公开(公告)号：US10806329B2

公开(公告)日：2020-10-20

申请号：US15879340

申请日：2018-01-24

Applicant: Canon U.S.A., Inc.

Inventor： Badr Elmaanaoui ,  Tzu-Yu Wu

IPC: A61B1/00 ,  A61B1/07 ,  G02B23/24 ,  A61B5/00 ,  G02B13/00

Abstract: Some embodiments of a device comprise a sheath, a first light-guiding component, a second light-guiding component, an optical-focusing component, and an optical-correction component. The second light-guiding component and the optical-focusing component are aligned on an optical axis. Also, the optical-correction component does not directly contact the optical-focusing component, and the optical-correction component is not positioned on the optical axis.

公开(公告)号：US20200264055A1

公开(公告)日：2020-08-20

申请号：US16820255

申请日：2020-03-16

Applicant: Canon U.S.A., Inc.

Inventor： Fernando DeCastro ,  Renee Howell ,  Sami Kanderian ,  Johnathan S. Coursey ,  Kenton C. Hasson ,  Scott Sundberg

IPC: G01K11/06 ,  G01K15/00 ,  B01L7/00 ,  B01L3/00 ,  C12Q1/6806

Abstract: The present invention relates to the use of one or more amplicons as temperature calibrators. In some embodiments, the calibrators may be used to calibrate the temperature of a microfluidic channel in which amplification and/or melt analysis is performed. In some embodiments, the amplicons may be genomic, ultra conserved elements and/or synthetic. The amplicon(s) may have a known or expected melt temperature(s). The calibrators may be added to primers of study or may follow or lead the primers of study in the channel. The amplicon(s) may be amplified and melted, and the temperature(s) at which the amplicon(s) melted may be determined. The measured temperature(s) may be compared to the known temperature(s) at which the amplicon(s) was expected to melt. The difference(s) between the measured and expected temperatures may be used to calibrate/adjust one or more temperature control elements used to control and/or detect the temperature of the channel.

公开(公告)号：US10743749B2

公开(公告)日：2020-08-18

申请号：US16131662

申请日：2018-09-14

Applicant: Canon U.S.A., Inc.

Inventor： Daisuke Yamada

IPC: A61B1/00 ,  G02B6/38 ,  A61B1/07 ,  A61B5/00

Abstract: A catheter system includes an electronic console; a catheter having a proximal end attachable to the console and a distal end configured to house therein an optical probe; an optical fiber configured to transmit from the console to the optical probe excitation radiation of a first wavelength, and configured to return to the console an optical response signal having a second wavelength longer than the first wavelength; a detector configured to detect intensity of the optical response signal; and a processor configured to determine, based on the detected intensity of the optical response signal, whether the catheter is properly connected to the console. The optical response signal is generated within the optical fiber itself in response to transmitting the excitation radiation therethrough. The optical response signal is an auto-fluorescence signal and/or Raman scattering signal generated from the optical fiber itself.

公开(公告)号：US20200253575A1

公开(公告)日：2020-08-13

申请号：US16863420

申请日：2020-04-30

Applicant: CANON U.S.A., INC.

Inventor： Mie Kunio

IPC: A61B6/00 ,  G06T7/30 ,  G06T7/20 ,  A61B90/00 ,  G06T7/12 ,  G06K9/34 ,  G06K9/46 ,  G06T7/00

Abstract: A method for processing angiography image data by using an imaging catheter path that is directly detected from the angiography data as a co-registration path or using detected marker locations from the angiography data to generate a co-registration path. If the acquired angiography data includes synchronized cardiac phase signals and a predetermined quantity of angiography image frames not including contrast media, then a directly detected imaging catheter path is used as the co-registration path. Otherwise the co-registration path is determined based upon detected marker locations from the angiography image data.

公开(公告)号：US10732400B2

公开(公告)日：2020-08-04

申请号：US16509292

申请日：2019-07-11

Applicant: Canon U.S.A., Inc. ,  The General Hospital Corporation

Inventor： Mitsuhiro Ikuta ,  Dongkyun Kang ,  Dukho Do ,  Guillermo Tearney

IPC: G02B23/24 ,  A61B1/00 ,  A61B1/06 ,  A61B1/07 ,  G02B27/42 ,  H04N5/225

Abstract: A spectrally encoded endoscopic probe. The probe has a light guiding component, a light focusing component, and a grating component. The probe is configured such that a set of light beams of multiple wavelengths are diffracted by the grating component in different orders at substantially the same angle. The set of light beams includes at least 3 light beams. Each light beam among the set of light beams is associated with a different wavelength.

公开(公告)号：US10674985B2

公开(公告)日：2020-06-09

申请号：US16044881

申请日：2018-07-25

Applicant: CANON U.S.A., INC.

