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公开(公告)号：US20210277443A1
公开(公告)日：2021-09-09
申请号：US16755190
申请日：2018-09-13
Inventor： Yoon-Keun KIM , Pyung Lim HAN , Jin-young PARK
IPC: C12Q1/686 , C12Q1/6869 , C12N15/10
Abstract: The present invention relates to a method of diagnosing Alzheimer's dementia by bacterial metagenomic analysis, and more particularly, to a method of diagnosing Alzheimer's dementia and mild cognitive impairment by analyzing an increase or decrease in contents of specific bacterial extracellular vesicles by performing bacterial metagenomic analysis using normal person and subject-derived samples. The extracellular vesicles secreted from bacteria present in the environment are absorbed into the body and penetrate into brain tissue to have a direct influence on a cognitive function such as Alzheimer's dementia, and since Alzheimer's dementia is difficult to be diagnosed early before symptoms are shown, effective treatment is difficult. Therefore, by previously predicting the risk of the onset of mild cognitive impairment and Alzheimer's dementia through metagenomic analysis of bacterial extracellular vesicles using a human-derived sample according to the present invention, an Alzheimer's dementia risk group may be diagnosed and predicted early to delay the time of onset or prevent the onset of Alzheimer's dementia with proper cure, and after the onset of the disease, early diagnosis may be performed, thereby reducing the incidence of Alzheimer's dementia and increasing a therapeutic effect.
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公开(公告)号：US20210214324A1
公开(公告)日：2021-07-15
申请号：US17059754
申请日：2019-05-30
Inventor： Kong Joo Lee , Hee-Yoon Lee , Je Jin Lee , Hwang Suk Kim , Ji-wan Seo , Hongsoo Lee , Ji Soo Shin , Bo-kyung Kim
IPC: C07D303/18 , C07C35/21 , C07C43/23 , C07C235/56 , A23L33/10 , A61P35/04
Abstract: The present disclosure provides a novel biphenyl derivative compound or a pharmaceutically acceptable salt thereof. The biphenyl derivative compound or pharmaceutically acceptable salt thereof according to the present disclosure is a compound that increases Nm23-H1/NDPK activity and can inhibit cancer metastasis and growth. Thus, it exhibits excellent effects not only on the prevention, alleviation and treatment of cancer, but also on the suppression of cancer metastasis.
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公开(公告)号：US20210113144A1
公开(公告)日：2021-04-22
申请号：US17096135
申请日：2020-11-12
Inventor： In Kyoon LYOO , Han Byul CHO , Ga Hae HONG
Abstract: Provided is a method and apparatus for predicting a posttraumatic behavior problem that may predict a posttraumatic violent behavior problem of an individual, in detail, that may determine a biological phenotype of an individual experiencing a traumatic event within a predetermined period after the individual is exposed to the traumatic event, predict a violent symptom presentation probability of the individual based on the biological phenotype of the individual, and suggest an objective basis for preventive intervention in a development of posttraumatic stress disorder (PTSD) of the individual based on a prediction result.
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154.发明申请公开(公告)号：US20200321528A1
公开(公告)日：2020-10-08
申请号：US16304061
申请日：2018-03-09
Inventor： Sang Wook LEE , Dong Hoon SHIN
IPC: H01L51/00 , C01B32/194 , H01L21/322
Abstract: Provided are a method for manufacturing an electronic device capable of efficiently utilizing a material and a method for removing impurities using the same. The method for manufacturing an electronic device comprises the steps of: placing a transfer film on a plurality of functional layers which are positioned apart from each other on a source substrate; bringing a first transfer target into close contact with the lower surface of the transfer film by applying pressure to a portion of the transfer film that corresponds to the first transfer target from among the plurality of functional layers by using a probe; separating the transfer film from the source substrate in a state in which the first transfer target is in close contact with the lower surface; placing the transfer film on a target substrate in the state in which the first transfer target is in close contact with the lower surface; placing the first transfer target on the target substrate by applying pressure to a portion of the transfer film that corresponds to the first transfer target; and separating the transfer film from the target substrate in a state in which the first transfer target is positioned on the target surface.
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公开(公告)号：US20200256974A1
公开(公告)日：2020-08-13
申请号：US16699561
申请日：2019-11-30
Inventor： Jeong Tae KIM , Tae Hyeong HA
Abstract: Disclosed is an apparatus for tracking an object based on radar image reconstruction, the apparatus including a two-dimensional image producing unit configured to produce a two-dimensional image by collecting multiple one-dimensional radar signals from which clutter is removed, an object detecting unit configured to determine the presence or absence of an object from the two-dimensional image and estimate a two-dimensional position of the present object, and an object tracking unit configured to track a movement path of the object based on the two-dimensional position estimated by the object detecting unit.
