公开(公告)号：US08994937B2

公开(公告)日：2015-03-31

申请号：US13449612

申请日：2012-04-18

Applicant: Devin Alexander Mourey ,  James William Stasiak ,  Zhiyong Li

Inventor： Devin Alexander Mourey ,  James William Stasiak ,  Zhiyong Li

IPC: G01J3/44 ,  G01N21/27 ,  G01N21/65

CPC classification number: G01N21/274 ,  G01N21/278 ,  G01N21/658

Abstract: A surface enhanced Raman spectroscopy calibration curve generating system includes a SERS sensor, which includes a substrate and a plurality of sensing members formed on the substrate. Each of the sensing members includes a plurality of SERS signal amplifying structures. An inkjet dispensing device is to dispense different concentrations of a solution including a known analyte of interest onto the respective sensing members to form a concentration dependent array. A Raman spectrometer is to interrogate the concentration dependent array. A processor is operatively connected to each of the inkjet dispensing device and the Raman spectrometer. Computer-readable instructions are embedded on a non-transitory, tangible computer-readable medium and are executable by the processor. The computer-readable instructions are to automatically generate an intensity profile as a function of concentration for the concentration dependent array.

Abstract translation: 表面增强拉曼光谱校准曲线生成系统包括SERS传感器，其包括衬底和形成在衬底上的多个感测构件。 每个感测构件包括多个SERS信号放大结构。 喷墨分配装置是将不同浓度的包括已知分析物的溶液分配到相应的感测构件上以形成浓度依赖阵列。 拉曼光谱仪是询问浓度依赖阵列。 处理器可操作地连接到每个喷墨分配装置和拉曼光谱仪。 计算机可读指令嵌入在非暂时有形的计算机可读介质中，并且可由处理器执行。 计算机可读指令是自动生成作为浓度依赖阵列的浓度的函数的强度分布。

公开(公告)号：US20140218727A1

公开(公告)日：2014-08-07

申请号：US14342740

申请日：2011-10-26

Applicant: Zhiyong Li ,  Gary L. Vondran, JR.

Inventor： Zhiyong Li ,  Gary L. Vondran, JR.

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/4412 ,  B82Y15/00 ,  B82Y20/00 ,  G01N21/554 ,  G01N21/65 ,  G01N21/658 ,  Y10T29/49826

Abstract: An apparatus for use in a sensing application includes a body having a cavity containing an opening. The apparatus also includes a plurality of nano-fingers positioned in the cavity and a destructible cover covering the opening in the cavity to protect the plurality of nano-fingers, wherein the destructible cover is to be destroyed to enable access to the plurality of nano-fingers.

Abstract translation: 用于感测应用的装置包括具有包含开口的空腔的主体。 该装置还包括定位在空腔中的多个纳米手指和覆盖空腔中的开口的可破坏的盖，以保护多个纳米手指，其中可破坏的盖被破坏以使得能够接近多个纳米级手指， 手指。

公开(公告)号：US20140176942A1

公开(公告)日：2014-06-26

申请号：US14233957

申请日：2011-07-27

Applicant: Alexandre Bratkovski ,  Zhiyong Li

Inventor： Alexandre Bratkovski ,  Zhiyong Li

IPC: G01N21/65 ,  G01N21/01

CPC classification number: G01N21/658 ,  G01N21/01

Abstract: A surface enhanced Raman spectroscopy (SERS) apparatus employs a nanorod in an indentation in a surface of a substrate. The SERS apparatus includes the nanorod having a tip at a free end opposite to an end of the nanorod that is supported by the substrate indentation. The indentation has a tapered profile and supports the nanorod at a bottom of the indentation. The free end of the nanorod extends away from the indentation bottom. The SERS apparatus further includes a Raman-active material at a surface of one or both of the nanorod and the indentation. The indentation and the nanorod facilitate one or both of production and detection of a Raman scattering signal emitted by an analyte in a vicinity of the nanorod and indentation.

Abstract translation: 表面增强拉曼光谱（SERS）装置在衬底的表面中采用在压痕中的纳米棒。 SERS装置包括在由衬底压痕支撑的纳米棒的端部相对的自由端处具有尖端的纳米棒。 压痕具有锥形轮廓并且支撑在压痕底部的纳米棒。 纳米棒的自由端延伸远离压痕底部。 SERS装置还包括在纳米棒和凹陷中的一个或两个的表面处的拉曼活性材料。 压痕和纳米棒促进由纳米棒和压痕附近的分析物发射的拉曼散射信号的生成和检测中的一个或两个。

公开(公告)号：US08605281B2

公开(公告)日：2013-12-10

申请号：US13272987

申请日：2011-10-13

Applicant: Zhiyong Li

Inventor： Zhiyong Li

IPC: G01J3/44

CPC classification number: G01Q30/02 ,  G01N21/658 ,  G01Q70/12

Abstract: A probe for use in a sensing application includes an elongate body having a first end and a free end, wherein the first end is to be attached to a support. The probe also includes a plurality of nano-fingers having respective bases and tips, wherein each of the plurality of nano-fingers is attached to the free end and is composed of a flexible material, and wherein the plurality of nano-fingers are collapsed toward each other such that the tips of the plurality of nano-fingers are substantially in contact with each other.

