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131.发明授权Method of stabilizing lipid-rich plaque and method of preventing rupture thereof 失效稳定富含脂质的斑块的方法和防止其破裂的方法公开(公告)号：US07884106B2
公开(公告)日：2011-02-08
申请号：US10569642
申请日：2004-08-19
IPC分类号： A61K31/497
CPC分类号： A61K31/496 , A61K31/4439 , C07D401/12
摘要： A method of stabilizing lipid-rich plaques and method of preventing the rupture thereof, characterized in that an effective amount of 2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide, its acid adduct salt or a hydrate thereof is administered to patients with lipid-rich plaques. Prevention of plaque rupture and stabilization of plaques can be attained by reducing the occupancy of macrophages in lipid-rich plaques being unstable and tending to rupture among plaques being a lesion from a seat of atherosclerosis and simultaneously increasing the occupancy of collagen therein.
摘要翻译： 一种稳定富含脂质斑块的方法和防止其破裂的方法，其特征在于有效量的2- [4- [2-（苯并咪唑-2-基硫基）乙基]哌嗪-1-基] -N- [ 将2,4-二（甲硫基）-6-甲基-3-吡啶基]乙酰胺，其酸加成盐或其水合物给予富含脂质斑块的患者。 防止斑块破裂和斑块稳定可以通过减少富含脂质的斑块中的巨噬细胞的占有而变得不稳定并且趋于在来自动脉粥样硬化部位的病变的斑块之间破裂并同时增加其中的胶原占有量来实现。
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公开(公告)号：US07873453B2
公开(公告)日：2011-01-18
申请号：US11813887
申请日：2006-01-12
申请人： Hideyuki Kobayashi , Toru Sakaguchi , Shuji Endo , Atsushi Kojima
发明人： Hideyuki Kobayashi , Toru Sakaguchi , Shuji Endo , Atsushi Kojima
IPC分类号： A01B69/00
CPC分类号： B62D5/0472 , B62D5/0463 , B62D5/0466
摘要： The present invention provides a control apparatus for an electric power steering apparatus comprises: a steering assist command value calculating section; a current control section that calculates a voltage command value; and a motor driving section that drives a motor based on the voltage command value, wherein an assist power from the motor is applied to a steering system, the control apparatus is characterized in that an SAT measuring section, that inputs an angular speed and an angular acceleration of the motor, the steering assist command value and the torque signal therein so as to estimate an SAT, is provided, and the SAT obtained by the SAT measuring section is feedbacked to the steering assist command value via a feedback section composed of a phase compensating section and a gain section.
摘要翻译： 本发明提供一种电动助力转向装置的控制装置，包括：转向辅助指令值计算部; 电流控制部，其计算电压指令值; 以及电动机驱动部，其基于所述电压指令值驱动电动机，其中来自所述电动机的辅助动力被施加到转向系统，所述控制装置的特征在于，SAT测量部输入角速度和角度 提供电动机的加速度，转向辅助指令值和其中的转矩信号以估计SAT，并且由SAT测量部分获得的SAT通过由相位组成的反馈部分反馈到转向辅助指令值 补偿部分和增益部分。
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公开(公告)号：US20100147292A1
公开(公告)日：2010-06-17
申请号：US12088628
申请日：2006-09-13
IPC分类号： A61M11/00
CPC分类号： A61M11/02 , A61M11/001 , A61M11/005 , A61M11/06 , A61M15/00 , A61M15/0021
摘要： A mouthpiece (150A) has an aerosol lead-out flow passage (104), an aerosol lead-out opening (105), and an exhalation discharge opening (106). The lead-out flow passage (104) includes a first flow passage (104A) extending upward, a second flow passage (104B) extending obliquely forward from the first flow passage (104A), and a corner flow passage (104C) for connecting the first flow passage (104A) and second flow passage (104B) of the lead-out flow passage (104). The mouthpiece (150A) has a curvature portion (153) formed by curving that portion of the first flow passage (104A) wall surface which crosses the center line of the first flow passage (104A). The exhalation discharge opening (106) is provided in a wall surface defining the second flow passage (104B), at a position circumferentially displaced from the wall surface portion at which the curvature portion (153) is provided. In the mouthpiece and an inhaler with the mouthpiece, although an exhalation valve and, in addition, an inhalation valve are eliminated, leakage of aerosol from a pressure regulation opening and the exhalation opening is prevented irrespective of usage manners.
