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公开(公告)号：US20190082615A1
公开(公告)日：2019-03-21
申请号：US16104752
申请日：2018-08-17
Inventor： Swadeshmukul SANTRA , Swaminathan RAJARAMAN , Woo Hyoung LEE , Yunjun XU , Maria Gabriela Nogueira CAMPOS
Abstract: Described herein are devices, systems and methods for delivering therapeutic compositions to plants. Specifically exemplified herein is a device comprising a plurality of microneedles for creating pores in an effective area of a target plant and then applying a second device loaded with the therapeutic composition. The microneedle device is designed to impart pores that allow for access of the therapeutic composition to the plant vascular system including phloem.
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公开(公告)号：US20190067497A1
公开(公告)日：2019-02-28
申请号：US16052205
申请日：2018-08-01
Inventor： JAYAN THOMAS , CHAO LI , CHAIT RENDUCHINTALA
IPC: H01L31/0224 , H01M10/0525 , H01M10/04 , H02J7/35
Abstract: An integrated energy harvesting and storage device (IEHSD) includes a solar cell (SC) including an active layer between an optically transparent top electrode and a bottom electrode, and an energy storage device (SD) secured below the solar cell including a separator between a first electrode and a second electrode. The bottom electrode and the first or second electrode are electrically common with one another and are within a distance of ≤300 μm from one another.
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公开(公告)号：US20190058395A1
公开(公告)日：2019-02-21
申请号：US16105661
申请日：2018-08-20
Inventor： SEYED-MILAD TAYEBI , ISSA BATARSEH
Abstract: A two-stage microinverter for coupling a PV panel to a power grid includes a DC/DC converter stage having an input for coupling to the PV panel and a DC/AC inverter stage that has an output for coupling to the grid, with at least one DC link capacitor between the DC/DC converter and DC/AC inverter stage. A synchronous controller that includes a loop compensator coupled to a mixer is between an analog-to-digital converter (ADC) and a phase-locked loop (PLL) for coupling to an output voltage from the grid. The ADC receives a DC link voltage from the DC link capacitor. An output of the PLL is for controlling a timing of sampling by the ADC of the DC link voltage so that the ADC samples the DC link voltage when an AC component of a ripple voltage on the DC link voltage intersects an average value of the DC link voltage.
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公开(公告)号：US10192142B2
公开(公告)日：2019-01-29
申请号：US15204493
申请日：2016-07-07
Inventor： Wasfy Mikhael , Ahmed Aldhahab
Abstract: A computer executed method for supervised facial recognition comprising the operations of preprocessing, feature extraction and recognition. Preprocessing may comprise dividing received face images into several subimages, converting the different face image (or subimage) dimensions into a common dimension and/or converting the datatypes of all of the face images (or subimages) into an appropriate datatype. In feature extraction, 2D DMWT is used to extract information from the face images. Application of the 2D DMWT may be followed by FastICA. FastICA, or, in cases where FastICA is not used, 2D DMWT, may be followed by application of the l2-norm and/or eigendecomposition to obtain discriminating and independent features. The resulting independent features are fed into the recognition phase, which may use a neural network, to identify an unknown face image.
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公开(公告)号：US20190002463A1
公开(公告)日：2019-01-03
申请号：US16070137
申请日：2017-01-17
Applicant: Memorial Sloan-Kettering Cancer Center , The Regents of The University of California , University of Central Florida Research Foundation, Inc. , The Broad Institute, Inc.
Inventor： Derek Shieh Tan , Corinne N. Foley , Gustavo Moura-Letts , James McKerrow , Sivaraman Dandapani , Rahul Edwankar , Alyssa Verano , Debopam Chakrabarti , Braken Roberts
IPC: C07D471/04 , A61P33/06 , A61P33/00
Abstract: The present disclosure provides compounds of Formula (I′), Formula (II), and Formula (III). The compounds described herein may useful in treating and/or preventing protozoan infections in a subject in need thereof, treating and/or preventing trypanosomal infections (e.g., Trypanosoma cruzi (T. cruzi) or Trypanosoma brucei infections) and/or plasmodial infections in a subject in need thereof, treating and/or preventing diseases in a subject in need thereof (e.g., Chagas disease, malaria, and/or sleeping sickness), and may be useful in treating and/or preventing infectious diseases in a subject in need thereof. Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including a compound described herein.
