公开(公告)号：US08605281B2

公开(公告)日：2013-12-10

申请号：US13272987

申请日：2011-10-13

Applicant: Zhiyong Li

Inventor： Zhiyong Li

IPC: G01J3/44

CPC classification number: G01Q30/02 ,  G01N21/658 ,  G01Q70/12

Abstract: A probe for use in a sensing application includes an elongate body having a first end and a free end, wherein the first end is to be attached to a support. The probe also includes a plurality of nano-fingers having respective bases and tips, wherein each of the plurality of nano-fingers is attached to the free end and is composed of a flexible material, and wherein the plurality of nano-fingers are collapsed toward each other such that the tips of the plurality of nano-fingers are substantially in contact with each other.

Abstract translation: 用于感测应用的探针包括具有第一端和自由端的细长主体，其中第一端将附接到支撑件。 探针还包括具有各自的基部和尖端的多个纳米手指，其中多个纳米手指中的每一个附着到自由端并且由柔性材料构成，并且其中多个纳米手指朝向 彼此使得多个纳米指的尖端基本上彼此接触。

公开(公告)号：US20130195721A1

公开(公告)日：2013-08-01

申请号：US13879245

申请日：2010-10-20

Applicant: Zhiyong Li ,  R. Stanley Williams

Inventor： Zhiyong Li ,  R. Stanley Williams

IPC: G01N21/65

CPC classification number: G01N21/658 ,  G01N21/648

Abstract: A metallic-nanofinger device for chemical sensing. The device includes a substrate, and a plurality of nanofingers. A nanofinger includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger are to self-arrange into a close-packed configuration with at least one analyte molecule disposed between at least the metallic cap and a second metallic cap of respective nanofinger and second nanofinger. A morphology of the metallic cap is to generate a shifted plasmonic-resonance peak associated with amplified luminescence from the analyte molecule. A coating encapsulating the metallic cap to respond upon exposure to a liquid, and a chemical-sensing chip including the metallic-nanofinger device are also provided.

Abstract translation: 用于化学感应的金属纳米膜装置。 该装置包括基板和多个纳米装置。 纳米针框包括柔性柱和与柔性柱的顶点相连的金属帽。 至少纳米酮和第二纳米酮将自排列成紧密堆积的构型，其中至少一个分析物分子设置在至少金属盖和相应的纳芬酮和第二纳米酮之间的第二金属盖之间。 金属帽的形态是产生与来自分析物分子的放大发光相关的移位等离子体共振峰。 还提供了包封金属盖以在暴露于液体时响应的涂层，以及包括金属纳米酮装置的化学感测芯片。

公开(公告)号：US08477303B2

公开(公告)日：2013-07-02

申请号：US13014688

申请日：2011-01-26

Applicant: Alexandre M Bratkovski ,  Wei Wu ,  Zhiyong Li

Inventor： Alexandre M Bratkovski ,  Wei Wu ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B82Y20/00

Abstract: A reconfigurable surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a stimulus responsive material to move nanorods of a plurality between inactive and active configurations. The apparatus includes the plurality of nanorods and the stimulus responsive material. The system further includes a Raman signal detector. The method of reconfigurable SERS includes providing the plurality of nanorods and exposing the stimulus responsive material to a stimulus. The exposure causes a change in one or more of a size, a shape and a volume of the stimulus responsive material that moves the nanorods between the inactive and active configurations. The active configuration facilitates one or both of production and detection of a Raman scattering signal emitted by the analyte.

Abstract translation: 可重新配置的表面增强拉曼光谱（SERS）装置，系统和方法使用刺激响应材料来移动多个非活动和活动配置之间的纳米棒。 该装置包括多个纳米棒和刺激响应材料。 该系统还包括拉曼信号检测器。 可重新配置的SERS的方法包括提供多个纳米棒并将刺激响应材料暴露于刺激。 暴露导致在非活性和活动配置之间移动纳米棒的刺激响应材料的尺寸，形状和体积中的一种或多种的变化。 活性配置有利于分析物发射的拉曼散射信号的生成和检测中的一个或两个。

