公开(公告)号：US08144832B2

公开(公告)日：2012-03-27

申请号：US12606913

申请日：2009-10-27

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  A61B6/04

CPC classification number: H05H7/10 ,  A61B6/4258 ,  A61N5/1049 ,  A61N2005/1061 ,  A61N2005/1087 ,  H01J3/029 ,  H01J35/06 ,  H01J35/14 ,  H05H13/04

Abstract: The invention comprises an X-ray tomography method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. In various embodiments, 3-D images are generated from a series of 2-D X-rays images; the X-ray source and detector are stationary while the patient rotates; the 2-D X-ray images are generated using an X-ray source proximate a charged particle beam in a charged particle cancer therapy system; and the X-ray tomography system uses an electron source having a geometry that enhances an electron source lifetime, where the electron source is used in generation of X-rays. The X-ray tomography system is optionally used in conjunction with systems used to both move and constrain movement of the patient, such as semi-vertical, sitting, or laying positioning systems. The X-ray images are optionally used in control of a charged particle cancer therapy system.

Abstract translation: 本发明包括与多轴带电粒子或癌肿瘤的质子束放射治疗结合使用的X射线断层摄影方法和装置。 在各种实施例中，从一系列2-D X射线图像生成3-D图像; X射线源和检测器在患者旋转时是静止的; 使用在带电粒子癌症治疗系统中的带电粒子束附近的X射线源产生2-D X射线图像; 并且X射线断层摄影系统使用具有增强电子源寿命的几何形状的电子源，其中电子源用于产生X射线。 X射线断层摄影系统可选地与用于移动和约束患者运动的系统结合使用，例如半垂直，坐着或铺设定位系统。 X射线图像任选用于控制带电粒子癌症治疗系统。

公开(公告)号：US08067748B2

公开(公告)日：2011-11-29

申请号：US12497829

申请日：2009-07-06

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H05H13/02 ,  H05H13/04

CPC classification number: A61N5/1049 ,  A61N2005/1061 ,  A61N2005/1087 ,  H01J3/14 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises a charged particle beam acceleration and optional extraction method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, concentrating magnetic field magnets, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括带电粒子束加速度和与癌性肿瘤的带电粒子束放射治疗结合使用的任选的提取方法和装置。 描述了同步加速器的新颖设计特征。 特别地，描述了转子磁体，边缘聚焦磁体，集中磁场磁体和提取元件，其使得同步加速器的总体尺寸最小化，提供严格控制的质子束，直接减小所需磁场的尺寸，直接减少所需的操作功率， 并且即使在从同步加速器提取质子的过程中也允许同步加速器中的质子的持续加速。

公开(公告)号：US20110284760A1

公开(公告)日：2011-11-24

申请号：US13196395

申请日：2011-08-02

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: G21K1/08 ,  H05H15/00

CPC classification number: A61N5/10 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises a charged particle cancer therapy system or synchrotron system using one or more switches to introduce a corresponding one or more resistors into a circuit linking a power supply to a magnet or an inductor during an applied power recovery phase between acceleration cycles of the synchrotron, which reduces time of reduction in power from an active applied power to a power suitable for use with a subsequent injection of charged particles into the synchrotron.

Abstract translation: 本发明包括使用一个或多个开关的带电粒子癌症治疗系统或同步加速器系统，以在相同的加速器的加速循环期间的施加的功率恢复阶段期间将相应的一个或多个电阻器引入到将电源连接到磁体或电感器的电路中 ，其将功率从主动施加功率降低到适用于随后将带电粒子注入同步加速器中的功率的时间减少。

公开(公告)号：US07953205B2

公开(公告)日：2011-05-31

申请号：US12637918

申请日：2009-12-15

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  G21K5/10

CPC classification number: A61N5/1049 ,  A61N5/1064 ,  A61N2005/1061 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises an X-ray system that is orientated to provide X-ray images of a patient in the same orientation as viewed by a proton therapy beam, is synchronized with patient respiration, is operable on a patient positioned for proton therapy, and does not interfere with a proton beam treatment path. Preferably, the synchronized system is used in conjunction with a negative ion beam source, synchrotron, and/or targeting method apparatus to provide an X-ray timed with patient respiration and performed immediately prior to and/or concurrently with particle beam therapy irradiation to ensure targeted and controlled delivery of energy relative to a patient position resulting in efficient, precise, and/or accurate noninvasive, in-vivo treatment of a solid cancerous tumor with minimization of damage to surrounding healthy tissue in a patient using the proton beam position verification system.