摘要翻译： 吸嘴（150A）具有气溶胶引出流路（104），气溶胶引出口（105）和呼气排出口（106）。 引出流路（104）包括向上延伸的第一流路（104A），从第一流路（104A）向斜前方延伸的第二流路（104B），以及用于将 第一流路（104A）和第一流出通道（104B）。 接口（150A）具有通过使与第一流路（104A）的中心线交叉的第一流路（104A）壁面的部分弯曲而形成的曲率部（153）。 呼出排出口（106）设置在限定第二流路（104B）的壁面的与设置曲率部（153）的壁面部周向偏移的位置。 在接口管和具有接口管的吸入器中，尽管排气阀和另外的吸入阀被消除，但是无论使用方式如何，都可以防止气溶胶从压力调节开口和呼气口泄漏。
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公开(公告)号：US20090308524A1
公开(公告)日：2009-12-17
申请号：US11919180
申请日：2006-04-24
CPC分类号： B32B5/26 , D04H1/4374 , D04H1/559 , Y10T442/602
摘要： A stretch nonwoven fabric 10 includes an elastic fiber layer 1 and inelastic fiber layers 2 and 3 having substantial inelasticity on the respective sides of the elastic fiber layer 1. The fiber layers 1, 2, and 3 are joined together over the entire area by thermal fusion at fiber intersections while the fibers of the elastic fiber layer 1 remain the fibrous form. The inelastic fiber layers 2 and 3 have part of their fibers enter the elastic fiber layer 1 and/or the elastic fiber layer has part of its fibers enter the inelastic fiber layers 2 and 3. The stretch nonwoven fabric is preferably produced by stacking an elastic fiber web and an inelastic fiber web on each other, applying a through-air system hot air treatment to the stack while the webs are in a non-united state to obtain a fibrous sheet having the webs united together, stretching the fibrous sheet in at least one direction, and releasing the fibrous sheet from the stretched state.
摘要翻译： 拉伸无纺布10包括弹性纤维层1和在弹性纤维层1的各侧上具有显着非弹性的非弹性纤维层2和3。纤维层1,2和3通过热量在整个区域上接合在一起 在纤维交叉处融合，而弹性纤维层1的纤维保持纤维状。 非弹性纤维层2和3的一部分纤维进入弹性纤维层1和/或弹性纤维层的一部分纤维进入非弹性纤维层2,3。拉伸无纺布优选通过将弹性纤维层 纤维网和非弹性纤维网彼此之间，在纤维网处于非联合状态时，将通气系统热空气处理施加到堆叠，以获得具有纤维网的纤维片材结合在一起，将纤维片材拉伸在 至少一个方向，并且从拉伸状态释放纤维片材。
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公开(公告)号：US07618515B2
公开(公告)日：2009-11-17
申请号：US11270461
申请日：2005-11-10
IPC分类号： C23F1/00
CPC分类号： H01L21/67069 , H01J37/32642 , Y10S156/915
摘要： In a plasma etching apparatus for performing a plasma etching on a surface of a substrate mounted on a susceptor in a processing vessel, a focus ring is installed to surround the substrate and has a first region at an inner side on a surface thereof, in which an average surface roughness is small such that a reaction product produced during an etching processing is not captured to be deposited, and a second region at an outer side from the first region, in which an average surface roughness is large such that a reaction product produced during the etching process is captured to be deposited. A boundary between the first and the second region is a part where an etching amount is relatively significantly changed compared to other parts while the focus ring is equipped in the plasma etching apparatus and the plasma etching is performed on the substrate.