Abstract translation: 用于感测应用的探针包括具有第一端和自由端的细长主体，其中第一端将附接到支撑件。 探针还包括具有各自的基部和尖端的多个纳米手指，其中多个纳米手指中的每一个附着到自由端并且由柔性材料构成，并且其中多个纳米手指朝向 彼此使得多个纳米指的尖端基本上彼此接触。

公开(公告)号：US08477303B2

公开(公告)日：2013-07-02

申请号：US13014688

申请日：2011-01-26

Applicant: Alexandre M Bratkovski ,  Wei Wu ,  Zhiyong Li

Inventor： Alexandre M Bratkovski ,  Wei Wu ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B82Y20/00

Abstract: A reconfigurable surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a stimulus responsive material to move nanorods of a plurality between inactive and active configurations. The apparatus includes the plurality of nanorods and the stimulus responsive material. The system further includes a Raman signal detector. The method of reconfigurable SERS includes providing the plurality of nanorods and exposing the stimulus responsive material to a stimulus. The exposure causes a change in one or more of a size, a shape and a volume of the stimulus responsive material that moves the nanorods between the inactive and active configurations. The active configuration facilitates one or both of production and detection of a Raman scattering signal emitted by the analyte.

Abstract translation: 可重新配置的表面增强拉曼光谱（SERS）装置，系统和方法使用刺激响应材料来移动多个非活动和活动配置之间的纳米棒。 该装置包括多个纳米棒和刺激响应材料。 该系统还包括拉曼信号检测器。 可重新配置的SERS的方法包括提供多个纳米棒并将刺激响应材料暴露于刺激。 暴露导致在非活性和活动配置之间移动纳米棒的刺激响应材料的尺寸，形状和体积中的一种或多种的变化。 活性配置有利于分析物发射的拉曼散射信号的生成和检测中的一个或两个。

公开(公告)号：US08462333B2

公开(公告)日：2013-06-11

申请号：US12905891

申请日：2010-10-15

Applicant: Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Michael Josef Stuke ,  Lars Helge Thylen ,  Fung Suong Ou ,  Min Hu

Inventor： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Michael Josef Stuke ,  Lars Helge Thylen ,  Fung Suong Ou ,  Min Hu

IPC: G01J3/44

CPC classification number: G01N21/658

Abstract: An apparatus for performing SERS includes a substrate and flexible nano-fingers, each of the nano-fingers having a first end attached to the substrate, a free second end, and a body portion extending between the first end and the second end, in which the nano-fingers are arranged in an array on the substrate. The apparatus also includes an active material layer disposed on each of the second ends of the plurality of nano-fingers, in which the nano-fingers are to be in a substantially collapsed state in which the active layers on at least two of the nano-fingers contact each other under dominant attractive forces between the plurality of nano-fingers and in which the active material layers are to repel each other when the active material layers are electrostatically charged.

Abstract translation: 用于执行SERS的装置包括基底和柔性纳米指，每个纳米指具有连接到基底的第一端，自由的第二端和在第一端和第二端之间延伸的主体部分，其中 纳米手指以阵列排列在基板上。 该装置还包括设置在多个纳米手指的每个第二端上的活性材料层，其中纳米指状物将处于基本上塌陷的状态，其中在至少两个纳米手指上的活性层， 手指在多个纳米手指之间的主导吸引力下彼此接触，并且当活性材料层被静电充电时，活性材料层将彼此排斥。

公开(公告)号：US08404491B2

公开(公告)日：2013-03-26

申请号：US12916299

申请日：2010-10-29

Applicant: Zhiyong Li ,  Michael Josef Stuke ,  Shih-Yuan Wang ,  Huei Pei Kuo

Inventor： Zhiyong Li ,  Michael Josef Stuke ,  Shih-Yuan Wang ,  Huei Pei Kuo

IPC: G01N21/76

CPC classification number: G01N33/5438 ,  B82Y15/00 ,  G01N21/648 ,  G01N21/658 ,  Y10T436/25

Abstract: A luminescent chemical sensor integrated with at least one molecular trap. The luminescent chemical sensor includes at least one molecular trap and at least one metallic-nanofinger device integrated with at least one molecular trap. The molecular trap includes a plurality of electrodes that trap at least one analyte molecule. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofinger of the plurality includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with the analyte molecule. A method for using, and a chemical-analysis apparatus including the luminescent chemical sensor are also provided.

