公开(公告)号：US20100305140A1

公开(公告)日：2010-12-02

申请号：US12303643

申请日：2007-06-11

申请人： William Brown ,  Daniel Page ,  Sanjay Srivastava ,  Christopher Walpole ,  Zhong-Yong Wei ,  Hua Yang

发明人： William Brown ,  Daniel Page ,  Sanjay Srivastava ,  Christopher Walpole ,  Zhong-Yong Wei ,  Hua Yang

IPC分类号： A61K31/496 ,  C07D403/10 ,  C07D401/12 ,  A61K31/4184 ,  A61K31/454 ,  A61P1/00

CPC分类号： C07D413/14 ,  C07D235/08 ,  C07D401/06 ,  C07D403/06 ,  C07D417/14

摘要： Compounds of formula I or pharmaceutically acceptable salts thereof: wherein X, A, R1, R2, R3 and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

摘要翻译： 式I化合物或其药学上可接受的盐：其中X，A，R 1，R 2，R 3和R 4如说明书中所定义，以及盐和药物组合物，包括化合物的制备。 它们可用于治疗，特别是治疗疼痛。

公开(公告)号：US20100058423A1

公开(公告)日：2010-03-04

申请号：US12198173

申请日：2008-08-26

申请人： Ledley (Buddy) Yaussy ,  Ke Yu ,  William Brown

发明人： Ledley (Buddy) Yaussy ,  Ke Yu ,  William Brown

IPC分类号： H04N7/173

CPC分类号： H04N7/17318 ,  H04N21/4722 ,  H04N21/6581 ,  H04N21/8173

摘要： Methods, apparatus, and computer program products for providing interactive services used with a time sensitive interactive application are provided. A request is received for interactive services that corresponds to a program. A program identification (ID) for the program is determined. An interactive application that corresponds to the program is determined based on the program ID, where the interactive application has a corresponding interactive application ID. The interactive application ID that corresponds to the interactive application for the program is provided.

摘要翻译： 提供了用于提供与时间敏感的交互式应用程序一起使用的交互式服务的方法，设备和计算机程序产品。 接收到对应于程序的交互式服务的请求。 确定程序的程序标识（ID）。 基于程序ID确定对应于程序的交互式应用程序，其中交互式应用程序具有相应的交互式应用程序ID。 提供了与程序的交互式应用程序相对应的交互式应用程序ID。

公开(公告)号：US07618471B2

公开(公告)日：2009-11-17

申请号：US11452451

申请日：2006-06-13

申请人： William Brown ,  Peter Rezac ,  William Skrivan ,  Oren Bernstein

发明人： William Brown ,  Peter Rezac ,  William Skrivan ,  Oren Bernstein

IPC分类号： B01D46/18

CPC分类号： H01M8/04164

摘要： A device for recovering liquid droplets from a fluid flow stream including a rotatable element comprising wall elements configured to partially enclose a volume with an annular perimeter wall that includes an inside surface radially offset from and facing an axial center, a fixed base wall supports the rotatable element about the axial center, an input fluid conduit delivers the fluid flow stream into the fluid volume, means for rotating the rotatable element for generating a centrifugal force capable of forming a layer of liquid held by the centrifugal force against the inside surface, and an output liquid conduit disposed to collect liquid from the layer of liquid, wherein the layer of liquid rotates with the inside surface with a tangential velocity vector and the collection aperture is fixed in position opposed to the tangential velocity vector such that liquid in the layer of liquid enters the collection aperture.

摘要翻译： 一种用于从流体流中回收液滴的装置，包括可旋转元件，该可旋转元件包括被构造成部分地围绕一体积的环形周边壁的壁元件，所述环形周边壁包括径向偏离并面向轴向中心的内表面，固定底壁支撑可旋转 元件围绕轴向中心，输入流体导管将流体流动流输送到流体体积中，用于旋转可旋转元件以产生能够形成通过离心力保持的液体层抵靠内表面的离心力的装置，以及 输出液体导管设置成从液体层收集液体，其中液体层与内表面以切向速度矢量一起旋转，并且收集孔固定在与切向速度矢量相对的位置，使得液体层中的液体 进入收集孔。

公开(公告)号：US07560045B2

公开(公告)日：2009-07-14

申请号：US11467371

申请日：2006-08-25

申请人： William Brown ,  Myrna Serrano ,  Oscar David Redwine

发明人： William Brown ,  Myrna Serrano ,  Oscar David Redwine

IPC分类号： C09K5/04

CPC分类号： C09K5/045 ,  C09K2205/24 ,  C10M129/74 ,  C10M145/26 ,  C10M145/36 ,  C10M171/008 ,  C10M2207/2835 ,  C10M2209/1033 ,  C10M2209/1085 ,  C10M2209/1095 ,  C10N2220/302 ,  C10N2230/02 ,  C10N2230/12 ,  C10N2230/64 ,  C10N2240/30 ,  F25B2400/18

摘要： This invention describes a new refrigerant/lubricant combination for use in stationary and mobile refrigeration and air conditioning applications. In these applications, the refrigerant and lubricant must be soluble in each other (e.g., miscible) to ensure adequate lubricant circulation from the compressor, through the condenser, expansion device, and evaporator, and back to the compressor. Insufficient lubricant circulation will result in compressor failure. Low temperature solubility is particularly important to ensure lubricant flow through the cold evaporator. In addition, the lubricant and refrigerant combination should be stable in the presence of steel, and aluminum and copper containing metals. This invention describes the combination of refrigerant difluoroethane (e.g. R-152a) and polar, oxygenated lubricants, particular polyalkylene glycols (PAGs) and polyolesters (POEs) which may be used as a replacement for R-134a.