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Patent Agency Ranking
146.发明申请公开(公告)号：US20180344764A1
公开(公告)日：2018-12-06
申请号：US15779123
申请日：2016-11-23
Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate , UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Inventor： Kenneth LIECHTY , Sudipta SEAL , Robert GORMAN
CPC classification number: C12N15/113 , A61K33/24 , A61K47/549 , A61K47/55 , A61K47/6923 , C12N2310/141 , C12N2310/351
Abstract: The present disclosure relates to wound treatment and therapy and the promotion of tissue regeneration following injury. In particular, it relates to a microRNA-146a and nanoceria conjugate for improving wound healing and, in some embodiments, preventing adverse ventricular remodeling following myocardial infarction.
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公开(公告)号：US20180339913A1
公开(公告)日：2018-11-29
申请号：US15956468
申请日：2018-04-18
Inventor： Sudipta SEAL , Swetha BARKAM , Amitava ADHIKARY
Abstract: Cerium oxide nanoparticles (CNPs) have been proven to exhibit antioxidant properties attributed to its surface oxidation states (Ce4+ to Ce3+ and vice versa) mediated at the oxygen vacancies on the surface of CNPs. Different anions in precursor cerium salts were used to prepare CNPs resulting in disclosed CNPs with varying physicochemical properties such as dispersion stability, hydrodynamic size, and the signature surface chemistry. The antioxidant catalytic activity and oxidation potentials of different CNPs have been significantly altered with the change of anions in the precursor salts. For one, CNPs prepared using precursor salts containing NO3− and Cl− ions exhibited increased antioxidant activity than previously thought possible. The change in oxidation potentials of CNPs with the change in concentration of the nitrate and chloride ions indicates the disclosed CNP's have different surface chemistry and antioxidant properties. These compositions and methods of their synthesis are disclosed.
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公开(公告)号：US20180330826A1
公开(公告)日：2018-11-15
申请号：US15976274
申请日：2018-05-10
Inventor： Thomas T.h. Wan , Varadraj Gurupur
Abstract: A method of treating a patient to prevent heart failure readmission can include identifying one or more risk factors for the patient, and selecting one or more interventions relating to the one or more risk factors in a graphical user interface (GUI) of a treatment support system. The method also includes receiving a statistical score of the one or more interventions to determine the effect of the one or more selected interventions on heart failure readmission, and treating the patient as a function of the received statistical score using the one or more interventions.
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公开(公告)号：US20180314004A1
公开(公告)日：2018-11-01
申请号：US15932800
申请日：2018-04-26
Inventor： Sasan Fathpour , Amirmahdi Honardoost , Saeed Khan
CPC classification number: G02B6/132 , G02B6/12002 , G02B6/12004 , G02B6/1228 , G02B2006/1204 , G02B2006/12061 , G02B2006/12097 , G02B2006/12142 , G02B2006/12188
Abstract: A photonic integrated circuit and a method of fabrication are provided which includes: a substrate; a first optical waveguide disposed, at least in part, extending across the substrate, the first optical waveguide being configured to transmit a first mode of light; and a second optical waveguide located at least partially over the first optical waveguide, the second optical waveguide being configured to transmit a second mode of light, wherein the first optical waveguide is vertically coupled to the second optical waveguide through a third optical waveguide disposed below the second waveguide.
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公开(公告)号：US10085444B2
公开(公告)日：2018-10-02
申请号：US14109027
申请日：2013-12-17
Inventor： Swadeshmukul Santra
Abstract: A silica-based nanoformulation and method is used to treat citrus canker, inhibit the growth of mold and mildew, and add nutrients to soil used for agricultural purposes. The nanotechnology-enabled copper-loaded, silica nanoformulation (CuSiNP/NG) design is a “revolutionary re-invention” of Cu for safe application because it provides a formulation with maximum abundance of ionic Cu, provides sustained and optimal Cu ion release for long-term disease protection, better adherence to plant surfaces and structural surfaces due to gel-based nanostructure of CuSiNG, thus avoiding multiple spray applications and reducing the amount of Cu used in comparison to existing Cu compounds without compromising antibacterial activity. Thus, the silica-based nanoformulation releases copper in non-toxic quantities to the environment and the silica matrix provides an environmentally safe host material with a flexible design that is optimized to provide specific antifungal and antibacterial remediation using infrequent applications.
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