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141.发明授权Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same 有权用于诊断和治疗黑素瘤的Arg-Gly-Asp-共轭α-黑素细胞刺激激素杂交肽，包括转移性黑素瘤及与其相关的方法公开(公告)号：US09005575B2
公开(公告)日：2015-04-14
申请号：US13321942
申请日：2010-05-28
申请人： Yubin Miao , Jianquan Yang
发明人： Yubin Miao , Jianquan Yang
CPC分类号： C07K14/68 , A61K38/00 , A61K51/082 , A61K51/086 , A61K51/088 , C12N9/88
摘要： The present invention is directed to novel non-invasive diagnostic and therapeutic tools/compounds comprising a hybride cyclic peptide which utilizes a cyclic peptide chelating group wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compound according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
摘要翻译： 本发明涉及新颖的非侵入性诊断和治疗工具/化合物，其包含利用环肽螯合基团的杂环环肽，其中所述化合物结合MSH受体以成像和治疗癌症，特别是黑素瘤，包括转移性黑素瘤 体内。 本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。 新型成像探针能够检测癌细胞黑素瘤细胞，以及它们在组织中的转移扩散。 这代表了使用非侵入性分子成像技术在黑素瘤的诊断和治疗中包括转移性黑素瘤的量子进步。 本发明的新型探针也可用于启动黑素瘤的治疗以及监测患者对化疗治疗的反应和用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。
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公开(公告)号：US20150038434A1
公开(公告)日：2015-02-05
申请号：US14514472
申请日：2014-10-15
发明人： Wei Yang , Yi-Qun Shi
IPC分类号： C07K7/54
CPC分类号： C07K7/56 , A61K31/407 , A61K38/00 , C07K7/54 , C07K14/68
摘要： Melanocortin receptor-specific cyclic peptides of the formula where R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification, compositions and formulations including the peptides of the foregoing formula or salts thereof, and methods of preventing, ameliorating or treating melanocortin-1 receptor-mediated or responsive diseases, indications, conditions and syndromes.
摘要翻译： 其中R1，R2，R3，R4，R5，R6，R7，R8和R9如说明书中所定义的黑皮质素受体特异性环肽，包括上述式的肽的组合物和制剂或其盐，以及方法 预防，改善或治疗黑皮质素-1受体介导或反应性疾病，适应症，病症和综合征。
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公开(公告)号：US08877890B2
公开(公告)日：2014-11-04
申请号：US13910422
申请日：2013-06-05
发明人： Wei Yang , Yi-Qun Shi
IPC分类号： A61P3/04 , C07K7/56 , A61K31/407 , C07K7/54 , C07K14/68
CPC分类号： C07K7/56 , A61K31/407 , A61K38/00 , C07K7/54 , C07K14/68
摘要： Melanocortin receptor-specific cyclic peptides of the formula where R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification, compositions and formulations including the peptides of the foregoing formula or salts thereof, and methods of preventing, ameliorating or treating melanocortin-1 receptor-mediated or responsive diseases, indications, conditions and syndromes.
摘要翻译： 其中R1，R2，R3，R4，R5，R6，R7，R8和R9如说明书中所定义的黑皮质素受体特异性环肽，包括上述式的肽的组合物和制剂或其盐，以及方法 预防，改善或治疗黑皮质素-1受体介导或反应性疾病，适应症，病症和综合征。
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144.发明授权Bifunctional hormone having alpha-MSH activity and natriuretic peptide activity and uses thereof 有权具有α-MSH活性和利尿钠肽活性的双功能激素及其用途公开(公告)号：US08822413B2
公开(公告)日：2014-09-02
申请号：US12168513
申请日：2008-07-07
申请人： Krishna G. Peri , Abdelkrim Habi
发明人： Krishna G. Peri , Abdelkrim Habi
CPC分类号： C07K14/575 , C07K14/58 , C07K14/68 , C07K14/685 , C07K2319/00
摘要： A bifunctional hormone exhibiting an alpha-MSH activity and a natriuretic peptide activity is described. The bifunctional hormone comprises for example a first domain having alpha-MSH related hormonal activity covalently linked to a second domain having natriuretic peptide related hormonal activity. The bifunctional hormone of the present invention is useful for example for the prevention and/or treatment of renal related diseases or conditions, such as acute renal failure (ARF) or acute kidney injury (AKI).
摘要翻译： 描述了表现出α-MSH活性和利尿钠肽活性的双功能激素。 双功能激素包括例如具有与具有利钠肽相关激素活性的第二结构域共价连接的α-MSH相关激素活性的第一结构域。 本发明的双功能激素可用于例如用于预防和/或治疗肾相关疾病或病症，例如急性肾功能衰竭（ARF）或急性肾损伤（AKI）。
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公开(公告)号：US20130296256A1
公开(公告)日：2013-11-07
申请号：US13910422
申请日：2013-06-05
发明人： Wei Yang , Yi-Qun Shi
IPC分类号： C07K7/54
CPC分类号： C07K7/56 , A61K31/407 , A61K38/00 , C07K7/54 , C07K14/68
摘要： Melanocortin receptor-specific cyclic peptides of the formula where R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification, compositions and formulations including the peptides of the foregoing formula or salts thereof, and methods of preventing, ameliorating or treating melanocortin-1 receptor-mediated or responsive diseases, indications, conditions and syndromes.