公开(公告)号：US08404491B2

公开(公告)日：2013-03-26

申请号：US12916299

申请日：2010-10-29

Applicant: Zhiyong Li ,  Michael Josef Stuke ,  Shih-Yuan Wang ,  Huei Pei Kuo

Inventor： Zhiyong Li ,  Michael Josef Stuke ,  Shih-Yuan Wang ,  Huei Pei Kuo

IPC: G01N21/76

CPC classification number: G01N33/5438 ,  B82Y15/00 ,  G01N21/648 ,  G01N21/658 ,  Y10T436/25

Abstract: A luminescent chemical sensor integrated with at least one molecular trap. The luminescent chemical sensor includes at least one molecular trap and at least one metallic-nanofinger device integrated with at least one molecular trap. The molecular trap includes a plurality of electrodes that trap at least one analyte molecule. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofinger of the plurality includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with the analyte molecule. A method for using, and a chemical-analysis apparatus including the luminescent chemical sensor are also provided.

Abstract translation: 与至少一个分子阱集成的发光化学传感器。 发光化学传感器包括至少一个分子阱和至少一个与至少一个分子陷阱集成的金属纳米酮装置。 分子阱包括捕获至少一种分析物分子的多个电极。 金属纳米装置包括衬底和与衬底耦合的多个纳米器件。 多个纳米针板包括柔性柱和联接到柔性柱的顶点的金属帽。 至少纳米角蛋白和多个纳米针的第二纳米梳理器将自分配成与分析物分子紧密堆积的构型。 还提供了使用方法和包括发光化学传感器的化学分析装置。

公开(公告)号：US20130070241A1

公开(公告)日：2013-03-21

申请号：US13233671

申请日：2011-09-15

Applicant: Zhiyong Li

Inventor： Zhiyong Li

IPC: G01N21/64 ,  G01J3/44

CPC classification number: G01N21/658

Abstract: An asymmetrical-nanofinger device for surface-enhanced luminescence. The device includes a substrate, and a plurality of nanofingers coupled with the substrate. The plurality of nanofingers includes a primary nanofinger having a primary active-material cap, and a secondary nanofinger having a secondary active-material cap. An average diameter of the primary active-material cap is substantially greater than an average diameter of the secondary active-material cap. The primary nanofinger and secondary nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with an analyte molecule disposed between the primary active-material cap and the secondary active-material cap. A method for fabricating the asymmetrical-nanofinger device, and an optical apparatus including an optical component that includes the asymmetrical-nanofinger device are also provided.

Abstract translation: 用于表面增强发光的非对称纳米方形器件。 该器件包括衬底和与衬底耦合的多个纳米器件。 多个纳米针包括具有主要活性材料帽的初级纳米针，和具有次级活性材料帽的次级纳米针。 初级活性材料盖的平均直径基本上大于第二活性材料盖的平均直径。 多个纳米针的初级纳米针和次级纳米针将自动排列成紧密堆积的构型，分析物分子设置在主活性材料帽和辅助活性材料帽之间。 还提供了一种用于制造非对称纳米酮装置的方法，以及包括包括非对称纳米装置的光学部件的光学装置。

公开(公告)号：US20120220068A1

公开(公告)日：2012-08-30

申请号：US13450414

申请日：2012-04-18

Applicant: Christopher J. Petti ,  Mohamed M. Hilali ,  Theodore Smick ,  Venkatesan Murali ,  Kathy J. Jackson ,  Zhiyong Li ,  Gopalakrishna Prabhu

Inventor： Christopher J. Petti ,  Mohamed M. Hilali ,  Theodore Smick ,  Venkatesan Murali ,  Kathy J. Jackson ,  Zhiyong Li ,  Gopalakrishna Prabhu

IPC: H01L31/0376 ,  H01L31/18

CPC classification number: H01L31/1892 ,  H01L31/0747 ,  H01L31/1864 ,  Y02E10/50

Abstract: A semiconductor assembly is described in which a support element is constructed on a surface of a semiconductor lamina. Following formation of the thin lamina, which may have a thickness about 50 microns or less, the support element is formed, for example by plating, or by application of a precursor and curing in situ, resulting in a support element which may be, for example, metal, ceramic, polymer, etc. This is in contrast to pre-formed support element which is affixed to the lamina following its formation, or to a donor wafer from which the lamina is subsequently cleaved.Fabricating the support element in situ may avoid the use of adhesives to attach the lamina to a permanent support element. In some embodiments, this process flow allows the lamina to be annealed at high temperature, then to have an amorphous silicon layer formed on each face of the lamina following that anneal.