Abstract translation: 本发明包括X射线系统，该X射线系统被定向以提供与质子治疗束相同的取向的患者的X射线图像，与患者呼吸同步，可对位于质子治疗的患者进行操作，并且 不干扰质子束处理路径。 优选地，同步系统与负离子束源，同步加速器和/或靶向方法装置结合使用以提供与患者呼吸定时并在颗粒束治疗照射之前和/或同时进行的X射线，以确保 靶向和受控的相对于患者位置的能量传递，导致使用质子束位置验证系统以最小化对患者周围健康组织的损伤的最小化对固体癌性肿瘤的有效，精确和/或准确的非侵入性，体内治疗 。

公开(公告)号：US07940894B2

公开(公告)日：2011-05-10

申请号：US12492515

申请日：2009-06-26

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J35/06 ,  H01J35/14 ,  A61N5/10

CPC classification number: A61N5/1049 ,  A61N2005/1061 ,  A61N2005/1087 ,  H01J3/14 ,  H05H7/10 ,  H05H13/04

Abstract: The system uses an X-ray imaging system having an elongated lifetime. Further, the system uses an X-ray beam that lies in substantially the same path as a charged particle beam path of a particle beam cancer therapy system. The system creates an electron beam that strikes an X-ray generation source located proximate to the charged particle beam path. By generating the X-rays near the charged particle beam path, an X-ray path running collinear, in parallel with, and/or substantially in contact with the charged particle beam path is created. The system then collects X-ray images of localized body tissue region about a cancerous tumor. Since, the X-ray path is essentially the charged particle beam path, the generated image is usable for precisely target the tumor with a charged particle beam.

Abstract translation: 该系统使用具有延长寿命的X射线成像系统。 此外，该系统使用位于与粒子束癌治疗系统的带电粒子束路径基本相同的路径中的X射线束。 该系统产生电子束，该电子束撞击位于带电粒子束路径附近的X射线产生源。 通过在带电粒子束路径附近产生X射线，产生与带电粒子束路径并联并且/或基本上与带电粒子束路径接触的X射线路径。 然后系统收集关于癌性肿瘤的局部的身体组织区域的X射线图像。 由于X射线路径基本上是带电粒子束路径，所以生成的图像可用于用带电粒子束精确地靶向肿瘤。

公开(公告)号：US07939809B2

公开(公告)日：2011-05-10

申请号：US12425683

申请日：2009-04-17

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H05H13/04

CPC classification number: H05H7/10 ,  A61N5/10 ,  A61N2005/1087 ,  H05H13/04

Abstract: The invention comprises a charged particle beam extraction method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. The system uses a radio-frequency (RF) cavity system to induce betatron oscillation of a charged particle stream. Sufficient amplitude modulation of the charged particle stream causes the charged particle stream to hit a material, such as a foil. The foil decreases the energy of the charged particle stream, which decreases a radius of curvature of the charged particle stream in the synchrotron sufficiently to allow a physical separation of the reduced energy charged particle stream from the original charged particle stream. The physically separated charged particle stream is then removed from the system by use of an applied field and deflector.

Abstract translation: 本发明包括与癌肿瘤的带电粒子束放射治疗结合使用的带电粒子束提取方法和装置。 该系统使用射频（RF）空腔系统来诱导带电粒子流的贝塔振荡。 带电粒子流的足够的幅度调制导致带电粒子流撞击诸如箔的材料。 箔片降低了带电粒子流的能量，这减少了同步加速器中的带电粒子流的曲率半径，以允许从原始带电粒子流物理分离还原能带电粒子流。 然后通过使用施加的场和偏转器将物理分离的带电粒子流从系统中移除。

