公开(公告)号：US08674125B2

公开(公告)日：2014-03-18

申请号：US13777799

申请日：2013-02-26

Applicant: Centre National de la Recherche Scientifique (C.N.R.S.) ,  Ecole Nationale Superieure de Chimie de Montpellier ,  Universite Sidi Mohammed Ben Abdellah

Inventor： Marc Taillefer ,  Hamid Kaddouri ,  Fouad Ouazzani ,  Armelle Ouali

IPC: C07F9/28

CPC classification number: C07F9/5045 ,  C07F9/5022

Abstract: A method for the creation of a carbon-carbon (C—C) bond or of a carbon-heteroatom (C-HE) bond includes reacting a compound carrying a leaving group with a nucleophilic compound carrying a carbon atom or a heteroatom (HE) capable of replacing the leaving group, thus creating a C—C or C-HE bond, in which process the reaction is carried out in the presence of an effective amount of a catalytic system comprising at least one copper/butadienylphosphine complex.

Abstract translation: 产生碳 - 碳（CC）键或碳 - 杂原子（C-HE）键的方法包括使带有离去基团的化合物与携带碳原子的亲核化合物或能够 代替离去基团，从而产生CC或C-HE键，其中反应在有效量的包含至少一种铜/丁二烯基膦络合物的催化体系的存在下进行。

公开(公告)号：US20140031276A1

公开(公告)日：2014-01-30

申请号：US13921998

申请日：2013-06-19

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  INSTITUT PASTEUR

Inventor： Jerome Estaquier ,  Mireille Laforge ,  Anna Senik

IPC: A61K38/00 ,  A61K31/496 ,  A61K31/7072 ,  A61K38/05 ,  A61K45/06

CPC classification number: A61K38/05 ,  A61K31/404 ,  A61K31/4525 ,  A61K31/47 ,  A61K31/496 ,  A61K31/7072 ,  A61K38/005 ,  A61K45/06 ,  C07K5/06052 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/463 ,  Y02A50/465

Abstract: A compound is provided which has a structure I: A-B-C and a method for administering the compound is also provided for use in the prophylaxis and/or treatment of a viral infection, and in particular for preventing and/or inhibiting viral replication, in which A is a quinoline or quinoline-like group, B is a sole amino acid or a peptide or polypeptide having a given amino acid sequence, and C is an O-phenoxy group. According to one embodiment, the compound is a protease inhibitor such as a caspase inhibitor, and the inhibitor can be Q-VD-OPh (N-(2-(quinolyl)valylaspartyl-(2,6-difluorophenoxy)methyl ketone), optionally in an O-methylated form. Antiviral compositions and kits are also provided.

Abstract translation: 提供了具有结构I：ABC的化合物，并且还提供了用于施用化合物的方法用于预防和/或治疗病毒感染，特别是用于预防和/或抑制病毒复制，其中A 是喹啉或喹啉类基团，B是唯一的氨基酸或具有给定氨基酸序列的肽或多肽，C是O-苯氧基。 根据一个实施方案，化合物是蛋白酶抑制剂，例如胱天蛋白酶抑制剂，并且抑制剂可以是Q-VD-OPh（N-（2-（喹啉基）缬氨酰天竺葵酰基 - （2,6-二氟苯氧基）甲基酮），任选地 还提供了抗病毒组合物和试剂盒。

公开(公告)号：US20040170952A1

公开(公告)日：2004-09-02

申请号：US10043160

申请日：2002-01-14

Applicant: C.N.R.S. ,  I.N.R.A.

Inventor： Rima Zoorob ,  Charles Auffray ,  Anne-Marie Chausse

IPC: C12Q001/70 ,  C12Q001/68 ,  C07H021/04

CPC classification number: C12Q1/6881 ,  C12Q1/6827 ,  C12Q1/6869 ,  C12Q1/6883 ,  C12Q2600/156

Abstract: The invention relates to nucleic acid molecules which make it possible to detect those genes of the MHC involved in the phenomena of resistance or susceptibility to the development of virus-induced tumours. The primers developed from said molecules can be used in a method of genotyping farmed birds, and particularly chickens, characterised in that it comprises: amplification of a sample of nucleic acid originating from the animal to be studied using one or more pairs of primers capable of hybridising specifically with the nucleic acid of a polymorphic region of the Rfp-Y or B systems of the MHC of said birds, and detection of the PCR products obtained.

Abstract translation: 本发明涉及使得能够检测MHC参与抗病毒或对病毒诱导的肿瘤发展的易感性的那些基因的核酸分子。 从所述分子开发的引物可以用于对养殖的鸟，特别是鸡进行基因分型的方法，其特征在于，其包括：使用一种或多种能够进行研究的引物对来源于待研究的动物的核酸样品的扩增 与所述禽类的MHC的Rfp-Y或B系统的多态性区域的核酸特异性杂交，检测获得的PCR产物。

公开(公告)号：US11807762B2

公开(公告)日：2023-11-07

申请号：US17296176

申请日：2019-11-18

Applicant: SOCIETE BIC ,  UNIVERSITE DE HAUTE ALSACE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

Inventor： Karine Mougin ,  Feriel Ghellal ,  Arnaud Spangenberg ,  Romain Metillon ,  Olivier Albenge

IPC: C09D11/17 ,  C09D11/16 ,  C09D11/02

CPC classification number: C09D11/17 ,  C09D11/02 ,  C09D11/16

Abstract: There is a process for preparing in situ an aqueous gel ink with variable color having the following steps:



(i) preparing a gel-based matrix of aqueous ink comprising a reducing agent,
(ii) adding a solution of metallic salts,
(iii) adding iron powder to obtain an aqueous gel ink with variable color,
wherein the steps (ii) and (iii) can be interchanged.