Abstract translation: 描述了半导体组件，其中在半导体层的表面上构造支撑元件。 形成厚度约为50微米或更小的薄层之后，例如通过镀覆或通过施加前体和原位固化来形成支撑元件，得到支撑元件，其可以用于 例如，金属，陶瓷，聚合物等。这与预先形成的支撑元件形成对比，该预制形成的支撑元件在其形成之后固定到层板上，或者与施加器晶片相接触，该晶片随后被切割。 原位制造支撑元件可以避免使用粘合剂将薄片附着到永久支撑元件上。 在一些实施例中，该工艺流程允许薄层在高温下退火，然后在该退火之后具有在层的每个表面上形成的非晶硅层。

公开(公告)号：US08183220B2

公开(公告)日：2012-05-22

申请号：US12577900

申请日：2009-10-13

Applicant: Jixing Liu ,  Bin Yang ,  Xi Lan ,  Xiangping Yin ,  Yinmei Bai ,  Xiaorong Han ,  Xuerui Li ,  Baoyu Li ,  Yuping Fang ,  Zhiyong Li

Inventor： Jixing Liu ,  Bin Yang ,  Xi Lan ,  Xiangping Yin ,  Yinmei Bai ,  Xiaorong Han ,  Xuerui Li ,  Baoyu Li ,  Yuping Fang ,  Zhiyong Li

IPC: A61K48/00 ,  C12N15/113 ,  C12N15/42 ,  C12N15/85

CPC classification number: A61K39/135 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/552 ,  C12N15/1131 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2770/32134 ,  C12N2830/20 ,  C12N2840/203

Abstract: A double-effective vaccine vector against foot-and-mouth disease virus having a bicistronic expression vector sequence, the bicistronic expression vector sequence is an antisense gene sequence capable of conjugating with 5′ UTR of RNA of the foot-and-mouth disease virus genome and an intact sequence of VP1 structural protein gene of the foot-and-mouth disease virus. Animal experiments show that the vaccine vector provides double effects in terms of gene therapy and gene immunization for the prevention and treatment of foot-and-mouth disease in animals. Also provided are construction methods and methods of use of the vaccine vector.

Abstract translation: 双顺反子表达载体序列是一种双重有效的口蹄疫病毒疫苗载体，双顺反子表达载体序列是能够与口蹄疫病毒基因组RNA的5'UTR共轭的反义基因序列 和口蹄疫病毒的VP1结构蛋白基因的完整序列。 动物实验表明疫苗载体在基因治疗和基因免疫方面提供了双重效果，用于预防和治疗动物口蹄疫。 还提供了疫苗载体的构建方法和使用方法。

公开(公告)号：US20120113418A1

公开(公告)日：2012-05-10

申请号：US13383078

申请日：2009-07-08

Applicant: David A. Fattal ,  Jingjing Li ,  Zhiyong Li ,  Shih-Yuan Wang

Inventor： David A. Fattal ,  Jingjing Li ,  Zhiyong Li ,  Shih-Yuan Wang

IPC: G01J3/44 ,  H01L21/20 ,  H01L33/06 ,  B82Y40/00 ,  B82Y99/00

CPC classification number: G01N21/658 ,  B82Y20/00

Abstract: A light amplifying device for surface enhanced Raman spectroscopy is disclosed herein. The device includes a dielectric layer having two opposed surfaces. A refractive index of the dielectric layer is higher than a refractive index of a material or environment directly adjacent thereto. At least one opening is formed in one of the two opposed surfaces of the dielectric layer, and at least one nano-antenna is established on the one of the two opposed surfaces of the dielectric layer. A gain region is positioned in the dielectric layer or adjacent to another of the two opposed surfaces of the dielectric layer.

