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公开(公告)号：US5693019A
公开(公告)日：1997-12-02
申请号：US575345
申请日：1995-12-20
申请人： Marshall S. Kriesel
发明人： Marshall S. Kriesel
CPC分类号： A61M5/1409 , A61M5/152 , A61J1/201 , A61J1/2075 , A61J1/2082 , A61J1/2096 , A61M2205/197 , A61M2209/045 , A61M5/1407 , A61M5/14248 , Y10S128/12
摘要： An apparatus for accurately infusing medicinal agents into an ambulatory patient at specific rates over extended periods of time. The apparatus is of a compact, low profile, laminate construction and includes either an elastic distendable membrane, or a thin barrier member which, in cooperation with a thin planar base defines a fluid chamber having a fluid outlet. The apparatus includes an internal stored energy source which functions to controllably expel the medicinal agents from the apparatus. The stored energy source may comprise either a distendable elastomeric membrane of an expandable sponge like cellular mass.
摘要翻译： 一种用于在长时间内以特定速率准确地将药剂注入流动患者的装置。 该装置具有紧凑的薄型层合结构，并且包括弹性膨胀膜或薄的阻挡构件，其与薄平面基底配合限定具有流体出口的流体室。 该装置包括内部存储的能源，其功能是可控制地将药剂从该装置排出。 存储的能量源可以包括可膨胀海绵的膨胀弹性体膜，如细胞块。
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公开(公告)号：US5620420A
公开(公告)日：1997-04-15
申请号：US432219
申请日：1995-05-01
申请人： Marshall S. Kriesel
发明人： Marshall S. Kriesel
CPC分类号： A61M5/1409 , A61M5/152 , A61M2205/197 , A61M5/1407 , A61M5/14248 , Y10S128/12
摘要： An apparatus for accurately infusing medicinal agents into an ambulatory patient at specific rates over extended periods of time. The apparatus is of a compact, low profile, laminate construction and includes an elastic distendable membrane, which, in cooperation with a thin planar base defines a fluid chamber having a fluid outlet. Disposed within the fluid chamber is a thin fluid permeable member which precisely controls the rate of fluid flow through the fluid outlet.
摘要翻译： 一种用于在长时间内以特定速率准确地将药剂注入流动患者的装置。 该装置具有紧凑的薄型层合结构，并且包括弹性膨胀膜，其与薄平面基底协作限定具有流体出口的流体室。 设置在流体室内的是一种薄流体可渗透构件，其精确地控制通过流体出口的流体流速。
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公开(公告)号：US5531683A
公开(公告)日：1996-07-02
申请号：US271378
申请日：1994-07-06
CPC分类号： A61M5/2448 , A61M5/2429 , A61M2005/2414 , A61M2005/3104 , A61M2005/3117 , A61M2005/3121 , A61M5/20 , A61M5/2459 , A61M5/3145 , A61M5/348 , A61M5/5013 , A61M5/502
摘要： A device for intermixing a first component, such as a parenteral fluid with a second component, such as an immobilized drug carried by a scaffold to form a beneficial agent which, following the mixing step, can be dispensed directly from the device for infusion into a patient. The device includes novel mechanisms for mateably interconnecting a container, such as a glass vial containing the first component with a housing having a fluid outlet which houses a sealed container containing the second component, and then for controllably mixing the components under sterile conditions to form an injectable solution which is automatically dispensed through the fluid outlet of the device.
