alkyl group having carbon atoms of 1 to 3, --(CHR')N--CR".dbd.CR"--(CHR')M--, ##STR2## (in which R' and R" are each independently hydrogen atom, lower alkyl group having carbon atoms of 1 to 3 or hydroxy group, and n and m are equal to 0, 1, 2 or 3) and Y indicates oxygen atom or sulfur atom; their acid or alkali salts and hydrate thereof are useful as antiallergic agents.

    Nicotinic acid derivatives
    136.
    发明授权
    Nicotinic acid derivatives 失效
    烟酸衍生物

    公开(公告)号：US4556715A

    公开(公告)日：1985-12-03

    申请号：US544897

    申请日：1983-10-24

    申请人： Tsutomu Irikura ,  Seigo Suzue ,  Kodo Okada

    发明人： Tsutomu Irikura ,  Seigo Suzue ,  Kodo Okada

    IPC分类号： A61K31/4406 ,  A61K31/455 ,  A61P3/06 ,  C07D213/80

    CPC分类号： C07D213/80

    摘要： This invention relates to compounds, 4-(4-substituted phenylalkyloxy) phenylalkyl nicotinates, represented by the following structural formula I and its salts, the methods for preparations thereof. ##STR1## wherein n.sub.1 is an integer from 2 to 6 inclusive, provided that n.sub.1 and n.sub.2 are not 1 at the same time, n.sub.1 is an integer from 1 to 6 inclusive, and X means chlorine or fluorine atom.

    摘要翻译： 本发明涉及由以下结构式I表示的化合物，4-（4-取代苯基烷氧基）苯基烷基烟酸酯及其盐，其制备方法。 其中n1为2〜6的整数，其中，n1和n2同时为1，n1为1〜6的整数，X为氯或氟原子。

    Pyrazolo�1,5-a!pyridines
    137.
    发明授权
    Pyrazolo�1,5-a!pyridines 失效
    吡唑并[8,1-a {9个吡啶

    公开(公告)号：US4097483A

    公开(公告)日：1978-06-27

    申请号：US719328

    申请日：1976-08-31

    申请人： Tsutomu Irikura

    发明人： Tsutomu Irikura

    IPC分类号： C07D417/04 ,  C07D401/02

    CPC分类号： C07D417/04 ,  Y10S514/929

    摘要： The present invention provides substituted pyrazolo�1,5-a!pyridine derivatives expressed by a compound of the general formula (I), ##STR1## (wherein: X is hydrogen atom or methyl group; R is hydrogen atom, straight or branched lower alkyl group, lower alkoxy group, lower alkylthio group, dialkylamino group, alkyleneimino group, and morpholino group; R.sub.1 is different from R and is hydrogen atom, straight or branched lower alkyl group, lower alkoxy alkyl group, and dialkylamino group). The compound of the present invention can be prepared by reacting a compound of the general formula (II), ##STR2## in which X and R are as shown hereinbefore, with a compound of the general formula (III), in which R.sub.1 is as shown hereinbefore, R.sub.1 COOH (III) or with a functional derivative of the compound of the general formula (III).

    摘要翻译： 本发明提供由通式（I）的化合物，其中：X是氢原子或甲基; R是氢原子，直链的（I）表示的取代的吡唑并[1,5-a]吡啶衍生物 或支链低级烷基，低级烷氧基，低级烷硫基，二烷基氨基，亚烷基亚氨基和吗啉代基; R1不同于R，为氢原子，直链或支链低级烷基，低级烷氧基烷基和二烷基氨基） 。

    NUCLEIC ACID AMPLIFICATION CHIP
    139.
    发明公开
    NUCLEIC ACID AMPLIFICATION CHIP 审中-公开

    公开(公告)号：US20230302448A1

    公开(公告)日：2023-09-28

    申请号：US18020377

    申请日：2021-08-06

    申请人： KYORIN PHARMACEUTICAL CO., LTD.

    发明人： Keisuke GOHDA ,  Kentaro UMEI

    IPC分类号： B01L3/00 ,  B01L7/00

    CPC分类号： B01L3/502715 ,  B01L7/525 ,  B01L2300/0681 ,  B01L2300/0883 ,  B01L2300/18

    摘要： In a nucleic acid amplification chip, a filter is provided inside or outside a PCR reaction container with respect to a micro-flow channel. Here, the filter is fixed to the PCR reaction container via a fixing portion. In this case, since the fixing portion is formed, the reliability of fixing the filter to the PCR reaction container can be improved. For this reason, the leakage of an evaporated sample solution (aerosol) from a gap between the filter and the PCR reaction container can be suppressed. Further, since the fixing portion is formed, the leakage of the evaporated sample solution (aerosol) can be suppressed without increasing the thickness of the filter, so that the filter can be made thin. As a result, the overall thickness of the nucleic acid amplification chip can also be reduced, so that the degree of freedom in designing the nucleic acid amplification chip is improved.