公开(公告)号：US20220363619A1

公开(公告)日：2022-11-17

申请号：US17749293

申请日：2022-05-20

Applicant: NEONC Technologies, Inc.

Inventor： Thomas CHEN ,  Daniel LEVIN ,  Satish PUPPALI

IPC: C07C29/92 ,  C07C67/14 ,  C07C201/12 ,  A61K31/045 ,  C07C29/78 ,  C07C29/88 ,  C07C201/16 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/86

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

公开(公告)号：US11136285B2

公开(公告)日：2021-10-05

申请号：US16009396

申请日：2018-06-15

Applicant: Covestro Deutschland AG

Inventor： Thomas Knauf ,  Peter Drinda

IPC: B01J19/24 ,  B01J19/00 ,  C07C201/08 ,  C07C201/16 ,  B01J19/18

Abstract: The present invention relates to a process for the continuous production of nitrobenzene by the nitration of benzene with nitric acid and sulphuric acid under adiabatic conditions, not the entire production plant being shut down during a production stop, but the production plant being entirely or at least partly operated in recirculation mode. The invention further relates to a plant for producing nitrobenzene and to a method for operating a plant for producing nitrobenzene.

公开(公告)号：US20210292271A1

公开(公告)日：2021-09-23

申请号：US17258385

申请日：2019-07-03

Applicant: F.I.S. - Fabbrica Italiana Sintetici S.P.A. ,  AMGEN INC.

Inventor： Elena Brasola ,  Marco Di Silvestro

IPC: C07C205/12 ,  C07C201/16

Abstract: The present invention refers to a crystalline 2-fluoro-3-nitrotoluene compound of formula (I), and a process for the preparation thereof. Furthermore, the present invention relates to a process for the synthesis of a compound of formula (II) or salts thereof by means of the crystalline 2-fluoro-3-nitrotoluene.

公开(公告)号：US10745329B2

公开(公告)日：2020-08-18

申请号：US15742636

申请日：2016-07-08

Applicant: ARKEMA FRANCE ,  IFP ENERGIES NOUVELLES

Inventor： Ludivine Bouvier ,  Catherine Laroche ,  Julien Grandjean

IPC: B01J20/04 ,  B01J20/16 ,  B01J20/18 ,  B01J20/30 ,  C07C7/13 ,  C07C15/08 ,  C07C29/76 ,  C07C37/82 ,  C07C201/16 ,  C07C209/86 ,  C07C205/06 ,  C07C211/50

Abstract: The present invention relates to zeolite adsorbents based on agglomerated zeolite X crystals comprising barium, potassium and sodium. These adsorbents find applications in the separation of aromatic C8 isomer fractions and especially xylene.

公开(公告)号：US10457618B2

公开(公告)日：2019-10-29

申请号：US15220135

申请日：2016-07-26

Applicant: NEONC Technologies, Inc.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Puppali

IPC: C07C29/92 ,  A61K31/045 ,  C07C67/14 ,  C07C201/12 ,  C07C29/78 ,  C07C29/88 ,  C07C201/16 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/86

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

公开(公告)号：US10155719B2

公开(公告)日：2018-12-18

申请号：US15735014

申请日：2015-06-12

Applicant: NORAM International Limited ,  Steven D. Buchi ,  Alfred A. Guenkel

Inventor： Steven D. Buchi ,  Alfred A. Guenkel

IPC: C07C201/16 ,  C07C205/06 ,  C01C1/10 ,  C07C205/17 ,  C02F1/20 ,  C02F3/02 ,  C02F1/34 ,  C02F101/34 ,  C02F101/38 ,  C02F103/36

Abstract: A process for removing impurities from crude nitrated aromatic products obtained during the nitration of aromatic compounds. The nitrated aromatic products are purified by treatment with ammonia washing followed by caustic washing. The nitrophenolic-containing wash waters are treated to recover dissolved organics and ammonia, and the stripped ammonia-wash effluent is incinerated. Carbon dioxide, which can accumulate in the process, is purged to the caustic washer.

公开(公告)号：US10125088B2

公开(公告)日：2018-11-13

申请号：US15645055

申请日：2017-07-10

Applicant: Josef Meissner GmbH & Co. KG

Inventor： Jürgen Pöhlmann ,  Heinrich Hermann ,  Mirko Händel ,  Jürgen Gebauer ,  Tim Bergmann

IPC: C07C201/16 ,  B01J19/24 ,  B01D11/04 ,  B01D19/00

Abstract: The present invention relates to a method for purifying raw dinitrotoluenes resulting from dinitration of toluene in the presence of a nitric acid/sulfuric acid/nitrating acid mixture, and a device or plant for performing the method, and a corresponding production plant for producing dinitrotoluene, characterized in that (a) the raw dinitrotoluenes are first subjected to a wash with at least one washing medium after separation of the nitrating acid mixture, followed by a separation of the washing medium; and that (b) subsequently the washed dinitrotoluenes resulting from method step (a) are subjected to stripping (stripping gas treatment) with at least one gas (stripping gas).