公开(公告)号：US20100207552A1

公开(公告)日：2010-08-19

申请号：US12542155

申请日：2009-08-17

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H05H13/04

CPC classification number: A61N5/10 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises a charged particle beam acceleration, extraction, and/or targeting method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, concentrating magnetic field magnets, winding and control coils, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括与癌性肿瘤的带电粒子束放射治疗一起使用的带电粒子束加速，提取和/或靶向方法和装置。 描述了同步加速器的新颖设计特征。 特别地，描述了旋转磁体，边缘聚焦磁体，集中磁场磁体，绕组和控制线圈以及提取元件，其使得同步加速器的总体尺寸最小化，提供严格控制的质子束，直接直接减小所需磁场的尺寸 降低了所需的操作功率，并且即使在从同步加速器提取质子的过程中也允许同步加速器中质子的持续加速。

公开(公告)号：US20100141183A1

公开(公告)日：2010-06-10

申请号：US12707533

申请日：2010-02-17

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H05H13/04

CPC classification number: A61N5/10 ,  A61N5/1049 ,  A61N5/1067 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention relates generally to treatment of solid cancers. More particularly, the invention relates to enhancing synchrotron acceleration cycle usage efficiency by adjusting the synchrotron's acceleration cycle to correlate with a patient's respiration rate where efficiency refers to the duty cycle or the percentage of acceleration cycles used to deliver charged particles to the tumor. The system senses patient respiration and controls timing of negative ion beam formation, injection of charged particles into a synchrotron, acceleration of the charged particles, and extraction to yield delivery of the particles to the tumor at a predetermine period of the patient's respiration cycle. Independent control of charged particle energy and intensity is maintained during the timed irradiation therapy. Multi-field irradiation ensures efficient delivery of Bragg peak energy to the tumor while spreading ingress energy about the tumor.

Abstract translation: 本发明一般涉及固体癌的治疗。 更具体地，本发明涉及通过调节同步加速器的加速循环来增强同步加速循环的使用效率，以与患者的呼吸速率相关联，其中效率是指用于将带电粒子递送到肿瘤的占空比或加速循环的百分比。 该系统感测患者呼吸并控制负离子束形成的时间，将带电粒子注入同步加速器，加速带电粒子和提取以在患者呼吸周期的预定时间段内将颗粒递送至肿瘤。 在定时照射治疗期间，保持对带电粒子能量和强度的独立控制。 多场照射可以有效地将布拉格峰值能量递送到肿瘤，同时扩散肿瘤周围的进入能量。

公开(公告)号：US20100091948A1

公开(公告)日：2010-04-15

申请号：US12636725

申请日：2009-12-12

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: G21K5/00 ,  A61N5/10 ,  H05H15/00

CPC classification number: H05H7/10 ,  A61N5/1049 ,  A61N2005/1087 ,  A61N2005/1097 ,  H05H13/04

Abstract: This invention relates generally to treatment of solid cancers. More particularly, the invention relates to a computer controlled patient positioning, immobilization, and repositioning method and apparatus used in conjunction with multi-field charged particle cancer therapy coordinated with patient respiration patterns and further in combination with charged particle beam injection, acceleration, extraction, and/or targeting methods and apparatus.

Abstract translation: 本发明一般涉及固体癌的治疗。 更具体地说，本发明涉及一种计算机控制的患者定位，固定和重新定位方法和装置，与多场带电粒子癌症治疗结合使用，与患者呼吸模式协调，并且进一步与带电粒子束注射，加速，提取， 和/或靶向方法和装置。

公开(公告)号：US20100008466A1

公开(公告)日：2010-01-14

申请号：US12561675

申请日：2009-09-17

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: G01N23/04 ,  A61B5/08

CPC classification number: H05H13/04 ,  A61N5/1049 ,  A61N2005/1087

Abstract: The invention comprises a patient respiration monitoring and/or control method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. The respiration monitoring system uses thermal and/or force sensors to determine where a patient is in a respiration cycle in combination with a feedback signal control delivered to the patient to inform the patient when breath control is required. The resulting breath control is timed with charged particle delivery to the tumor to enhance accuracy, precision, and/or efficiency of tumor treatment.

Abstract translation: 本发明包括与癌症肿瘤的多轴带电粒子或质子束放射治疗结合使用的患者呼吸监测和/或控制方法和装置。 呼吸监测系统使用热和/或力传感器来确定患者在呼吸循环中的位置，并结合传送给患者的反馈信号控制，以在需要呼吸控制时通知患者。 所得到的呼吸控制与带电颗粒递送到肿瘤的时间同步以提高肿瘤治疗的准确性，精确度和/或效率。