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公开(公告)号：US07991480B2
公开(公告)日：2011-08-02
申请号：US11846280
申请日：2007-08-28
申请人： Jeffrey E. Stahmann , Rodney W. Salo , Jihong Qu
发明人： Jeffrey E. Stahmann , Rodney W. Salo , Jihong Qu
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0565
摘要： Electrodes for tissue stimulation and sensing can comprise a support with nanostructures disposed on the support. Pairs of the electrodes can be placed in close proximity to one another. When electrical energy is supplied to the electrodes, an electrical field (and possibly an electrical current) can be established between the nanostructures on the electrodes. The nanostructures may have cells disposed thereon, for example myocardial cells, myocardial progenitor cells, neural cells and/or stem cells. In addition, the electrodes can be arranged in arrays.
摘要翻译： 用于组织刺激和感测的电极可以包括具有设置在支撑体上的纳米结构的支撑体。 电极对可以彼此靠近放置。 当向电极提供电能时，可以在电极上的纳米结构之间建立电场（和可能的电流）。 纳米结构可以具有设置在其上的细胞，例如心肌细胞，心肌祖细胞，神经细胞和/或干细胞。 此外，电极可以排列成阵列。
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公开(公告)号：US07991468B2
公开(公告)日：2011-08-02
申请号：US11554135
申请日：2006-10-30
申请人： Jeffrey E. Stahmann , Bruce Tockman , Randy Westlund , Rene H. Wentkowski , Russell E. Anderson
发明人： Jeffrey E. Stahmann , Bruce Tockman , Randy Westlund , Rene H. Wentkowski , Russell E. Anderson
IPC分类号： A61N1/362
CPC分类号： A61N1/36514 , A61N1/3622 , A61N1/365 , A61N1/368 , A61N1/3712
摘要： A method for allowing cardiac signals to be sensed and pacing pulse vectors to be delivered between two or more electrodes. In one embodiment, cardiac signals are sensed and pacing pulse vectors are delivered between least one of a first left ventricular electrode and a second left ventricular electrode. Alternatively, cardiac signals are sensed and pacing pulse vectors are delivered between different combinations of the first and second left ventricular electrodes and a first supraventricular electrode. In addition, cardiac signals are sensed and pacing pulse vectors are delivered between different combinations of the first and second left ventricular electrode, the first supraventricular electrode and a conductive housing. In an additional embodiment, a first right ventricular electrode is used to sense cardiac signals and provide pacing pulses with different combinations of the first and second left ventricular electrodes, the first supraventricular electrode and the housing.
摘要翻译： 一种用于允许感测心脏信号的方法和用于在两个或更多个电极之间递送起搏脉冲矢量的方法。 在一个实施例中，感测心脏信号，并且在第一左心室电极和第二左心室电极中的至少一个之间递送起搏脉冲矢量。 或者，感测心脏信号，并且起搏脉冲矢量在第一和第二左心室电极和第一室上电极的不同组合之间递送。 此外，感测心脏信号，并且起搏脉冲矢量在第一和第二左心室电极，第一室上电极和导电壳体的不同组合之间递送。 在另外的实施例中，第一右心室电极用于感测心脏信号并且提供具有第一和第二左心室电极，第一室上电极和外壳的不同组合的起搏脉冲。
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143.发明授权公开(公告)号：US07983759B2
公开(公告)日：2011-07-19
申请号：US10323606
申请日：2002-12-18
IPC分类号： A61N1/37
CPC分类号： A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/053 , A61B5/0816 , A61B5/0826 , A61B5/091 , A61B5/1116 , A61B5/1118 , A61B5/4878 , A61B5/686 , A61B5/746 , A61B7/02 , A61N1/08
摘要： Systems, devices and methods for reporting multiple health-related parameters are disclosed. One aspect is a programmable device having machine executable instructions for performing a method to report multiple parameters related to a health condition of a patient. In various embodiments, a number of trended health-related parameters, a number of predetermined events corresponding to the number of trended health-related parameters, and a number of alerts associated with the predetermined events are acquired. The number of trended health-related parameters, the number of predetermined events, and the number of alerts are communicated in a manner suitable for use in determining the health condition of the patient. Other aspects and embodiments are provided herein.