摘要翻译： 用于将第一组分（例如肠胃外流体）与第二组分（例如由支架携带的固定化药物）混合以形成有益剂的装置，其可以在混合步骤之后直接从用于输注的装置中分配 患者。 该装置包括用于将容器（例如包含第一部件的玻璃小瓶）与具有流体出口的壳体可互换地互连的新颖机构，该壳体容纳包含第二组分的密封容器，然后在无菌条件下可控地混合组分以形成 注射溶液，其通过装置的流体出口自动分配。
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公开(公告)号：US5514090A
公开(公告)日：1996-05-07
申请号：US284357
申请日：1994-08-02
CPC分类号： A61J1/20 , A61M5/1409 , A61M5/152 , Y10S128/12
摘要： An apparatus for controllably intermixing two or more components in a sterile, closed environment to produce a flowable substance and then for expelling the flowable substance from the apparatus at a precisely controlled rate. The apparatus is particularly useful for medical applications and includes a dispenser portion with its own stored energy member for dispensing the flowable mixture and a coupling mechanism for coupling a drug vial to the dispenser portion for the controlled mixing of a medicament contained within the drug vial with a diluent stored within the dispenser portion of the apparatus via a sterile pathway.
摘要翻译： 一种用于在无菌，封闭环境中可控地混合两种或多种组分的装置，以产生可流动物质，然后以精确控制的速率从装置中排出可流动物质。 该设备对于医疗应用特别有用，并且包括具有其自己的储存能量构件以分配可流动混合物的分配器部分和用于将药物小瓶耦合到分配器部分的联接机构，用于将包含在药物瓶内的药物的受控混合与 通过无菌途径储存在装置的分配器部分内的稀释剂。
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公开(公告)号：US5468226A
公开(公告)日：1995-11-21
申请号：US192035
申请日：1994-02-03
申请人： Marshall S. Kriesel
发明人： Marshall S. Kriesel
CPC分类号： A61M5/1409 , A61M5/152 , A61J1/201 , A61J1/2075 , A61J1/2082 , A61J1/2096 , A61M2205/197 , A61M2209/045 , A61M5/1407 , A61M5/14248 , Y10S128/12
摘要： An apparatus for accurately infusing medicinal agents into an ambulatory patient at specific rates over extended periods of time. The apparatus is of a compact, low profile, laminate construction and includes either an elastic distendable membrane, or a thin barrier member which, in cooperation with a thin planar base defines a fluid chamber having a fluid outlet. The apparatus includes an internal stored energy source which functions to controllably expel the medicinal agents from the apparatus. The stored energy source may comprise either a distendable elastomeric membrane of an expandable sponge like cellular mass.
摘要翻译： 一种用于在长时间内以特定速率准确地将药剂注入流动患者的装置。 该装置具有紧凑的薄型层合结构，并且包括弹性膨胀膜或薄的阻挡构件，其与薄平面基底配合限定具有流体出口的流体室。 该装置包括内部存储的能源，其功能是可控制地将药剂从该装置排出。 存储的能量源可以包括可膨胀海绵的膨胀弹性体膜，如细胞块。
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136.发明授权Fluid dispensing apparatus including mounting base for a plurality of fluid dispensing devices 失效流体分配装置包括用于多个流体分配装置的安装基座
公开(公告)号：US5433709A
公开(公告)日：1995-07-18
申请号：US156685
申请日：1993-11-22
申请人： Marshall S. Kriesel
发明人： Marshall S. Kriesel
CPC分类号： A61M5/152 , A61M5/1409 , A61M5/16827
摘要： An infusion apparatus for delivering beneficial agents, such as drugs to a patient at substantially a constant rate. The device uniquely includes a manifold system to which a plurality of elastomeric bladder type infusion devices are connected. Each infusion device includes an internally disposed functional substrate which carries the beneficial agent so that it can be mixed with the fluid as the fluid is being introduced into the device to distend the bladder to make it an energy source for controllably dispensing the solution mixture to the manifold system and thence to a patient. The manifold system includes control valves which permit fluid from selected infusion devices to be disposed from the apparatus.
