公开(公告)号：US11939308B2

公开(公告)日：2024-03-26

申请号：US17059754

申请日：2019-05-30

Applicant: EWHA UNIVERSITY—INDUSTRY COLLABORATION FOUNDATION

Inventor： Kong Joo Lee ,  Hee-Yoon Lee ,  Je Jin Lee ,  Hwang Suk Kim ,  Ji-Wan Seo ,  Hongsoo Lee ,  Ji Soo Shin ,  Bo-kyung Kim

IPC: C07D303/18 ,  A23L33/10 ,  A61P35/04 ,  C07C35/21 ,  C07C43/23 ,  C07C235/56

CPC classification number: C07D303/18 ,  A23L33/10 ,  A61P35/04 ,  C07C35/21 ,  C07C43/23 ,  C07C235/56

Abstract: The present disclosure provides a novel biphenyl derivative compound or a pharmaceutically acceptable salt thereof. The biphenyl derivative compound or pharmaceutically acceptable salt thereof according to the present disclosure is a compound that increases Nm23-H1/NDPK activity and can inhibit cancer metastasis and growth. Thus, it exhibits excellent effects not only on the prevention, alleviation and treatment of cancer, but also on the suppression of cancer metastasis.

公开(公告)号：US20240324447A1

公开(公告)日：2024-09-26

申请号：US18609445

申请日：2024-03-19

Applicant: Samsung Electronics Co., Ltd. ,  Ewha University - Industry Collaboration Foundation

Inventor： Hwang Suk Kim ,  Youngmin You ,  Chung Thanh PHAM ,  Sreenivas AVULA ,  Joonghyuk Kim ,  Yongsik Jung ,  Hyeonho Choi

IPC: H10K85/30 ,  C07F1/00 ,  C09K11/06 ,  H10K50/12

CPC classification number: H10K85/371 ,  C07F1/00 ,  C09K11/06 ,  C09K2211/1059 ,  C09K2211/188 ,  H10K50/121

Abstract: An organometallic compound represented by Formula 1:




wherein X1 is N or C(R1), and X2 is N or C(R2); at least one of X1 and X2 is N; Y1 is a single bond, O, S, Se, N(R3), C(R3)(R4), Si(R3)(R4), Ge(R3)(R4), B(R3), P(R3), P(═O)(R3), S(═O)2, or C(═O); n1 is 0, 1, or 2; A1 and A2 are each independently a C5-C30 carbocyclic group or a C1-C30 heterocyclic group; wherein the remaining substituent groups are as defined herein.

公开(公告)号：US20210206706A1

公开(公告)日：2021-07-08

申请号：US17059762

申请日：2019-05-30

Applicant: EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION

Inventor： Kong Joo Lee ,  Hee-Yoon Lee ,  Je Jin Lee ,  Hongsoo Lee ,  Ji-wan Seo ,  Hwang Suk Kim ,  Bo-kyung Kim ,  Ji Soo Shin

IPC: C07C43/23 ,  C07C49/175 ,  A61K31/337 ,  A61K31/12 ,  A61K31/09 ,  A61P35/00 ,  A61K9/00 ,  A23L33/00 ,  A23L33/10

Abstract: The present disclosure provides a novel biphenyl derivative compound, an optical isomer thereof or a pharmaceutically acceptable salt thereof. The biphenyl derivative compound, optical isomer thereof or pharmaceutically acceptable salt thereof according to the present disclosure may induce cancer cell death by damaging mitochondria and inducing ATP depletion in cells which are in a nutrient-starved state such as a glucose-starved state, which is the normal environment of cancer cells. In addition, it is an Nm23-H1/NDPK activity-increasing substance that may suppress cancer metastasis and growth. Thus, it exhibits excellent effects not only on the prevention, alleviation and treatment of cancer, but also on the suppression of cancer metastasis.

公开(公告)号：US12043594B2

公开(公告)日：2024-07-23

申请号：US17059762

申请日：2019-05-30

Applicant: EWHA UNIVERSITY—INDUSTRY COLLABORATION FOUNDATION

Inventor： Kong Joo Lee ,  Hee-Yoon Lee ,  Je Jin Lee ,  Hongsoo Lee ,  Ji-wan Seo ,  Hwang Suk Kim ,  Bo-kyung Kim ,  Ji Soo Shin

IPC: C07C43/23 ,  A23L33/00 ,  A23L33/10 ,  A61K9/00 ,  A61K31/09 ,  A61K31/12 ,  A61K31/337 ,  A61P35/00 ,  C07C49/175

CPC classification number: C07C43/23 ,  A23L33/10 ,  A23L33/40 ,  A61K9/0056 ,  A61K31/09 ,  A61K31/12 ,  A61K31/337 ,  A61P35/00 ,  C07C49/175 ,  A23V2002/00

Abstract: The present disclosure provides a novel biphenyl derivative compound, an optical isomer thereof or a pharmaceutically acceptable salt thereof. The biphenyl derivative compound, optical isomer thereof or pharmaceutically acceptable salt thereof according to the present disclosure may induce cancer cell death by damaging mitochondria and inducing ATP depletion in cells which are in a nutrient-starved state such as a glucose-starved state, which is the normal environment of cancer cells. In addition, it is an Nm23-H1/NDPK activity-increasing substance that may suppress cancer metastasis and growth. Thus, it exhibits excellent effects not only on the prevention, alleviation and treatment of cancer, but also on the suppression of cancer metastasis.

公开(公告)号：US20210214324A1

公开(公告)日：2021-07-15

申请号：US17059754

申请日：2019-05-30

Applicant: EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION

Inventor： Kong Joo Lee ,  Hee-Yoon Lee ,  Je Jin Lee ,  Hwang Suk Kim ,  Ji-wan Seo ,  Hongsoo Lee ,  Ji Soo Shin ,  Bo-kyung Kim

IPC: C07D303/18 ,  C07C35/21 ,  C07C43/23 ,  C07C235/56 ,  A23L33/10 ,  A61P35/04

Abstract: The present disclosure provides a novel biphenyl derivative compound or a pharmaceutically acceptable salt thereof. The biphenyl derivative compound or pharmaceutically acceptable salt thereof according to the present disclosure is a compound that increases Nm23-H1/NDPK activity and can inhibit cancer metastasis and growth. Thus, it exhibits excellent effects not only on the prevention, alleviation and treatment of cancer, but also on the suppression of cancer metastasis.