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公开(公告)号：US20230241396A1
公开(公告)日：2023-08-03
申请号：US18002179
申请日：2021-06-18
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor： Michael John CARR , Rizwan BASHIRULLAH
CPC classification number: A61N1/36139 , A61N1/36153 , A61N1/0556 , A61N1/36053
Abstract: The present invention provides an implantable neuromodulation system for delivering an electrical signal to a nerve to stimulate, inhibit or block conduction of action potentials in the nerve. The system comprises a neural interface device comprising first and second electrodes; a signal generator and a first closed-loop controller configured to generate a control signal based a property of the signal based on a measured voltage across the first and second electrodes, and cause the signal generator to adjust the electrical signal to modify the property of the signal.
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公开(公告)号：US11589827B2
公开(公告)日：2023-02-28
申请号：US16622675
申请日：2018-06-22
Applicant: GALVANI BIOELECTRONICS LIMITED , UCL BUSINESS LTD
Inventor： Kirill Aristovich , David Holder , Daniel Chew , Matteo Donega
Abstract: There is provided a nerve activity monitoring method that includes receiving an input signal indicative of activity in a nerve of a subject; receiving physiological data indicative of physiological activity in the subject; establishing a relationship between the physiological data and the input signal; identifying a plurality of periodic portions in the input signal based on the relationship between the physiological data and the input signal; and outputting the periodic portions identified.
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公开(公告)号：US11577082B2
公开(公告)日：2023-02-14
申请号：US16347940
申请日：2017-11-08
Applicant: Galvani Bioelectronics Limited , Université Côte d'Azur , Centre Nationale de La Recherche Scientifique
Inventor： Philippe Blancou , Nicolas Glaichenhaus , Arun Sridhar
Abstract: Devices and methods for the stimulation of neural signaling of an apical splenic nerve, the device having a transducer for placement on or around the apical splenic nerve, and a signal generator to generate a signal that stimulates or inhibits the neural activity of the apical splenic nerve to produce a physiological response. The transducer has at least one electrode, and the signal generator is a voltage or current source. The stimulation electrical signal has a frequency of between 1 Hz and 50 Hz.
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公开(公告)号：US20230025428A1
公开(公告)日：2023-01-26
申请号：US17780210
申请日：2020-11-27
Applicant: Galvani Bioelectronics Limited
Inventor： Morten Hansen , Sebastien Ouchouche , Benjamin Yaffe , Cindy Au , Kurtis Gross , Shivkumar Sabesan , Kenneth Douglas Rys
Abstract: A neural delivery device for delivery a neural interface device into an abdominal cavity for implantation within a patient, wherein the neural delivery device is configured to be inserted through a sealed port of an insertion tube, and wherein the neural delivery device comprises an opening at a distal end of the neural delivery device for the neural interface device.
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公开(公告)号：US20230015707A1
公开(公告)日：2023-01-19
申请号：US17846379
申请日：2022-06-22
Applicant: Galvani Bioelectronics Limited
Inventor： Faisal ZAIDI , Sebastien OUCHOUCHE
Abstract: An extravascular of intravascular neural interface is disclosed containing electrodes for neurostimulation of the vessel. The devices are housed in flexible substrates formed from a multilumen tubing housing conductors for electrodes positioned in a distal serpentine shaped end of the device. The distal serpentine shaped end includes rows or strips of electrodes or coil electrodes.
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Patent Agency Ranking
公开(公告)号：US20220409890A1
公开(公告)日：2022-12-29
申请号：US17872829
申请日：2022-07-25
Applicant: Galvani Bioelectronics Limited
Inventor： Matteo Donega , Daniel John Chew , Margarita J. Vervoordeldonk , Isha Gupta
Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.
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公开(公告)号：US11452867B2
公开(公告)日：2022-09-27
申请号：US16955331
申请日：2018-12-20
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor： Matteo Donega , Daniel John Chew , Margarita J. Vervoordeldonk , Isha Gupta
Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.
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公开(公告)号：US20220296886A1
公开(公告)日：2022-09-22
申请号：US17619572
申请日：2020-06-17
Applicant: Galvani Bioelectronics Limited
Inventor： Rizwan Bashirullah , Gerald Edwin Hunsberger
Abstract: A neuromodulation device for measuring an evoked response comprising a first electrode; a second electrode, wherein the first and second electrodes are alternately configured as a stimulation electrode; a sensing electrode for sensing an evoked response to a stimulus pulse; and a controller configured to measure an evoked response at the sensing electrode after a stimulus pulse at a first stimulation electrode configuration and after a stimulus pulse at a second alternate stimulation electrode configuration, and to add said pair of measurements.
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公开(公告)号：US11446502B2
公开(公告)日：2022-09-20
申请号：US16955264
申请日：2018-12-20
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor： Matteo Donega , Daniel John Chew , Isha Gupta
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is associated with a neurovascular bundle, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders. The invention provides improved ways of treating inflammatory disorders which minimize off-target effects.
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公开(公告)号：US20220206083A1
公开(公告)日：2022-06-30
申请号：US17594924
申请日：2020-05-01
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor： Ellen KAPLAN , Cindy AU , Pey-Jiun KO
Abstract: A test fixture (20) for testing continuity in at least one electrode of a neuromodulation device. The test fixture may comprise a substrate (22), at least one electrically conductive pad (24a) disposed on the substrate for reducing pressure applied to the at least one electrode when the electrically conductive pad makes contact with an exposed surface of the electrode, and a wire (26a) extending from the at least one electrically conductive pad. The pad may be formed of a non-abrasive material, such as conductive foam or smooth metal. The substrate may be a probe formed with a number of slots for holding pads and routing wires, a mandrel with openings for holding pads and routing wires, and a flexible circuit with exposed smooth metal surfaces. The test fixture may be suitable for testing cuff-like and paddle-like devices.
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