摘要翻译： 公开了用于报告多个健康相关参数的系统，设备和方法。 一个方面是具有用于执行报告与患者的健康状况相关的多个参数的方法的机器可执行指令的可编程设备。 在各种实施例中，获取多个趋势健康相关参数，对应于趋势健康相关参数的数量的预定事件的数量以及与预定事件相关联的警报的数量。 趋势健康相关参数的数量，预定事件的数量和警报的数量以适合用于确定患者的健康状况的方式传达。 本文提供了其它方面和实施例。
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公开(公告)号：US07979115B2
公开(公告)日：2011-07-12
申请号：US11972405
申请日：2008-01-10
IPC分类号： A61B5/05
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0535 , A61B5/1116 , A61B5/4869 , A61N1/36521 , A61N1/36535
摘要： This patent document discusses systems, devices, and methods for increasing a sensitivity or specificity of thoracic fluid detection in a subject and differentiating between pleural effusion and pulmonary edema. In one example, a thoracic impedance measurement circuit senses a thoracic impedance signal. In another example, a processor receives the thoracic impedance signal and determines whether such thoracic impedance signal is “significant.” A significant thoracic impedance signal indicates the presence of thoracic fluid and may be recognized by comparing the thoracic impedance signal (or variation thereof) to a thoracic impedance threshold. When a significant thoracic impedance signal is recognized, the processor is adapted to detect one or both of: a pleural effusion indication and a pulmonary edema indication using one or a combination of: physiologic information, patient symptom information, and posture information. In another example, the thoracic impedance threshold is adjusted using such physiologic, patient symptom, or posture information.
摘要翻译： 该专利文献讨论了用于增加受试者胸部液体检测的敏感性或特异性并区分胸腔积液和肺水肿的系统，装置和方法。 在一个示例中，胸部阻抗测量电路感测胸部阻抗信号。 在另一示例中，处理器接收胸部阻抗信号并确定这种胸部阻抗信号是否“显着”。显着的胸部阻抗信号表示胸腔存在，并且可以通过将胸部阻抗信号（或其变化）与 胸阻抗阈值。 当识别出显着的胸部阻抗信号时，处理器适合于使用生理信息，患者症状信息和姿势信息中的一个或组合来检测胸腔积液指示和肺水肿指示之一或两者。 在另一个例子中，使用这种生理，患者症状或姿势信息来调整胸阻抗阈值。
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公开(公告)号：US20110166449A1
公开(公告)日：2011-07-07
申请号：US13044003
申请日：2011-03-09
IPC分类号： A61B6/00
CPC分类号： A61N1/37 , A61N1/3718
摘要： An implantable medical apparatus comprises a solid state electronic circuit, an ionizing radiation exposure sensor, an ionizing radiation dose rate sensor, and a controller circuit. The ionizing radiation exposure sensor is configured to detect an exposure of the solid state electronic circuit to ionizing radiation, and generate an indication of a non-single-event-upset (non-SEU) effect to the solid state electronic circuit from the exposure to ionizing radiation, wherein the sensor comprises an accumulated ionizing radiation exposure sensor. The controller circuit is configured to blank the indication from the accumulated ionizing radiation exposure sensor when the radiation dose rate sensor indicates that flux ionizing radiation exceeds a flux ionizing radiation threshold.
摘要翻译： 一种可植入医疗装置，包括固态电子电路，电离辐射曝光传感器，电离辐射剂量率传感器和控制器电路。 电离辐射曝光传感器被配置为检测固态电子电路对电离辐射的曝光，并且产生对固态电子电路的非单事件不适（非SEU）效应的指示，从曝光到 电离辐射，其中所述传感器包括累积的电离辐射曝光传感器。 控制器电路被配置为当辐射剂量率传感器指示通量电离辐射超过通量电离辐射阈值时，从累积的电离辐射曝光传感器中消除指示。
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公开(公告)号：US20110160783A1
公开(公告)日：2011-06-30
申请号：US12974774
申请日：2010-12-21
CPC分类号： A61N1/08
摘要： An implantable or other ambulatory device, such as a pacer, defibrillator, or other cardiac function management device, can use imaging information, such as one or more of cardiac functional magnetic resonance imaging (fMRI) information or cardiac magnetic resonance imaging (MRI) information, such as for helping optimize one or more parameters of the implantable or other ambulatory device.
摘要翻译： 诸如起搏器，去纤颤器或其他心脏功能管理装置之类的可植入或其它移动装置可以使用成像信息，例如心脏功能磁共振成像（fMRI）信息或心脏磁共振成像（MRI）信息中的一种或多种 ，例如用于帮助优化可植入或其他移动装置的一个或多个参数。
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147.发明申请公开(公告)号：US20110144526A1
公开(公告)日：2011-06-16
申请号：US13033081
申请日：2011-02-23
IPC分类号： A61B5/053
CPC分类号： A61B5/0537 , A61B5/0002 , A61B5/0538 , A61B5/4869 , A61B5/4878
摘要： This patent document discusses, among other things, systems, devices, and methods for enhancing detection of pulmonary edema using, in addition to thoracic impedance, one or a combination of: physiologic information about a subject, at least one statistical parameter, a user-programmable detection level, at least one parameter associated with a previous pulmonary edema event, and patient symptom information about the subject. In one example, a (base) thoracic impedance threshold is modified to an adjusted thoracic impedance threshold. The adjusted thoracic impedance threshold provides an increased sensitivity of pulmonary edema detection as compared to the base thoracic impedance threshold. In another example, an alert is provided to a subject, a caregiver, or other user based on a pulmonary edema indication determined by the present systems, devices, and methods. In a further example, a therapy (provided to the subject) is adjusted or initiated in response to the pulmonary edema indication.