摘要翻译： 本发明描述了一种用于固定和移动制冷和空调应用的新的制冷剂/润滑剂组合。 在这些应用中，制冷剂和润滑剂必须彼此溶解（例如，可混溶），以确保从压缩机，冷凝器，膨胀装置和蒸发器的充分的润滑剂循环，并返回到压缩机。 润滑剂循环不足会导致压缩机故障。 低温溶解度对于确保润滑剂流经冷蒸发器是特别重要的。 此外，润滑剂和制冷剂组合应在钢铁，铝和含铜金属的存在下稳定。 本发明描述了可用作R-134a的替代物的制冷剂二氟乙烷（例如R-152a）和极性，含氧润滑剂，特定聚亚烷基二醇（PAG）和多元醇酯（POE）的组合。

公开(公告)号：US20080262038A1

公开(公告)日：2008-10-23

申请号：US10596853

申请日：2005-01-05

申请人： William Brown ,  Andrew Griffin ,  Christopher Walpole

发明人： William Brown ,  Andrew Griffin ,  Christopher Walpole

IPC分类号： A61K31/4545 ,  C07D211/00 ,  C07D401/02 ,  A61P25/22 ,  A61P25/00 ,  A61K31/4535 ,  A61K31/445

CPC分类号： C07D417/06 ,  C07D211/70 ,  C07D401/06

摘要： Compounds of Formula: wherein R1, R2, and R3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

摘要翻译： 其中R 1，R 2和R 3的化合物如说明书中所定义，以及其盐，对映体和 制备包含该化合物的药物组合物。 它们可用于治疗，特别是治疗疼痛。

公开(公告)号：US07421848B2

公开(公告)日：2008-09-09

申请号：US11270838

申请日：2005-11-10

申请人： William Brown

发明人： William Brown

IPC分类号： F25B45/00

CPC分类号： F25B45/00 ,  B60H1/00585 ,  F25B2345/001 ,  F25B2345/003 ,  Y10T137/4471

摘要： An automated hose clearing after refrigerant charge method and appropriate apparatus is provided. The method includes detecting a pressure differential between the interiors of a high and low pressure hose on an air conditioning charging unit, determining if a pressure differential exceeds a predetermined threshold and temporarily providing fluid communication between the interiors of the high and low pressure hoses.

摘要翻译： 提供制冷剂充注方法后的自动软管清理和适当的装置。 该方法包括检测空调充电单元上的高压软管和低压软管的内部之间的压差，确定压力差是否超过预定阈值，并临时提供高压和低压软管内部之间的流体连通。

公开(公告)号：US20080070946A1

公开(公告)日：2008-03-20

申请号：US11576824

申请日：2005-10-05

申请人： Yevgeni Besidski ,  William Brown ,  Magali Harter ,  Yin Hu ,  Shawn Johnstone ,  Paul Jones ,  Denis Labrecque ,  Alexander Munro ,  Christopher Walpole

发明人： Yevgeni Besidski ,  William Brown ,  Magali Harter ,  Yin Hu ,  Shawn Johnstone ,  Paul Jones ,  Denis Labrecque ,  Alexander Munro ,  Christopher Walpole

IPC分类号： A61K31/428 ,  A61K31/4436 ,  A61K31/4535 ,  A61P11/00 ,  A61P25/04 ,  C07D211/06 ,  C07D213/04 ,  C07D277/68

CPC分类号： C07D417/12 ,  C07D277/64

摘要： The present invention relates to new compounds, or salts, solvates or solvated salts thereof, processes for their preparation and to new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.

摘要翻译： 本发明涉及新化合物或其盐，溶剂合物或溶剂化盐，其制备方法及其制备中使用的新中间体，含有所述化合物的药物组合物和所述化合物在治疗中的用途。

公开(公告)号：US20080000254A1

公开(公告)日：2008-01-03

申请号：US11477592

申请日：2006-06-30

申请人： Travis Bakker ,  William Brown

发明人： Travis Bakker ,  William Brown

IPC分类号： F25B45/00 ,  F25B43/04

CPC分类号： F25B45/00 ,  B60H1/00585

摘要： An apparatus and method for displaying pressure on electrically driven analog-display pressure gauges. A diagnostic service equipment for a vehicle having a refrigerant system, the refrigerant system having a plumbing circuit for transferring a refrigerant between the diagnostic service equipment and the refrigerant system of the vehicle; a high side refrigerant conduit having a first connection, a second connection and a third connection, wherein the first connection is connected to the plumbing circuit and the second connection is connected to the refrigerant system; a low side refrigerant conduit having a first connection, a second connection and a third connection, wherein the first connection is connected to the plumbing circuit and the second connection is connected to the refrigerant system; and pressure transducers attached to each of the third connection of the high side refrigerant conduit and the low side refrigerant conduit, wherein the pressure transducers measure pressure of the high side and low side refrigerant conduits and convert the pressure into electrical signals to drive an analog-display pressure gauge.

