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公开(公告)号：US06468982B1
公开(公告)日：2002-10-22
申请号：US08880576
申请日：1997-06-23
Applicant: David B. Weiner , William V. Williams , Bin Wang
Inventor： David B. Weiner , William V. Williams , Bin Wang
IPC: A61K4800
CPC classification number: C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N15/87 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , Y02A50/464 , Y02A90/26 , Y10S435/975 , Y10S514/818
Abstract: Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an individual, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein which comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen, a hyperproliferative cell associated protein or a protein associated with autoimmune disease respectively. In each case, nucleotide sequence is operably linked to regulatory sequences to enable expression in the cells. The nucleic acid molecule is free of viral particles and capable of being, expressed in said cells. The cells may be contacted cells with a cell stimulating agent. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
Abstract translation: 公开了个体对病原体感染的预防和治疗免疫的方法，与过度增殖细胞和自身免疫疾病相关的疾病。 所述方法包括对个体的细胞施用包含编码蛋白质的核苷酸序列的核酸分子的步骤，所述核苷酸序列包含与病原体抗原的表位相同或基本上相似的至少一个表位，相关的过度增殖细胞 蛋白质或与自身免疫疾病相关的蛋白质。 在每种情况下，核苷酸序列可操作地连接到调节序列以使得能够在细胞中表达。 核酸分子不含病毒颗粒，能够在所述细胞中表达。 细胞可以与细胞刺激剂接触细胞。 公开了预防和治疗个体免受HIV感染的方法。 公开了用于本发明的实践方法的药物组合物和试剂盒。
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142.发明授权公开(公告)号：US06436878B1
公开(公告)日：2002-08-20
申请号：US09607185
申请日：2000-06-29
IPC: C09K700
CPC classification number: C08F222/40 , C08F220/28 , C08F226/02 , C09K8/12 , C09K8/24
Abstract: The invention relates to a rheology stabilizer or thinner for high-temperature high-pressure high-mineralized degree drilling fluids, methods of their preparation and use. The rheology stabilizer is a copolymer synthesized by an olefinic acid, ester of an olefinic acid, a sulfonic acid containing unsaturated linkage(s), an amide or imide containing unsaturated linkage(s), a quaternary compound containing olefinic linkage(s) reacting chemically with phosphorous acid or hypophosphorous acid, more particularly, copolymer of acrylic acid, 2-hydroxypropyl acrylate, N-(4-sulfophenyl)-maleimide, allyltrimethylammonium chloride and phosphorous acid. The copolymers have very high resistance to high-temperature high-pressure high-valence ions, can high-effectively adjust the rheology and thixotropy of drilling fluids, and can be used as the rheology stabilizer, thinner, clay and shale stabilizer of drilling fluids.
Abstract translation: 本发明涉及用于高温高压高矿化度钻井液的流变稳定剂或稀释剂，其制备和使用方法。 流变稳定剂是由烯属酸，烯属酸的酯，含不饱和键的磺酸，含不饱和键的酰胺或酰亚胺合成的共聚物，含有烯键的化合物的季铵化合物 更优选的是丙烯酸，丙烯酸2-羟丙酯，N-（4-磺基苯基）马来酰亚胺，烯丙基三甲基氯化铵和亚磷酸的共聚物。 该共聚物对高温高压高价离子具有非常高的耐受性，可以高效地调节钻井液的流变学和触变性，可用作钻井液的流变稳定剂，稀释剂，粘土和页岩稳定剂。
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公开(公告)号：US5830876A
公开(公告)日：1998-11-03
申请号：US453349
申请日：1995-05-30
Applicant: David B. Weiner , William V. Williams , Bin Wang
Inventor： David B. Weiner , William V. Williams , Bin Wang
CPC classification number: C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , C12N15/87 , A61K2039/53 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , Y10S435/975 , Y10S514/818
Abstract: A method of immunizing an individual against pathogen is disclosed. Also disclosed is a method of treating an individual who has a hyperproliferative disease, or of treating an individual who is infected by a pathogen. Specifically, the individual is injected with bupivacaine along with DNA in an expressible form, the DNA encoding an antigen. The encoded antigen can be from a protein from the pathogen or from a protein associated with the hyperproliferative disease.