摘要翻译： 该专利文献尤其涉及用于增强肺水肿检测的系统，装置和方法，除胸部阻抗之外，还包括以下之一或组合：关于受试者的生理信息，至少一个统计参数， 可编程检测水平，与先前的肺水肿事件相关联的至少一个参数，以及关于受试者的患者症状信息。 在一个示例中，（基底）胸部阻抗阈值被修改为经调整的胸部阻抗阈值。 与基础胸廓阻抗阈值相比，经调整的胸廓阻抗阈值提供了肺水肿检测的灵敏度增加。 在另一示例中，基于由本系统，设备和方法确定的肺水肿指示，向受检者，照顾者或其他用户提供警报。 在另一个实例中，响应于肺水肿指示调整或启动治疗（提供给受试者）。
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公开(公告)号：US07899534B2
公开(公告)日：2011-03-01
申请号：US11624035
申请日：2007-01-17
IPC分类号： A61N1/362
CPC分类号： A61N1/37247 , A61N1/3627 , A61N1/37235
摘要： A medical device programmer and a method of operation in which a first data value is received and used in the execution of one or more algorithms. One or more suggested pulse generator settings are calculated from the one or more algorithms based on the first data value, and the one or more suggested pulse generator settings are displayed on an interactive display screen of the medical device programmer. In one embodiment, the first data value is a duration interval of a QRS complex. From the duration interval, suggestions are made as to one or more ventricular chambers in which to provide pacing pulses. Additionally, pacing intervals for an AV delay are suggested based on measured P-R intervals, or pacing intervals for an LV offset are suggested based on a measured duration interval of a V-V-interval between a right ventricular event and a left ventricular event.
摘要翻译： 一种医疗设备编程器和操作方法，其中在执行一个或多个算法时接收并使用第一数据值。 基于第一数据值从一个或多个算法计算一个或多个建议的脉冲发生器设置，并且一个或多个建议的脉冲发生器设置显示在医疗设备编程器的交互式显示屏幕上。 在一个实施例中，第一数据值是QRS复数的持续时间间隔。 从持续时间间隔，建议一个或多个心室，其中提供起搏脉冲。 另外，基于测量的P-R间隔建议AV延迟的起搏间隔，或者基于右心室事件和左心室事件之间的V-V间隔的测量持续时间间隔来建议LV偏移的起搏间隔。
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149.发明申请SYSTEM AND METHOD FOR CORRELATION OF PATIENT HEALTH INFORMATION AND IMPLANT DEVICE DATA 有权用于相关患者健康信息和植入装置数据的系统和方法公开(公告)号：US20110046692A1
公开(公告)日：2011-02-24
申请号：US12941377
申请日：2010-11-08
IPC分类号： A61N1/362
CPC分类号： A61B5/0006 , A61B5/044 , A61B5/743 , A61B5/7445 , G06F19/00
摘要： A system and method for correlating health related data for display. The system includes a medical device recording data and a display producing device which correlates the data and simultaneously displays different types of data or displays two sets of the same type of data along with the circumstances at which the two sets of data were recorded. Such displays aid a physician in prescribing and ascertaining the efficacy of cardiac therapies.
摘要翻译： 将健康相关数据相关联以进行显示的系统和方法。 该系统包括记录数据的医疗设备和显示产生设备，其与数据相关并且同时显示不同类型的数据或显示两组相同类型的数据以及记录两组数据的情况。 这样的显示器有助于医师处方和确定心脏疗法的功效。
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公开(公告)号：US07894914B2
公开(公告)日：2011-02-22
申请号：US11846246
申请日：2007-08-28
申请人： Jeffrey E. Stahmann , Rodney W. Salo , Jihong Qu
发明人： Jeffrey E. Stahmann , Rodney W. Salo , Jihong Qu
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/056 , A61N1/0565 , A61N1/375 , Y10S977/931
摘要： Electrodes for tissue stimulation and sensing can comprise a support with nanostructures disposed on the support. Pairs of the electrodes can be placed in close proximity to one another. When electrical energy is supplied to the electrodes, an electrical field (and possibly an electrical current) can be established between the nanostructures on the electrodes. The nanostructures may have cells disposed thereon, for example myocardial cells, myocardial progenitor cells, neural cells and/or stem cells. In addition, the electrodes can be arranged in arrays.
摘要翻译： 用于组织刺激和感测的电极可以包括具有设置在支撑体上的纳米结构的支撑体。 电极对可以彼此靠近放置。 当向电极提供电能时，可以在电极上的纳米结构之间建立电场（和可能的电流）。 纳米结构可以具有设置在其上的细胞，例如心肌细胞，心肌祖细胞，神经细胞和/或干细胞。 此外，电极可以排列成阵列。
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