There also is an aqueous gel ink with variable color obtained according to the process of the disclosure, having a reducing agent, metallic nanoparticles and iron powder.
There further is a writing instrument having an aqueous gel ink with variable color according to the disclosure.

公开(公告)号：US20230111123A1

公开(公告)日：2023-04-13

申请号：US17905125

申请日：2021-02-25

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  C.N.R.S. ,  UNIVERSITE GRENOBLE ALPES

Inventor： Maxime LEGALLAIS ,  Bassem SALEM ,  Thierry BARON ,  Romain GWOZIECKI ,  Marc PLISSONNIER

IPC: C30B25/16 ,  H01L21/02 ,  C30B25/18 ,  C30B25/20 ,  C30B29/40 ,  C23C16/30 ,  C23C16/44 ,  C23C16/455

Abstract: A method for producing an aluminium nitride (AlN)-based layer on a structure with the basis of silicon (Si) or with the basis of a III-V material, may include several deposition cycles performed in a plasma reactor comprising a reaction chamber inside which is disposed a substrate having the structure. Each deposition cycle may include at least the following: deposition of aluminium-based species on an exposed surface of the structure, the deposition including at least one injection into the reaction chamber of an aluminium (Al)-based precursor; and nitridation of the exposed surface of the structure, the nitridation including at least one injection into the reaction chamber of a nitrogen (N)-based precursor and the formation in the reaction chamber of a nitrogen-based plasma. During the formation of the nitrogen-based plasma, a non-zero polarisation voltage Vbias_substrate may be applied to the substrate.

公开(公告)号：US11448656B2

公开(公告)日：2022-09-20

申请号：US16037150

申请日：2018-07-17

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  CONICET (CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS) ,  INSTITUT JEAN PAOLI & IRENE CALMETTES ,  UNIVERSITÉ D'AIX-MARSEILLE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Inventor： Juan Iovanna ,  Virginia Pasquinelli ,  Maria Madgalena Gherardi ,  Hector Eduardo Chuluyan ,  Ana Inès Rovetta ,  Delfina Pena ,  Véronica Edith Garcia

IPC: G01N33/569 ,  C07K14/35 ,  G01N33/68 ,  C12N5/078

Abstract: The present invention concerns a composition comprising at least three peptides derived from Mycobacterium tuberculosis antigen Rv2626c, its use in the diagnostic of latently infected Mycobacterium tuberculosis (LTBI) subjects, corresponding methods of use and kits.

公开(公告)号：US11352627B2

公开(公告)日：2022-06-07

申请号：US16758274

申请日：2018-10-24

Applicant: UNIVERSITE DE PARIS ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

Inventor： Sandrine Bourdoulous ,  Anaïs Domingot ,  Camille Faure

IPC: C12N15/113 ,  C12Q1/68

Abstract: This invention relates to an agent that modulates the activity of a micro ribonucleic acid (miRNA), said miRNA being selected from the group consisting of miRNA 429-3p, miRNA 29c-3p, miRNA 29b-3p, miRNA 200a-3p, miRNA 200b-3p, miRNA 200c-3p, miRNA 141-3p, miRNA 15a-5p, miRNA 15b-5p, miRNA 16-5p, miRNA 424-5p, miRNA 497-5p, miRNA 615-3p, miRNA 451a-5p and miRNA 542-5p, for use in the treatment of HER2-dependent cancer.

公开(公告)号：US11340239B2

公开(公告)日：2022-05-24

申请号：US16684618

申请日：2019-11-15

Applicant: Bio-Rad Europe GMBH ,  Centre National De La Recherche Scientifique (C.N.R.S.)

Inventor： Francois Rieunier ,  Isabelle Giuliani ,  Sylvie Villard-Saussine

IPC: G01N33/74 ,  C07K14/58

Abstract: The present invention relates to a polypeptide carrying a human BNP(1-32) epitope according to Formula (I): a1-R1-X1-FGRKMDR-X2-R2-a2 as well as ligands specific of the FGRKMDR epitope.

公开(公告)号：US20220098047A1

公开(公告)日：2022-03-31

申请号：US17429982

申请日：2020-02-11

Applicant: IMERTECH SAS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) ,  UNIVERSITÉ PAUL SABATIER TOULOUSE III

Inventor： Marie CLAVERIE ,  Cyril AYMONIER ,  Christel CAREME ,  François MARTIN ,  Christophe LE ROUX ,  Mathilde POIRIER ,  Pierre MICOUD

IPC: C01B33/22 ,  C01G17/00

Abstract: Methods for making a synthetic mineral and methods for making synthetic mineral precursors and the products of said methods.

公开(公告)号：US10723999B2

公开(公告)日：2020-07-28

申请号：US15106714

申请日：2014-12-19

Applicant: KALLISTEM ,  UNIVERSITÉ CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) ,  ECOLE NORMALE SUPERIEURE DE LYON

Inventor： Marie-Hélène Perrard ,  Philippe Durand ,  Laurent David

IPC: C12N5/076 ,  C12N5/075

Abstract: The present invention relates to a process for in vitro spermatogenesis from male germinal tissue comprising conducting maturation of testicular tissue comprising germ cells in a bioreactor which is made of a biomaterial and comprises at least one cavity wherein the germinal tissue is placed, and recovering elongated spermatids and/or spermatozoa.