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公开(公告)号：US08492517B2
公开(公告)日：2013-07-23
申请号：US13472914
申请日：2012-05-16
申请人： Wei Yang , Yi-Qun Shi
发明人： Wei Yang , Yi-Qun Shi
IPC分类号： A61P3/04 , A61K31/407
CPC分类号： C07K7/56 , A61K31/407 , A61K38/00 , C07K7/54 , C07K14/68
摘要： Melanocortin receptor-specific cyclic peptides of the formula where R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification, compositions and formulations including the peptides of the foregoing formula or salts thereof, and methods of preventing, ameliorating or treating melanocortin-1 receptor-mediated or responsive diseases, indications, conditions and syndromes.
摘要翻译： 其中R1，R2，R3，R4，R5，R6，R7，R8和R9如说明书中所定义的黑皮质素受体特异性环肽，包括上述式的肽的组合物和制剂或其盐，以及方法 预防，改善或治疗黑皮质素-1受体介导或反应性疾病，适应症，病症和综合征。
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公开(公告)号：US20130012432A1
公开(公告)日：2013-01-10
申请号：US13580042
申请日：2011-02-28
申请人： Kilian Waldemar Conde-Frieboes , Jane Spetzler , Ulrich Sensfuss , Birgitte Schjellerup Wulff , Henning Thoegersen , Jens Christian Norrild
发明人： Kilian Waldemar Conde-Frieboes , Jane Spetzler , Ulrich Sensfuss , Birgitte Schjellerup Wulff , Henning Thoegersen , Jens Christian Norrild
IPC分类号： A61K38/12 , A61P3/10 , A61P3/04 , A61P3/00 , A61P35/00 , A61P15/00 , A61P9/12 , A61P1/16 , A61P19/08 , A61P19/02 , A61P29/00 , A61P37/06 , C07K7/56 , A61P9/00
CPC分类号： C07K14/68
摘要： The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.
摘要翻译： 本发明涉及有效调节一种或多种黑皮质素受体类型的新型肽化合物，治疗中化合物的用途，包括向有需要的患者施用化合物的治疗方法，以及使用 药物制造中的化合物。 本发明的化合物在治疗肥胖以及与肥胖相关的各种疾病或病症方面特别有意义。
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148.发明授权公开(公告)号：US07935786B2
公开(公告)日：2011-05-03
申请号：US11807159
申请日：2007-05-25
申请人： Bjarne Due Larsen
发明人： Bjarne Due Larsen
IPC分类号： C07K14/00
CPC分类号： C07K14/665 , A61K38/00 , A61K47/64 , A61K47/65 , A61K47/67 , B82Y5/00 , C07K1/1075 , C07K14/575 , C07K14/57545 , C07K14/675 , C07K14/68 , C07K14/685 , C07K14/695 , C07K2319/31
摘要： The invention is directed to a pharmacologically active peptide conjugate having a reduced tendency towards enzymatic cleavage comprising a pharmacologically active peptide sequence (X) and a stabilising peptide sequence (Z) of 4-20 amino acid residues covalently bound to X.
摘要翻译： 本发明涉及具有减少的酶切割趋势的药理学活性肽缀合物，其包含与X共价结合的4-20个氨基酸残基的药理学活性肽序列（X）和稳定肽序列（Z）。
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149.发明申请公开(公告)号：US20090186020A1
公开(公告)日：2009-07-23
申请号：US11929046
申请日：2007-10-30
CPC分类号： A61K38/34 , A61K47/6811 , C07H21/04 , C07K14/68 , C07K16/00 , C07K2317/56 , C07K2317/64 , C07K2318/10 , C07K2319/00
摘要： Melanocortin receptor binding mimetibody polypeptides are disclosed. Polynucleotides encoding these polypeptides, cells comprising these polynucleotides or expressing the mimetibodies, and methods of making and using the forgoing are also disclosed.
摘要翻译： 公开了黑皮质素受体结合模拟体多肽。 还公开了编码这些多肽的多核苷酸，包含这些多核苷酸的细胞或表达模拟物，以及制备和使用前述方法。
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公开(公告)号：US20080146779A1
公开(公告)日：2008-06-19
申请号：US11970722
申请日：2008-01-08
IPC分类号： C07K7/00
摘要： The present invention relates to novel chimeric peptides and templates containing a combination of antagonist and agonist endogenous ligand residues. In particular, the present invention relates to novel chimeric peptides and templates thereof based upon melanocortin agonist peptides and agouti related protein (AGRP). The present invention provides multifunctional chimeric peptides having specific bioactivity at melanocortin receptors and their use as drugs to treat various diseases and conditions.
摘要翻译： 本发明涉及包含拮抗剂和激动剂内源性配体残基的组合的新型嵌合肽和模板。 特别地，本发明涉及基于黑皮质素激动剂肽和agouti相关蛋白（AGRP）的新型嵌合肽及其模板。 本发明提供了在黑皮质素受体具有特异性生物活性的多功能嵌合肽及其用作治疗各种疾病和病症的药物。
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