Inventor： Mie Kunio

IPC: G06K9/00 ,  A61B6/00 ,  G06T7/30 ,  G06T7/20 ,  A61B90/00 ,  G06T7/12 ,  G06K9/34 ,  G06K9/46 ,  G06T7/00 ,  G06T7/181 ,  G06T7/11 ,  G06K9/44

Abstract: A method for processing angiography image data by using an imaging catheter path that is directly detected from the angiography data as a co-registration path or using detected marker locations from the angiography data to generate a co-registration path. If the acquired angiography data includes synchronized cardiac phase signals and a predetermined quantity of angiography image frames not including contrast media, then a directly detected imaging catheter path is used as the co-registration path. Otherwise the co-registration path is determined based upon detected marker locations from the angiography image data.

公开(公告)号：US10670511B2

公开(公告)日：2020-06-02

申请号：US16520134

申请日：2019-07-23

Applicant: Canon U.S.A., Inc. ,  University of Maryland, College Park

Inventor： Giuliano Scarcelli ,  Jitao Zhang ,  Antonio Fiore ,  Hanyoup Kim

IPC: G01N21/00 ,  G01N15/14 ,  G01N15/00 ,  G01N21/63 ,  G01N15/10

Abstract: The present invention relates to a method and system for a label-free cell analysis based on Brillouin light scattering techniques. Combined with microfluidic technologies according to the present invention, Brillouin spectroscopy constitutes a powerful tool to analyze physical properties of cells in a contactless non-disturbing manner. Specifically, subcellular mechanical information can be obtained by analyzing the Brillouin spectrum of a cell. Furthermore, a novel configuration of Brillouin spectroscopy is provided to enable simultaneous analysis of multiple points in a cell sample.

公开(公告)号：US10598594B2

公开(公告)日：2020-03-24

申请号：US15909699

申请日：2018-03-01

Applicant: University of Maryland, College Park ,  Canon U.S.A., Inc.

Inventor： Giuliano Scarcelli ,  Jitao Zhang ,  Hanyoup Kim

IPC: G01N21/00 ,  G01N21/63 ,  G01N15/14 ,  H01S3/30 ,  G01N15/10

Abstract: The present invention relates to a method and system for identifying mechanical properties of a cell nucleus through a label-free cell analysis based on Brillouin light scattering techniques. The present application additionally provides a method and system for identifying cancerous cells based on mechanical properties of the cell nucleus.

公开(公告)号：US10578422B2

公开(公告)日：2020-03-03

申请号：US15617928

申请日：2017-06-08

Applicant: Canon U.S.A. Inc. ,  The General Hospital Corporation

Inventor： Daisuke Yamada ,  Guillermo J Tearney

IPC: G01B9/02 ,  A61B5/00

Abstract: One or more devices, systems, methods and storage mediums for performing continuously, full range optical coherence tomography (OCT) without losing A-lines are provided. Examples of such applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for cardio and/or ophthalmic applications, and being obtained via one or more optical instruments, such as, but not limited to, optical probes (e.g., common path probes), catheters, endoscopes, phase shift units (e.g., galvanometer scanner) and bench top systems. Preferably, the OCT devices, systems methods and storage mediums include or involve a phase shift device including at least a galvanometer scanner. The galvanometer scanner is preferably applied with or to a voltage with a triangle shape, the voltage having continuity or absolute constant frequency to obtain continuous images without losing any A-lines. The method(s) may include background subtraction, image shifting to compensate phase shifts and a DC noise reduction algorism.

公开(公告)号：US20200054378A1

公开(公告)日：2020-02-20

申请号：US16539769

申请日：2019-08-13

Applicant: Canon U.S.A., Inc.

Inventor： Matthew Michael Kincaid ,  Derek John Hugger ,  Barret Daniels ,  Takahisa Kato ,  Brian Ninni ,  John E. Longan

IPC: A61B18/02 ,  A61B90/00 ,  A61B34/10 ,  A61B6/03

Abstract: A medical guidance apparatus (100) includes a base assembly (110) configured to be attached to a subject and a guide (150) configured to be removably mated with the base assembly (110). The base assembly (110) has an opening (160), and the guide (150) includes a rotatable ring (152) and an arc member (154). The arc member (154) includes a first end (162) and a second end (164), the first end of the arc member is connected to the rotatable ring (152) and the second end extends diametrically opposite to the first end across the rotatable ring. A probe holder (600) is mounted on the arc member (154) so as to hold a needle-like instrument (2161) at a desired angle relative to an axis (Ax) of the rotatable ring (152). In some embodiments, the arc member is monolithically integrated with the rotatable ring. In other embodiments, the arc member is pivotable and/or completely removable from the rotating ring.