摘要翻译： 一种用于在电驱动的模拟显示压力表上显示压力的装置和方法。 一种具有制冷剂系统的车辆的诊断服务设备，所述制冷剂系统具有用于在诊断服务设备和车辆的制冷剂系统之间传送制冷剂的管道回路; 具有第一连接件，第二连接件和第三连接件的高侧制冷剂管道，其中所述第一连接件连接到所述管道电路，并且所述第二连接件连接到所述制冷剂系统; 具有第一连接件，第二连接件和第三连接件的低侧制冷剂导管，其中所述第一连接件连接到所述管道电路，并且所述第二连接件连接到所述制冷剂系统; 以及附接到高侧制冷剂管道和低侧制冷剂管道的每个第三连接处的压力传感器，其中压力传感器测量高侧和低侧制冷剂管道的压力，并将压力转换成电信号以驱动模拟 - 显示压力表。

公开(公告)号：US07229994B2

公开(公告)日：2007-06-12

申请号：US10477642

申请日：2002-05-16

申请人： William Brown ,  Christopher Walpole ,  Niklas Plobeck

发明人： William Brown ,  Christopher Walpole ,  Niklas Plobeck

IPC分类号： A61K31/496 ,  A61K31/495

CPC分类号： C07D295/155 ,  C07D233/24 ,  C07D307/52 ,  C07D333/20

摘要： Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, and pyridine N-oxide; R2 is independently selected from ethyl and isopropyl; R3 is independently selected from hydrogen and fluoro; R4 is independently selected from —OH, —NH2 and —NHSO2R5; and R5 is independently selected from hydrogen, —CF3 and C1–C6 alkyl, or salts thereof or separate enantiomers and salts thereof; where each R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6 alkyl, NO2, CF3, C1–C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as separate enantiomers of the compounds and salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.

摘要翻译： 通式I R 1的化合物选自苯基，吡啶基，噻吩基，呋喃基，咪唑基，吡咯基，三唑基，噻唑基和吡啶N-氧化物中的任何一种; R 2独立地选自乙基和异丙基; R 3独立地选自氢和氟; R 4独立地选自-OH，-NH 2和-NHSO 2 R 5; 和R 5独立地选自氢，-CF 3 3和C 1 -C 6烷基，或盐 或其单独的对映体和盐; 其中每个R 1杂芳环可以任选和独立地被1,2或3个选自直链和支链C 1 -C 6的取代基取代。 烷基，NO 2，CF 3，C 1 -C 6烷氧基，氯，氟，溴， 和碘。 杂芳环上的取代可以在所述环体系上的任何位置进行; 在本申请中公开和要求保护，以及包含新化合物的化合物和盐和药物组合物的分开的对映异构体及其在治疗中的用途，特别是在治疗疼痛，焦虑和功能性胃肠道疾病中的用途。

公开(公告)号：US20070116013A1

公开(公告)日：2007-05-24

申请号：US11264716

申请日：2005-11-01

申请人： William Brown ,  Richard Muirhead ,  Francis Reddington

发明人： William Brown ,  Richard Muirhead ,  Francis Reddington

IPC分类号： H04L12/28 ,  H04L12/56

CPC分类号： G06Q10/06 ,  H04L67/22

摘要： Methods, systems, and computer program products are provided for workflow decision management. Embodiments include maintaining a device state history; identifying a device usage pattern in dependence upon the device state history; identifying a workflow scenario in dependence upon the device usage pattern; identifying a workflow in dependence upon the workflow scenario; executing the workflow; identifying a user reaction to the execution of the workflow; identifying an unsuccessful device-controlling action in dependence upon the user reaction; and modifying the workflow in dependence upon the identified unsuccessful device-controlling action. Typical embodiment also include recording, as a representation of a negative user reaction, a determined change between the device attribute value set by executing the workflow and the current value of the device attribute in a user reaction log.

摘要翻译： 提供方法，系统和计算机程序产品用于工作流决策管理。 实施例包括维护设备状态历史; 根据设备状态历史识别设备使用模式; 根据设备使用模式识别工作流场景; 根据工作流场景识别工作流; 执行工作流; 识别用户对所述工作流的执行的反应; 根据用户反应确定不成功的设备控制动作; 以及根据所识别的不成功的设备控制动作修改工作流程。 典型的实施例还包括将用户反应日志中通过执行工作流所设置的设备属性值与设备属性的当前值之间的确定的变化记录为负用户反应的表示。