摘要翻译： 在用于在安装在处理容器中的基座上的基板的表面进行等离子体蚀刻的等离子体蚀刻装置中，安装有聚焦环以围绕基板并且在其表面的内侧具有第一区域，其中 平均表面粗糙度小，使得在蚀刻处理期间产生的反应产物不被捕获以沉积，并且在平均表面粗糙度大的第一区域的外侧的第二区域，使得产生的反应产物 在蚀刻过程中被捕获以被沉积。 第一区域和第二区域之间的边界是与其他部分相比蚀刻量相对显着变化的部分，而在等离子体蚀刻装置中配备聚焦环，并且在基板上进行等离子体蚀刻。
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136.发明申请METHOD FOR REDUCTION, STABILIZATION AND PREVENTION OF RUPTURE OF LIPID RICH PLAQUE 审中-公开减少，稳定和防止破碎的富含PLAQUE的方法公开(公告)号：US20090275595A1
公开(公告)日：2009-11-05
申请号：US11721402
申请日：2005-12-09
IPC分类号： A61K31/497
CPC分类号： A61K31/497 , A61K31/47 , A61K2300/00
摘要： There is to provide is an agent for reduction of a lipid rich plaque, stabilization of a lipid rich plaque and/or prevention of rupture of a lipid rich plaque in an atherosclerotic lesion comprising an effective amount of 2-[4-[2-(benzimidazole-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide (hereinafter, referred to as compound 1), its pharmaceutically acceptable salt or a hydrate thereof and Pitavastatin, and a pharmaceutically acceptable carrier, wherein the agent is intended to be simultaneously administered, or separately administered with interval of time to a patient in need thereof. There is also to provide a method for reduction of a lipid rich plaque, stabilization of a lipid rich plaque and/or prevention of rupture of a lipid rich plaque in an atherosclerotic lesion, comprising simultaneously administering, or separately administering with interval of time an effective amount of the compound 1, its pharmaceutically acceptable salt or a hydrate thereof and an effective amount of Pitavastatin to a patient in need thereof.
摘要翻译： 提供的是减少富含脂质的斑块，稳定富含脂质的斑块和/或预防动脉粥样硬化病变中脂质丰富斑块破裂的药剂，其包含有效量的2- [4- [2-（ 苯并咪唑-2-基硫基）乙基]哌嗪-1-基] -N- [2,4-双（甲硫基）-6-甲基-3-吡啶基]乙酰胺（以下称为化合物1），其药学上可接受的盐 或其水合物和匹伐他汀，以及药学上可接受的载体，其中所述试剂旨在同时施用或分开施用于有需要的患者的时间间隔。 还提供减少富含脂质的斑块，稳定富含脂质的斑块和/或防止动脉粥样硬化病变中富含脂质斑块的破裂的方法，其包括同时施用或分开施用一段时间间隔的有效 化合物1的量，其药学上可接受的盐或其水合物和有效量的匹伐他汀给有需要的患者。
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公开(公告)号：US20090255902A1
公开(公告)日：2009-10-15
申请号：US12491962
申请日：2009-06-25
CPC分类号： H01L21/67069 , H01J37/32642 , Y10S156/915
摘要： In a plasma etching apparatus for performing a plasma etching on a surface of a substrate mounted on a susceptor in a processing vessel, a focus ring is installed to surround the substrate and has a first region at an inner side on a surface thereof, in which an average surface roughness is small such that a reaction product produced during an etching processing is not captured to be deposited, and a second region at an outer side from the first region, in which an average surface roughness is large such that a reaction product produced during the etching process is captured to be deposited. A boundary between the first and the second region is a part where an etching amount is relatively significantly changed compared to other parts while the focus ring is equipped in the plasma etching apparatus and the plasma etching is performed on the substrate.
摘要翻译： 在用于在安装在处理容器中的基座上的基板的表面进行等离子体蚀刻的等离子体蚀刻装置中，安装有聚焦环以围绕基板并且在其表面的内侧具有第一区域，其中 平均表面粗糙度小，使得在蚀刻处理期间产生的反应产物不被捕获以沉积，并且在平均表面粗糙度大的第一区域的外侧的第二区域，使得产生的反应产物 在蚀刻过程中被捕获以被沉积。 第一区域和第二区域之间的边界是与其他部分相比蚀刻量相对显着变化的部分，而在等离子体蚀刻装置中配备聚焦环，并且在基板上进行等离子体蚀刻。
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公开(公告)号：US20090234538A1
公开(公告)日：2009-09-17
申请号：US11908887
申请日：2006-03-17
申请人： CaoMinh Ta , ChunHao Jiang , Hideyuki Kobayashi
发明人： CaoMinh Ta , ChunHao Jiang , Hideyuki Kobayashi
IPC分类号： B62D5/04
CPC分类号： B62D5/0463 , B62D5/046 , H02P21/0089 , H02P21/04
摘要： Disclosed herein is a method for controlling an electric power steering system, wherein a motor is controlled by vector control and driven by a current command value calculated on the basis of a parameter such as a steering torque to provide a steering assist power to a vehicle steering system, and further wherein the current command value is limited on the basis of desired output characteristics and a desired angular speed during a field-weakening control and a non-field-weakening control of the vector control.