Abstract translation: 与至少一个分子阱集成的发光化学传感器。 发光化学传感器包括至少一个分子阱和至少一个与至少一个分子陷阱集成的金属纳米酮装置。 分子阱包括捕获至少一种分析物分子的多个电极。 金属纳米装置包括衬底和与衬底耦合的多个纳米器件。 多个纳米针板包括柔性柱和联接到柔性柱的顶点的金属帽。 至少纳米角蛋白和多个纳米针的第二纳米梳理器将自分配成与分析物分子紧密堆积的构型。 还提供了使用方法和包括发光化学传感器的化学分析装置。

公开(公告)号：US20130070241A1

公开(公告)日：2013-03-21

申请号：US13233671

申请日：2011-09-15

Applicant: Zhiyong Li

Inventor： Zhiyong Li

IPC: G01N21/64 ,  G01J3/44

CPC classification number: G01N21/658

Abstract: An asymmetrical-nanofinger device for surface-enhanced luminescence. The device includes a substrate, and a plurality of nanofingers coupled with the substrate. The plurality of nanofingers includes a primary nanofinger having a primary active-material cap, and a secondary nanofinger having a secondary active-material cap. An average diameter of the primary active-material cap is substantially greater than an average diameter of the secondary active-material cap. The primary nanofinger and secondary nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with an analyte molecule disposed between the primary active-material cap and the secondary active-material cap. A method for fabricating the asymmetrical-nanofinger device, and an optical apparatus including an optical component that includes the asymmetrical-nanofinger device are also provided.

Abstract translation: 用于表面增强发光的非对称纳米方形器件。 该器件包括衬底和与衬底耦合的多个纳米器件。 多个纳米针包括具有主要活性材料帽的初级纳米针，和具有次级活性材料帽的次级纳米针。 初级活性材料盖的平均直径基本上大于第二活性材料盖的平均直径。 多个纳米针的初级纳米针和次级纳米针将自动排列成紧密堆积的构型，分析物分子设置在主活性材料帽和辅助活性材料帽之间。 还提供了一种用于制造非对称纳米酮装置的方法，以及包括包括非对称纳米装置的光学部件的光学装置。

公开(公告)号：US08390804B2

公开(公告)日：2013-03-05

申请号：US12697136

申请日：2010-01-29

Applicant: Michael J. Stuke ,  Alexandre M. Bratkovski ,  Min Hu ,  Huei Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Shih-Yuan (Sy) Wang ,  Wei Wu

Inventor： Michael J. Stuke ,  Alexandre M. Bratkovski ,  Min Hu ,  Huei Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Shih-Yuan (Sy) Wang ,  Wei Wu

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01N21/658

Abstract: A surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a plurality of nanorods configured to vibrate. The apparatus includes the nanorods having tips at free ends opposite an end attached to a substrate. The tips are configured to adsorb an analyte and to vibrate at a vibration frequency. The apparatus further includes a vibration source configured to vibrate the free ends of the nanorods at the vibration frequency in a back-and-forth motion. Vibration of the nanorods is configured to facilitate detection of a Raman scattering signal emitted by the analyte adsorbed on the nanorod tips. The system further includes a synchronous detector configured to receive the Raman signal and to be gated cooperatively with the vibration of the nanorods. The method includes inducing a vibration of the nanorods, illuminating the vibrating tips to produce a Raman signal, and detecting the Raman signal using the detector.

Abstract translation: 表面增强拉曼光谱（SERS）装置，系统和方法采用配置成振动的多个纳米棒。 该装置包括纳米棒，其具有与连接到基底的端部相对的自由端处的尖端。 尖端被配置为吸附分析物并以振动频率振动。 该装置还包括一个振动源，其构造成以往复运动的振动频率使纳米棒的自由端振动。 纳米棒的振动被配置为便于检测由吸附在纳米棒尖端上的分析物发射的拉曼散射信号。 该系统还包括一个同步检测器，其被配置为接收拉曼信号并与纳米棒的振动协同地门控。 该方法包括诱导纳米棒的振动，照亮振动尖端以产生拉曼信号，以及使用检测器检测拉曼信号。

公开(公告)号：US08314932B2

公开(公告)日：2012-11-20

申请号：US12771440

申请日：2010-04-30

Applicant: Fung Suong Ou ,  Zhiyong Li ,  Min Hu ,  Wei Wu

Inventor： Fung Suong Ou ,  Zhiyong Li ,  Min Hu ,  Wei Wu

IPC: G01J3/44

CPC classification number: G02B1/12 ,  G01N21/658

Abstract: A surface-enhanced Raman spectroscopy device includes a substrate, and an ultraviolet cured resist disposed on the substrate. The ultraviolet cured resist has a pattern of cone-shaped protrusions, where each cone-shaped protrusion has a tip with a radius of curvature equal to or less than 10 nm. The ultraviolet cured resist is formed of a predetermined ratio of a photoinitiator, a cross-linking agent, and a siloxane based backbone chain. A Raman signal-enhancing material is disposed on each of the cone-shaped protrusions.

Abstract translation: 表面增强拉曼光谱装置包括基板和设置在基板上的紫外线固化抗蚀剂。 紫外线固化抗蚀剂具有锥形突起的图案，其中每个锥形突起具有等于或小于10nm的曲率半径的尖端。 紫外线固化的抗蚀剂由光引发剂，交联剂和基于硅氧烷的主链以预定比例形成。 拉曼信号增强材料设置在每个锥形突起上。