摘要翻译： 一种用于以基本恒定的速率向患者递送诸如药物的有益药物的输液装置。 该装置独特地包括多个弹性体膀胱型输注装置连接到的歧管系统。 每个输注装置包括内部设置的功能性基底，其承载有益剂，使得当流体被引入装置以便使囊膨胀以使其成为可控地将溶液混合物分配到 歧管系统，从而到患者。 歧管系统包括控制阀，其允许来自选定的输注装置的流体从装置中排出。
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公开(公告)号：US5372578A
公开(公告)日：1994-12-13
申请号：US53722
申请日：1993-06-17
CPC分类号： A61M5/152
摘要： A liquid delivery apparatus including a housing having internal walls that define a chamber, a support disposed within the housing and having a central portion, an edge portion circumscribing the central portion and including a liquid passageway in communication with the chamber of the housing. The liquid passageway has an inlet and an outlet.
摘要翻译： 一种液体输送装置，包括具有限定腔室的内壁的壳体，设置在壳体内并具有中心部分的支撑件，围绕中心部分的边缘部分，并且包括与壳体的腔室连通的液体通道。 液体通道具有入口和出口。
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公开(公告)号：US5336180A
公开(公告)日：1994-08-09
申请号：US54152
申请日：1993-04-26
CPC分类号： A61M5/1409 , A61M5/152
摘要： An apparatus for controllably intermixing two or more components in a sterile, closed environment to produce a flowable substance and then for expelling the flowable substance from the apparatus at a precisely controlled rate. The apparatus is particularly useful for medical applications and includes a dispenser portion with its own stored energy element provided in the form of an elastomeric membrane and a coupling mechanism for coupling a drug vial to the dispenser portion for controlled mixing a medicament contained within the drug vial with a diluent stored within the dispenser portion of the apparatus via a sterile pathway.
摘要翻译： 一种用于在无菌，封闭环境中可控地混合两种或多种组分的装置，以产生可流动物质，然后以精确控制的速率从装置中排出可流动物质。 该装置对于医疗应用特别有用，并且包括具有以弹性体膜形式提供的其自身存储的能量元件的分配器部分和用于将药物小瓶耦合到分配器部分的联接机构，用于控制混合药物瓶内包含的药物 其中稀释剂通过无菌途径储存在装置的分配器部分内。
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公开(公告)号：US5122116A
公开(公告)日：1992-06-16
申请号：US513917
申请日：1990-04-24
CPC分类号： A61M5/1409 , A61M5/152
摘要： An apparatus for controllably intermixing two or more components in a sterile, closed environment to produce a flowable substance and then for expelling the flowable substance from the apparatus at a precisely controlled rate. The apparatus is particularly useful for medical applications and includes a dispenser portion with its own stored energy element provided in the form of an elastomeric membrane and a coupling mechanism for coupling a drug vial to the dispenser portion for controlled mixing a medicament contained within the drug vial with a diluent stored within the dispenser portion of the apparatus via a sterile pathway.
摘要翻译： 一种用于在无菌，封闭的环境中可控地混合两种或更多种组分的装置，以产生可流动物质，然后以精确控制的速率从装置中排出可流动物质。 该装置对于医疗应用特别有用，并且包括具有以弹性体膜形式提供的其自身存储的能量元件的分配器部分和用于将药物小瓶耦合到分配器部分的联接机构，用于控制混合药物瓶内包含的药物 其中稀释剂通过无菌途径储存在装置的分配器部分内。
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公开(公告)号：US07220245B2
公开(公告)日：2007-05-22
申请号：US10855425
申请日：2004-05-26
申请人： Marshall S. Kriesel
发明人： Marshall S. Kriesel
CPC分类号： A61M5/148 , A61M5/141 , A61M5/14244 , A61M5/2448 , A61M39/22 , A61M2005/14506 , A61M2205/0244 , A61M2205/7545 , A61M2207/00
摘要： A compact fluid dispenser for use in controllably dispensing fluid medicaments, such as, antibiotics, oncolytics, hormones, steroids, blood clotting agents, analgesics, and like medicinal agents from prefilled containers at a uniform rate. The dispenser uniquely includes a stored energy source that is provided in the form of a substantially constant-force, compressible-expandable wave spring that provides the force necessary to continuously and uniformly expel fluid from the device reservoir. The device further includes a fluid flow control assembly that precisely controls the flow of medicament solution to the patient.
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