Abstract translation: 本文公开了一种用于表面增强拉曼光谱的光放大装置。 该装置包括具有两个相对表面的电介质层。 电介质层的折射率高于与其直接相邻的材料或环境的折射率。 至少一个开口形成在电介质层的两个相对表面之一中，并且至少一个纳米天线被建立在电介质层的两个相对表面之一上。 增益区域位于电介质层中或邻近电介质层的两个相对表面中的另一个。

公开(公告)号：US08173452B1

公开(公告)日：2012-05-08

申请号：US12980424

申请日：2010-12-29

Applicant: Christopher J. Petti ,  Mohamed M. Hilali ,  Theodore Smick ,  Venkatesan Murali ,  Kathy J. Jackson ,  Zhiyong Li ,  Gopalakrishna Prabhu

Inventor： Christopher J. Petti ,  Mohamed M. Hilali ,  Theodore Smick ,  Venkatesan Murali ,  Kathy J. Jackson ,  Zhiyong Li ,  Gopalakrishna Prabhu

IPC: H01L21/00

CPC classification number: H01L31/1892 ,  H01L31/0747 ,  H01L31/1864 ,  Y02E10/50

Abstract: A semiconductor assembly is described in which a support element is constructed on a surface of a semiconductor lamina. Following formation of the thin lamina, which may have a thickness about 50 microns or less, the support element is formed, for example by plating, or by application of a precursor and curing in situ, resulting in a support element which may be, for example, metal, ceramic, polymer, etc. This is in contrast to a rigid or semi-rigid pre-formed support element which is affixed to the lamina following its formation, or to a donor wafer from which the lamina is subsequently cleaved. Fabricating the support element in situ may avoid the use of adhesives to attach the lamina to a permanent support element; such adhesives may be unable to tolerate processing temperatures and conditions required to complete the device. In some embodiments, this process flow allows the lamina to be annealed at high temperature, then to have an amorphous silicon layer formed on each face of the lamina following that anneal. A device may be formed which comprises the lamina, such as a photovoltaic cell.

Abstract translation: 描述了半导体组件，其中在半导体层的表面上构造支撑元件。 形成厚度约为50微米或更小的薄层之后，例如通过镀覆或通过施加前体和原位固化来形成支撑元件，得到支撑元件，其可以用于 例如，金属，陶瓷，聚合物等。这与刚性或半刚性的预成形支撑元件形成对比，该刚性或半刚性的预成型支撑元件在其形成之后固定到层板上，或者与施加器晶片相接触，其中层板随后被切割。 原位制造支撑元件可以避免使用粘合剂将薄片附着到永久支撑元件上; 这种粘合剂可能不能容忍完成装置所需的加工温度和条件。 在一些实施例中，该工艺流程允许薄层在高温下退火，然后在该退火之后具有在层的每个表面上形成的非晶硅层。 可以形成包括层的器件，例如光伏电池。

公开(公告)号：US08134702B1

公开(公告)日：2012-03-13

申请号：US12574379

申请日：2009-10-06

Applicant: David A. Fattal ,  Zhiyong Li ,  Qiangfei Xia

Inventor： David A. Fattal ,  Zhiyong Li ,  Qiangfei Xia

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01N21/658 ,  Y10T29/49865

Abstract: An optical device for surface enhanced Raman spectroscopy includes a substrate, and at least one antenna established thereon. The at least one antenna including at least two segments, where each segment is formed of a metal having a predetermined volume and a predetermined contact angle with respect to the substrate. A gap is located between the two segments. The gap has a controllable size such that the at least one antenna resonates at a predetermined frequency that corresponds with the gap.

Abstract translation: 用于表面增强拉曼光谱的光学装置包括衬底和建立在其上的至少一个天线。 所述至少一个天线包括至少两个段，其中每个段由具有预定体积的金属和相对于衬底的预定接触角形成。 两个部分之间有间隙。 间隙具有可控制的尺寸，使得至少一个天线以与间隙对应的预定频率谐振。