Abstract translation: 公开了免疫个体对病原体的方法。 还公开了治疗具有过度增殖性疾病的个体或治疗被病原体感染的个体的方法。 具体地说，个体以可表达形式的DNA注射布比卡因，编码抗原的DNA。 编码的抗原可以来自病原体的蛋白质或来自与过度增殖性疾病相关的蛋白质。
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公开(公告)号：US5593972A
公开(公告)日：1997-01-14
申请号：US125012
申请日：1993-09-21
Applicant: David B. Weiner , William V. Williams , Bin Wang
Inventor： David B. Weiner , William V. Williams , Bin Wang
CPC classification number: C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , C12N15/87 , A61K2039/53 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , Y10S435/975 , Y10S514/818
Abstract: Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an individual, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein which comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen, a hyperproliferative cell associated protein or a protein associated with autoimmune disease respectively. In each case, nucleotide sequence is operably linked to regulatory sequences to enable expression in the cells. The nucleic acid molecule is free of viral particles and capable of being expressed in said cells. The cells may be contacted cells with a cell stimulating agent. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
Abstract translation: 公开了个体对病原体感染的预防和治疗免疫的方法，与过度增殖细胞和自身免疫疾病相关的疾病。 所述方法包括对个体的细胞施用包含编码蛋白质的核苷酸序列的核酸分子的步骤，所述核苷酸序列包含与病原体抗原的表位相同或基本上相似的至少一个表位，相关的过度增殖细胞 蛋白质或与自身免疫疾病相关的蛋白质。 在每种情况下，核苷酸序列可操作地连接到调节序列以使得能够在细胞中表达。 核酸分子不含病毒颗粒，能够在所述细胞中表达。 细胞可以与细胞刺激剂接触细胞。 公开了预防和治疗个体免受HIV感染的方法。 公开了用于本发明的实践方法的药物组合物和试剂盒。
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公开(公告)号：US20230029788A1
公开(公告)日：2023-02-02
申请号：US17962691
申请日：2022-10-10
Applicant: Jiayi CHEN , Bin Wang
Inventor： Jiayi CHEN , Bin Wang
IPC: H04L9/32
Abstract: A method of deploying a certificate, an electronic device, and a storage medium are provided, which relate to a field of an artificial intelligence technology, in particular to cloud computing, network security and other technical fields. A specific implementation solution includes: determining site domain name information for at least one certificate to be deployed, in response to a certificate deployment request from a client, wherein the certificate deployment request is for at least one certificate of network security protocol; determining, from at least one certificate identification information related to the client, target certificate identification information matched with the site domain name information; and acquiring certificate attribute information corresponding to the target certificate identification information, so that the at least one certificate is deployed to at least one website based on the certificate attribute information.
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Patent Agency Ranking
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公开(公告)号：US10346002B2
公开(公告)日：2019-07-09
申请号：US14915371
申请日：2013-09-30
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , Yang Luo , Zhi-Yuan Jing , Bin Wang , YanYan Ou
Inventor： Yang Luo , Zhi-Yuan Jing , Bin Wang , YanYan Ou
IPC: G06F3/0484 , G06F11/36 , G06F8/30 , H04L29/08 , G06F9/451
Abstract: A proxy tool can be controlled by injecting widget code into application code of a response to an application request. That response is returned client device such that when the application and widget code are processed, the widget code inserts a widget viewable with the rendered application code. Upon a determination that a subsequent request from the client device corresponds to user interaction with the widget and not the rendered application code, a state of the proxy tool is updated based on the sub sequent request.
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公开(公告)号：US10206997B2
公开(公告)日：2019-02-19
申请号：US14356414
申请日：2011-11-10
Applicant: Bin Wang , Shuang Geng
Inventor： Bin Wang , Shuang Geng
IPC: A61K31/195 , A61K31/20 , A61K31/30 , A61K31/7004 , A61K36/05 , A61K39/29 , A61K9/00 , A61K39/39 , C12N7/00 , A61K39/12 , A61K39/00
Abstract: Provided herein is a vaccine that combines a vaccine facilitator and a DNA construct encoding an antigen to elicit antigen-specific antibody responses, wherein the vaccine facilitator is a Na/K pump inhibitor. Cellular entry of the DNA is accelerated as compared to other vaccines that do not contain the vaccine facilitator.
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公开(公告)号：US09747441B2
公开(公告)日：2017-08-29
申请号：US13564797
申请日：2012-08-02
CPC classification number: G06F21/56 , G06F21/54 , G06F21/577
Abstract: A method, system and program product for preventing phishing attacks, wherein the method comprises: acquiring links in a Web page; classifying the acquired links according link types; and determining whether a phishing attack exists according to the classified links, wherein the links are classified into two types: internal links belonging to the same domain as the address of the Web page, and external links belonging to a different domain from the address of the Web page. By carrying out the method or system according to the above one or more embodiments of the present disclosure, since it is first detected whether a Web page is a fake website of a phishing attack before displaying the reproduced Web page to the user and the user is warned upon detecting a fake website, unnecessary losses due to phishing attacks can be prevented.
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