公开(公告)号：US20170305835A1

公开(公告)日：2017-10-26

申请号：US15645055

申请日：2017-07-10

Applicant: Josef Meissner GmbH & Co. KG

Inventor： Dr. Jürgen PÖHLMANN ,  Dr. Heinrich HERMANN ,  Dr. Mirko HÄNDEL ,  Jürgen GEBAUER ,  Tim BERGMANN

IPC: C07C201/16 ,  B01D11/04 ,  B01J19/24 ,  B01D19/00

CPC classification number: C07C201/16 ,  B01D11/0488 ,  B01D19/0005 ,  B01J19/24 ,  B01J2219/24 ,  Y02P20/582 ,  C07C205/06

Abstract: The present invention relates to a method for purifying raw dinitrotoluenes resulting from dinitration of toluene in the presence of a nitric acid/sulfuric acid/nitrating acid mixture, and a device or plant for performing the method, and a corresponding production plant for producing dinitrotoluene, characterized in that (a) the raw dinitrotoluenes are first subjected to a wash with at least one washing medium after separation of the nitrating acid mixture, followed by a separation of the washing medium; and that (b) subsequently the washed dinitrotoluenes resulting from method step (a) are subjected to stripping (stripping gas treatment) with at least one gas (stripping gas).

公开(公告)号：US20170152210A1

公开(公告)日：2017-06-01

申请号：US15320807

申请日：2015-06-22

Applicant: COVESTRO DEUTSCHLAND AG

Inventor： Thomas KNAUF ,  Peter DRINDA ,  Stefan WERSHOFEN ,  Klaus-Gerd GRUNER ,  Volker HARTJES

IPC: C07C201/08 ,  B01J19/24 ,  C07C201/16

CPC classification number: C07C201/08 ,  B01J19/24 ,  B01J2208/00637 ,  B01J2208/00646 ,  B01J2208/00716 ,  B01J2219/00033 ,  B01J2219/24 ,  C07C201/16 ,  C07C205/06

Abstract: This invention relates to methods for producing chemical products, wherein the one or more feed materials are reacted to form a chemical product or a chemical composition. The invention further relates to plants for performing such methods, said plants being designed in such a way that, during an interruption of the methods, no input of at least one feed material into the reaction occurs and the plant parts not affected by a revision measure, maintenance measure, repair measure, or cleaning measure are operated in so-called re-circulation mode. It is thereby achieved, among other things, that only the affected plant part needs to be shut down for the time of the measure, which can be advantageous with regard to the productivity and economy of the method and the quality of the produced products. Finally, the invention relates to methods for operating plants in the event that individual plant parts are taken out of service.

公开(公告)号：US09428441B2

公开(公告)日：2016-08-30

申请号：US14916210

申请日：2014-09-01

Applicant: BASF SE

Inventor： Yuan Shen Dai ,  Katharina Spuhl ,  Renate Hempel

IPC: C07C205/00 ,  C07C201/16 ,  C07C201/08 ,  C07C205/06

CPC classification number: C07C201/16 ,  C07C201/08 ,  C07C205/06

Abstract: A process for the preparation of dintrotoluene which comprises (a) nitrating toluene with a nitrating acid, wherein said nitrating acid is a mixture of nitric acid and sulfuric acid, in one or more nitration steps, and separating the nitrating acid from the process stream thus formed, wherein a crude mixture comprising dinitrotoluene and a fraction of said nitrating acid dissolved therein is obtained, said crude mixture further comprising at least 50 ppm of HCN, and (b) washing the crude dinitrotoluene containing mixture in one or more washing steps, wherein, before the first washing step is carried out, the crude mixture is distilled and/or stripped to remove HCN therefrom, wherein a crude dinitrotoluene containing mixture which is essentially free of HCN is obtained.

Abstract translation: 一种制备二苯并芴的方法，其包括（a）在一个或多个硝化步骤中将硝酸与硝酸反应，其中所述硝酸是硝酸和硫酸的混合物，并将硝酸与工艺流分离，因此 形成，其中获得包含二硝基甲苯和所述硝酸的一部分溶解在其中的粗混合物，所述粗混合物还包含至少50ppm的HCN，和（b）在一个或多个洗涤步骤中洗涤含有二硝基甲苯的粗混合物，其中 ，在进行第一洗涤步骤之前，将粗混合物蒸馏和/或汽提以从其中除去HCN，其中获得基本上不含HCN的粗二硝基甲苯混合物。