摘要翻译： 本文公开了一种用于控制电动助力转向系统的方法，其中，通过矢量控制来控制电动机，并且通过基于诸如转向转矩的参数计算的电流指令值来驱动电动机，以向车辆转向装置提供转向辅助动力 系统，并且其中所述电流指令值在所述矢量控制的场弱化控制和非弱磁控制期间，基于期望的输出特性和期望的角速度来限制。
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公开(公告)号：US20090035527A1
公开(公告)日：2009-02-05
申请号：US11919118
申请日：2006-04-25
CPC分类号： B29C55/18 , A61F13/15593 , A61F13/15699 , A61F13/15707 , A61F13/4902 , B32B37/0084 , B32B37/144 , B32B2038/0028 , B32B2307/51 , D04H1/49 , D04H1/498 , D04H1/593 , D04H3/16 , Y10T156/1023 , Y10T428/2457 , Y10T428/24826
摘要： In a process of producing a stretch sheet, a strip-shaped laminate sheet 10A having an elastically stretchable elastic layer 1 and substantially inelastic, inelastic fiber layers 2 and 3 partially joined to each other at bonds 4 or a strip-shaped fibrous sheet containing an elastic component and a substantially inelastic component and having embossed regions formed by embossing in parts is stretched in directions starting from the bonds 4 or the embossed regions to obtain a stretch sheet 10. The stretch sheet has raised ridges and recessed grooves extending in the direction perpendicular to the stretch direction, and the bonds 4 or the embossed regions are present in the ridges.
摘要翻译： 在制造拉伸片材的方法中，具有弹性伸缩性弹性层1和基本上无弹性的非弹性纤维层2和3的带状层压片10A在粘合剂4处彼此部分连接或者带状纤维片材 弹性部件和基本上非弹性的部件，并且具有通过在部件中压花形成的压花区域在从接合点4或压纹区域开始的方向上被拉伸，以获得拉伸片10.拉伸片材具有凸脊和凹槽，其沿垂直方向延伸 并且在脊中存在结合体4或压花区域。
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公开(公告)号：US20070235955A1
公开(公告)日：2007-10-11
申请号：US11247357
申请日：2005-10-12
IPC分类号： B60G21/055 , B60G17/016
CPC分类号： B60G11/27 , B60G17/0162 , B60G21/0551 , B60G21/0553 , B60G2202/41 , B60G2204/82 , B60G2204/8304
摘要： A hydraulic pressure control apparatus for stabilizers controls hydraulic fluid in a hydraulic communication path hydraulically connecting cylinders each operatively connected to each stabilizer of a vehicle. The apparatus includes a spool valve provided in the hydraulic communication path. The spool valve includes a housing, a spool accommodated in the housing, first and second spool chambers defined by the spool and the housing, and a biasing member for biasing the spool. The apparatus further includes first, second, and third hydraulic communication passages, hydraulically connecting an accumulator hydraulically connected to the second spool chamber and the hydraulic communication path, hydraulically connecting the first spool chamber and the hydraulic communication path, and hydraulically connecting the spool chamber and the accumulator respectively, first, second, and third solenoid valves provided in the first, second, and third hydraulic communication passages respectively, and a control device for controlling the first, second and third valves.
摘要翻译： 一种用于稳定器的液压控制装置控制液压连接路径中的液压流体，液压连接液压缸连接到车辆的每个稳定器。 该装置包括设置在液压连通路径中的滑阀。 滑阀包括壳体，容纳在壳体中的阀芯，由阀芯和壳体限定的第一和第二阀芯室以及用于偏压阀芯的偏压元件。 该装置还包括第一，第二和第三液压连通通道，液压连接液压连接到第二滑阀室的液压连接通道和液压连接路径，液压连接第一滑阀室和液压连通路径，以及液压连接滑阀室和 蓄电池分别设置在第一，第二和第三液压连通通道中的第一，第二和第三电磁阀，以及用于控制第一，第二和第三阀的控制装置。
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