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Patent Agency Ranking
公开(公告)号：US10732160B2
公开(公告)日：2020-08-04
申请号：US15900224
申请日：2018-02-20
Applicant: Ewha University—Industry Collaboration Foundation , Korea University Research and Business Foundation
Inventor： Ah Jeong Son , Beelee Chua , Hyun Jeong Lim
Abstract: The present invention relates to a portable analyzer for detecting bisphenol A, which comprises an aptamer specifically binding to bisphenol A, and a method for detecting bisphenol A using the same. The analyzer of the present invention can analyze a small amount of a sample collected from a contaminated environment in a field at a level similar to a laboratory environment, thereby having an effect of enabling a more immediate and accurate detection and quantification of bisphenol A.
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157.发明授权公开(公告)号：US10714479B2
公开(公告)日：2020-07-14
申请号：US16127442
申请日：2018-09-11
Applicant: Gachon University of Industry—Academic cooperation Foundation , Ewha University—Industry Collaboration Foundation
Inventor： Seongjae Cho , Hyungsoon Shin
IPC: H01L27/108 , H01L29/78 , H01L29/04 , H01L29/16 , H01L21/02 , H01L21/308 , H01L29/66 , H01L21/3213 , H01L21/265 , H01L29/08 , H01L29/06
Abstract: The present invention provides a polysilicon-based 1T DRAM cell device having a FinFET structure and its fabrication method. In the present invention, a semiconductor layer (for example, a polysilicon layer) having a relatively low crystallinity is intentionally formed on the upper layer of the active fin to physically trap the holes accumulated in the conventional cell body, thereby remarkably improving the retention time. A polysilicon-based 1T DRAM cell device having a FinFET structure can also increase the operating efficiency by raising the gate's channel control force and implement the batch process with the functional blocks in the CPU that already have the FinFET structure.
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公开(公告)号：US10703812B2
公开(公告)日：2020-07-07
申请号：US15382277
申请日：2016-12-16
Inventor： Kyunglim Lee , Dong Hae Shin , Mi-Sun Kim , Mi Young Kim , Jeehye Maeng , Hee-Won Lee
IPC: A61K38/16 , C07K16/24 , A61K39/395 , C07K14/47 , A61K38/19 , A61P27/14 , C07K14/52 , A61K9/14 , A61K9/20 , A61K9/48 , A61K39/00
Abstract: The present invention relates to a receptor-binding domain of an IgE-dependent histamine releasing factor (HRF), and a use thereof, and more specifically, ascertains, as an HRF structural region, and a FL domain and an H2 domain which bind to a receptor of HRF existing in a cell membrane, ascertains the C-terminus domain of the HRF, and ascertains that a material binding thereto inhibits IL-8 secretion, thereby determining that the FL and H2 domains and the C-terminus domain can be utilized in: the development of a therapeutic agent for treatment and prevention of HRF-related disease including allergic diseases such as asthma, bronchitis, chronic obstructive pulmonary disease, bronchiectasis, rhinitis, atopic dermatitis, hives (urticaria), hay fever, conjunctivitis, and anaphylaxis; inflammatory diseases such as bronchitis, pneumonia, arthritis, nephritis, psoriasis, dermatitis, Crohn's disease, enteritis, gingivitis, arteriosclerosis, coronary arteritis, hepatitis, Behcet's disease, bladder cancer, prostatitis, pyelonephritis, glomerulonephritis, osteomyelitis, thyroiditis, uveitis, abdominal cavity inflammation, meningitis, pulmonary fibrosis and rheumatoid arthritis; and malaria, and a method for screening for the HRF-related diseases.
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公开(公告)号：US20200166466A1
公开(公告)日：2020-05-28
申请号：US16689123
申请日：2019-11-20
Inventor： Jerome Kartham HYUN , Syazwani MOHD NOOR , Han-Sol JANG , Jin-Ho CHOY
IPC: G01N21/81
Abstract: The present disclosure relates to a colorimetric humidity sensor and a method of preparing the same, and in the colorimetric humidity sensor that is an ultrafast colorimetric humidity sensor including a colorimetric member including humidity-responsive particles configured in a disordered monolayer arrangement on a substrate, the humidity-responsive particles are amorphous, porous, and polydispersed microspheres, and the colorimetric humidity sensor indicates a color change according to humidity upon light irradiation.
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160.发明授权公开(公告)号：US10418129B2
公开(公告)日：2019-09-17
申请号：US15531213
申请日：2015-11-26
Inventor： Wan Kyu Kim , Yea Jee Kwon , Hae Seung Lee
Abstract: The present invention relates to a virtual drug screening method with high prediction accuracy based on various biological activities extracted from multiple drug screening data, without using structures or structural attribute information of target proteins or compounds; an intensive screening library constructing method; and a system therefor.
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